Within-animal variation as an indication of the minimal magnitude of the critical effect size for continuous toxicological parameters applicable in the benchmark dose approach

Risk Analysis

Volumn 26, Issue 4, 2006, Pages 867-880

  Dekkers, Susan ^a   Telman, Jan ^a   Rennen, Monique A J ^a   Appel, Marco J ^a   De Heer, Cees ^a  

^a TNO   (Netherlands)

Author keywords

Adverse effect; Benchmark approach; Critical effect size; Within animal variation

Indexed keywords

BENCHMARKING; BIODIVERSITY; DATA REDUCTION; ERROR ANALYSIS; PARAMETER ESTIMATION; RISK ASSESSMENT;

ADVERSE EFFECTS; BENCHMARK APPROACH; CRITICAL EFFECT SIZE (CES); WITHIN-ANIMAL VARIATION;

TOXICITY;

INTRASPECIFIC VARIATION; RODENT; TEMPORAL VARIATION; TOXICITY; VARIANCE ANALYSIS;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; CIRCADIAN RHYTHM; CLINICAL CHEMISTRY; CONTROLLED STUDY; EFFECT SIZE; FEMALE; HEMATOLOGY; MALE; NONHUMAN; RAT; REVIEW; SEX DIFFERENCE; TOXICITY TESTING; TOXICOLOGICAL PARAMETERS;

ANALYSIS OF VARIANCE; ANIMALS; DATA INTERPRETATION, STATISTICAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; POISONS; RATS; RATS, WISTAR; RISK ASSESSMENT; TOXICOLOGY;

ANIMALIA;

EID: 33748426204     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2006.00784.x     Document Type: Review

References (9)

1. Crump, K. S. (1984). A new method for determining allowable daily intakes. Fundamental and Applied Toxicology, 4, 854-871.
2. Dekkers, S., de Heer, C., & Rennen, M. A. J. (2001). Critical effect sizes in toxicological risk assessment: A comprehensive and critical evaluation. Environmental Toxicology and Pharmacology, 10(1-2), 33-52.
3. Gaylor, D. W., & Slikker, W. (2004). Role of the standard deviation in the estimation of benchmark doses with continuous data. Risk Analysis, 24(6), 1683-1687.
4. Health Council of the Netherlands. (2003). Benchmark Dose Method: Health-Based Recommended Exposure Limits in New Perspective, Publication No. 2003/06. The Hague: Health Council of the Netherlands.
5. Sebastián-Gámbaro, M. A., Lirón-Hernández, F. J., & Fuentes-Arderiu, X. (1997). Intra- and inter-individual biological variability data bank. European Journal of Clinical Chemistry and Clinical Biochemistry, 35, 845-852.
6. Slob, W. (2002). Dose-response modeling of continuous endpoints. Toxicological Science, 66(2), 298-312.
7. Slob, W., & Pieters, M. N. (1998). A probabilistic approach for deriving acceptable human intake limits and human health risks from toxicological studies: General framework. Risk Analysis, 18(6), 787-798.
8. U.S. EPA (Environmental Protection Agency). (1995). The Use of the Benchmark Dose Approach in Health Risk Assessment. EPA/630/R-94/007. Washington: U.S. Environmental Protection Agency.
9. Vermeire, T. G., Jager, T., Janssen, G., Bos, P. M. J., & Pieters, M. N. (2001). A probabilistic human health risk assessment for environmental exposure to dibutylphthalate. Human and Ecological Risk Assessment, 7, 1663-1679.