Ascending aorta dilatation in aortic valve disease: Morphological analysis of medial changes

Heart and Vessels

Volumn 21, Issue 4, 2006, Pages 213-220

  Agozzino, Lucio ^a   Santè, Pasquale ^a   Ferraraccio, Franca ^a   Accardo, Marina ^a   De Feo, Marisa ^a   De Santo, Luca Salvatore ^a   Nappi, Gianantonio ^a   Agozzino, Manuela ^b   Esposito, Salvatore ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Aneurysm; Aortic root; Aortic valve; Electron microscopy; Medial degeneration

Indexed keywords

ADULT; ADVENTITIA; AGED; ANEURYSM; ANEURYSM RUPTURE; AORTA ATHEROSCLEROSIS; AORTA DISSECTION; AORTA INTIMA; AORTA MEDIA; AORTA VALVE DISEASE; AORTITIS; ARTERY DILATATION; ARTICLE; ASCENDING AORTA; CELL DEGENERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ECHOCARDIOGRAPHY; ELASTIC FIBER; ELECTRON MICROSCOPY; EXTRACELLULAR MATRIX; FEMALE; FIBROSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; NECROSIS; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; STATISTICAL SIGNIFICANCE; STUDENT T TEST; TREATMENT PLANNING; ULTRASTRUCTURE;

AGED; AGED, 80 AND OVER; AORTA; AORTIC VALVE INSUFFICIENCY; DILATATION, PATHOLOGIC; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED;

EID: 33748431971     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00380-005-0891-z     Document Type: Article

References (42)

1. TE Guiney MJ Davies DJ Parker GJ Leech A Leatham 1987 The aetiology and course of isolated severe aortic regurgitation: A clinical, pathological and ecocardiographic study Br Heart J 58 358-368 3676022 1:STN:280:BieD2M%2Fkt1M%3D
2. HM Awadalla JG Salloum HV Andereson 2004 Three-dimensional reconstruction of a rotational abdominal aortogram showing a renal artery aneurysm Heart Vessels 19 101-102 15042396 10.1007/ s00380-003-0713-0
3. S Ohtsubo T Itoh K Furukawa K Rikitake Y Okazaki M Natsuali 2002 Geometrical difference between an ascending aneurysm and a root aneurysm in valve sparing operations Jpn J Thorac Cardiovasc Surg 50 59-65 11905059 10.1055/s-2002-20154
4. MG Barnett AC Fiore KJ Vaca TW Milligan HB Barner 1995 Tailoring aortoplasty for repari of fusiform ascending aortic aneurysms Ann Thorac Surg 59 497-501 7847974 1:STN:280:ByqC2M%2FmsF0%3D 10.1016/ 0003-4975(94)00946-5
5. D Bonderman E Gharehbaghi-Schnell G Wollenek G Maurer H Baumgartner IM Lang 1999 Mechanisms underlying aortic dilatation in congenital aortic valve malformation Circulation 99 2138-2143 10217654 1:STN:280:DyaK1M3jtl2qsA%3D%3D
6. MG Keane SE Wiegers T Plappert A Pochettino J Bavaria M Sutton 2000 Bicuspid aortic valves are associated with aortic dilatation out of proportion to coexistent valvular lesions Circulation 102 III-351:STN:280:DC%2BD3M%2FlvFOqug%3D%3D
7. XM Mueller HT Tevaearai CY Genton M Hurni P Ruchat AP Fischer F Stumpe LK von Segesser 1997 Drawback of aortoplasty for aneurysm of the ascending aorta associated with aoritc valve disease Ann Thorac Surg 63 762-766 9066398 1:STN:280:ByiB3MbgvFw%3D 10.1016/S0003-4975(97)00008-8
8. M Bauer M Pasic R Meyer N Goetze U Bauer H Siniawski R Hetzer 2002 Morphometric analysis of aortic media in patients with bicuspid and tricuspid aortic valve Ann Thorac Surg 74 58-62 12118804 10.1016/ S0003-4975(02)03650-0
9. MJF Bechtel F Noack F Sayk AW Erasmi C Bartels HH Sievers 2003 Histopathological grading of ascending aortic aneurysm: Comparison of patients with bicuspid versus tricuspid aortic valve J Heart Valve Dis 12 54-59
10. M de Sa Y Moshkovitz J Butany TE David 1999 Histologic abnormalities of the ascending aorta and pulmonary trunk in patients with bicuspid aortic valve disease: Clinical relevance to the Ross procedure J Thorac Cardiovasc Surg 118 588-594 10504620 1:STN:280:DyaK1Mvjs1aluw%3D%3D 10.1016/S0022-5223(99)70002-4
11. E Arbustini 1998 Three novel mutations in the fibrillin gene (FBN1) in Marfan syndrome patients. Eur J Hum Genet 6 60
12. U Francke MA Berg K Tynan T Breen W Liu T Aoyama C Gasner DC Miller H Furthmayr 1995 A Gly I 127Ser mutation in an EGF-like domain of the fibrillin-1 gene is a risk factor for ascending aortic aneurysm and dissection. Am J Hum Genet 56 1287-1296 1:CAS:528:DyaK2MXmvVWmt7w%3D
13. J Erdheim 1929 Medionecrosis aortae idiopathica Virchows Arch 273 454-479 10.1007/BF02158989
14. TJ Schlatmann AE Becker 1977 Histologic changes in the normal aging aorta: Implications for dissecting aortic aneurysm. Am J Cardiol 39 13-20 1:STN:280:CSiD1cvpt1c%3D
15. TJ Schlatmann AE Becker 1977 Pathogenesis of dissecting aortic aneurysm of the aorta. Comparative histopathologic study of significance of medial changes Am J Cardiol 39 21-26 831424 1:STN:280:CSiD1cvpt1M%3D 10.1016/S0002-9149(77)80005-2
16. KJ Grande RP Cochran PG Reinhal KS Kunzelman 1998 Stress variations in the human aortic root and valve: The role of anatomic asymmetry Ann Biomed Eng 26 534-545 9662146 1:STN:280:DyaK1czisVGhsQ%3D%3D 10.1114/ 1.122
17. SJ Choo G McRae JP Olomon G St. George W Davis CL Burleson-Bowles D Pang HH Luo D Vavra DT Cheung JH Oury CM Duran 1999 Aortic root geometry: pattern of differences between leaflets and sinuses of Valsalva J Heart Valve Dis 8 407-415 10461241 1:STN:280:DyaK1MzptVensA%3D%3D
18. KJ Grande RP Cochran PG Reiinhall KS Kunzelman 2000 Mechanism of aortic valve incompetence: Finite element modeling of aortic root dilatation Ann Thorac Surg 69 1851-1857 10892936 1:STN:280:DC%2BD3czkvFShtw%3D%3D 10.1016/S0003-4975(00)01307-2
19. RJ Okamoto JE Wagenseil WR De Long SJ Peterson NT Kouchoukos TM Sundt 3rd 2002 Mechanical properties of dilated human ascending aorta Ann Biomed Eng 30 624-635 12108837 10.1114/1.1484220
20. C Stefanadis J Dernellis P Toutouzas 1999 Mechanical properties of the aorta determined by the pressure-diameter relation Pathol Biol 47 696-704 10522260 1:STN:280:DyaK1MvltFOmug%3D%3D
21. H Hayashi H Kawamata K Ichikawa 2004 Rupture of a thoracic aortic aneurysm: A rare adverse reaction following systemic tissue plasminogen activator infusion Heart Vessels 19 42-44 10.1007/s00380-003-0746-4
22. M Cotrufo LS Santo S Esposito A Renzulli A Della Corte M De Feo C Marra L Agozzino 2001 Asymmetric medial degeneration of the intrapericardial aorta in aortic valve disease Int J Cardiol 81 37-41 11690663 1:STN:280:DC%2BD3MnktVOjsw%3D%3D 10.1016/S0167-5273(01)00526-5
23. R Bellitti A Caruso M Festa V Mazzei S Iesu A Falco M Cotrufo L Agozzino 1985 Prolapse of the "floppy" aortic valve as a cause of aortic regurgitation. A clinico-morphologic study Int J Cardiol 9 399-410 I 4077299 1:STN:280:BimD1cvlvVw%3D 10.1016/0167-5273(85)90234-7
24. L Agozzino F De Vivo A Falco L De Luca Tupputi Schinosa M Cotrufo 1994 Non-inflammatory aortic root disease and floppy aortic valve as cause of isolated regurgitation: A clinico-morphologic study Int J Cardiol 45 129-134 7960251 1:STN:280:ByqD2cfptFw%3D 10.1016/0167-5273(94)90268-2
25. L Agozzino F Ferraraccio S Esposito A Trocciola A Parente A Della Corte M De Feo M Cotrufo 2002 Medial degeneration does not involve uniformly the whole ascending aorta: Morphological, biochemical and clinical correlation Eur J Cardiothorac Surg 21 675-682 11932167 1:STN:280:DC%2BD387pvFeluw%3D%3D 10.1016/S1010-7940(02)00022-2
26. S Westaby S Saito K Anastasiadis M Moorjani XY Jin 2002 Aortic root remodelling in atheromatous aneurysms: The role of selected sinus repair Eur J Cardiothorac Surg 21 459-464 11888763 10.1016/S1010-7940(01)01155-1
27. M Cotrufo A Della Corte LS De Santo M De Feo FE Covino G Dialetto 2003 Asymmetric medial degeneration of the ascending aorta in aortic valve disease: A pilot study on the surgical management J Heart Valve Dis 12 127-133 12701781
28. MJ Roman RB Devereux R Kramer-Fox J O'Laughlin 1989 Two-dimensional echocardiographic aortic root dimensions in normal children and adults Am J Cardiol 64 507-512 2773795 1:STN:280:BiaA2s7ltVA%3D 10.1016/ 0002-9149(89)90430-X
29. A Redaelli E Di Martino A Gamba AM Procopio R Fumero 1997 Assessment of the influence of the compliant aortic root on aortic valve mechanics by means of a geometrical model Med Eng Phys 19 696-710 9450254 1:STN:280:DyaK1c7htF2htg%3D%3D 10.1016/S1350-4533(97)00033-7
30. T Guiney G Leech MJ Davies A Wilson J Parker A Leatham 1981 Non-inflammatory aortic root disease: An important cause of aortic regurgitation. Ecocardiographic and histologic correlation Am J Cardiol 47 42510.1016/0002-9149(81)90776-1
31. K Niwa JK Perloff SM Bhuta H Laks DC Drinkwater JS Child PD Miner 2001 Structural abnormalities of great arterial walls in congenital heart disease: Light and electron microscopic analyses Circulation 103 393-400 11157691 1:STN:280:DC%2BD3M3is1aksw%3D%3D
32. WI Schievink B Mokri 1995 Familial aorto-cervicocephalic arterial dissections and congenitally bicuspid aortic valve Stroke 26 1935-1940 7570751 1:STN:280:BymD38votlw%3D
33. RT Pachulski AL Weinberg KL Chan 1991 Aortic aneurysm in patients with functionally normal or minimally stenotic bicuspid aortic valve Am J Cardiol 67 781-782 2006634 1:STN:280:By6C2svgtF0%3D 10.1016/ 0002-9149(91)90544-U
34. JL Parai RG Masters VM Walley WA Stinson JP Veinot 1999 Aortic medial changes associated with bicuspid aortic value: Myth or reality? Can J Cardiol 15 1233-1238 1:STN:280:DC%2BD3c%2FkslShtw%3D%3D
35. ML Kirby TF Gale DE Stewart 1983 Neural crest cells contribute to normal aorticopulmonary septation Science 220 1059-1061 6844926 1:STN:280:BiyC1MjjvFU%3D
36. C Ihling T Szombathy K Nampoothiri J Haendeler F Beyersdorf M Uhl AM Zeiher HE Schaefer 1999 Cystic medial degeneration of the aorta is associated with p-53 accumulation, Bax upregulation, apoptotic cell death, and cell proliferation Heart 82 286-293 10455077 1:STN:280:DyaK1MzoslahsQ%3D%3D
37. A Lopez-Candales DR Holmes S Liao MJ Scott SA Wickline RW Thompson 1997 Decreased vascular smooth muscle density in medial degeneration of human abdominal aortic aneurysms Am J Pathol 150 993-1007 9060837 1:STN:280:ByiB3MvksFM%3D
38. MR Bennett 1999 Apoptosis of vascular smooth muscle cells in vascular remodeling and atherosclerotic plaque rupture Cardiovasc Res 41 361-368 10341835 1:CAS:528:DyaK1MXht12ru7w%3D 10.1016/S0008-6363(98)00212-0
39. V Lesauskaite P Tanganelli C Sassi E Neri F Diciolla L Ivanoviene MC Epistolato AV Ralinga C Alessandrini D Spina 2001 Smooth muscle cells of the media in the dilatative pathology of ascending thoracic aorta: morphology, immunoreactivity for osteopontin, matrix metalloproteinases, and their inhibitors Hum Pathol 32 1003-1011 11567232 1:STN:280:DC%2BD3MrhvFOlsQ%3D%3D 10.1053/hupa.2001.27107
40. FX Schmid K Bielenberg S Holmer K Lehle B Djavidani C Prasser C Wiesenack D Birnbaum 2004 Structural and biomolecular changes in aorta and pulmonary trunk of patients with aortic aneurysm and valve disease: implications for the Ross procedure Eur J Cardiothorac Surg 25 748-753 15082277 10.1016/j.ejcts.2004.02.028
41. VL Rowe SL Stevens TT Reddick MB Freeman R Donnell RC Carroll MH Goldman 2000 Vascular smooth muscle cell apoptosis in aneurysmal, occlusive, and normal human aortas J Vasc Surg 31 567-576 10709071 1:STN:280:DC%2BD3c7nsFKksw%3D%3D 10.1016/S0741-5214(00)90319-7
42. A Saraste K Pulkki 2000 Morphologic and biochemical hallmarks of apoptosis Cardiovasc Res 45 528-537 10728374 1:CAS:528:DC%2BD3cXltVGlsg%3D%3D 10.1016/S0008-6363(99)00384-3