Nonhuman sialic acid Neu5Gc is very low in human embryonic stem cell-derived neural precursors differentiated with B27/N2 and noggin: Implications for transplantation

Experimental Neurology

Volumn 201, Issue 2, 2006, Pages 525-529

  Nasonkin, Igor O ^a   Koliatsos, Vassilis E ^b  

^a Division of Neuropathology   (United States)

^b Neurology   (United States)

Author keywords

Human embryonic stem cells; Immunogenicity; Neu5Gc; Neural differentiation; Sialic; Transplantation

Indexed keywords

NOGGIN; PROTEIN NEU5GC; SIALIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CLINICAL PROTOCOL; CULTURE MEDIUM; EMBRYONIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOGENICITY; MEMBRANE STRUCTURE; NERVE CELL; PRIORITY JOURNAL;

BRAIN-DERIVED NEUROTROPHIC FACTOR; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; EMBRYONIC STEM CELLS; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION; HUMANS; KARYOTYPING; NEURONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIALIC ACIDS; STEM CELL TRANSPLANTATION; STEM CELLS; TIME FACTORS;

EID: 33748421753     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2006.05.002     Document Type: Article

References (16)

1. Anderson D.J., Mostov K.E., and Blobel G. Mechanisms of integration of de novo-synthesized polypeptides into membranes: signal-recognition particle is required for integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5. Proc. Natl. Acad. Sci. U. S. A. 80 (1983) 7249-7253
2. Bardor M., Nguyen D.H., Diaz S., and Varki A. Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells. J. Biol. Chem. 280 (2005) 4228-4237
3. Brundin P., Pogarell O., Hagell P., Piccini P., Widner H., Schrag A., Kupsch A., Crabb L., Odin P., Gustavii B., Bjorklund A., Brooks D.J., Marsden C.D., Oertel W.H., Quinn N.P., Rehncrona S., and Lindvall O. Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease. Brain 123 Pt 7 (2000) 1380-1390
4. Chen G., Qian H., Starzl T., Sun H., Garcia B., Wang X., Wise Y., Liu Y., Xiang Y., Copeman L., Liu W., Jevnikar A., Wall W., Cooper D.K., Murase N., Dai Y., Wang W., Xiong Y., White D.J., and Zhong R. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat. Med. 11 (2005) 1295-1298
5. Chou H.H., Takematsu H., Diaz S., Iber J., Nickerson E., Wright K.L., Muchmore E.A., Nelson D.L., Warren S.T., and Varki A. A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 11751-11756
6. Gerrard L., Rodgers L., and Cui W. Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling. Stem Cells 23 (2005) 1234-1241
7. Isacson O. The production and use of cells as therapeutic agents in neurodegenerative diseases. Lancet Neurol. 2 (2003) 417-424
8. Martin M.J., Muotri A., Gage F., and Varki A. Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat. Med. 11 (2005) 228-232
9. Mitalipova M., Calhoun J., Shin S., Wininger D., Schulz T., Noggle S., Venable A., Lyons I., Robins A., and Stice S. Human embryonic stem cell lines derived from discarded embryos. Stem Cells 21 (2003) 521-526
10. Okuda T., Tagawa K., Qi M.L., Hoshio M., Ueda H., Kawano H., Kanazawa I., Muramatsu M., and Okazawa H. Oct-3/4 repression accelerates differentiation of neural progenitor cells in vitro and in vivo. Brain Res. Mol. Brain Res. 132 (2004) 18-30
11. Price, P.J., Goldsborough, M.D., Tilkins, M.L., 1998. Embryonic stem cell serum replacement. In International Patent Application WO 98/30679.
12. Shimozaki K., Nakashima K., Niwa H., and Taga T. Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures. Development 130 (2003) 2505-2512
13. Tabar V., Panagiotakos G., Greenberg E.D., Chan B.K., Sadelain M., Gutin P.H., and Studer L. Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain. Nat. Biotechnol. 23 (2005) 601-606
14. Tangvoranuntakul P., Gagneux P., Diaz S., Bardor M., Varki N., Varki A., and Muchmore E. Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 12045-12050
15. Taylor C.J., Bolton E.M., Pocock S., Sharples L.D., Pedersen R.A., and Bradley J.A. Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching. Lancet 366 (2005) 2019-2025
16. Zhu A., and Hurst R. Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum. Xenotransplantation 9 (2002) 376-381