A fenbendazole oral drench in addition to an ivermectin pour-on reduces parasite burden and improves feedlot and carcass performance of finishing heifers compared with endectocides alone

Journal of Animal Science

Volumn 84, Issue 8, 2006, Pages 2243-2250

  Reinhardt, C D ^a   Hutcheson, J P ^b   Nichols, W T ^b  

^a KANSAS STATE UNIVERSITY   (United States)

^b MERCK ANIMAL HEALTH   (United States)

Author keywords

Doramectin; Fenbendazole; Finishing heifer; Internal parasite; Ivermectin

Indexed keywords

ANTHELMINTIC AGENT; DORAMECTIN; DRUG DERIVATIVE; FENBENDAZOLE; IVERMECTIN;

ANIMAL; ANIMAL PARASITOSIS; ARTICLE; BODY COMPOSITION; CATTLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; TOPICAL DRUG ADMINISTRATION; WEIGHT GAIN;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ANIMALS; ANTHELMINTICS; BODY COMPOSITION; CATTLE; FEMALE; FENBENDAZOLE; HELMINTHIASIS, ANIMAL; IVERMECTIN; WEIGHT GAIN;

BOS TAURUS; COOPERIA; TRICHOSTRONGYLUS;

EID: 33748438881     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/jas.2005-598     Document Type: Article

References (26)

1. Alva-Valdes, R., D. H. Wallace, J. E. Holste, J. R. Egerton, J. L. Cox, J. W. Wooden, and R. A. Barrick. 1986. Efficacy of ivermectin in a topical formulation against induced gastrointestinal and pulmonary nematode infections, and naturally acquired grubs and lice in cattle. Am. J. Vet. Res. 47:2389-2392.
2. Armour, J., W. F. H. Jarrett, and F. W. Jennings. 1966. Experimental Ostertagia circumcincta infections in sheep: Development and pathogenesis of a single infection. Am. J. Vet. Res. 27:1267-1278.
3. Bliss, D. H., R. Muser, W. Kvasnicka, L. Krysl, L. Laurence, and R. Lastovica. 1991. Comparative evaluation of fenbendazole (5 mg/ kg of BW) administered in a 6-day feeding and ivermectin (100-200 meg/kg of BW) administered subcutaneous. Proc. Am. Assoc. Vet. Parasit., Seattle, WA.
4. Conder, G. A., K. A. Rooney, E. F. Illyes, D. S. Keller, T. R. Meinert, and N. B. Logan. 1998. Field efficacy of doramectin pour-on against naturally-acquired, gastrointestinal nematodes of cattle in North America. Vet. Parasitol. 77:259-265.
5. Couvillion, C. E., L. M. Pote, C. Siefker, and N. B. Logan. 1997. Efficacy of doramectin for treatment of experimentally induced infection with gastrointestinal nematodes in calves. Am. J. Vet. Res. 58:282-285.
6. Cox, D. D., and A. C. Todd. 1962. Survey of gastrointestinal parasitism in Wisconsin dairy cattle. J. Am. Vet. Med. Assoc. 141:706-709.
7. FDA. 2003. Panacur/SafeGuard (fenbendazole) suspension 10%. Freedom of Information Summary. NADA 128-620. Rockville, MD.
8. FDA. 2004. Noramectin (ivermectin) pour-on for cattle. Freedom of Information Summary. ANADA 200-272. Rockville, MD.
9. Fiel, C. A., C. A. Saumell, P. E. Steffan, and E. M. Rodriguez. 2001. Resistance of Cooperia to ivermectin treatments in grazing cattle of the Humid Pampa, Argentina. Vet. Parasitol. 97:211-217.
10. Fox, M. T., D. Gerrelli, S. R. Pitt, D. E. Jacobs, E. M. Gill, and D. L. Gale. 1989a. Ostertagia ostertagi infection in the calf: Effects of a trickle challenge on appetite, digestibility, rate of passage of digesta and live BW gain. Res. Vet. Sci. 47:294-298.
11. Fox, M. T., D. Gerrelli, S. R. Pitt, D. E. Jacobs, E. M. Gill, and D. L. Gale. 1989b. Ostertagia ostertagi infection in the calf: Effects of a trickle challenge on the hormonal control of digestive and metabolic function. Res. Vet. Sci. 47:299-304.
12. Fox, M. T. 1997. Pathophysiology of infection with gastrointestinal nematodes in domestic ruminants: Recent developments. Vet. Parasitol. 72:285-297.
13. Fox, M. T., U. E. Uche, C. Vaillant, S. Ganabadi, and J. Calam. 2002. Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf. Vet. Parasitol. 105:285-301.
14. Gómez-Muñoz, M. T., A. Canals-Caballero, S. Almeria, P. Pasquali, D. S. Zarlenga, and L. C. Gasbarre. 2004. Inhibition of bovine T lymphocyte responses by extracts of the stomach worm Ostertagia ostertagi. Vet. Parasitol. 120:199-214.
15. Guichon, P. T., G. K. Jim, C. W. Booker, O. C. Schunicht, B. K. Wildman, and J. R. Brown. 2000. Relative cost effectiveness of treatment of feedlot calves with ivermectin versus treatment with a combination of fenbendazole, permethrin and fenthion. J. Am. Vet. Med. Assn. 216:1965-1969.
16. Lee, R. W. 1985. Feedlot performance of steers given different anthelmintic treatments. Kansas State Univ. Agric. Exp. Sta. Report of Progress 474. Kansas State Univ. Agric. Exp. Sta. Cooperative Ext. Serv., Manhattan.
17. McLeay, L. M., N. Anderson, J. B. Bingley, and D. A. Titchen. 1973. Effects on abomasal function of Ostertagia circumcincta infections in sheep. Parasitology 66:241-257.
18. Miller, J. E., and D. G. Morrison. 1992. Effect of fenbendazole and ivermectin on development of strongylate nematode eggs and larvae in calf feces. Vet. Parasitol. 43:265-270.
19. Myers, G. H., and R. J. Grant. 1988. Effects of fenbendazole and ivermectin on performance of feedlot cattle. Agric. Prac. 9:40-42.
20. Ritchie, D. J. S., N. Anderson, and J. Armour. 1966. Experimental Ostertagia ostertagi infections in calves: Parasitology and pathogenesis of a single infection. Am. J. Vet. Res. 27:659-667.
21. Smith, R. A., K. C. Rogers, S. Husae, M. I. Wray, R. T. Brandt, J. P. Hutcheson, W. T. Nichols, R. F. Taylor, J. R. Rains, and C. T. McCauley. 2000. Pasture deworming and (or) subsequent feedlot deworming with fenbendazole. I. Effects on grazing performance, feedlot performance and carcass traits in yearling steers. Bovine Pract. 34:104-114.
22. Snider, T. G., J. C. Williams, P. A. Karns, T. L. Romaire, H. E. Trammel, and M. T. Kearney. 1986. Immunosuppression of lymphocyte blastogenesis in cattle infected with Ostertagia ostertagi and/or Trichostrongylus axei. Vet. Immunol. Immunopathol. 11:251-264.
23. Sykes, A. R., and R. L. Coop. 1977. Intake and utilization of food by growing sheep with abomasal damage caused by daily dosing with Ostertagia circumcincta larvae. J. Agric. Sci. 88:671-677.
24. Taylor, R. F., D. H. Bliss, R. T. Brandt, Jr., W. T. Nichols, J. R. Rains, J. P. Hutcheson, and R. A. Smith. 2000. Pasture deworming and (or) subsequent feedlot deworming with fenbendazole. II. Effects on abomasal worm counts and abomasal pathology of yearling steers. Bovine Pract. 34:115-123.
25. Wiggin, C. J., and H. C. Gibbs. 1990. Adverse immune reactions and the pathogenesis of Ostertagia ostertagi infections in calves. Am. J. Vet. Res. 51:825-832.
26. Williams, J. C., A. DeRosa, Y. Nakamura, and A. F. Loyacano. 1997. Comparative efficacy of ivermectin pour-on, albendazole, oxfendazole and fenbendazole against Ostertagia ostertagi inhibited larvae, other gastrointestinal nematodes and lungworm of cattle. Vet. Parasitol. 73:73-82.