Extremely low-level, short-term mechanical stimulation increases cancellous and cortical bone density and muscle mass of children with low bone density: A pilot study

Endocrinologist

Volumn 16, Issue 3, 2006, Pages 128-132

  Pitukcheewanont, Pisit ^a   Safani, David ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE

Author keywords

Bone density; Computed tomography; Mechanical loading; Osteoporosis

Indexed keywords

ALKALINE PHOSPHATASE;

ARTICLE; BONE DENSITY; CANCELLOUS BONE; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CORTICAL BONE; ENZYME BLOOD LEVEL; FEMALE; HUMAN; MECHANICAL STIMULATION; MUSCLE MASS; SCHOOL CHILD;

EID: 33748481727     PISSN: 10512144     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ten.0000217885.60398.27     Document Type: Article

References (35)

1. Gilsanz V, Gibbens DT, Carlson M, et al. Peak trabecular vertebral density: a comparison of adolescent and adult females. Calcif Tissue Int. 1988;43:260-262.
2. Bonjour JP, Theintz G, Buchs B, et al. Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab. 1991;73:555-563.
3. Mosekilde L, Mosekilde L. Sex differences in age-related changes in vertebral body size, density and biomechanical competence in normal individuals. Bone. 1990;11:67-73.
4. Theintz G, Buchs B, Rizzoli R, et al. Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. J Clin Endocrinol Metab. 1992;75:1060-1065.
5. Ferrari S, Rizzoli R, Slosman D, et al. Familial resemblance for bone mineral mass is expressed before puberty. J Clin Endocrinol Metab. 1998;83:358-361.
6. Loro ML, Sayre J, Roe TF, et al. Early identification of children predisposed to low peak bone mass and osteoporosis later in life. J Clin Endocrinol Metab. 2000;85:3908-3918.
7. Bass S, Pearce G, Bradney M, et al. Exercise before puberty may confer residual benefits in bone density in adulthood: studies in active prepubertal and retired female gymnasts. J Bone Miner Res. 1998;13:500-507.
8. Slemenda CW, Miller JZ, Hui SL, et al. Role of physical activity in the development of skeletal mass in children. J Bone Miner Res. 1991;6:1227-1233.
9. Teegarden D, Proulx WR, Kern M, et al. Previous physical activity relates to bone mineral measures in young women. Med Sci Sports Exerc. 1996;28:105-113.
10. Haapasalo H, Kannus P, Sievänen H, et al. Long-term unilateral loading and bone mineral density and content in female squash players. Calcif Tissue Int. 1994;54:249-255.
11. Kannus P, Haapasalo H, Sankelo M, et al. Effect of starting age of physical activity on bone mass in the dominant arm of tennis and squash players. Ann Intern Med. 1995;123:27-31.
12. Osteoporosis Prevalence Report: 2002, 2010 and 2020. Washington, DC: National Osteoporosis Foundation.
13. Rubin C, Xu G, Judex S. The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli. FASEB J. 2001;15:2225-2229.
14. Rubin CT, Turner AS, Muller R, et al. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, non-invasive mechanical intervention. J Bone Miner Res. 2002;17:349-357.
15. Judex SL, Donahue R, Rubin CT. Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton. FASEB J. 2002;16:1280-1282.
16. Rubin C, Recker R, Cullen D, et al. Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety. J Bone Miner Res. 2004;19:343-351.
17. Verschueren SM, Roelants M, Delecluse C, et al. Effect of 6-month whole body vibration training on hip density, muscle strength, and postural control in postmenopausal women: a randomized controlled pilot study. J Bone Miner Res. 2004;19:352-359.
18. Ward K, Alsop C, Caulton J, et al. Low magnitude mechanical loading is osteogenic in children with disabling conditions. J Bone Miner Res. 2004;19:360-369.
19. Gilsanz V, Skaggs DL, Kovanlikaya A, et al. Differential effects of race on the axial and appendicular skeletons of children. J Clin Endocrinol Metab. 1998;83:1420-1426.
20. Tanner JM. Physical growth and development. In: Forfar JO, Arnell CC, eds. Textbook of Pediatrics, 2nd ed. Edinburgh: Churchill Livingstone; 1978:249-303.
21. Fritton JC, Rubin CT, Qin YX, et al. Whole-body vibration in the skeleton: development of a resonance-based testing device. Ann Biomed Eng. 1997;25:831-839.
22. Rubin C, Pope M, Fritton JC, et al. Transmissibility of 15-hertz to 35-hertz vibrations to the human hip and lumbar spine: determining the physiologic feasibility of delivering low-level anabolic mechanical stimuli to skeletal regions at greatest risk of fracture because of osteoporosis. Spine. 2003;28:2621-2627.
23. Gilsanz V, Boechat MI, Roe TF, et al. Gender differences in vertebral body sizes in children and adolescents. Radiology. 1994;190:673-677.
24. Cann CE. Why, when and how to measure bone mass: a guide for the beginning user. In: Frey GD, Yester MV., eds Expanding the Role of Medical Physics in Nuclear Medicine. Woodbury, NY: AIP Publishing; 1991:250-279.
25. Kalender WA. Effective dose values in bone mineral measurements by photon absorptiometry and computed tomography. Osteoporosis Int. 1992;2:82-87.
26. Goulding A, Jones IE, Taylor RW, et al. More broken bones: a 4-year double cohort study of young girls with and without distal forearm fractures. J Bone Miner Res. 2000;15:2011-2018.
27. Raab DM, Smith EL, Crenshaw TD, et al. Bone mechanical properties after exercise training in young and old rats. J Appl Physiol. 1990;68:130-134.
28. Rubin CT, Bain SD, McLeod KJ. Suppression of the osteogenic response in the aging skeleton. Calcif Tissue Int. 1992;50:306-513.
29. Das WJ, Der G. Transformation Der Knochen. Berlin, Germany: Hirschwald; 1892.
30. Fritton S, McLeod K, Rubin C. Quantifying the strain history of bone: spatial uniformity and self-similarity of low-magnitude strains. J Biomech. 2000;33:317-326.
31. Huang RP, Rubin CT, McLeod KJ. Changes in postural muscle dynamics as a function of age. J Gerontol A Biol Sci Med Sci. 1999;54:B352-357.
32. Booth F, Golnick P. Effects of disuse on the structure and function of skeletal muscle. Med Sci Sports Exerc. 1983;15:415-420.
33. Lacey JV Jr, Mink PJ, Lubin JH, et al. Menopausal hormone replacement therapy and risk of ovarian cancer. JAMA. 2002;288:334-341.
34. Martin R, Burr D, Sharkey N. Skeletal Tissue Mechanics. New York: Springer; 1998.
35. Brown T, Pedersen D, Gray M, et al. Toward an identification of mechanical parameters initiating periosteal remodeling: a combined experimental and analytic approach. J Biomech. 1990;23:893-905.