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Volumn 3, Issue 4, 2006, Pages 397-401

A commentary on neuronal degeneration and cell death in Guam ALS and PD: An evolutionary process of understanding

Author keywords

Gene environment interaction; Genetic susceptibility; Mitochondrial dysfunction

Indexed keywords

CELL DEATH; DEGENERATIVE DISEASE; GENE INTERACTION; GENETIC SUSCEPTIBILITY; GUAM; HUMAN; NERVE DEGENERATION; PRIORITY JOURNAL; REVIEW;

EID: 33748472083     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720506778249425     Document Type: Review
Times cited : (15)

References (62)
  • 1
    • 78651041685 scopus 로고
    • Degenerative disease of the central nervous system in New Guinea. The endemic occurrence of "kuru" in the native population
    • Gadjusek DC, Zigas V. Degenerative disease of the central nervous system in New Guinea. The endemic occurrence of "kuru" in the native population. N Engl J Med 257: 974-978 (1957).
    • (1957) N Engl J Med , vol.257 , pp. 974-978
    • Gadjusek, D.C.1    Zigas, V.2
  • 2
    • 0345737522 scopus 로고
    • Motor-neuron disease in natives of New Guinea
    • Gadjusek DC. Motor-neuron disease in natives of New Guinea. N Engl J Med 268: 474-476 (1963).
    • (1963) N Engl J Med , vol.268 , pp. 474-476
    • Gadjusek, D.C.1
  • 4
    • 77049177827 scopus 로고
    • Epidemiological investigations of amyotrophic lateral sclerosis. 1. Preliminary report on geographic distributions, with special reference to the Mariana Islands, including clinical, pathological observations
    • Kurl, LT, Mulder DW. Epidemiological investigations of amyotrophic lateral sclerosis. 1. Preliminary report on geographic distributions, with special reference to the Mariana Islands, including clinical, pathological observations. Neurology 4:355-378, 438-448 (1954).
    • (1954) Neurology , vol.4 , pp. 355-378
    • Kurl, L.T.1    Mulder, D.W.2
  • 5
    • 0002808017 scopus 로고
    • Amyotrophic lateral sclerosis in Japan
    • (Eds: Vinken PJ, Bruyn GW), Elsevier Publishing Company New York
    • Shiraki H, Yase Y. Amyotrophic lateral sclerosis in Japan. In: 'Handbook of Clinical Neurology, Vol. 22'. (Eds: Vinken PJ, Bruyn GW), Elsevier Publishing Company New York, p. 353-419 (1975).
    • (1975) Handbook of Clinical Neurology, Vol. 22 , vol.22 , pp. 353-419
    • Shiraki, H.1    Yase, Y.2
  • 6
    • 0033621144 scopus 로고    scopus 로고
    • Natural experimental models: The global search for biomedical paradigms among traditional, modernizing,, modern populations
    • Garruto RM, Little MA, James GD, Brown DE. Natural experimental models: the global search for biomedical paradigms among traditional, modernizing,, modern populations. Proc Natl Acad Sci USA 96: 10536-10543 (1999).
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10536-10543
    • Garruto, R.M.1    Little, M.A.2    James, G.D.3    Brown, D.E.4
  • 8
    • 0020078435 scopus 로고
    • Amyotrophic lateral sclerosis, parkinsonism syndromes in high incidence among the Auyu, Jakai people in West New Guinea
    • Gadjusek DC, Salazar AM. Amyotrophic lateral sclerosis, parkinsonism syndromes in high incidence among the Auyu, Jakai people in West New Guinea. Neurology 32: 107-126 (1982).
    • (1982) Neurology , vol.32 , pp. 107-126
    • Gadjusek, D.C.1    Salazar, A.M.2
  • 9
    • 0037828307 scopus 로고    scopus 로고
    • Biochemical, ultrastructural study of neurofibrillary tangles in amyotrophic lateral sclerosis/parkinsonism-dementia complex in the Kii Peninsula of Japan
    • Itoh N, Ishiguro K, Arai H, Kokubo Y, Sasaki R, Narita Y, et al. Biochemical, ultrastructural study of neurofibrillary tangles in amyotrophic lateral sclerosis/parkinsonism-dementia complex in the Kii Peninsula of Japan. J Neuropath Exper Neurol 62: 791-798 (2003).
    • (2003) J Neuropath Exper Neurol , vol.62 , pp. 791-798
    • Itoh, N.1    Ishiguro, K.2    Arai, H.3    Kokubo, Y.4    Sasaki, R.5    Narita, Y.6
  • 11
    • 73049132762 scopus 로고
    • Parkinsonism-dementia complex, an endemic disease on the isl, of Guam. I. Clinical features
    • Hirano A, Kurl, LT, Krooth RS, Lessel S. Parkinsonism-dementia complex, an endemic disease on the isl, of Guam. I. Clinical features. Brain 84: 642-661 (1961a).
    • (1961) Brain , vol.84 , pp. 642-661
    • Hirano, A.1    Kurl, L.T.2    Krooth, R.S.3    Lessel, S.4
  • 12
    • 0000035923 scopus 로고
    • Parkinsonism-dementia complex, an endemic disease on the isl, of Guam. II. Pathological features
    • Hirano A, Malamud N, Kurl, LT. Parkinsonism-dementia complex, an endemic disease on the isl, of Guam. II. Pathological features. Brain 84: 662-679 (1961b).
    • (1961) Brain , vol.84 , pp. 662-679
    • Hirano, A.1    Malamud, N.2    Kurl, L.T.3
  • 13
    • 0025331812 scopus 로고
    • Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonismdementia complex: An immunohistochemical study
    • Matsumoto S, Hirano A, Goto S. Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonismdementia complex: An immunohistochemical study. Neurology 40: 975-979 (1990).
    • (1990) Neurology , vol.40 , pp. 975-979
    • Matsumoto, S.1    Hirano, A.2    Goto, S.3
  • 14
    • 33748444069 scopus 로고
    • Distribution of Alzheimer's neurofibrillary changes in amyotrophic lateral sclerosis
    • Nakai Y. Distribution of Alzheimer's neurofibrillary changes in amyotrophic lateral sclerosis. Wakayama Igaku 20: 355-370 (1969).
    • (1969) Wakayama Igaku , vol.20 , pp. 355-370
    • Nakai, Y.1
  • 15
    • 0024589232 scopus 로고
    • Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis, parkinsonismdementia on Guam
    • Shankar SK, Yanagihara R, Garruto RM, Grundke-Iqbal I, Kosik KS, Gadjusek DC. Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis, parkinsonismdementia on Guam. Ann Neurol 25: 146-151 (1989).
    • (1989) Ann Neurol , vol.25 , pp. 146-151
    • Shankar, S.K.1    Yanagihara, R.2    Garruto, R.M.3    Grundke-Iqbal, I.4    Kosik, K.S.5    Gadjusek, D.C.6
  • 16
    • 0000544474 scopus 로고
    • Amyotrophic lateral sclerosis: Fifty cases observed on Guam
    • Arnold A, Edgren DC, Palladino VS. Amyotrophic lateral sclerosis: Fifty cases observed on Guam. J Nerv Ment Dis 177: 135-139 (1953).
    • (1953) J Nerv Ment Dis , vol.177 , pp. 135-139
    • Arnold, A.1    Edgren, D.C.2    Palladino, V.S.3
  • 17
    • 0002272076 scopus 로고
    • Progress in the pathology of motor neuron diseases
    • (Ed: Zimmerman HM), Grune, Stratton New York
    • Hirano A. Progress in the pathology of motor neuron diseases. In: 'Progress in Neuropathology, Vol. II'. (Ed: Zimmerman HM), Grune, Stratton New York, p. 181-215 (1973).
    • (1973) Progress in Neuropathology, Vol. II , vol.2 , pp. 181-215
    • Hirano, A.1
  • 18
    • 0020437641 scopus 로고
    • An update on long-term in vivi, in vitro studies designed to identify a virus as a cause of amyotropihc lateral sclerosis, parkinsonism-dementia, Parkinson disease
    • (Ed: Rowl, LP), Raven Press New York
    • Gibbs CJ Jr, Gadusek DC. An update on long-term in vivi, in vitro studies designed to identify a virus as a cause of amyotropihc lateral sclerosis, parkinsonism-dementia, Parkinson disease. In: 'Advances in Neurology, Vol. 36, Human Motor Neuron Disease'. (Ed: Rowl, LP), Raven Press New York, p. 343-353 (1982).
    • (1982) Advances in Neurology, Vol. 36, Human Motor Neuron Disease , vol.36 , pp. 343-353
    • Gibbs Jr., C.J.1    Gadusek, D.C.2
  • 19
    • 84873778711 scopus 로고
    • Food practices in ALS foci in Japan, the Marianas, New Guinea
    • Whiting MG. Food practices in ALS foci in Japan, the Marianas, New Guinea. Fed Proc 23: 1343-1345 (1964).
    • (1964) Fed Proc , vol.23 , pp. 1343-1345
    • Whiting, M.G.1
  • 20
    • 0015504203 scopus 로고
    • The pathogenesis of amyotrophic lateral sclerosis
    • Yase Y. The pathogenesis of amyotrophic lateral sclerosis. Lancet 2: 292-296 (1972).
    • (1972) Lancet , vol.2 , pp. 292-296
    • Yase, Y.1
  • 21
    • 0026076318 scopus 로고
    • Pacific paradigms of environmentally induced neurological disorders: Clinical, epidemiological, molecular perspectives
    • Garruto RM. Pacific paradigms of environmentally induced neurological disorders: clinical, epidemiological, molecular perspectives. NeuroToxicology 12: 12347-12378 (1991).
    • (1991) NeuroToxicology , vol.12 , pp. 12347-12378
    • Garruto, R.M.1
  • 22
    • 0021926745 scopus 로고
    • Disappearance of high incidence amyotrophic lateral sclerosis, parkinsonism-dementia on Guam
    • Garruto RM, Yanagihara R, Gajdusek DC. Disappearance of high incidence amyotrophic lateral sclerosis, parkinsonism-dementia on Guam. Neurology 35: 193-198 (1985a).
    • (1985) Neurology , vol.35 , pp. 193-198
    • Garruto, R.M.1    Yanagihara, R.2    Gajdusek, D.C.3
  • 23
    • 0023777955 scopus 로고
    • 2-amino-3 (methylamino)-propionic acid in cycad-derived foods is an unlikely cause of amyotrophic lateral sclerosis/parkinsonism
    • Duncan MW, Kopin IJ, Garruto RM, Lavine L, Markey SP. 2-amino-3 (methylamino)-propionic acid in cycad-derived foods is an unlikely cause of amyotrophic lateral sclerosis/parkinsonism. Lancet 2: 631-632 (1988).
    • (1988) Lancet , vol.2 , pp. 631-632
    • Duncan, M.W.1    Kopin, I.J.2    Garruto, R.M.3    Lavine, L.4    Markey, S.P.5
  • 24
    • 0025343142 scopus 로고
    • 2-amino-3 (methylamino)-propanoic acid (BMAA) in cycad flour: An unlikely cause of amyotrophic lateral sclerosis, parkinsonism dementia of Guam
    • Duncan MW, Steele JC, Kopin IJ, Markey SP. 2-amino-3 (methylamino)- propanoic acid (BMAA) in cycad flour: An unlikely cause of amyotrophic lateral sclerosis, parkinsonism dementia of Guam. Neurology 40: 767-772 (1990).
    • (1990) Neurology , vol.40 , pp. 767-772
    • Duncan, M.W.1    Steele, J.C.2    Kopin, I.J.3    Markey, S.P.4
  • 25
    • 0011209984 scopus 로고
    • Imaging of calcium, aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam
    • Garruto RM, Fukatsu R, Yanagihara R, Gajdusek DC, Hook G, Fiori CE. Imaging of calcium, aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam. PNAS 81: 1875-1879 (1984).
    • (1984) PNAS , vol.81 , pp. 1875-1879
    • Garruto, R.M.1    Fukatsu, R.2    Yanagihara, R.3    Gajdusek, D.C.4    Hook, G.5    Fiori, C.E.6
  • 26
    • 0022407541 scopus 로고
    • Intraneuronal deposition of calcium, aluminium in amyotrophic lateral sclerosis of Guam
    • Garruto RM, Swyt C, Fiori CE, Yanagihara R, Gajdusek DC. Intraneuronal deposition of calcium, aluminium in amyotrophic lateral sclerosis of Guam. Lancet 326: 1353 (1985b).
    • (1985) Lancet , vol.326 , pp. 1353
    • Garruto, R.M.1    Swyt, C.2    Fiori, C.E.3    Yanagihara, R.4    Gajdusek, D.C.5
  • 27
    • 0020000591 scopus 로고
    • Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis, parkinsonism-dementia of Guam
    • Perl DP, Gajdusek DC, Garruto RM, Yanigahara RT, Gibbs CJ Jr. Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis, parkinsonism-dementia of Guam. Science 217: 1053-1055 (1982).
    • (1982) Science , vol.217 , pp. 1053-1055
    • Perl, D.P.1    Gajdusek, D.C.2    Garruto, R.M.3    Yanigahara, R.T.4    Gibbs Jr., C.J.5
  • 28
    • 0023181410 scopus 로고
    • Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to plant exicitant neurotoxin
    • Spencer PS, Nunn PB, Hugon J, Ludopth AC, Ross SM, Roy DN, et al. Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to plant exicitant neurotoxin. Science 237: 517-522 (1987).
    • (1987) Science , vol.237 , pp. 517-522
    • Spencer, P.S.1    Nunn, P.B.2    Hugon, J.3    Ludopth, A.C.4    Ross, S.M.5    Roy, D.N.6
  • 32
    • 0022920314 scopus 로고
    • Neurodegenerative disorders of the western Pacific: The search for mechanisms of pathogenesis
    • Garruto RM, Yase Y. Neurodegenerative disorders of the western Pacific: the search for mechanisms of pathogenesis. Trends Neurosci 9: 368-374 (1986).
    • (1986) Trends Neurosci , vol.9 , pp. 368-374
    • Garruto, R.M.1    Yase, Y.2
  • 33
    • 0021335961 scopus 로고
    • Calcium, vitamin D metabolism in Guamanian Chamorros with amyotrophic lateral sclerosis, parkinsonism-dementia
    • Yanagihara R, Garruto, RM, Gajdusek DC, Tomita A, Uchikawa T, Konagaya Y, et al. Calcium, vitamin D metabolism in Guamanian Chamorros with amyotrophic lateral sclerosis, parkinsonism-dementia. Ann Neurol 15: 42-48 (1984).
    • (1984) Ann Neurol , vol.15 , pp. 42-48
    • Yanagihara, R.1    Garruto, R.M.2    Gajdusek, D.C.3    Tomita, A.4    Uchikawa, T.5    Konagaya, Y.6
  • 34
    • 0037177086 scopus 로고    scopus 로고
    • Cycad neurotoxins, consumption of flying foxes,, ALS-PCD disease in Guam
    • Cox PA, Sacks OW. Cycad neurotoxins, consumption of flying foxes,, ALS-PCD disease in Guam. Neurology 58: 956-959 (2002).
    • (2002) Neurology , vol.58 , pp. 956-959
    • Cox, P.A.1    Sacks, O.W.2
  • 35
  • 36
    • 0016165696 scopus 로고
    • The experimental pathology of cycad toxicity with special reference to oncogenic effects
    • Dastur DK, Palekar RS. The experimental pathology of cycad toxicity with special reference to oncogenic effects. Ind J Cancer March: 33-49 (1974).
    • (1974) Ind J Cancer , vol.MARCH , pp. 33-49
    • Dastur, D.K.1    Palekar, R.S.2
  • 37
    • 0032966179 scopus 로고    scopus 로고
    • The Guam cycad toxin methylazoxymethanol damages neuronal DNA, modulated Tua mRNA expression, excitotoxicity
    • Esclaire F, Kisby G, Spencer, P, Milne J, Lesort M, Hugon J. The Guam cycad toxin methylazoxymethanol damages neuronal DNA, modulated Tua mRNA expression, excitotoxicity. Exp Neurol 155: 11-21 (1999).
    • (1999) Exp Neurol , vol.155 , pp. 11-21
    • Esclaire, F.1    Kisby, G.2    Spencer, P.3    Milne, J.4    Lesort, M.5    Hugon, J.6
  • 38
    • 0023697638 scopus 로고
    • Determination of B-N-methylamino-L-alanine (BMAA) in plant (Cycas circinalis L.), animal tissue by precolumn dramatization with 9-fluorenylmethyl chloroformate (FMOC), reversed-phase high-performance liquid chromotography
    • Kisby GE, Roy DN, Spencer PS. Determination of B-N-methylamino-L-alanine (BMAA) in plant (Cycas circinalis L.), animal tissue by precolumn dramatization with 9-fluorenylmethyl chloroformate (FMOC), reversed-phase high-performance liquid chromotography. J Neurosci Methods 26: 45-54 (1988).
    • (1988) J Neurosci Methods , vol.26 , pp. 45-54
    • Kisby, G.E.1    Roy, D.N.2    Spencer, P.S.3
  • 39
    • 0026058704 scopus 로고
    • Neuron-specific thresholds of aluminum toxicity in vitro: A comparative analysis of dissociated fetal rabbit hippocampal, motor neuron-enriched cultures
    • Strong MJ, Garruto RM. Neuron-specific thresholds of aluminum toxicity in vitro: a comparative analysis of dissociated fetal rabbit hippocampal, motor neuron-enriched cultures. Laboratory Investigation 66: 243-249 (1991).
    • (1991) Laboratory Investigation , vol.66 , pp. 243-249
    • Strong, M.J.1    Garruto, R.M.2
  • 41
    • 0028024631 scopus 로고
    • Dose-dependent selective supression of light (NFL), medium (NFM) but not heavy (NFH) molecular weight neurofilament mRNA levels in acute aluminum neurotoxicity
    • Strong MJ, Mao K, Nerurkar VR, Wakayama I, Yanagihara R, Garruto RM. Dose-dependent selective supression of light (NFL), medium (NFM) but not heavy (NFH) molecular weight neurofilament mRNA levels in acute aluminum neurotoxicity. Molecular, Cellular Neurosciences 5: 319-326 (1994).
    • (1994) Molecular, Cellular Neurosciences , vol.5 , pp. 319-326
    • Strong, M.J.1    Mao, K.2    Nerurkar, V.R.3    Wakayama, I.4    Yanagihara, R.5    Garruto, R.M.6
  • 42
    • 0027476977 scopus 로고
    • Immunocytochemical, ultrastructural evidence of dendritic degeneration in motor neurons of aluminum intoxicated rabbits
    • Wakayama I, Nerurkar VR, Garruto RM. Immunocytochemical, ultrastructural evidence of dendritic degeneration in motor neurons of aluminum intoxicated rabbits. Acta Neuropathol 85: 122-128 (1993).
    • (1993) Acta Neuropathol , vol.85 , pp. 122-128
    • Wakayama, I.1    Nerurkar, V.R.2    Garruto, R.M.3
  • 43
    • 0029801115 scopus 로고    scopus 로고
    • Comparative study of chronic aluminum-induced neurofilamentous aggregates with intracytoplasmic inclusions of amyotrophic lateral sclerosis
    • Wakayama I, Nerurkar VR, Strong MJ, Garruto RM. Comparative study of chronic aluminum-induced neurofilamentous aggregates with intracytoplasmic inclusions of amyotrophic lateral sclerosis. Acta Neuropathol 92: 545-554 (1996).
    • (1996) Acta Neuropathol , vol.92 , pp. 545-554
    • Wakayama, I.1    Nerurkar, V.R.2    Strong, M.J.3    Garruto, R.M.4
  • 44
    • 0031059652 scopus 로고    scopus 로고
    • Slow dendritic transport of dissociated mouse hippocampal neurons exposed to aluminum
    • Wakayama I, Song K-J, Nerurkar VR, Yoshida S, Garruto RM. Slow dendritic transport of dissociated mouse hippocampal neurons exposed to aluminum. Brain Research 748: 237-240 (1997).
    • (1997) Brain Research , vol.748 , pp. 237-240
    • Wakayama, I.1    Song, K.-J.2    Nerurkar, V.R.3    Yoshida, S.4    Garruto, R.M.5
  • 45
    • 0028879270 scopus 로고
    • Effects of calcium-deficient diets on manganese deposition in the central nervous system, bones of rats
    • Abstracts of the 10th International Neurotoxicology Conference, Little Rock, Arkansas, September 28-October 1, 1992
    • Yasui M, Ota K, Garruto RM. Effects of calcium-deficient diets on manganese deposition in the central nervous system, bones of rats. Abstracts of the 10th International Neurotoxicology Conference, Little Rock, Arkansas, September 28-October 1, 1992. Neurotoxicology 16: 511-517 (1995).
    • (1995) Neurotoxicology , vol.16 , pp. 511-517
    • Yasui, M.1    Ota, K.2    Garruto, R.M.3
  • 46
    • 0014123886 scopus 로고
    • Amyotrophic lateral sclerosis/parkinsonism dementia complex of Guam. IV. Familial, genetic investigations
    • Plato CC, Reed DM, Elizan TS, Kurl, LT. Amyotrophic lateral sclerosis/parkinsonism dementia complex of Guam. IV. Familial, genetic investigations. Am J Hum Gen 19: 617-632 (1967).
    • (1967) Am J Hum Gen , vol.19 , pp. 617-632
    • Plato, C.C.1    Reed, D.M.2    Elizan, T.S.3    Kurl, L.T.4
  • 47
    • 0014491086 scopus 로고
    • Amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: Further genetic investigations
    • Plato CC, Cruz MT, Kurl, LT. Amyotrophic lateral sclerosis/parkinsonism- dementia complex of Guam: Further genetic investigations. Am J Hum Genet 21: 133-141 (1969).
    • (1969) Am J Hum Genet , vol.21 , pp. 133-141
    • Plato, C.C.1    Cruz, M.T.2    Kurl, L.T.3
  • 48
    • 0023032507 scopus 로고
    • Amyotrophic lateral sclerosis, parkinsonism-dementia complex of Guam: A 25-year prospective case-control study
    • Plato CC, Garruto RM, Fox KM, Gadjusek DC. Amyotrophic lateral sclerosis, parkinsonism-dementia complex of Guam: A 25-year prospective case-control study. Am J Epidemiol 124: 643-656 (1986).
    • (1986) Am J Epidemiol , vol.124 , pp. 643-656
    • Plato, C.C.1    Garruto, R.M.2    Fox, K.M.3    Gadjusek, D.C.4
  • 49
    • 0037438648 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis, parkinsonism-dementia complex of Guam: Changing incidence rates during the past 60 years
    • Plato CC, Garruto RM, Galasko D, Craig UK, Plato M, Gamst A, et al. Amyotrophic lateral sclerosis, parkinsonism-dementia complex of Guam: Changing incidence rates during the past 60 years. Am J Epidemiol 157:149-157 (2003).
    • (2003) Am J Epidemiol , vol.157 , pp. 149-157
    • Plato, C.C.1    Garruto, R.M.2    Galasko, D.3    Craig, U.K.4    Plato, M.5    Gamst, A.6
  • 50
  • 52
    • 0027464394 scopus 로고
    • Potential role of an addictive genetic component in the cause of amyotrophic lateral sclerosis, parkinsonism-dementia in the Western Pacific
    • Bailey-Wilson JE, Plato CC, Elston RC, Garruto RM. Potential role of an addictive genetic component in the cause of amyotrophic lateral sclerosis, parkinsonism-dementia in the Western Pacific. Am J Med Gen 45: 68-86 (1993).
    • (1993) Am J Med Gen , vol.45 , pp. 68-86
    • Bailey-Wilson, J.E.1    Plato, C.C.2    Elston, R.C.3    Garruto, R.M.4
  • 54
    • 0042165931 scopus 로고    scopus 로고
    • Neurodegeneration in amyotrophic lateral sclerosis: The role of oxidative stress, altered homeostasis of metals
    • Carri MT, Ferri A, Cozzolino M, Calabrese L, Rotilio G. Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress, altered homeostasis of metals. Brain Reseach Bulletin 61: 365-374 (2003).
    • (2003) Brain Reseach Bulletin , vol.61 , pp. 365-374
    • Carri, M.T.1    Ferri, A.2    Cozzolino, M.3    Calabrese, L.4    Rotilio, G.5
  • 57
  • 58
    • 3242668604 scopus 로고    scopus 로고
    • Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription, replication
    • Coskun PE, Beal MF, Wallace DC. Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription, replication. PNAS 101: 10726-10731 (2004).
    • (2004) PNAS , vol.101 , pp. 10726-10731
    • Coskun, P.E.1    Beal, M.F.2    Wallace, D.C.3
  • 59
    • 10644229290 scopus 로고    scopus 로고
    • The mitochondrial RNA polymerase contributes critically to promotor specificity in mammalian cells
    • Gaspari M, Falkenberg M, Larsson N-G, Gustafsson CM. The mitochondrial RNA polymerase contributes critically to promotor specificity in mammalian cells. EMBO 23: 4606-4614 (2004).
    • (2004) EMBO , vol.23 , pp. 4606-4614
    • Gaspari, M.1    Falkenberg, M.2    Larsson, N.-G.3    Gustafsson, C.M.4
  • 60
  • 62
    • 23844451376 scopus 로고    scopus 로고
    • A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders
    • Hermosura MC, Nayakanti H, Dorovkov MV, Calderon FR, Ryazanov AG, Haymer DS, et al. A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. PNAS 102: 11510-11515 (2005).
    • (2005) PNAS , vol.102 , pp. 11510-11515
    • Hermosura, M.C.1    Nayakanti, H.2    Dorovkov, M.V.3    Calderon, F.R.4    Ryazanov, A.G.5    Haymer, D.S.6


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