Phase II study of unrelated cord blood transplantation for adults with high-risk hematologic malignancies

Bone Marrow Transplantation

Volumn 38, Issue 6, 2006, Pages 421-426

  Lekakis, L ^a   Giralt, S ^a   Couriel, D ^a   Shpall, E J ^a   Hosing, C ^a   Khouri, I F ^a   Anderlini, P ^a   Korbling, M ^a   Martin, T ^b   Champlin, R E ^a   de Lima, M ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; DACLIZUMAB; FLUDARABINE; MELPHALAN; METHOTREXATE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE LEUKEMIA; ADULT; ARTICLE; BLOOD TRANSFUSION; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE ACTIVITY; DISEASE FREE SURVIVAL; DONOR SELECTION; FEMALE; GRAFT FAILURE; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HIGH RISK PATIENT; HLA MATCHING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; LYMPHOMA; MALE; MORTALITY; MULTIPLE MYELOMA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PUVA; RISK ASSESSMENT; SURVIVAL RATE; SURVIVAL TIME; TREATMENT DURATION; TREATMENT OUTCOME; WHOLE BODY RADIATION;

ADULT; ANTILYMPHOCYTE SERUM; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MELPHALAN; METHOTREXATE; MIDDLE AGED; MYELOABLATIVE AGONISTS; RECURRENCE; RISK FACTORS; TACROLIMUS; TRANSPLANTATION CONDITIONING; VIDARABINE; WHOLE-BODY IRRADIATION;

EID: 33748425732     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/sj.bmt.1705467     Document Type: Article

References (23)

1. Appelbaum FR. The current status of hematopoietic cell transplantation. Annu Rev Med 2003; 54: 491-512.
2. Barker JN, Weisdorf DJ, Wagner JE. Creation of a double chimera after the transplantation of umbilical-cord blood from two partially matched unrelated donors. N Engl J Med 2001; 344: 1870-1871.
3. Rocha V, Labopin M, Sanz G, Arcese W, Schwerdtfeger R, Bosi A et al. Transplants of umbilical cord blood or bone marrow from unrelated donors in adults with Acute Leukemia. N Engl J Med 2004; 351: 2276-2285.
4. Gluckman E, Rocha V, Arcese W, Michel G, Sanz G, Chan KW et al. Factors associated with outcomes of unrelated cord blood transplant: Guidelines for donor choice. Exp Hematol 2004; 32: 397-407.
5. Laughlin MJ, Eapen M, Rubinstein P, Wagner JE, Zhang MJ, Champlin RE et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004; 351: 2265-2275.
6. Haut PR, Gonzalez-Ryan L, Wang LJ, Olszewski M, Morgan E, Kletzel M. Induction of a transient graft vs leukemia effect following unrelated cord blood transplantation. Pediatr Transplant 2002; 6: 348-351.
7. Gardiner CM, Carver J, Abraham BL, Wilson JB, Huisman TH. Differential cytotoxicity of cord blood and bone marrow-derived natural killer cells. Blood 1998; 91: 207-213.
8. Przepiorka D, Weisdorf D, Martin P, Klingemman HG, Beatty P, Hows J et al. 1994 consensus conference on acute GVHD grading. Bone Marrow Transplant 1994; 15: 824-828.
9. Thall PF, Simon RM, Estey EH. Bayesian sequential monitoring designs for single-arm clinical trials with multiple outcomes. Stat Med 1995; 14: 357-379.
10. Laughlin MJ, Barker J, Barbach B, Koc ON, Rizzieri DA, Wagner JE et al. Hematopoietic engraftment and survival in adults recipients of umbilical-cord blood from unrelated donors. N Engl J Med 2001; 344: 1815-1822.
11. Rubinstein P, Carrier C, Scaradavou A, Kurtzberg J, Adamson J, Migliaccio AR et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 1998; 339: 1565-1577.
12. Cornetta K, Laughlin M, Carter S, Wall D, Weinthal J, Delaney C et al. Umbilical cord blood transplantation in adults: Results of the prospective Cord Blood Transplantation (COBLT). Biol Blood Marrow Transplant 2005; 11: 149-160.
13. Sanz GF, Saavedra S, Phanelles D, Senent L, Cervera J, Barragan E et al. Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood 2001; 98: 2332-2338.
14. Barker JN, Weisdorf DJ, Defor TE, Blazar BR, McGlave PB, Miller JS et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005; 105: 1343-1347.
15. Takahashi S, Iseki T, Ooi J, Tomonari A, Takasugi K, Shimohakamada Y et al. Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood 2004; 104: 3813-3820.
16. Przepiorka D, Petropoulos D, Mullen CA, Danielson M, Mattewada V, Chan KW. Tacrolimus for prevention of graft-versus-host disease after mismatched unrelated donor cord blood transplantation. Bone Marrow Transplant 1999; 12: 1291-1295.
17. Miyakoshi S, Yuji K, Kami M, Kusumi E, Kishi Y, Kobayashi K et al. Successful engraftment after reduced-intensity umbilical cord blood transplantation for adult patients with advanced hematological diseases. Clin Cancer Res 2004; 10: 3586-3592.
18. Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, Miller JS, Wagner JE. Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced intensity conditioning. Blood 2003; 102: 1915-1919.
19. Meijer E, Bloem AC, Dekker AW, Verdonck LF. Effect of antithymocyte globulin on quantitative immune recovery and graft-versus-host disease after partially T-cell-depleted bone marrow transplantation: A comparison between recipients of matched related and matched unrelated donor grafts. Transplantation 2003; 75: 1910-1913.
20. Peled T, Mandel J, Goudsmid RN, Landor C, Hasson N, Harati D et al. Pre-clinical development of cord blood-derived progenitor cell graft expanded ex vivo with cytokines and the polyamine copper chelator tetraethylenepentamine. Cytotherapy 2004; 6: 344-355.
21. McNiece I, Harrington J, Turney J, Kellner J, Shpall EJ. Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells. Cytotherapy 2004; 6: 311-317.
22. Shpall E, Quinones R, Giller R, Zeng C, Baron AE, Jones RB et al. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant 2002; 8: 376-381.
23. de Lima M, St John LS, Wieder ED, Lee MS, McMannis J, Karandish S et al. Double-chimaerism after transplantation of two human leucocyte antigen mismatched, unrelated cord blood units. Brit J Haem 2002; 119: 773-776.