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1
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0037822263
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Pharmacology of airway inflammation in asthma and COPD
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Caramori G, Adcock I. Pharmacology of airway inflammation in asthma and COPD. Pulm Pharmacol Ther 2003; 16:247-277.
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(2003)
Pulm Pharmacol Ther
, vol.16
, pp. 247-277
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Caramori, G.1
Adcock, I.2
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2
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33748557909
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Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease
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NHLBI/WHO workshop report. Bethesda, Maryland: National Heart, Lung and Blood Institute
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Pauwels RA, Buist AS, Ma P, et al. and the GOLD Scientific Committee. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. NHLBI/WHO workshop report. NIH Publication no. 2701:1-100. Bethesda, Maryland: National Heart, Lung and Blood Institute. 2005. http://goldcopd.com/download. asp?intId=231 (Accessed 10 July 2006).
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(2005)
NIH Publication No. 2701
, pp. 1-100
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Pauwels, R.A.1
Buist, A.S.2
Ma, P.3
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3
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0141928029
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Chronic obstructive pulmonary disease: Molecular and cellular mechanisms
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Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J 2003; 22:672-688.
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(2003)
Eur Respir J
, vol.22
, pp. 672-688
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Barnes, P.J.1
Shapiro, S.D.2
Pauwels, R.A.3
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4
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28244497299
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Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations
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Mallia P, Johnston SL. Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations. Proc Am Thorac Soc 2005; 2:361-366.
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(2005)
Proc Am Thorac Soc
, vol.2
, pp. 361-366
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Mallia, P.1
Johnston, S.L.2
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5
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33745832657
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Progress in chronic obstructive pulmonary disease genetics
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Silverman EK. Progress in chronic obstructive pulmonary disease genetics. Proc Am Thorac Soc 2006; 3:405-408. An excellent review covering study design as well as much of the information regarding the early papers examining gene-environment interactions.
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(2006)
Proc Am Thorac Soc
, vol.3
, pp. 405-408
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Silverman, E.K.1
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7
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21744432715
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The protease inhibitor PI*S allele and COPD: A meta-analysis
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Dahl M, Hersh CP, Ly NP, et al. The protease inhibitor PI*S allele and COPD: a meta-analysis. Eur Respir J 2005; 26:67-76. A meta-analysis of α1-antitrypsin polymorphisms in COPD.
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(2005)
Eur Respir J
, vol.26
, pp. 67-76
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Dahl, M.1
Hersh, C.P.2
Ly, N.P.3
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8
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30344460320
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Matrix metalloproteinase-9 promoter polymorphism associated with upper lung dominant emphysema
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Ito I, Nagai S, Handa T, Muro S, et al. Matrix metalloproteinase-9 promoter polymorphism associated with upper lung dominant emphysema. Am J Respir Crit Care Med 2005; 172:1378-1382. This paper demonstrates that MMP9 is associated with a specific subtype of COPD - upper-lung emphysema - and emphasizes the need to phenotype patients carefully.
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(2005)
Am J Respir Crit Care Med
, vol.172
, pp. 1378-1382
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Ito, I.1
Nagai, S.2
Handa, T.3
Muro, S.4
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9
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26244453991
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A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease
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Kelleher CM, Silverman EK, Broekelmann T, et al. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2005; 33:355-362. This is the first paper to describe the use of rare-variant analysis techniques in COPD, making use of the fact that patients with cutis laxa, a rare genetic syndrome related to improper elastic-fibre processing, often get emphysema in childhood.
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(2005)
Am J Respir Cell Mol Biol
, vol.33
, pp. 355-362
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Kelleher, C.M.1
Silverman, E.K.2
Broekelmann, T.3
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10
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19944417988
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Association analysis of tissue inhibitor of metalloproteinase2 gene polymorphisms with COPD in Egyptians
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Hegab AE, Sakamoto T, Uchida Y, et al. Association analysis of tissue inhibitor of metalloproteinase2 gene polymorphisms with COPD in Egyptians. Respir Med 2005; 99:107-110. Paper demonstrates that TIMPs as well as MMPs may be important in the genetics of COPD.
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(2005)
Respir Med
, vol.99
, pp. 107-110
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Hegab, A.E.1
Sakamoto, T.2
Uchida, Y.3
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11
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31544455025
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The SERPINE2 gene is associated with chronic obstructive pulmonary disease
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DeMeo D, Mariani TJ, Lange C, et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet 2006; 178:253-264. The first use of the strategy of selecting candidate genes within a linkage region via gene-expression patterns in relevant tissues.
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(2006)
Am J Hum Genet
, vol.178
, pp. 253-264
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DeMeo, D.1
Mariani, T.J.2
Lange, C.3
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12
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33745831888
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The genetics of asthma: ADAM33 as an example of a susceptibility gene
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Holgate ST, Yang Y, Haitchi HM, et al. The genetics of asthma: ADAM33 as an example of a susceptibility gene. Proc Am Thorac Soc 2006; 3:440-443.
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(2006)
Proc Am Thorac Soc
, vol.3
, pp. 440-443
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Holgate, S.T.1
Yang, Y.2
Haitchi, H.M.3
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13
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33645214183
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Association of IL8, CXCR2 and TNF-alpha polymorphisms and airway disease
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Matheson MC, Ellis JA, Raven J, et al. Association of IL8, CXCR2 and TNF-alpha polymorphisms and airway disease. J Hum Genet 2006; 51:196-203. This paper indicates that CXCR2 rather than CXCR8 polymorphisms may be important for neutrophil recruitment in COPD.
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(2006)
J Hum Genet
, vol.51
, pp. 196-203
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Matheson, M.C.1
Ellis, J.A.2
Raven, J.3
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14
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20844457302
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Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma
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Stemmler S, Arinir U, Klein W, et al. Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma. Genes Immun 2005; 6:225-230. This paper indicates that CXCR2 rather than CXCR8 polymorphisms may be important for neutrophil recruitment in COPD.
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(2005)
Genes Immun
, vol.6
, pp. 225-230
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Stemmler, S.1
Arinir, U.2
Klein, W.3
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15
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23844553925
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Polymorphisms in the interleukin-8 gene in patients with chronic obstructive pulmonary disease
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Arinir U, Klein W, Rohde G, et al. Polymorphisms in the interleukin-8 gene in patients with chronic obstructive pulmonary disease. Electrophoresis 2005; 26:2888-2891.
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(2005)
Electrophoresis
, vol.26
, pp. 2888-2891
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Arinir, U.1
Klein, W.2
Rohde, G.3
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16
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20244379268
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Polymorphisms of TNFalpha, IL1beta, and IL1RN genes in chronic obstructive pulmonary disease
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Hegab AE, Sakamoto T, Saitoh W, et al. Polymorphisms of TNFalpha, IL1beta, and IL1RN genes in chronic obstructive pulmonary disease. Biochem Biophys Res Commun 2005; 329:1246-1252. This paper demonstrates that specific interleukin-1β haplotypes were associated with different ethnic groups.
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(2005)
Biochem Biophys Res Commun
, vol.329
, pp. 1246-1252
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Hegab, A.E.1
Sakamoto, T.2
Saitoh, W.3
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17
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14844319340
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Tumor necrosis factor-alpha gene promoter polymorphism is not associated with smoking-related COPD in Thailand
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Chierakul N, Wongwisutikul P, Vejbaesya S, Chotvilaiwan K. Tumor necrosis factor-alpha gene promoter polymorphism is not associated with smoking-related COPD in Thailand. Respirology 2005; 10:36-39.
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(2005)
Respirology
, vol.10
, pp. 36-39
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Chierakul, N.1
Wongwisutikul, P.2
Vejbaesya, S.3
Chotvilaiwan, K.4
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18
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13144260653
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TNFa-, TNFb-, IL-6-, and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary disease
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Seifart C, Dempfle A, Plagens A, et al. TNFa-, TNFb-, IL-6-, and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary disease. Tissue Antigens 2005; 65:93-100. This paper suggests that increased inflammation in COPD may relate to polymorphisms in the anti-inflammatory gene interleukin-10.
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(2005)
Tissue Antigens
, vol.65
, pp. 93-100
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Seifart, C.1
Dempfle, A.2
Plagens, A.3
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19
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17144418583
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Association of gene polymorphisms of tumour necrosis factor-alpha and interleukin-13 with chronic obstructive pulmonary disease in Han nationality in Beijing
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Jiang L, He B, Zhao MW, et al. Association of gene polymorphisms of tumour necrosis factor-alpha and interleukin-13 with chronic obstructive pulmonary disease in Han nationality in Beijing. Chin Med J (Engl) 2005;118:541-547. This paper shows an association of TNFa and interleukin-13 polymorphisms with increased risk of COPD in smokers rather than with COPD itself.
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(2005)
Chin Med J (Engl)
, vol.118
, pp. 541-547
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Jiang, L.1
He, B.2
Zhao, M.W.3
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20
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23744487887
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Interleukin-1β gene polymorphisms associated with COPD
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Asada M, Yamaya M, Ebihara S, et al. Interleukin-1β gene polymorphisms associated with COPD. Chest 2005; 128:1072-1073. This paper demonstrates an association of interleukin-1β polymorphisms with COPD in Japanese subjects.
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(2005)
Chest
, vol.128
, pp. 1072-1073
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Asada, M.1
Yamaya, M.2
Ebihara, S.3
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21
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26444608592
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Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease
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Hoffjan S, Stemmler S, Parwez Q, et al. Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease. BMC Med Genet 2005; 6:34.
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(2005)
BMC Med Genet
, vol.6
, pp. 34
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Hoffjan, S.1
Stemmler, S.2
Parwez, Q.3
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22
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13544270803
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The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases
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Cipriano C, Caruso C, Lio D, et al. The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases. Int J Immunogenet 2005; 32:13-18.
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(2005)
Int J Immunogenet
, vol.32
, pp. 13-18
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Cipriano, C.1
Caruso, C.2
Lio, D.3
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23
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4344689086
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The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
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Celedon JC, Lange C, Raby BA, et al. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet 2004; 13:1649-1656.
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(2004)
Hum Mol Genet
, vol.13
, pp. 1649-1656
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Celedon, J.C.1
Lange, C.2
Raby, B.A.3
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24
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20444420528
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Transforming growth factor-beta1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population
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Su ZG, Wen FQ, Feng YL, et al. Transforming growth factor-beta1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population. Acta Pharmacol Sin 2005; 26:714-720.
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(2005)
Acta Pharmacol Sin
, vol.26
, pp. 714-720
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Su, Z.G.1
Wen, F.Q.2
Feng, Y.L.3
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25
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33646591271
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Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function
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Young RP, Hopkins R, Black PN, et al. Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function. Thorax 2006; 61:394-399. This paper shows that genetic variants of SOD and catalase are associated with impaired lung function in COPD.
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(2006)
Thorax
, vol.61
, pp. 394-399
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Young, R.P.1
Hopkins, R.2
Black, P.N.3
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26
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33646338619
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Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease
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Juul K, Tybjaerg-Hansen A, Marklund S, et al. Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006; 173:858-864. Using both cross-sectional and prospective methods this paper shows that the G allele and CG/GG phenotype of the 213 SOD3 polymorphism is associated with increased antioxidant capacity and protects against the development of COPD.
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(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 858-864
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Juul, K.1
Tybjaerg-Hansen, A.2
Marklund, S.3
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27
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19644371310
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Polymorphisms for microsomal epoxide hydrolase and genetic susceptibility to COPD
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Park JY, Chen L, Wadhwa N, Tockman MS. Polymorphisms for microsomal epoxide hydrolase and genetic susceptibility to COPD. Int J Mol Med 2005; 15:443-448. This paper demonstrates that xenobiotic enzymes may modify the risk for the development of COPD.
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(2005)
Int J Mol Med
, vol.15
, pp. 443-448
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Park, J.Y.1
Chen, L.2
Wadhwa, N.3
Tockman, M.S.4
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28
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19844376460
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Glutathione S-transferase P1 and lung function in patients with alpha1-antitrypsin deficiency and COPD
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Rodriguez F, de la Roza C, Jardi R, et al. Glutathione S-transferase P1 and lung function in patients with alpha1-antitrypsin deficiency and COPD. Chest 2005; 127:1537-1543. The frequency of the glutathione S-transferase P1 105V polymorphism was identical in COPD patients and the general population but the frequency was significantly increased in patients with α1-antitrypsin deficiency and was associated with reduced lung function, emphasizing gene-environment effects.
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(2005)
Chest
, vol.127
, pp. 1537-1543
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Rodriguez, F.1
De La Roza, C.2
Jardi, R.3
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29
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0037304945
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Acquired somatic mutations in the molecular pathogenesis of COPD
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Anderson GP, Bozinovski S. Acquired somatic mutations in the molecular pathogenesis of COPD. Trends in Pharmacol Sci 2003; 24:71-76.
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(2003)
Trends in Pharmacol Sci
, vol.24
, pp. 71-76
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Anderson, G.P.1
Bozinovski, S.2
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30
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33646363561
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Polymorphisms of p53 and p21 genes in chronic obstructive pulmonary disease
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Lee YL, Chen W, Tsai WK, et al. Polymorphisms of p53 and p21 genes in chronic obstructive pulmonary disease. J Lab Clin Med 2006; 147:228-233. The frequencies of genotypes of p53 codon 72 and p21CIP codon 31 were significantly different between the COPD and the control groups.
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(2006)
J Lab Clin Med
, vol.147
, pp. 228-233
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Lee, Y.L.1
Chen, W.2
Tsai, W.K.3
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31
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21844431677
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Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations
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Hersh CP, DeMeo DL, Lange C, et al. Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol 2005; 33:71-78. This paper demonstrates the difficulty in replicating gene associations in patients with COPD and discusses many of the reasons for this and the controls necessary to improve replication rates.
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(2005)
Am J Respir Cell Mol Biol
, vol.33
, pp. 71-78
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Hersh, C.P.1
DeMeo, D.L.2
Lange, C.3
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32
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33646251821
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Genetic association analysis of functional impairment in chronic obstructive pulmonary disease
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Hersh CP, DeMeo DL, Lazarus R, et al. Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005; 173:977-984. This study highlights the importance of not only the need to examine multiple SNPs or haplotypes in each subject but to compare these with a range of biomarkers for the disease.
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(2005)
Am J Respir Crit Care Med
, vol.173
, pp. 977-984
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Hersh, C.P.1
DeMeo, D.L.2
Lazarus, R.3
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33
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13144306071
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Genome-wide association studies for common diseases and complex traits
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Hirschhorn JN, Daly MJ. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 2005; 6:95-108. This paper reviews the huge potential and complications of performing genome-wide studies on complex diseases such as COPD.
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(2005)
Nat Rev Genet
, vol.6
, pp. 95-108
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Hirschhorn, J.N.1
Daly, M.J.2
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