Genetic mechanism of aspirin-induced urticaria/angioedema

Current Opinion in Allergy and Clinical Immunology

Volumn 6, Issue 4, 2006, Pages 266-270

  Kim, Seung Hyun ^a   Ye, Young Min ^a   Lee, Soo Keol ^b   Park, Hae Sim ^a,c  

^a Ajou University School of Medicine   (South Korea)

^b Dong Ah University   (South Korea)

^c Ajou University Medical Center   (South Korea)

Author keywords

Aspirin induced urticaria; Gene polymorphism; Histamine; HLA marker; Leukotriene related genes

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; CYCLOOXYGENASE 2; HISTAMINE METHYLTRANSFERASE; HISTAMINE RECEPTOR; IMMUNOGLOBULIN E RECEPTOR; LEUKOTRIENE C4 SYNTHASE; PEPTIDOLEUKOTRIENE; HISTAMINE; HLA DQ ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; HLA-DRB1 ANTIGEN;

ALLELE; ANGIONEUROTIC EDEMA; DISEASE ASSOCIATION; DRUG SENSITIVITY; GENETIC ANALYSIS; GENETIC CODE; GENETIC POLYMORPHISM; HLA SYSTEM; HUMAN; IN VITRO STUDY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; URTICARIA; BLOOD; CHEMICALLY INDUCED DISORDER; DRUG HYPERSENSITIVITY; GENETICS; IMMUNOLOGY; MICROBIOLOGY;

ANGIONEUROTIC EDEMA; ASPIRIN; DRUG HYPERSENSITIVITY; HISTAMINE; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; URTICARIA;

EID: 33748465178     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/01.all.0000235899.57182.d4     Document Type: Review

References (22)

1. Simon RA. Adverse respiratory reactions to aspirin and nonsteroidal anti-inflammatory drugs. Curr Allergy Asthma Rep 2004; 4:17-24.
2. Sanchez-Borges M, Capriles-Hulett A, Caballero-Fonseca F. Cutaneous reactions to aspirin and nonsteroidal anti-inflammatory drugs. Clin Rev Allergy Immunol 2003; 24:125-136.
3. Pierzchalska M, Mastalerz L, Sanak M, et al. A moderate and unspecific release of cysteinyl leukotrienes by aspirin from peripheral blood leucocytes precludes its value for aspirin sensitivity testing in asthma. Clin Exp Allergy 2000; 30:1785-1791.
4. Antczak A, Montuschi P, Kharitonov S, Gorski et al. Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma. Am J Respir Crit Care Med 2002; 166:301-306.
5. Christie PE, Tagari P, Ford-Hutchinson AW, et al. Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects. Am Rev Respir Dis 1991; 143:1025-1029.
6. Oosaki R, Mizushima Y, Mita H, et al. Urinary leukotriene E4 and 11-dehydrothromboxane B2 in patients with aspirin-sensitive asthma. Allergy 1997; 52:470-473.
7. Kim SH, Park HS. The pathogenesis of nonsteroidal anti-inflammatory drug induced asthma. Curr Opin Allergy Immunol 2006; 6:17-22. This review summarizes recent findings on the pathogenic mechanism and molecular genetic mechanisms in AIA. The authors suggest that promoter polymorphisms of three variants of CYSLTR1 could contribute to the characteristic finding of cysteinyl leukotriene overproduction. It was emphasized that the HLA DPB1*0301 allele can be a strong gene marker for the AIA phenotype.
8. Sousa AR, Parikh A, Scadding G, et al. Leukotriene-receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitis. N Engl J Med 2002; 347:1493-1499.
9. Kim SH, Park HS, Choi JH, et al. A strong association of three genetic variants of CYSLTR1 with ASA-intolerant asthma phenotype. J Allergy Clin Immunol 2005; 115:S134.
10. Grattan CE. Aspirin sensitivity and urticaria. Clin Exp Dermatol 2003; 28:123-127.
11. Mathelier-Fusade P. Drug-induced urticaria. Clin Rev Allergy Immunol 2006; 30:19-24.
12. Mastalerz L, Setkowicz M, Szeczeklik A. Mechanism of chronic urticaria exacerbation by aspirin. Curr Allergy Asthma Rep 2005; 5:277-283.
13. Ye YM, Kim JE, Nahm DI, et al. Characteristics of chronic urticaria with aspirin sensitivity. Korean J Asthma Allergy Clin Immunol 2005; 25:194-199.
14. Kim SH, Choi JH, Lee KW, et al. The HLA-DRB1*1302-DQB1*0609- DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. Clin Exp Allergy 2005; 35:339-344. This is the first study to demonstrate that the DRB1*1302-DQB1*0609-DPB1*0201 haplotype might be a strong genetic marker to determine the phenotype of AIU.
15. Erbagei Z. Multiple NSAID intolerance in chronic idiopathic urticaria is correlated with delayed, pronounced and prolonged autoreactivity. J Dermatol 2004; 31:376-382.
16. Gamboa P, Sanz ML, Caballero MR, et al. The flow-cytometric determination of basophil activation induced by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is useful for in vitro diagnosis of the NSAID hypersensitivity syndrome. Clin Exp Allergy 2004; 34:1448-1457.
17. Mastalerz L, Setkowicz M, Sanak M, Szczeklik A. Hypersensitivity to aspirin: common eicosanoid alterations in urticaria and asthma. J Allergy Clin Immunol 2004; 113:771-775.
18. Mastalerz L, Setkowicz M, Sanak M, et al. Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant. Br J Dermatol 2006; 154:256-260. This paper reports two families showing familial aggregations of AIU, and emphasizes the contribution of the LTC4S-444C allele in conjunction with common deletion of GSTM1 (the gene encoding glutathione S-transferase) as a genetic mechanism.
19. Torres-Galvan MJ, Ortega N, Sanchez-Garcia F, et al. LTC4-synthase A-444C polymorphism: lack of association with NSAID-induced isolated periorbital angioedema in a Spanish population. Ann Allergy Asthma Immunol 2001; 87:506-510.
20. Kim SH, Choi JH, Holloway JW, et al. Leukotriene-related gene polymorphisms in patients with ASA-induced urticaria and ASA-intolerant asthma: differing contributions of ALOX5 polymorphism in Korean population. J Korean Med Sci 2005; 20:926-931. This was the first study to demonstrate that ALOX5 might be a potentially important gene in AIU susceptibility in the Korean population, and that promoter polymorphism of the ALOX5 gene might contribute to AIU susceptibility relative to AIA.
21. Choi JH, Kim SH, Suh CH, et al. Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. J Korean Med Sci 2005; 20:367-372. This study screened known SNPs of histamine-related genes and demonstrated that FcεRI, HRH1, and HRH2 gene polymorphisms were not associated with the phenotype of AIU.
22. Bae JS, Kim SH, Kang YM, et al. Significant association of FcεR1α promoter polymorphism with aspirin-intolerant chronic urticaria. Korean J Asthma Allergy Clin Immunol 2005; 25:S249.