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The role of iodine in thyroid autoimmunity: From chickens to humans: A review
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Iodide induces thyroid autoimmunity in patients with endemic goitre: A randomised, double-blind, placebo-controlled trial
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The effect of iodine administration on the development of thyroid autoimmunity in patients with non-toxic goitre
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Increased major histocompatibility complex (MHC) expression in nontoxic goitres is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies
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The Sardinian Autoimmunity Study: 3. Studies on circulating antithyroid antibodies in Sardinian schoolchildren: Relationship to goitre prevalence and thyroid function
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Thyroid cancer and thyroiditis in Salta, Argentina: A 40-yr study in relation to iodine prophylaxis
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Harach HR, Escalante DA, Day ES: Thyroid cancer and thyroiditis in Salta, Argentina: a 40-yr study in relation to iodine prophylaxis. Endocrinol Pathol 2002, 13:175-181.
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Fine-needle aspiration biopsy of the thyroid in an area of endemic goitre: Influence of restored sufficient iodine supplementation on the clinical significance of cytological results
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Iodized oil treatment for endemic goiter does not induce the surge of positive serum concentrations of anti-thyroglobulin or anti-microsomal autoantibodies
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Knobel M, Medeiros-Neto G: Iodized oil treatment for endemic goiter does not induce the surge of positive serum concentrations of anti-thyroglobulin or anti-microsomal autoantibodies. J Endocrinol Invest 1986, 9:321-324.
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Endemic goitre in Senegal-thyroid function, etiological factors and treatment with oral iodized oil
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Lazarus JH, Parkes AB, John R, et al.: Endemic goitre in Senegal-thyroid function, etiological factors and treatment with oral iodized oil. Acta Endocrinol 1992, 126:149-154.
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Residual goitre in the postiodization phase: Iodine status, thiocyanate exposure and autoimmunity
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Marwaha RK, Tandon N, Gupta N, et al.: Residual goitre in the postiodization phase: iodine status, thiocyanate exposure and autoimmunity. Clin Endocrinol 2003, 59:682-681. This large study shows that other factors apart from autoimmunity are important in the postiodization phase.
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Clin Endocrinol
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Marwaha, R.K.1
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Introduction of iodized salt to severely iodine-deficient children does not provoke thyroid autoimmunity: A one-year prospective trial in northern Morocco
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Zimmermann MB, Moretti D, Chaouki N, et al.: Introduction of iodized salt to severely iodine-deficient children does not provoke thyroid autoimmunity: a one-year prospective trial in northern Morocco. Thyroid 2003, 13:199-203. This carefully conducted prospective trial shows no long-term increase in thyroid Ab.
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Thyroid
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Zimmermann, M.B.1
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The role of iodine in the development of autoimmune thyroiditis
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The incorporation of dietary iodine into thyroglobulin increases its immunogenicity
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Recognition of thyroglobulin auto-antigenic epitopes by murine T and B cells
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Iodide excess induces apoptosis in thyroid cells through a P53-independent mechanism involving oxidative stress
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Vitale M, Di Matola T, D'Ascoli F, et al.: Iodide excess induces apoptosis in thyroid cells through a P53-independent mechanism involving oxidative stress. Endocrinology 2000, 141:598-605.
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Iodine excess and thyroid autoimmunity
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Bournaud C, Orgiazzi J: Iodine excess and thyroid autoimmunity. J Endocrinol Invest 2003, 26:49-56. This is an up-to-date review of the topic.
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Increased prevalence of thyroglobulin antibodies in Sri Lankan schoolgirls - Is iodine the cause?
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Premawardhana LD, Parkes AB, Smyth PP, et al.: Increased prevalence of thyroglobulin antibodies in Sri Lankan schoolgirls - is iodine the cause? Eur J Endocrinol 2000, 143:185-188.
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Evolution of thyroid autoimmunity during iodine prophylaxis-the Sri Lankan experience
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Mazziotti G, Premawardhana LDKE, Parkes AB, et al.: Evolution of thyroid autoimmunity during iodine prophylaxis-the Sri Lankan experience. Eur J Endocrinol 2003, 149:1003-1110. This paper describes Ab prevalence during a 3-year time span in the same iodine-exposed population.
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Okosieme OE, Premawardhana LDKE, Jayasinghe A, et al.: Thyroglobulin epitope recognition in a post iodine-supplemented Sri Lankan population. Clin Endocrinol 2003, 94:319-330. This study defines Tg epitopes in relation to iodide-induced autoimmunity.
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Iodination of human thyroglobulin (Tg) alters its immunoreactivity. I. Iodination alters multiple epitopes of human Tg
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Thyroid autoimmunity is associated with higher urinary iodine concentrations in a iodine-deficient area of northwestern Greece
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Effect of iodinated contrast media on thyroid function in adults
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Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease
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