A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy: A randomized controlled trial of supervised treatment of psoriasis vulgaris in a day-care setting

British Journal of Dermatology

Volumn 155, Issue 4, 2006, Pages 800-807

  Van De Kerkhof, P C M ^a   Van Der Valk, P G M ^a   Swinkels, O Q J ^a   Kucharekova, M ^a   De Rie, M A ^b   De Vries, H J C ^b   Damstra, R ^c   Oranje, A P ^d   De Waard Van Der Spek, F B ^d   Van Neer, P ^e   Lijnen, R L P ^e   Kunkeler, A C M ^f   Van Hees, C ^f   Haertlein, N G J ^g   Hol, C W ^g  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c NIJ SMELLINGHE HOSPITAL   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e LAURENTIUS HOSPITAL   (Netherlands)

^f Diaconessenhuis Voorburg ^*  (Netherlands)

^g LEO Pharma   (Netherlands)

Author keywords

Calcipotriol; Day care; Dithranol; Psoriasis; Randomized controlled trial; Treatment

Indexed keywords

CALCIPOTRIOL; CORTICOSTEROID; DITHRANOL;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERANCE; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PRIORITY JOURNAL; PSORIASIS VULGARIS; RANDOMIZED CONTROLLED TRIAL; SKIN IRRITATION; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANTHRALIN; CALCITRIOL; DAY CARE; DERMATOLOGIC AGENTS; DRUG ADMINISTRATION SCHEDULE; HUMANS; MIDDLE AGED; OINTMENTS; PROSPECTIVE STUDIES; PSORIASIS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 33748452857     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2006.07393.x     Document Type: Article

References (23)

1. 3 (MC 903) in a double-blind study. Br J Dermatol 1988; 119:223-30.
2. Cunliffe WJ, Berth-Jones J, Claudy A et al. Comparative study of calcipotriol (MC 903) ointment and betamethasone 17-valerate ointment in patients with psoriasis vulgaris. J Am Acad Dermatol 1992; 26:736-43.
3. Kragballe K, Gjertsen BT, de Hoop D et al. Double blind right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Lancet 1991; 337:193-6.
4. Bruce S, Epinette WW, Funicella T et al. Comparative study of calcipotriene (MC 903) ointment and fluocinonide ointment in the treatment of psoriasis. J Am Acad Dermatol 1994; 31:755-9.
5. Mason J, Mason AR, Cork MJ. Topical preparations for the treatment of psoriasis: a systematic review. Br J Dermatol 2002; 146:351-64.
6. Mortensen L, Kragballe K, Wegmann E et al. Treatment of psoriasis vulgaris with topical calcipotriol has no short-term effect on calcium or bone metabolism. Acta Derm Venereol (Stockh) 1993; 73:300-4.
7. Guzzo C, Lazarus G, Goffe B et al. Topical calcipotriene has no short-term effect on calcium and bone metabolism of patients with psoriasis. J Am Acad Dermatol 1996; 34:429-33.
8. Ramsay CA, Berth-Jones J, Brundin G et al. Long-term use of topical calcipotriol in chronic plaque psoriasis. Dermatology 1994; 189:260-4.
9. Kragballe K, Fogh K, Søgaard H. Long-term efficacy and tolerability of topical calcipotriol in psoriasis. Results of an open study. Acta Derm Venereol (Stockh) 1991; 71:475-8.
10. Cullen SI. Long-term effectiveness and safety of topical calcipotriene for psoriasis. Calcipotriene study group. South Med J 1996; 89:1053-6.
11. Gerritsen MJP. Dithranol. In: Textbook of Psoriasis (van de Kerkhof PCM, ed.), 2nd edn. Oxford: Blackwell Science, 2003; 170-90.
12. Swinkels OQJ, Prins M, Veenhuis RT et al. Effectiveness and side effects of UVB-phototherapy, dithranol inpatient therapy and a care instruction program of short contact dithranol in moderate to severe psoriasis. Eur J Dermatol 2004; 14:159-65.
13. Berth-Jones J, Chu AC, Dodd WAH et al. A multi-centre, parallel group comparison of calcipotriol ointment and short-contact dithranol therapy in chronic plaque psoriasis. Br J Dermatol 1992; 127:266-71.
14. Hartman M, Prins M, Swinkels OQJ et al. Cost effectiveness analysis of a psoriasis care instruction programme with dithranol compared with UVB phototherapy and inpatient dithranol treatment. Br J Dermatol 2002; 147:538-44.
15. Prins M, Krabbe PFM, Swinkels OQJ et al. Health-related quality of life of patients with moderate to severe psoriasis. The effect of short contact dithranol treatment in a care instruction program, UVB phototherapy, and in patient dithranol treatment. Acta Derm Venereol (Stockh) 2005; 85:304-10.
16. de Mare S, Calis N, den Hartog G, van de Kerkhof PCM. Outpatient treatment with short-contact dithranol: the impact of frequent concentration adjustments. Acta Derm Venereol (Stockh) 1989; 69:449-51.
17. van der Vleuten CJM, de Jong EMGJ, Rulo EFHC et al. In-patient treatment with calcipotriol versus dithranol in refractory psoriasis. Eur J Dermatol 1995; 5:676-9.
18. van de Kerkhof PCM, de Hoop D, de Korte J et al. Patient compliance and disease management in the treatment of psoriasis in the Netherlands. Dermatology 2000; 200:292-8.
19. Fredricksson T, Pettersson V. Severe psoriasis - oral therapy with a new retinoid. Dermatologica 1978; 157:238-44.
20. Elashoff JD. nQuery Adviser® User's Guide, Version 2.0. Los Angeles, CA: Dixon Associates, 1997.
21. Guenther L, Cambazard F, van de Kerkhof PCM et al. Efficacy and safety of a new combination of calcipotriol and betamethasone dipropionate (once or twice daily) compared to calcipotriol (twice daily) in the treatment of psoriasis vulgaris: a randomized, double-blind, vehicle-controlled clinical trail. Br J Dermatol 2002; 147:316-23.
22. Poyner T, Hughes IW, Dass DK et al. Long-term treatment of chronic plaque psoriasis with calcipotriol. J Dermatol Treat 1993; 4:173-7.
23. Ohgawara A, Kobayashi H, Tagami H et al. Long-term treatment with MC903 (calcipotriol) ointment in patients with psoriasis vulgaris: an open clinical trial. Rinsho Iyaku 1995; 11:2589-607.