Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase

Biotechnology Letters

Volumn 28, Issue 20, 2006, Pages 1633-1636

  Chidananda, C ^a   Rao, L Jagan Mohan ^a   Sattur, A P ^a  

^a CENTRAL FOOD TECHNOLOGICAL RESEARCH INSTITUTE   (India)

Author keywords

Aldose reductase; Diabetes; Hyperglycemia; Inhibitor; Penicillium frequentans; Sclerotiorin

Indexed keywords

ALDOSE REDUCTASE; DIABETES; HYPERGLYCEMIA; PENICILLIUM FREQUENTANS; SCLEROTIORIN;

DISEASES; ENZYMES; FERMENTATION;

ENZYME INHIBITION;

ALDEHYDE REDUCTASE; ANTIINFECTIVE AGENT; BENZOPYRAN DERIVATIVE; SCLEROTIORIN;

ANIMAL; ARTICLE; BACILLUS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; LENS; PENICILLIUM; RAT;

ALDEHYDE REDUCTASE; ANIMALS; ANTI-BACTERIAL AGENTS; BACILLUS; BENZOPYRANS; LENS, CRYSTALLINE; PENICILLIUM; RATS;

PENICILLIUM; PENICILLIUM GLABRUM;

EID: 33748528109     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-006-9133-4     Document Type: Article

References (12)

1. Arai N, Shiomi K, Tomoda H, Tabata N, Yang DJ, Masuma R, Kawakubo T, Omura S (1995) Isochromophilones III-VI, inhibitors of acyl-CoA: cholesterol acyltransferase produced by Penicillium multicolor FO-3216. J Antibiot 48:696-702
2. 5Cl, a chlorine-containing metabolic product of Penicillium sclerotiorum van Beyma. Biochem J 34:1419-1421
3. Fujimoto H., Matsudo T, Yamaguchi A, Yamazaki M (1990) Two new fungal azaphilones from Talaromyces luteus, with monoamine oxidase inhibitory effect. Heterocycles 30:607-616
4. Kador PE (1998) The role of aldose reductase in the development of diabetic complications. Med Res Rev 8:325-352
5. Kador PE, Robinson WG, Kinoshita JH (1985) The pharmacology of aldose reductase inhibitors. Ann Rev Pharmacol Toxicol 25:691-714
6. Kim HY, Oh JH (1999) Screening of Korean forest plants for rat lens aldose reductase inhibition. Biosci Biotechnol Biochem 63:184-188
7. Omura S, Tanaka H, Matsuzaki K, Ikeda H, Masuma R (1993) Isochromophilones I and II, novel inhibitors against gp120-CD4 binding from Penicillium sp. J Antibiot 46:1908-1911
8. Owais M, Sharad KS, Shehbaz A, Saleemuddin M (2005) Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine Salmonellosis. Phytomedicine 12:229-235
9. Pairet L, Wrigley SK, Chetland I, Reynolds EE, Hayes MA, Holloway J, Ainsworth AM, Katzer W, Cheng X-M, Hupe DJ, Charlton P, Doherty AM (1995) Azaphilones with endothelin receptor binding activity produced by Penicillium sclerotiorum: taxonomy, fermentation, isolation, structural elucidation and biological activity. J Antibiot 48:913-923
10. Rao KCS, Divakar S, Babu KN, Karanth NG, Sattur AP (2002) Nigerloxin, a novel inhibitor of aldose reductase and lipoxygenase with free radical scavenging activity from Aspergillus niger CFR-W-105. J Antibiot 55:789-793
11. Rao KCS, Divakar S, Srinivas M, Babu KN, Karanth NG, Sattur AP (2003) Asperaldin, a new aldose reductase inhibitor from Aspergillus niger CFR-1046. J Antibiot 56:173-176
12. Tomoda H, Matsushima C, Tabata N, Namatame I, Tanaka H, Bamberger MJ, Arai H, Fukazawa M, Inoue K, Omura S (1999) Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones. J Antibiot 52:160-170