Retinoids induce growth inhibition and apoptosis in mast cell tumor cell lines

Journal of Veterinary Medical Science

Volumn 68, Issue 8, 2006, Pages 797-802

  Ohashi, Emi ^a   Miyajima, Nozomi ^a   Nakagawa, Takayuki ^a   Takahashi, Tomoko ^b   Kagechika, Hiroyuki ^c   Mochizuki, Manabu ^a   Nishimura, Ryohei ^a   Sasaki, Nobuo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Canine; Mast cell tumor; Retinoid

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; RETINOIC ACID RECEPTOR; RETINOID;

ANIMAL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; DOG; DOG DISEASE; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; MAST CELL; MASTOCYTOSIS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; DOG DISEASES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; MAST CELLS; MASTOCYTOSIS; RECEPTORS, RETINOIC ACID; RETINOIDS;

EID: 33748456200     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.68.797     Document Type: Article

References (30)

1. Allegretto, E.A., McClurg, M.R., Lazarchik, S.B., Clemm, D.L., Kerner, S.A., Elgort, M.G., Boehm, M.F., White, S.K., Pike, J.W. and Heyman, R.A. 1993. Transactivation properties of retinoic acid and retinoid X receptors in mammalian cells and yeast. Correlation with hormone binding and effects of metabolism. J. Biol .Chem. 268: 26625-26633.
2. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
3. Furitsu, T., Tsujimura, T., Tono, T., Ikeda, H., Kitayama, H., Koshimizu, U., Sugahara, H., Butterfield, J.H., Ashman, L.K., Kanayama, Y., Matsuzawa Y., Kitamura, Y. and Kanakura, Y. 1993. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J. Clin. Invest. 92: 1736-1744.
4. Giguere, V., Ong, E.S., Segui, P. and Evans, R.M. 1987. Identification of a receptor for the morphogen retinoic acid. Nature 330: 624-629.
5. Hashimoto, Y., Petkovich, M., Gaub, M.P., Kagechika, H., Shudo, K. and Chambon, P. 1989. The retinoic acid receptors alpha and beta are expressed in the human promyelocytic leukemia cell line HL-60. Mol. Endocrinol. 3: 1046-1052.
6. Hong, S.H., Kadosawa, T., Nozaki, K., Mochizuki, M., Matsunaga, S., Nishimura, R. and Sasaki, N. 2000. In vitro retinoid-induced growth inhibition and morphologic differentiation of canine osteosarcoma cells. Am. J. Vet. Res. 61: 69-73.
7. Hong, S.H., Ohashi, E., Kadosawa, T., Mochizuki, M., Matsunaga, S., Nishimura, R. and Sasaki, N. 2000. Retinoid receptors and the induction of apoptosis in canine osteosarcoma cells. J. Vet. Med. Sci. 62: 469-472.
8. Irani, A.M., Nilsson, G., Miettinen, U., Craig, S.S., Ashman, L.K., Ishizaka, T., Zsebo, K.M. and Schwartz, L.B. 1992. Recombinant human stem cell factor stimulates differentiation of mast cells from dispersed human fetal liver cells. Blood 80: 3009-3021.
9. Ishiguro, T., Kadosawa, T., Mori, K., Takagi, S., Okumura, M. and Fujinaga, T. 2001. Establishment and characterization of a new canine mast cell tumor cell line. J. Vet. Med. Sci. 63: 1031-1034.
10. Ishizaka, T., Mitsui, H., Yanagida, M., Miura, T. and Dvorak, A.M. 1993. Development of human mast cells from their progenitors. Curr. Opin. Immunol. 5: 937-943.
11. Kastner, P., Mark, M. and Chambon, P. 1995. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83: 859-869.
12. Kinoshita, T., Koike, K., Mwamtemi, H.H., Ito, S., Ishida, S., Nakazawa, Y., Kurokawa, Y., Sakashita, K., Higuchi, T., Takeuchi, K., Sawai, N., Shiohara, M., Kamijo, T., Kawa, S., Yamashita, T. and Komiyama, A. 2000. Retinoic acid is a negative regulator for the differentiation of cord blood-derived human mast cell progenitors. Blood 95: 2821-2828.
13. Lehmann, J.M., Jong, L., Fanjul, A., Cameron, J.F., Lu, X.P., Haefner, P., Dawson, M.I. and Pfahl, M. 1992. Retinoids selective for retinoid X receptor response pathways. Science 258: 1944-1946.
14. London, C.A., Galli, S.J., Yuuki, T., Hu, Z.Q., Helfand, S.C. and Geissler, E.N. 1999. Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit. Exp. Hematol. 27: 689-697.
15. Ma, Y., Longley, B.J., Wang, X., Blount, J.L., Langley, K. and Caughey, G.H. 1999. Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms. J. Invest. Dermatol. 112: 165-170.
16. Mangelsdorf, D.J., Ong, E.S., Dyck, J.A. and Evans, R.M. 1990. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345: 224-229.
17. Marks, S.L., Song, M.D., Stannard, A.A. and Power, H.T. 1992. Clinical evaluation of etretinate for the treatment of canine solar-induced squamous cell carcinoma and preneoplastic lesions. J. Am. Acad. Dermatol. 27: 11-16.
18. Ohashi, E., Hong, S.H., Takahashi, T., Nakagawa, T., Mochizuki, M., Nishimura, R. and Sasaki, N. 2001. Effect of retinoids on growth inhibition of two canine melanoma cell lines. J. Vet. Med. Sci. 63: 83-86.
19. Patnaik, A.K., Ehler, W.J. and McEwen, E.G. 1984. Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs. Vet. Pathol. 21: 469-474.
20. Petkovich, M., Brand, N.J., Krust, A. and Chambon, P. 1987. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330: 444-450.
21. Takahashi, T., Kitani, S., Nagase, M., Mochizuki, M., Nishimura, R., Morita, Y. and Sasaki, N. 2001. IgG-mediated histamine release from canine mastocytoma-derived cells. Int. Arch. Allergy Immunol. 125: 228-235.
22. Tallman, M.S., Andersen, J.W., Schiffer, C.A., Appelbaum, F.R., Feusner, J.H., Ogden, A., Shepherd, L., Willman, C., Bloomfield, C.D., Rowe, J.M. and Wiernik, P.H. 1997. All-trans-retinoic acid in acute promyelocytic leukemia. New Engl. J. Med. 337: 1021-1028.
23. Thamm, D.H., Mauldin, E.A. and Vail, D.M. 1999. Prednisone and vinblastine chemotherapy for canine mast cell tumor - 41 Cases (1992-1997) J. Vet. Intern. Med. 13: 491-497.
24. Thornberry, N.A. and Lazebnik, Y. 1998. Caspases: enemies within. Science 281: 1312-1316.
25. Tsujimura, T., Furitsu, T., Morimoto, M., Kanayama, Y., Nomura, S., Matsuzawa, Y., Kitamura, Y. and Kanakura, Y. 1995. Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3. Int. Arch. Allergy Immunol. 106: 377-385.
26. Tsujimura, T., Furitsu, T., Morimoto, M., Isozaki, K., Nomura, S., Matsuzawa, Y., Kitamura, Y. and Kanakura, Y. 1994. Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation. Blood 83: 2619-2626.
27. Umemiya, H., Fukasawa, H., Ebisawa, M., Eyrolles, L., Kawachi, E., Eisenmann, G., Gronemeyer, H., Hashimoto, Y., Shudo, K. and Kagechika, H. 1997. Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J. Med. Chem. 40: 4222-4234.
28. Vail, D.M. 2001. Mast cell tumors. pp. 261-282. In: Small Animal Clinical Oncology, 3rd ed. (McEwen E.G. and Withrow S.J., eds), W. B. Saunders, Philadelphia.
29. White, S.D., Rosychuk, R.A., Scott, K.V., Trettien, A.L., Jonas, L. and Denerolle, P. 1993. Use of isotretinoin and etretinate for the treatment of benign cutaneous neoplasia and cutaneous lymphoma in dogs. J. Am. Vet. Med. Assoc. 202: 387-391.
30. White, S.D., Rosychuk, R.A., Scott, K.V., Hargis, A.M., Jonas, L. and Trettien, A. 1995. Sebaceous adenitis in dogs and results of treatment with isotretinoin and etretinate: 30 cases (1990-1994). J. Am. Vet. Med. Assoc. 207: 197-200.