Recurrent intramural hematoma of the small intestine in a severe hemophilia A patient with a high titer of factor VIII inhibitor: A case report and review of the literature

International Journal of Hematology

Volumn 84, Issue 2, 2006, Pages 166-169

  Katsumi, Akira ^a   Matsushita, Tadashi ^a   Hirashima, Kanji ^a   Iwasaki, Toshihiro ^a   Adachi, Tatsuya ^a   Yamamoto, Koji ^b   Kojima, Tetsuhito ^c   Takamatsu, Junki ^b   Saito, Hidehiko ^d   Naoe, Tomoki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY HOSPITAL   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

^d NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

Author keywords

Activated prothrombin complex concentrate; Hemophilia A; Inhibitor; Intramural hematoma; Small intestine

Indexed keywords

ACTIVATED PROTHROMBIN COMPLEX; BLOOD CLOTTING FACTOR 8 INHIBITOR; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ABDOMINAL PAIN; ADOLESCENT; ANAMNESIS; ANTIBODY TITER; CASE REPORT; CLINICAL FEATURE; DRUG EFFICACY; HEMOPHILIA A; HUMAN; INTESTINE HEMATOMA; JEJUNUM; MALE; RECURRENT DISEASE; REVIEW; TREATMENT OUTCOME;

ADOLESCENT; BLOOD COAGULATION FACTOR INHIBITORS; BLOOD COAGULATION FACTORS; HEMATOMA; HEMOPHILIA A; HUMANS; INTESTINAL DISEASES; JEJUNUM; MALE; TIME FACTORS;

EID: 33748437524     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.06053     Document Type: Review

References (31)

1. Mittal R, Spero JA, Lewis JH, et al. Patterns of gastrointestinal hemorrhage in hemophilia. Gastroenterology. 1985;88:515-522.
2. Gilles JG, Jacquemin MG, Saint-Remy JM. Factor VIII inhibitors. Thromb Haemost. 1997;78:641-646.
3. Kreuz W, Ettingshausen CE, Zyschka A, et al. Inhibitor development in previously untreated patients with hemophilia A: a prospective long-term follow-up comparing plasma-derived and recombinant products. Semin Thromb Hemost. 2002;28:285-290.
4. Lusher JM. Inhibitors in young boys with haemophilia. Baillieres Best Pract Res Clin Haematol. 2000;13:457-468.
5. Lusher JM. First and second generation recombinant factor VIII concentrates in previously untreated patients: recovery, safety, efficacy, and inhibitor development. Semin Thromb Hemost. 2002;28:273-276.
6. Scharrer I, Bray GL, Neutzling O. Incidence of inhibitors in haemophilia A patients-a review of recent studies of recombinant and plasma-derived factor VIII concentrates. Haemophilia. 1999;5:145-154.
7. Forbes CD, Barr RD, Prentice CR, Douglas AS. Gastrointestinal bleeding in haemophilia. Q J Med. 1973;42:503-511.
8. Cagnoni PJ, Aledort L. Gastrointestinal bleeding in hemophilia as a complication of the use of over the counter non-steroidal anti-inflammatory drugs. Am J Hematol. 1994;47:336-337.
9. Ramadan KM, Lowry JP, Wilkinson A, McNulty O, McMullin MF, Jones FG. Acute intestinal obstruction due to intramural haemorrhage in small intestine in a patient with severe haemophilia A and inhibitor. Eur J Haematol. 2005;75:164-166.
10. Khilnani MT, Marshak RH, Eliasoph J, Wolf BS. Intramural intestinal hemorrhage. Am J Roentgenol Radium Ther Nucl Med. 1964;92:1061-1071.
11. Santoro R, Iannaccaro P. Spontaneous intramural intestinal haemorrhage in a haemophiliac patient. Br J Haematol. 2004;125:419.
12. Ettingshausen CE, Saguer IM, Kreuz W. Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding-successful thrombolysis under heparin therapy. Eur J Pediatr. 1999;158(suppl 3):S180-182.
13. Gamba G, Maffe GC, Mosconi E, Tibaldi A, Di Domenico G, Frego R. Ultrasonographic images of spontaneous intramural hematomas of the intestinal wall in two patients with congenital bleeding tendency. Haematologica. 1995;80:388-389.
14. Tsuchie K, Suzuki M, Yamada M, Hoshino S, Chin H. Intramural hematoma of the small intestine due to hemophilia A: report of two cases [in Japanese]. Rinsho Hoshasen. 1985;30:1599-1602.
15. Eiland M, Han SY, Hicks GM Jr. Intramural hemorrhage of the small intestine. JAMA. 1978;239:139-142.
16. Sharma ID, Chandra D, Charan A, Sinha KN. Haemophilia presenting as acute mechanical small intestinal obstruction. J Indian Med Assoc. 1972;59:109-110.
17. Dodds WJ, Spitzer RM, Friedland GW Gastrointestinal roentgenographic manifestations of hemophilia. Am J Roentgenol Radium Ther Nucl Med. 1970;110:413-416.
18. Gordon RA, d'Avignon MB, Storch AE, Eyster ME. Intramural gastric hematoma in a hemophiliac with an inhibitor. Pediatrics. 1981;67:417-419.
19. Felson B. Intramural gastric lesion with sudden abdominal pain. JAMA. 1974;230:603-604.
20. Yoshimura H, Ohishi H, Inoue K, et al. Roentgenographic manifestations of intramural hematoma of the stomach in a hemophiliac male. Rinsho Hoshasen. 1978;23:1405-1408.
21. Wright FW, Matthews JM. Hemophilic pseudotumor of the stomach. Radiology. 1971;98:547-549.
22. Grossman H, Berdon WE, Baker DH. Reversible gastrointestinal signs of hemorrhage and edema in the pediatric age group. Radiology. 1965;84:33-39.
23. Horan P, Drake M, Patterson RN, Cuthbert RJ, Carey D, Johnston SD Acute onset dysphagia associated with an intramural oesophageal haematoma in acquired haemophilia. Eur J Gastroenterol Hepatol. 2003;15:205-207.
24. Chawla A, Blume MH, Insel J. Spontaneous intramural hematoma of the esophagus. Ann Intern Med. 2002;137:73-74.
25. Intragumtornchai T, Israsena S, Benjacholamard V, Lerdlum S, Benjavongkulchai S. Esophageal tuberculosis presenting as intramural esophagogastric hematoma in a hemophiliac patient. J Clin Gastroenterol. 1992;14:152-156.
26. Oldenburger D, Gundlach WJ. Intramural esophageal hematoma in a hemophiliac. An unusual cause of gastrointestinal bleeding. JAMA. 1977;237:800.
27. Jewett TC Jr, Caldarola V, Karp MP, Allen JE, Cooney DR. Intramural hematoma of the duodenum. Arch Surg. 1988;123:54-58.
28. Fripp RR, Karabus CD. Intussusception in haemophilia: a case report. S Afr Med J. 1977;52:617-618.
29. LeBlanc KE. Jejuno-jejunal intussusception in a hemophiliac: a case report. Ann Emerg Med. 1982;11:149-151.
30. Allen G, Aledort L. Therapeutic decision-making in inhibitor patients. Am J Hematol. 2006;81:71-72.
31. Berntorp E, Donfleld S, Waters J, et al. The FEIBA NovoSeven Comparative Study (FENOC)-a randomized evaluation of by-passing agents in hemophilia complicated by inhibitors. Blood. 2005;106:98a.