메뉴 건너뛰기




Volumn 177, Issue 6, 2006, Pages 3814-3820

Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; APOPTOSIS INHIBITOR; CD28 ANTIBODY; CD28 ANTIGEN; CD3 ANTIBODY; CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; DEATH RECEPTOR; DOUBLE STRANDED DNA ANTIBODY; FLICE INHIBITORY PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1H2KB; MITOGENIC AGENT; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; THYMIDINE; UNCLASSIFIED DRUG; VIRAL FLICE INHIBITORY PROTEIN MC159;

EID: 33748498462     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.6.3814     Document Type: Article
Times cited : (14)

References (38)
  • 1
    • 33645784245 scopus 로고    scopus 로고
    • Genetic disorders of programmed cell death in the immune system
    • Bidere, N., H. C. Su, and M. J. Lenardo. 2006. Genetic disorders of programmed cell death in the immune system. Annu. Rev. Immunol. 24: 321-352.
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 321-352
    • Bidere, N.1    Su, H.C.2    Lenardo, M.J.3
  • 2
    • 0345059209 scopus 로고    scopus 로고
    • An inherited disorder of lymphocyte apoptosis: The autoimmune lymphoproliferative syndrome
    • Straus, S. E., M. Sneller, M. J. Lenardo, J. M. Puck, and W. Strober. 1999. An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome. Ann. Intern. Med. 130: 591-601.
    • (1999) Ann. Intern. Med. , vol.130 , pp. 591-601
    • Straus, S.E.1    Sneller, M.2    Lenardo, M.J.3    Puck, J.M.4    Strober, W.5
  • 4
    • 0037204952 scopus 로고    scopus 로고
    • The Fas signaling pathway: More than a paradigm
    • Wajant, H. 2002. The Fas signaling pathway: more than a paradigm. Science 296: 1635-1636.
    • (2002) Science , vol.296 , pp. 1635-1636
    • Wajant, H.1
  • 5
    • 0041853690 scopus 로고    scopus 로고
    • Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    • Micheau, O., and J. Tschopp. 2003. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114: 181-190.
    • (2003) Cell , vol.114 , pp. 181-190
    • Micheau, O.1    Tschopp, J.2
  • 6
    • 0029834497 scopus 로고    scopus 로고
    • CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease
    • Smith, K. G., A. Strasser, and D. L. Vaux. 1996. CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease. EMBO J. 15: 5167-5176.
    • (1996) EMBO J. , vol.15 , pp. 5167-5176
    • Smith, K.G.1    Strasser, A.2    Vaux, D.L.3
  • 7
    • 0034655149 scopus 로고    scopus 로고
    • Caspase enzyme activity is not essential for apoptosis during thymocyte development
    • Doerfler, P., K. A. Forbush, and R. M. Perlmutter. 2000. Caspase enzyme activity is not essential for apoptosis during thymocyte development. J. Immunol. 164: 4071-4079.
    • (2000) J. Immunol. , vol.164 , pp. 4071-4079
    • Doerfler, P.1    Forbush, K.A.2    Perlmutter, R.M.3
  • 8
    • 17444386362 scopus 로고    scopus 로고
    • short leads to impaired T cell proliferation and an increased memory T cell pool after staphylococcal enterotoxin B injection
    • short leads to impaired T cell proliferation and an increased memory T cell pool after staphylococcal enterotoxin B injection. Eur. J. Immunol. 35: 1240-1249.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 1240-1249
    • Oehme, I.1    Neumann, F.2    Bosser, S.3    Zornig, M.4
  • 9
    • 1642433102 scopus 로고    scopus 로고
    • FLICE inhibitory protein expression inhibits T-cell activation
    • Tai, T. S., L. W. Fang, and M. Z. Lai. 2004. c-FLICE inhibitory protein expression inhibits T-cell activation. Cell Death Differ. 11: 69-79.
    • (2004) Cell Death Differ. , vol.11 , pp. 69-79
    • Tai, T.S.1    Fang, L.W.2    Lai, M.Z.3
  • 10
    • 0040189996 scopus 로고    scopus 로고
    • A dominant negative Fas-associated death domain protein mutant inhibits proliferation and leads to impaired calcium mobilization in both T-cells and fibroblasts
    • Hueber, A. O., M. Zornig, A. M. Bernard, M. Chautan, and G. Evan. 2000. A dominant negative Fas-associated death domain protein mutant inhibits proliferation and leads to impaired calcium mobilization in both T-cells and fibroblasts. J. Biol. Chem. 275: 10453-10462.
    • (2000) J. Biol. Chem. , vol.275 , pp. 10453-10462
    • Hueber, A.O.1    Zornig, M.2    Bernard, A.M.3    Chautan, M.4    Evan, G.5
  • 12
    • 0032546387 scopus 로고    scopus 로고
    • Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
    • Zhang, J., D. Cado, A. Chen, N. H. Kabra, and A. Winoto. 1998. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392: 296-300.
    • (1998) Nature , vol.392 , pp. 296-300
    • Zhang, J.1    Cado, D.2    Chen, A.3    Kabra, N.H.4    Winoto, A.5
  • 13
    • 0037397756 scopus 로고    scopus 로고
    • A function of Fas-associated death domain protein in cell cycle progression localized to a single amino acid at its C-terminal region
    • Hua, Z. C., S. J. Sohn, C. Kang, D. Cado, and A. Winoto. 2003. A function of Fas-associated death domain protein in cell cycle progression localized to a single amino acid at its C-terminal region. Immunity 18: 513-521.
    • (2003) Immunity , vol.18 , pp. 513-521
    • Hua, Z.C.1    Sohn, S.J.2    Kang, C.3    Cado, D.4    Winoto, A.5
  • 14
    • 18544383460 scopus 로고    scopus 로고
    • Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
    • Chun, H. J., L. Zheng, M. Ahmad, J. Wang, C. K. Speirs, R. M. Siegel, J. K. Dale, J. Puck, J. Davis, C. G. Hall, et al. 2002. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 419: 395-399.
    • (2002) Nature , vol.419 , pp. 395-399
    • Chun, H.J.1    Zheng, L.2    Ahmad, M.3    Wang, J.4    Speirs, C.K.5    Siegel, R.M.6    Dale, J.K.7    Puck, J.8    Davis, J.9    Hall, C.G.10
  • 16
    • 0347065342 scopus 로고    scopus 로고
    • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses
    • Chan, F. K., J. Shisler, J. G. Bixby, M. Felices, L. Zheng, M. Appel, J. Orenstein, B. Moss, and M. J. Lenardo. 2003. A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. J. Biol. Chem. 278: 51613-51621.
    • (2003) J. Biol. Chem. , vol.278 , pp. 51613-51621
    • Chan, F.K.1    Shisler, J.2    Bixby, J.G.3    Felices, M.4    Zheng, L.5    Appel, M.6    Orenstein, J.7    Moss, B.8    Lenardo, M.J.9
  • 19
    • 0036884315 scopus 로고    scopus 로고
    • T cell receptor ligation triggers novel nonapoptotic cell death pathways that are Fas-independent or Fas-dependent
    • Davidson, W. F., C. Haudenschild, I. Kwon, and M. S. Williams. 2002. T cell receptor ligation triggers novel nonapoptotic cell death pathways that are Fas-independent or Fas-dependent. J. Immunol. 169: 6218-6230.
    • (2002) J. Immunol. , vol.169 , pp. 6218-6230
    • Davidson, W.F.1    Haudenschild, C.2    Kwon, I.3    Williams, M.S.4
  • 20
    • 0032055166 scopus 로고    scopus 로고
    • Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation
    • Domen, J., K. L. Gandy, and I. L. Weissman. 1998. Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood 91: 2272-2282.
    • (1998) Blood , vol.91 , pp. 2272-2282
    • Domen, J.1    Gandy, K.L.2    Weissman, I.L.3
  • 21
    • 0028200629 scopus 로고
    • Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses
    • Selin, L. K., S. R. Nahill, and R. M. Welsh. 1994. Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J. Exp. Med. 179: 1933-1943.
    • (1994) J. Exp. Med. , vol.179 , pp. 1933-1943
    • Selin, L.K.1    Nahill, S.R.2    Welsh, R.M.3
  • 22
    • 0036301672 scopus 로고    scopus 로고
    • T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens
    • Brehm, M. A., A. K. Pinto, K. A. Daniels, J. P. Schneck, R. M. Welsh, and L. K. Selin. 2002. T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. Nat. Immunol. 3: 627-634.
    • (2002) Nat. Immunol. , vol.3 , pp. 627-634
    • Brehm, M.A.1    Pinto, A.K.2    Daniels, K.A.3    Schneck, J.P.4    Welsh, R.M.5    Selin, L.K.6
  • 23
    • 0032532008 scopus 로고    scopus 로고
    • Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice
    • Chan, F. K., A. Chen, and A. Winoto. 1998. Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice. J. Immunol. 161: 4252-4256.
    • (1998) J. Immunol. , vol.161 , pp. 4252-4256
    • Chan, F.K.1    Chen, A.2    Winoto, A.3
  • 24
    • 0034055383 scopus 로고    scopus 로고
    • Reduction of thymocyte numbers in transgenic mice expressing viral FLICE-inhibitory protein in a Fas-independent manner
    • OhYama, T., S. Tsukumo, N. Yajima, K. Sakamaki, and S. Yonehara. 2000. Reduction of thymocyte numbers in transgenic mice expressing viral FLICE-inhibitory protein in a Fas-independent manner. Microbiol. Immunol. 44: 289-297.
    • (2000) Microbiol. Immunol. , vol.44 , pp. 289-297
    • Ohyama, T.1    Tsukumo, S.2    Yajima, N.3    Sakamaki, K.4    Yonehara, S.5
  • 25
    • 24644491664 scopus 로고    scopus 로고
    • Constitutive NF- κB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice
    • Chugh, P., H. Matta, S. Schamus, S. Zachariah, A. Kumar, J. A. Richardson, A. L. Smith, and P. M. Chaudhary. 2005. Constitutive NF- κB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice. Proc. Natl. Acad. Sci. USA 102: 12885-12890.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 12885-12890
    • Chugh, P.1    Matta, H.2    Schamus, S.3    Zachariah, S.4    Kumar, A.5    Richardson, J.A.6    Smith, A.L.7    Chaudhary, P.M.8
  • 27
    • 0033538475 scopus 로고    scopus 로고
    • Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
    • Wang, J., L. Zheng, A. Lobito, F. K. Chan, J. Dale, M. Sneller, X. Yao, J. M. Puck, S. E. Straus, and M. J. Lenardo. 1999. Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell 98: 47-58.
    • (1999) Cell , vol.98 , pp. 47-58
    • Wang, J.1    Zheng, L.2    Lobito, A.3    Chan, F.K.4    Dale, J.5    Sneller, M.6    Yao, X.7    Puck, J.M.8    Straus, S.E.9    Lenardo, M.J.10
  • 28
    • 33644502594 scopus 로고    scopus 로고
    • Dendritic cell apoptosis in the maintenance of immune tolerance
    • Chen, M., Y. H. Wang, Y. Wang, L. Huang, H. Sandoval, Y. J. Liu, and J. Wang. 2006. Dendritic cell apoptosis in the maintenance of immune tolerance. Science 311: 1160-1164.
    • (2006) Science , vol.311 , pp. 1160-1164
    • Chen, M.1    Wang, Y.H.2    Wang, Y.3    Huang, L.4    Sandoval, H.5    Liu, Y.J.6    Wang, J.7
  • 29
    • 2542449195 scopus 로고    scopus 로고
    • T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis
    • Hao, Z., B. Hampel, H. Yagita, and K. Rajewsky. 2004. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J. Exp. Med. 199: 1355-1365.
    • (2004) J. Exp. Med. , vol.199 , pp. 1355-1365
    • Hao, Z.1    Hampel, B.2    Yagita, H.3    Rajewsky, K.4
  • 30
    • 1842477263 scopus 로고    scopus 로고
    • Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammation
    • Wu, W., L. Rinaldi, K. A. Fortner, J. Q. Russell, J. Tschopp, C. Irvin, and R. C. Budd. 2004. Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammation. J. Immunol. 172: 4724-4732.
    • (2004) J. Immunol. , vol.172 , pp. 4724-4732
    • Wu, W.1    Rinaldi, L.2    Fortner, K.A.3    Russell, J.Q.4    Tschopp, J.5    Irvin, C.6    Budd, R.C.7
  • 31
    • 0029076413 scopus 로고
    • Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice
    • Razvi, E. S., Z. Jiang, B. A. Woda, and R. M. Welsh. 1995. Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice. Am. J. Pathol. 147: 79-91.
    • (1995) Am. J. Pathol. , vol.147 , pp. 79-91
    • Razvi, E.S.1    Jiang, Z.2    Woda, B.A.3    Welsh, R.M.4
  • 33
    • 23844548539 scopus 로고    scopus 로고
    • Conditional Fas-associated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis
    • Zhang, Y., S. Rosenberg, H. Wang, H. Z. Imtiyaz, Y. J. Hou, and J. Zhang. 2005. Conditional Fas-associated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis. J. Immunol. 175: 3033-3044.
    • (2005) J. Immunol. , vol.175 , pp. 3033-3044
    • Zhang, Y.1    Rosenberg, S.2    Wang, H.3    Imtiyaz, H.Z.4    Hou, Y.J.5    Zhang, J.6
  • 35
    • 0036139833 scopus 로고    scopus 로고
    • Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function
    • Garvey, T. L., J. Bertin, R. M. Siegel, G. H. Wang, M. J. Lenardo, and J. I. Cohen. 2002. Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function. J. Virol. 76: 697-706.
    • (2002) J. Virol. , vol.76 , pp. 697-706
    • Garvey, T.L.1    Bertin, J.2    Siegel, R.M.3    Wang, G.H.4    Lenardo, M.J.5    Cohen, J.I.6
  • 36
    • 29144463250 scopus 로고    scopus 로고
    • Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition
    • Yang, J. K., L. Wang, L. Zheng, F. Wan, M. Ahmed, M. J. Lenardo, and H. Wu. 2005. Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition. Mol. Cell 20: 939-949.
    • (2005) Mol. Cell , vol.20 , pp. 939-949
    • Yang, J.K.1    Wang, L.2    Zheng, L.3    Wan, F.4    Ahmed, M.5    Lenardo, M.J.6    Wu, H.7
  • 37
    • 33646377433 scopus 로고    scopus 로고
    • Crystal structure of a viral FLIP: Insights into FLIP-mediated inhibition of death receptor signaling
    • Li, F. Y., P. D. Jeffrey, J. W. Yu, and Y. Shi. 2006. Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling. J. Biol. Chem. 281:2960-2968.
    • (2006) J. Biol. Chem. , vol.281 , pp. 2960-2968
    • Li, F.Y.1    Jeffrey, P.D.2    Yu, J.W.3    Shi, Y.4
  • 38
    • 33744531931 scopus 로고    scopus 로고
    • The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis
    • In press
    • Thurau, M., H. Evereu, M. Tapernoux, J. Tschopp, and M. Thome. 2006. The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis. Cell Death Differ. In press.
    • (2006) Cell Death Differ.
    • Thurau, M.1    Evereu, H.2    Tapernoux, M.3    Tschopp, J.4    Thome, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.