Evaluation of clioquinol activity towards transmissible spongiform encephalopathies (TSE) in cellular models and cell-free systems

Veterinary Research Communications

Volumn 30, Issue SUPPL. 1, 2006, Pages 253-255

  Formentin, Elena A M ^a   Puricelli, M ^a   Pollera, C ^a   Ponti, W ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Clioquinol; Copper; In vitro models; TSE

Indexed keywords

CLIOQUINOL; DIMETHYL SULFOXIDE; PRION PROTEIN;

ANIMAL CELL; ARTICLE; CELL FREE SYSTEM; CHEMOLUMINESCENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY TEST; DRUG EFFICACY; DRUG MECHANISM; MOUSE; NONHUMAN; PRION DISEASE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SAMPLE; SCRAPIE AGENT; VIRUS STRAIN; WESTERN BLOTTING;

EID: 33748432567     PISSN: 01657380     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11259-006-0054-4     Document Type: Article

References (4)

1. Brown, D.R., 2004. Role of the prion protein in copper turnover in astrocytes. Neurobiology of Disease, 15, 534-543
2. Harris, D.A., 2003. Trafficking, turnover and membrane topology of PrP. British Medical Bulletin, 66, 71-85
3. Nitzan, Y.B., Sekler, I., Frederickson, C.J., Coulter, D.A., Balani, R.V., Liang, S.L., Margulis, A., Hershfinkel, M. and Silverman, W.F., 2003. Clioquinol effects on tissue chelatable zinc in mice. Journal of Molecular Medicine, 81 (10), 637-644
4. Schaller, O., Fatzer, R., Stack, M., Clark, J., Cooley, W., Biffiger, K., Egli, S., Doherr, M., Vandevelde, M., Heim, D., Oesch, B. and Moser, M., 1999 Validation of a western immunoblotting procedure for bovine PrP(Sc) detection and its use as a rapid surveillance method for the diagnosis of bovine spongiform encephalopathy (BSE). Acta Neuropathologica, 98 (5), 437-443