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Volumn 4, Issue 3, 2006, Pages 161-175

Brain-targeted delivery of estradiol: Therapeutic potential and results obtained with a chemical delivery system approach

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; PROGESTERONE; SILDENAFIL;

EID: 33748374488     PISSN: 11759038     EISSN: 11759038     Source Type: Journal    
DOI: 10.2165/00137696-200604030-00004     Document Type: Review
Times cited : (9)

References (179)
  • 1
    • 0000853115 scopus 로고    scopus 로고
    • Estrogens and progestins
    • Hardman JG, Limbird LE, editors. Goodman & New York: McGraw-Hill
    • Williams CL, Stancel GM. Estrogens and progestins. In: Hardman JG, Limbird LE, editors. Goodman & Gilman's the pharmacological basis of therapeutics. New York: McGraw-Hill, 1996: 1411-40
    • (1996) Gilman's the Pharmacological Basis of Therapeutics , pp. 1411-1440
    • Williams, C.L.1    Stancel, G.M.2
  • 2
    • 0017911119 scopus 로고
    • Cardiovascular complications of oral contraceptives
    • Kaplan NM. Cardiovascular complications of oral contraceptives. Annu Rev Med 1978; 29: 31-40
    • (1978) Annu Rev Med , vol.29 , pp. 31-40
    • Kaplan, N.M.1
  • 3
    • 0021807939 scopus 로고
    • Oral contraceptives, lipids and cardiovascular disease
    • Fotherby K. Oral contraceptives, lipids and cardiovascular disease. Contraception 1985; 31: 367-94
    • (1985) Contraception , vol.31 , pp. 367-394
    • Fotherby, K.1
  • 4
    • 0029120477 scopus 로고
    • Benefits and risks of estrogen replacement therapy
    • Lobo RA. Benefits and risks of estrogen replacement therapy. Am J Obstet Gynecol 1995; 173: 982-9
    • (1995) Am J Obstet Gynecol , vol.173 , pp. 982-989
    • Lobo, R.A.1
  • 5
    • 0029890377 scopus 로고    scopus 로고
    • Molecular mechanism of estrogen carcinogenesis
    • Yager JD, Liehr JG. Molecular mechanism of estrogen carcinogenesis. Annu Rev Pharmacol Toxicol 1996; 36: 203-32
    • (1996) Annu Rev Pharmacol Toxicol , vol.36 , pp. 203-232
    • Yager, J.D.1    Liehr, J.G.2
  • 6
    • 0033252349 scopus 로고    scopus 로고
    • Use of HRT and the subsequent risk of cancer
    • Beral V, Banks E, Reeves G, et al. Use of HRT and the subsequent risk of cancer. J Epidemiol Biostat 1999; 4: 191-210
    • (1999) J Epidemiol Biostat , vol.4 , pp. 191-210
    • Beral, V.1    Banks, E.2    Reeves, G.3
  • 7
    • 0033401448 scopus 로고    scopus 로고
    • The Heart and Estrogen/Progestin Replacement Study: What have we learned and what questions remain?
    • Wells G, Herrington DM. The Heart and Estrogen/Progestin Replacement Study: what have we learned and what questions remain? Drugs Aging 1999; 15: 419-22
    • (1999) Drugs Aging , vol.15 , pp. 419-422
    • Wells, G.1    Herrington, D.M.2
  • 9
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
    • Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002; 288: 321-33
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3
  • 10
    • 0012868624 scopus 로고    scopus 로고
    • Effects of estrogen plus progestin on health-related quality of life
    • Hays J, Ockene JK, Brunner RL, et al. Effects of estrogen plus progestin on health-related quality of life. N Engl J Med 2003; 348: 1839-54
    • (2003) N Engl J Med , vol.348 , pp. 1839-1854
    • Hays, J.1    Ockene, J.K.2    Brunner, R.L.3
  • 11
    • 1842867053 scopus 로고    scopus 로고
    • Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The Women's Health Initiative randomized controlled trial
    • Anderson GL, Limacher M, Assaf AR, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 2004; 291: 1701-12
    • (2004) JAMA , vol.291 , pp. 1701-1712
    • Anderson, G.L.1    Limacher, M.2    Assaf, A.R.3
  • 12
    • 33645999979 scopus 로고    scopus 로고
    • Postmenopausal hormone therapy: New questions and the case for new clinical trials
    • Manson JA, Bassuk S, Harman SM, et al. Postmenopausal hormone therapy: new questions and the case for new clinical trials. Menopause 2006; 13: 139-47
    • (2006) Menopause , vol.13 , pp. 139-147
    • Manson, J.A.1    Bassuk, S.2    Harman, S.M.3
  • 13
    • 33645360172 scopus 로고    scopus 로고
    • Hormone therapy, timing of initiation, and cognition in women aged older than 60 years: The REMEMBER pilot study
    • MacLennan AH, Henderson VW, Paine BJ, et al. Hormone therapy, timing of initiation, and cognition in women aged older than 60 years: the REMEMBER pilot study. Menopause 2006; 13: 28-36
    • (2006) Menopause , vol.13 , pp. 28-36
    • MacLennan, A.H.1    Henderson, V.W.2    Paine, B.J.3
  • 14
    • 4644268401 scopus 로고    scopus 로고
    • Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis
    • Smith NL, Heckbert SR, Lemaitre RN, et al. Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis. JAMA 2004; 292: 1581-7
    • (2004) JAMA , vol.292 , pp. 1581-1587
    • Smith, N.L.1    Heckbert, S.R.2    Lemaitre, R.N.3
  • 16
    • 33748352789 scopus 로고    scopus 로고
    • NY Times Jan 31 [online].
    • Rabin R. Rethinking hormones, again. NY Times 2006 Jan 31 [online]. Available from URL: http://query.nytimes.com/gst/fullpage.html?.sec= health&res= 9907EEDA1E3FF932A05752C0A9609C8B63 [Accessed 2006 May 22]
    • (2006) Rethinking Hormones, Again
    • Rabin, R.1
  • 18
    • 0033304765 scopus 로고    scopus 로고
    • Estrogen actions in the central nervous system
    • McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr Rev 1999; 20: 279-307
    • (1999) Endocr Rev , vol.20 , pp. 279-307
    • McEwen, B.S.1    Alves, S.E.2
  • 19
    • 0033860724 scopus 로고    scopus 로고
    • Drugs with estrogen-like potency and brain activity: Potential therapeutic application for the CNS
    • Cyr M, Calon F, Morissette M, et al. Drugs with estrogen-like potency and brain activity: potential therapeutic application for the CNS. Curr Pharm Des 2000; 6: 1287-312
    • (2000) Curr Pharm des , vol.6 , pp. 1287-1312
    • Cyr, M.1    Calon, F.2    Morissette, M.3
  • 20
    • 0035293450 scopus 로고    scopus 로고
    • Effects of estrogen on congnition mood, and degenerative brain diseases
    • Shepherd JE. Effects of estrogen on congnition mood, and degenerative brain diseases. J Am Pharm Assoc 2001; 41: 221-8
    • (2001) J Am Pharm Assoc , vol.41 , pp. 221-228
    • Shepherd, J.E.1
  • 21
    • 0037397635 scopus 로고    scopus 로고
    • Estrogen and cognitive functioning in women
    • Sherwin BB. Estrogen and cognitive functioning in women. Endocr Rev 2003; 24: 133-51
    • (2003) Endocr Rev , vol.24 , pp. 133-151
    • Sherwin, B.B.1
  • 22
    • 0032213691 scopus 로고    scopus 로고
    • The roles of oestrogen in the male
    • Sharpe RM. The roles of oestrogen in the male. Trends Endocrinol Metab 1998; 9: 371-7
    • (1998) Trends Endocrinol Metab , vol.9 , pp. 371-377
    • Sharpe, R.M.1
  • 24
    • 0036118465 scopus 로고    scopus 로고
    • Biological role of estrogen and estrogen receptors
    • Nilsson S, Gustafsson JA. Biological role of estrogen and estrogen receptors. Crit Rev Biochem Mol Biol 2002; 37 (1): 1-28
    • (2002) Crit Rev Biochem Mol Biol , vol.37 , Issue.1 , pp. 1-28
    • Nilsson, S.1    Gustafsson, J.A.2
  • 25
    • 0037029739 scopus 로고    scopus 로고
    • Estrogen receptor-β immunoreactivity in the midbrain of adult rats: Regional, subregional, and cellular localization in the A10, A9, and A8 dopamine cell groups
    • Creutz LM, Kritzer MF. Estrogen receptor-β immunoreactivity in the midbrain of adult rats: regional, subregional, and cellular localization in the A10, A9, and A8 dopamine cell groups. J Comp Neurol 2002; 446: 288-300
    • (2002) J Comp Neurol , vol.446 , pp. 288-300
    • Creutz, L.M.1    Kritzer, M.F.2
  • 26
    • 0027445017 scopus 로고
    • Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat
    • Woolley CS, McEwen BS. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol 1993; 336: 293-306
    • (1993) J Comp Neurol , vol.336 , pp. 293-306
    • Woolley, C.S.1    McEwen, B.S.2
  • 27
    • 0028596087 scopus 로고
    • Sex hormone modulation of neural development in vitro
    • Lustig RH. Sex hormone modulation of neural development in vitro. Horm Behav 1994; 28: 383-95
    • (1994) Horm Behav , vol.28 , pp. 383-395
    • Lustig, R.H.1
  • 28
    • 0030942682 scopus 로고    scopus 로고
    • The epidemiology of estrogen replacement therapy and Alzheimer's disease
    • Henderson VW. The epidemiology of estrogen replacement therapy and Alzheimer's disease. Neurology 1997; 48 (5): S27-35
    • (1997) Neurology , vol.48 , Issue.5
    • Henderson, V.W.1
  • 29
    • 33644530696 scopus 로고    scopus 로고
    • Direct and indirect effects of estrogen on rat hippocampus
    • Prange-Kiel J, Rune GM. Direct and indirect effects of estrogen on rat hippocampus. Neuroscience 2006; 138: 765-72
    • (2006) Neuroscience , vol.138 , pp. 765-772
    • Prange-Kiel, J.1    Rune, G.M.2
  • 30
    • 0032907868 scopus 로고    scopus 로고
    • Novel mechanisms of estrogen action in the brain: New players in an old story
    • Toran-Allerand CD, Singh M, Setalo G. Novel mechanisms of estrogen action in the brain: new players in an old story. Front Neuroendocrinol 1999; 20: 97-121
    • (1999) Front Neuroendocrinol , vol.20 , pp. 97-121
    • Toran-Allerand, C.D.1    Singh, M.2    Setalo, G.3
  • 31
    • 0030993634 scopus 로고    scopus 로고
    • Estrogen stakes claim to cognition
    • Wickelgren I. Estrogen stakes claim to cognition. Science 1997; 276: 675-8
    • (1997) Science , vol.276 , pp. 675-678
    • Wickelgren, I.1
  • 32
    • 0035180875 scopus 로고    scopus 로고
    • Invited review: Estrogens effects on the brain: multiple sites and molecular mechanisms
    • McEwen BS. Invited review: estrogens effects on the brain: multiple sites and molecular mechanisms. J Appl Physiol 2001; 91: 2785-801
    • (2001) J Appl Physiol , vol.91 , pp. 2785-2801
    • McEwen, B.S.1
  • 33
    • 0032401010 scopus 로고    scopus 로고
    • Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death
    • Sawada H, Ibi M, Kihara T, et al. Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death. J Neurosci Res 1998; 54: 707-19
    • (1998) J Neurosci Res , vol.54 , pp. 707-719
    • Sawada, H.1    Ibi, M.2    Kihara, T.3
  • 34
    • 0033607705 scopus 로고    scopus 로고
    • Beta-estradiol attenuate amyloid beta-peptide toxicity via nicotinic receptors
    • Svensson A-L, Nordberg A. Beta-estradiol attenuate amyloid beta-peptide toxicity via nicotinic receptors. NeuroReport 1999; 10: 3485-9
    • (1999) NeuroReport , vol.10 , pp. 3485-3489
    • Svensson, A.-L.1    Nordberg, A.2
  • 35
    • 0033529941 scopus 로고    scopus 로고
    • The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties
    • Moosmann B, Behl C. The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties. Proc Natl Acad Sci U S A 1999; 96: 8867-72
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8867-8872
    • Moosmann, B.1    Behl, C.2
  • 36
    • 0034477196 scopus 로고    scopus 로고
    • Neuroprotective activities of estrogen: An update
    • Behl C, Manthey D. Neuroprotective activities of estrogen: an update. J Neurocytol 2000; 29: 351-8
    • (2000) J Neurocytol , vol.29 , pp. 351-358
    • Behl, C.1    Manthey, D.2
  • 37
    • 0142179253 scopus 로고    scopus 로고
    • Membrane receptors for oestrogen in the brain
    • Beyer C, Pawlak J, Karolczak M. Membrane receptors for oestrogen in the brain. J Neurochem 2003; 87: 545-50
    • (2003) J Neurochem , vol.87 , pp. 545-550
    • Beyer, C.1    Pawlak, J.2    Karolczak, M.3
  • 38
    • 0021321236 scopus 로고
    • Therapeutic considerations in the management of the climacteric
    • Upton GV. Therapeutic considerations in the management of the climacteric. J Reprod Med 1984; 29: 71-9
    • (1984) J Reprod Med , vol.29 , pp. 71-79
    • Upton, G.V.1
  • 39
    • 0021815424 scopus 로고
    • Role of female gonadal hormones in the CNS: Clinical and experimental aspects
    • Maggi A, Perez J. Role of female gonadal hormones in the CNS: clinical and experimental aspects. Life Sci 1985; 37: 893-906
    • (1985) Life Sci , vol.37 , pp. 893-906
    • Maggi, A.1    Perez, J.2
  • 40
    • 0028104495 scopus 로고
    • Gonadal hormones as promoters of structural synaptic plasticity: Cellular mechanisms
    • García-Segura LM, Chowen JA, Párducz A, et al. Gonadal hormones as promoters of structural synaptic plasticity: cellular mechanisms. Progr Neurobiol 1994; 44: 279-307
    • (1994) Progr Neurobiol , vol.44 , pp. 279-307
    • García-Segura, L.M.1    Chowen, J.A.2    Párducz, A.3
  • 41
    • 0028087659 scopus 로고
    • Evaluation of estrogen-treatment in female-patients with dementia of the Alzheimer-type
    • Ohkura T, Isse K, Akazawa K, et al. Evaluation of estrogen-treatment in female-patients with dementia of the Alzheimer-type. Endocr J 1994; 41: 361-71
    • (1994) Endocr J , vol.41 , pp. 361-371
    • Ohkura, T.1    Isse, K.2    Akazawa, K.3
  • 42
    • 0030591669 scopus 로고    scopus 로고
    • Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease
    • Tang M-X, Jacobs D, Stern Y, et al. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 1996; 346: 429-32
    • (1996) Lancet , vol.346 , pp. 429-432
    • Tang, M.-X.1    Jacobs, D.2    Stern, Y.3
  • 43
    • 0031911321 scopus 로고    scopus 로고
    • Cognitive function in nondemented older women who took estrogen after menopause
    • Jacobs DM, Tang M-X, Stern Y, et al. Cognitive function in nondemented older women who took estrogen after menopause. Neurology 1998; 50: 368-73
    • (1998) Neurology , vol.50 , pp. 368-373
    • Jacobs, D.M.1    Tang, M.-X.2    Stern, Y.3
  • 44
    • 0032481568 scopus 로고    scopus 로고
    • Estrogen therapy in postmenopausal women: Effects on cognitive function and dementia
    • Yaffe K, Sawaya G, Lieberburg I, et al. Estrogen therapy in postmenopausal women: effects on cognitive function and dementia. JAMA 1998; 279: 688-95
    • (1998) JAMA , vol.279 , pp. 688-695
    • Yaffe, K.1    Sawaya, G.2    Lieberburg, I.3
  • 45
    • 0033003028 scopus 로고    scopus 로고
    • Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: Results of a placebo-controlled, double-blind, pilot study
    • Asthana S, Craft S, Baker LD, et al. Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study. Psychoneuroendocrinology 1999; 24: 657-77
    • (1999) Psychoneuroendocrinology , vol.24 , pp. 657-677
    • Asthana, S.1    Craft, S.2    Baker, L.D.3
  • 46
    • 0032989956 scopus 로고    scopus 로고
    • Estrogen replacement therapy and cognitive decline in memory-impaired post-menopausal women
    • Costa MM, Reus VI, Wolkowitz OM, et al. Estrogen replacement therapy and cognitive decline in memory-impaired post-menopausal women. Biol Psychiatry 1999; 46: 182-8
    • (1999) Biol Psychiatry , vol.46 , pp. 182-188
    • Costa, M.M.1    Reus, V.I.2    Wolkowitz, O.M.3
  • 47
    • 0034021844 scopus 로고    scopus 로고
    • Higher levels of plasma estradiol and testosterone in healthy elderly men compared with age-matched women may protect aspects of explicit memory
    • Carlson LE, Sherwin BB. Higher levels of plasma estradiol and testosterone in healthy elderly men compared with age-matched women may protect aspects of explicit memory. Menopause 2000; 7: 168-77
    • (2000) Menopause , vol.7 , pp. 168-177
    • Carlson, L.E.1    Sherwin, B.B.2
  • 48
    • 0028267115 scopus 로고
    • Brain aromatization of androgens
    • Apr
    • Naftolin F. Brain aromatization of androgens. J Reprod Med 1994 Apr; 39 (4): 257-61
    • (1994) J Reprod Med , vol.39 , Issue.4 , pp. 257-261
    • Naftolin, F.1
  • 49
    • 0025365419 scopus 로고
    • Tissue distribution of a brain-enhanced chemical delivery system for estradiol
    • Rahimy MH, Simpkins JW, Bodor N. Tissue distribution of a brain-enhanced chemical delivery system for estradiol. Drug Des Deliv 1990; 6: 29-40
    • (1990) Drug des Deliv , vol.6 , pp. 29-40
    • Rahimy, M.H.1    Simpkins, J.W.2    Bodor, N.3
  • 50
    • 16644402955 scopus 로고    scopus 로고
    • Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes
    • MacLennan AH, Broadbent JL, Lester S, et al. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst Rev 2004; (4): CD002978
    • (2004) Cochrane Database Syst Rev , Issue.4
    • MacLennan, A.H.1    Broadbent, J.L.2    Lester, S.3
  • 51
    • 0003026989 scopus 로고    scopus 로고
    • Efficacy and safety of low, standard, and high dosages of an estradiol transdermal system (Esclim) compared with placebo on vasomotor symptoms in highly symptomatic menopausal patients
    • The Esclim Study Group
    • Utian WH, Burry KA, Archer DF, et al. Efficacy and safety of low, standard, and high dosages of an estradiol transdermal system (Esclim) compared with placebo on vasomotor symptoms in highly symptomatic menopausal patients. The Esclim Study Group. Am J Obstet Gynecol 1999; 181: 71-9
    • (1999) Am J Obstet Gynecol , vol.181 , pp. 71-79
    • Utian, W.H.1    Burry, K.A.2    Archer, D.F.3
  • 52
    • 0033973117 scopus 로고    scopus 로고
    • Efficacy and tolerability of a new 7-day transdermal estradiol patch versus placebo in hysterectomized women with postmenopausal complaints
    • von Holst T, Salbach B. Efficacy and tolerability of a new 7-day transdermal estradiol patch versus placebo in hysterectomized women with postmenopausal complaints. Maturitas 2000; 34: 143-53
    • (2000) Maturitas , vol.34 , pp. 143-153
    • Von Holst, T.1    Salbach, B.2
  • 53
    • 0033958335 scopus 로고    scopus 로고
    • Transdermal estrogen in the treatment of hot flushes in men with prostate cancer
    • Gerber GS, Zagaja GP, Ray PS, et al. Transdermal estrogen in the treatment of hot flushes in men with prostate cancer. Urology 2000; 55: 97-101
    • (2000) Urology , vol.55 , pp. 97-101
    • Gerber, G.S.1    Zagaja, G.P.2    Ray, P.S.3
  • 54
    • 0030929271 scopus 로고    scopus 로고
    • Better postural balance in elderly women receiving estrogens
    • Naessen T, Lindmark B, Larsen HC. Better postural balance in elderly women receiving estrogens. Am J Obstet Gynecol 1997; 177: 412-6
    • (1997) Am J Obstet Gynecol , vol.177 , pp. 412-416
    • Naessen, T.1    Lindmark, B.2    Larsen, H.C.3
  • 55
    • 0029002254 scopus 로고
    • Estrogen replacement therapy and postural stability in the elderly
    • Goebel JA, Birge SJ, Price SC, et al. Estrogen replacement therapy and postural stability in the elderly. Am J Otol 1995; 16: 470-4
    • (1995) Am J Otol , vol.16 , pp. 470-474
    • Goebel, J.A.1    Birge, S.J.2    Price, S.C.3
  • 56
    • 0032604249 scopus 로고    scopus 로고
    • Performance in functional balance tests during menopausal hormone replacement: A double-blind placebo-controlled study
    • Lindmark B, Lagerstrom C, Naessen T, et al. Performance in functional balance tests during menopausal hormone replacement: a double-blind placebo-controlled study. Physiother Res Int 1999; 4: 43-54
    • (1999) Physiother Res Int , vol.4 , pp. 43-54
    • Lindmark, B.1    Lagerstrom, C.2    Naessen, T.3
  • 57
    • 19044386094 scopus 로고    scopus 로고
    • Therapeutic options in female sexual dysfunction
    • Shepherd JE. Therapeutic options in female sexual dysfunction. J Am Pharm Assoc 2002; 42: 479-88
    • (2002) J Am Pharm Assoc , vol.42 , pp. 479-488
    • Shepherd, J.E.1
  • 58
    • 0036150856 scopus 로고    scopus 로고
    • Hormonal and genetic influences on arousal: Sexual and otherwise
    • Pfaff D, Frohlich J, Morgan M. Hormonal and genetic influences on arousal: sexual and otherwise. Trends Neurosci 2002; 25: 45-50
    • (2002) Trends Neurosci , vol.25 , pp. 45-50
    • Pfaff, D.1    Frohlich, J.2    Morgan, M.3
  • 59
    • 0031859092 scopus 로고    scopus 로고
    • Estradiol increases female sexual initiation independent of male responsiveness in rhesus monkeys
    • Zehr JL, Maestripieri D, Wallen K. Estradiol increases female sexual initiation independent of male responsiveness in rhesus monkeys. Horm Behav 1998; 33: 95-103
    • (1998) Horm Behav , vol.33 , pp. 95-103
    • Zehr, J.L.1    Maestripieri, D.2    Wallen, K.3
  • 60
    • 0036253422 scopus 로고    scopus 로고
    • Hormones, mood, sexuality, and the menopausal transition
    • Dennerstein L, Randolph J, Taffe J, et al. Hormones, mood, sexuality, and the menopausal transition. Fertil Steril 2002; 77 Suppl. 4: S42-S8
    • (2002) Fertil Steril , vol.77 , Issue.4 SUPPL.
    • Dennerstein, L.1    Randolph, J.2    Taffe, J.3
  • 61
    • 0037252621 scopus 로고    scopus 로고
    • Female sexual dysfunction in postmenopausal women: Systematic review of placebo-controlled trials
    • Modelska K, Cummings S. Female sexual dysfunction in postmenopausal women: systematic review of placebo-controlled trials. Am J Obstet Gynecol 2003; 188: 286-93
    • (2003) Am J Obstet Gynecol , vol.188 , pp. 286-293
    • Modelska, K.1    Cummings, S.2
  • 62
    • 0033540646 scopus 로고    scopus 로고
    • Sexual dysfunction in the United States: Prevalence and predictors
    • Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999; 281: 537-44
    • (1999) JAMA , vol.281 , pp. 537-544
    • Laumann, E.O.1    Paik, A.2    Rosen, R.C.3
  • 63
    • 1542270285 scopus 로고    scopus 로고
    • New evidence for the selective, long-lasting central effects of the brain-targeted estradiol, Estredox
    • Tapfer MK, Sebestyen L, Kurucz I, et al. New evidence for the selective, long-lasting central effects of the brain-targeted estradiol, Estredox. Pharmacol Biochem Behav 2004; 77: 423-9
    • (2004) Pharmacol Biochem Behav , vol.77 , pp. 423-429
    • Tapfer, M.K.1    Sebestyen, L.2    Kurucz, I.3
  • 64
    • 0014917225 scopus 로고
    • Nature of sex hormone effects on rat sex behavior: Specificity of effects and individual patterns of response
    • Pfaff D. Nature of sex hormone effects on rat sex behavior: specificity of effects and individual patterns of response. J Comp Physiol Psychol 1970; 73: 349-58
    • (1970) J Comp Physiol Psychol , vol.73 , pp. 349-358
    • Pfaff, D.1
  • 65
    • 0015900993 scopus 로고
    • Estrogen-activated sexual behavior in male rats
    • Sodersten P. Estrogen-activated sexual behavior in male rats. Horm Behav 1973; 4: 247-56
    • (1973) Horm Behav , vol.4 , pp. 247-256
    • Sodersten, P.1
  • 66
    • 0034687648 scopus 로고    scopus 로고
    • Another role highlighted for estrogens in the male: Sexual behavior
    • Simpson ER, Davis SR. Another role highlighted for estrogens in the male: sexual behavior. Proc Natl Acad Sci U S A 2000; 97: 14038-40
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 14038-14040
    • Simpson, E.R.1    Davis, S.R.2
  • 67
    • 0034687647 scopus 로고    scopus 로고
    • Abolition of male sexual behaviors in mice lacking estrogen receptors α and β (αβERKO)
    • Ogawa S, Chester AE, Hewitt SC, et al. Abolition of male sexual behaviors in mice lacking estrogen receptors α and β (αβERKO). Proc Natl Acad Sci U S A 2000; 97: 14737-41
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 14737-14741
    • Ogawa, S.1    Chester, A.E.2    Hewitt, S.C.3
  • 68
    • 0032545031 scopus 로고    scopus 로고
    • Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene
    • Honda S-I, Harada N, Ito S, et al. Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. Biochem Biophys Res Commun 1998; 252: 445-9
    • (1998) Biochem Biophys Res Commun , vol.252 , pp. 445-449
    • Honda, S.-I.1    Harada, N.2    Ito, S.3
  • 69
    • 0032695247 scopus 로고    scopus 로고
    • Role of oestrogen in male sexual behaviour: Insights from the natural model of aromatase deficiency
    • Oxf
    • Carani C, Rochira V, Faustini-Fustini M, et al. Role of oestrogen in male sexual behaviour: insights from the natural model of aromatase deficiency. Clin Endocrinol (Oxf) 1999; 51: 517-24
    • (1999) Clin Endocrinol , vol.51 , pp. 517-524
    • Carani, C.1    Rochira, V.2    Faustini-Fustini, M.3
  • 70
    • 0023197813 scopus 로고
    • Evidence for the reestablishment of copulatory behavior in castrated male rats with a brain-enhanced estradiol-chemical delivery system
    • Anderson WR, Simpkins JW, Brewster ME, et al. Evidence for the reestablishment of copulatory behavior in castrated male rats with a brain-enhanced estradiol-chemical delivery system. Pharmacol Biochem Behav 1987; 27: 265-71
    • (1987) Pharmacol Biochem Behav , vol.27 , pp. 265-271
    • Anderson, W.R.1    Simpkins, J.W.2    Brewster, M.E.3
  • 71
    • 0036629267 scopus 로고    scopus 로고
    • Barriers to remember: Brain-targeting chemical delivery systems and Alzheimer's disease
    • Bodor N, Buchwald P. Barriers to remember: brain-targeting chemical delivery systems and Alzheimer's disease. Drug Discov Today 2002; 7: 766-74
    • (2002) Drug Discov Today , vol.7 , pp. 766-774
    • Bodor, N.1    Buchwald, P.2
  • 72
    • 0033604631 scopus 로고    scopus 로고
    • Treatment of Alzheimer's disease
    • Mayeux R, Sano M. Treatment of Alzheimer's disease. N Engl J Med 1999; 341: 1670-9
    • (1999) N Engl J Med , vol.341 , pp. 1670-1679
    • Mayeux, R.1    Sano, M.2
  • 73
    • 0026970395 scopus 로고
    • Aging brain, aging mind
    • Selkoe DJ. Aging brain, aging mind. Sci Am 1992; 267 (3): 135-42
    • (1992) Sci Am , vol.267 , Issue.3 , pp. 135-142
    • Selkoe, D.J.1
  • 74
    • 0002520353 scopus 로고    scopus 로고
    • Outsmarting Alzheimer's disease
    • Gopinath L. Outsmarting Alzheimer's disease. Chem Br 1998; 34 (5): 38-40
    • (1998) Chem Br , vol.34 , Issue.5 , pp. 38-40
    • Gopinath, L.1
  • 75
    • 0036463370 scopus 로고    scopus 로고
    • Apoptosis-based anticancer drugs
    • Zhang JY. Apoptosis-based anticancer drugs. Nat Rev Drug Discov 2002; 1: 101-2
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 101-102
    • Zhang, J.Y.1
  • 76
    • 0034704547 scopus 로고    scopus 로고
    • Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: A randomized controlled trial
    • Mulnard RA, Cotman CW, Kawas C, et al. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. JAMA 2000; 283: 1007-15
    • (2000) JAMA , vol.283 , pp. 1007-1015
    • Mulnard, R.A.1    Cotman, C.W.2    Kawas, C.3
  • 77
    • 0036142037 scopus 로고    scopus 로고
    • Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy. The ILSA Study
    • Di Carlo A, Baldereschi M, Amaducci L, et al. Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy. The ILSA Study. J Am Geriatr Soc 2002; 50: 41-8
    • (2002) J Am Geriatr Soc , vol.50 , pp. 41-48
    • Di Carlo, A.1    Baldereschi, M.2    Amaducci, L.3
  • 78
    • 0029067838 scopus 로고
    • Possible acceleration of age effects on cognition following menopause
    • Halbreich U, Lumley LA, Palter S, et al. Possible acceleration of age effects on cognition following menopause. J Psychiatr Res 1995; 29: 153-63
    • (1995) J Psychiatr Res , vol.29 , pp. 153-163
    • Halbreich, U.1    Lumley, L.A.2    Palter, S.3
  • 79
    • 34547463160 scopus 로고    scopus 로고
    • Sex hormones influence human cognitive pattern
    • Kimura D. Sex hormones influence human cognitive pattern. Neuro Endocrinol Lett 2002; 23: 67-77
    • (2002) Neuro Endocrinol Lett , vol.23 , pp. 67-77
    • Kimura, D.1
  • 80
    • 20244383522 scopus 로고    scopus 로고
    • Sex differences in the brain
    • Kimura D. Sex differences in the brain. Sci Am 2002; 12: 32-7
    • (2002) Sci Am , vol.12 , pp. 32-37
    • Kimura, D.1
  • 82
    • 0027315530 scopus 로고
    • Sex hormone-related variations of cognitive performance in!Kung San hunter-gatherers of Namibia
    • Christiansen K. Sex hormone-related variations of cognitive performance in !Kung San hunter-gatherers of Namibia. Neuropsychobiology 1993; 27: 97-107
    • (1993) Neuropsychobiology , vol.27 , pp. 97-107
    • Christiansen, K.1
  • 84
    • 0032909791 scopus 로고    scopus 로고
    • Activating effects of cross-sex hormones on cognitive functioning: A study of short-term and long-term hormone effects in transsexuals
    • Slabbekoorn D, van Goozen SHM, Megens J, et al. Activating effects of cross-sex hormones on cognitive functioning: a study of short-term and long-term hormone effects in transsexuals. Psychoneuroendocrinology 1999; 24: 423-47
    • (1999) Psychoneuroendocrinology , vol.24 , pp. 423-447
    • Slabbekoorn, D.1    Van Goozen, S.H.M.2    Megens, J.3
  • 86
    • 0025485064 scopus 로고
    • Variations in sex-related cognitive abilities across the menstrual cycle
    • Hampson E. Variations in sex-related cognitive abilities across the menstrual cycle. Brain Cogn 1990; 14: 26-43
    • (1990) Brain Cogn , vol.14 , pp. 26-43
    • Hampson, E.1
  • 87
    • 0034538551 scopus 로고    scopus 로고
    • Sex hormones affect spatial abilities during the menstrual cycle
    • Hausmann M, Slabbekoorn D, Van Goozen SHM, et al. Sex hormones affect spatial abilities during the menstrual cycle. Behav Neurosci 2000; 114: 1245-50
    • (2000) Behav Neurosci , vol.114 , pp. 1245-1250
    • Hausmann, M.1    Slabbekoorn, D.2    Van Goozen, S.H.M.3
  • 88
    • 0036132622 scopus 로고    scopus 로고
    • Implicit memory varies across the menstrual cycle: Estrogen effects in young women
    • Maki PM, Rich JB, Rosenbaum RS. Implicit memory varies across the menstrual cycle: estrogen effects in young women. Neuropsychologia 2002; 40: 518-29
    • (2002) Neuropsychologia , vol.40 , pp. 518-529
    • Maki, P.M.1    Rich, J.B.2    Rosenbaum, R.S.3
  • 89
    • 0032702248 scopus 로고    scopus 로고
    • Can estrogen keep you smart? Evidence from clinical studies
    • Sherwin BB. Can estrogen keep you smart? Evidence from clinical studies. J Psychiatry Neurosci 1999; 24: 315-21
    • (1999) J Psychiatry Neurosci , vol.24 , pp. 315-321
    • Sherwin, B.B.1
  • 90
    • 0032191239 scopus 로고    scopus 로고
    • Estrogen and memory in a transsexual population
    • Miles C, Green R, Sanders G, et al. Estrogen and memory in a transsexual population. Horm Behav 1998; 34: 199-208
    • (1998) Horm Behav , vol.34 , pp. 199-208
    • Miles, C.1    Green, R.2    Sanders, G.3
  • 91
    • 0033963348 scopus 로고    scopus 로고
    • Use of estrogen in young girls with Turner syndrome: Effects on memory
    • Ross JL, Roeltgen D, Feuillan P, et al. Use of estrogen in young girls with Turner syndrome: effects on memory. Neurology 2000; 54: 164-70
    • (2000) Neurology , vol.54 , pp. 164-170
    • Ross, J.L.1    Roeltgen, D.2    Feuillan, P.3
  • 92
    • 0029900525 scopus 로고    scopus 로고
    • "Add-back" estrogen reverses cognitive deficits induced by a gonadotropin-releasing hormone agonist in women with leiomyomata uteri
    • Sherwin BB, Tulandi T. "Add-back" estrogen reverses cognitive deficits induced by a gonadotropin-releasing hormone agonist in women with leiomyomata uteri. J Clin Endocrinol Metab 1996; 81: 2545-9
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2545-2549
    • Sherwin, B.B.1    Tulandi, T.2
  • 94
    • 0041883787 scopus 로고    scopus 로고
    • Preliminary evidence that estrogen protects against age-related hippocampal atrophy
    • Eberling JL, Wu C, Haan MN, et al. Preliminary evidence that estrogen protects against age-related hippocampal atrophy. Neurobiol Aging 2003; 24: 725-32
    • (2003) Neurobiol Aging , vol.24 , pp. 725-732
    • Eberling, J.L.1    Wu, C.2    Haan, M.N.3
  • 95
    • 0033531762 scopus 로고    scopus 로고
    • Effect of estrogen on brain activation patterns in postmenopausal women during working memory tasks
    • Shaywitz SE, Shaywitz BA, Pugh KR, et al. Effect of estrogen on brain activation patterns in postmenopausal women during working memory tasks. JAMA 1999; 281: 1197-202
    • (1999) JAMA , vol.281 , pp. 1197-1202
    • Shaywitz, S.E.1    Shaywitz, B.A.2    Pugh, K.R.3
  • 96
    • 0034942434 scopus 로고    scopus 로고
    • Estrogen and cerebrovascular physiology and pathophysiology
    • Jun
    • Pelligrino DA, Galea E. Estrogen and cerebrovascular physiology and pathophysiology. Jpn J Pharmacol. 2001 Jun; 86 (2): 137-58
    • (2001) Jpn J Pharmacol , vol.86 , Issue.2 , pp. 137-158
    • Pelligrino, D.A.1    Galea, E.2
  • 97
    • 0035800209 scopus 로고    scopus 로고
    • Estrogen protects neuronal cells from amyloid beta-induced apoptotic cell death
    • Hosoda T, Nakajima H, Honjo H. Estrogen protects neuronal cells from amyloid beta-induced apoptotic cell death. Neuroreport 2001; 12: 1965-70
    • (2001) Neuroreport , vol.12 , pp. 1965-1970
    • Hosoda, T.1    Nakajima, H.2    Honjo, H.3
  • 98
    • 0035800196 scopus 로고    scopus 로고
    • Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt
    • Zhang L, Rubinow DR, Xaing G, et al. Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt. Neuroreport 2001; 12: 1919-23
    • (2001) Neuroreport , vol.12 , pp. 1919-1923
    • Zhang, L.1    Rubinow, D.R.2    Xaing, G.3
  • 99
    • 0034720686 scopus 로고    scopus 로고
    • Ovariectomy and 17β-estradiol modulate the levels of Alzheimer's amyloid β peptides in brain
    • Petanceska SS, Nagy V, Frail D, et al. Ovariectomy and 17β-estradiol modulate the levels of Alzheimer's amyloid β peptides in brain. Neurology 2000; 54: 2212-7
    • (2000) Neurology , vol.54 , pp. 2212-2217
    • Petanceska, S.S.1    Nagy, V.2    Frail, D.3
  • 100
    • 0009770157 scopus 로고    scopus 로고
    • Estrogen and ApoE: Drug discovery implications
    • Fillit HM, O'Connell AW, editors. New York: Springer
    • Smith JD, Levin JA. Estrogen and ApoE: drug discovery implications. In: Fillit HM, O'Connell AW, editors. Drug discovery and development for Alzheimer's disease 2000. New York: Springer, 2002: 129-36
    • (2002) Drug Discovery and Development for Alzheimer's Disease 2000 , pp. 129-136
    • Smith, J.D.1    Levin, J.A.2
  • 101
    • 0036270344 scopus 로고    scopus 로고
    • Modulation of Aβ peptides by estrogen in mouse models
    • Zheng H, Xu H, Uljon SN, et al. Modulation of Aβ peptides by estrogen in mouse models. J Neurochem 2002; 80: 191-6
    • (2002) J Neurochem , vol.80 , pp. 191-196
    • Zheng, H.1    Xu, H.2    Uljon, S.N.3
  • 102
    • 0035795715 scopus 로고    scopus 로고
    • Chemical andropause and amyloid-β peptide
    • Gandy S, Almeida OP, Fonte J, et al. Chemical andropause and amyloid-β peptide. JAMA 2001; 285: 2195-6
    • (2001) JAMA , vol.285 , pp. 2195-2196
    • Gandy, S.1    Almeida, O.P.2    Fonte, J.3
  • 103
    • 0035577367 scopus 로고    scopus 로고
    • Preclinical and clinical challenges in the development of disease-modifying therapies for Alzheimer's disease
    • Scorer CA. Preclinical and clinical challenges in the development of disease-modifying therapies for Alzheimer's disease. Drug Discov Today 2001; 6: 1207-19
    • (2001) Drug Discov Today , vol.6 , pp. 1207-1219
    • Scorer, C.A.1
  • 104
    • 10744229403 scopus 로고    scopus 로고
    • Steroid hormones and neurosteroids in normal and pathological aging of the nervous system
    • Schumacher M, Weill-Engerer S, Liere P, et al. Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Prog Neurobiol 2003; 71: 3-29
    • (2003) Prog Neurobiol , vol.71 , pp. 3-29
    • Schumacher, M.1    Weill-Engerer, S.2    Liere, P.3
  • 105
    • 0030856295 scopus 로고    scopus 로고
    • The effect of estrogen replacement therapy on cognitive function in women: A critical review of the literature
    • Haskell SG, Richardson ED, Horwitz RI. The effect of estrogen replacement therapy on cognitive function in women: a critical review of the literature. J Clin Epidemiol 1997; 50: 1249-64
    • (1997) J Clin Epidemiol , vol.50 , pp. 1249-1264
    • Haskell, S.G.1    Richardson, E.D.2    Horwitz, R.I.3
  • 106
    • 0030748719 scopus 로고    scopus 로고
    • A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: The Baltimore Longitudinal Study of Aging
    • Kawas C, Resnick S, Morrison A, et al. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology 1997; 48: 1517-21
    • (1997) Neurology , vol.48 , pp. 1517-1521
    • Kawas, C.1    Resnick, S.2    Morrison, A.3
  • 107
    • 0031899264 scopus 로고    scopus 로고
    • Estrogen-replacement therapy and Alzheimer's disease in the Italian Longitudinal Study on Aging
    • Baldereschi M, Di Carlo A, Lepore V, et al. Estrogen-replacement therapy and Alzheimer's disease in the Italian Longitudinal Study on Aging. Neurology 1998; 50: 996-1002
    • (1998) Neurology , vol.50 , pp. 996-1002
    • Baldereschi, M.1    Di Carlo, A.2    Lepore, V.3
  • 108
    • 0031921363 scopus 로고    scopus 로고
    • Postmenopausal estrogen use and Parkinson's disease with and without dementia
    • Marder K, Tang M-X, Alfaro B, et al. Postmenopausal estrogen use and Parkinson's disease with and without dementia. Neurology 1998; 50: 1141-3
    • (1998) Neurology , vol.50 , pp. 1141-1143
    • Marder, K.1    Tang, M.-X.2    Alfaro, B.3
  • 109
    • 0034551768 scopus 로고    scopus 로고
    • Estrogen is essential for maintaining nigrostriatal dopamine neurons in primates: Implications for Parkinson's disease and memory
    • Leranth C, Roth RH, Elswoth JD, et al. Estrogen is essential for maintaining nigrostriatal dopamine neurons in primates: implications for Parkinson's disease and memory. J Neurosci 2000; 20: 8604-9
    • (2000) J Neurosci , vol.20 , pp. 8604-8609
    • Leranth, C.1    Roth, R.H.2    Elswoth, J.D.3
  • 110
    • 0029886801 scopus 로고    scopus 로고
    • Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer's disease
    • Schneider LS, Farlow MR, Henderson VW, et al. Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer's disease. Neurology 1996; 46: 1580-4
    • (1996) Neurology , vol.46 , pp. 1580-1584
    • Schneider, L.S.1    Farlow, M.R.2    Henderson, V.W.3
  • 111
    • 0034700965 scopus 로고    scopus 로고
    • Endogenous estrogen levels and Alzheimer's disease among postmenopausal women
    • Manly JJ, Merchant CA, Jacobs DM, et al. Endogenous estrogen levels and Alzheimer's disease among postmenopausal women. Neurology 2000; 54: 833-7
    • (2000) Neurology , vol.54 , pp. 833-837
    • Manly, J.J.1    Merchant, C.A.2    Jacobs, D.M.3
  • 112
    • 0036186427 scopus 로고    scopus 로고
    • Endogenous estradiol in elderly individuals: Cognitive and noncognitive associations
    • Senanarong V, Vannasaeng S, Poungvarin N, et al. Endogenous estradiol in elderly individuals: cognitive and noncognitive associations. Arch Neurol 2002; 59: 385-9
    • (2002) Arch Neurol , vol.59 , pp. 385-389
    • Senanarong, V.1    Vannasaeng, S.2    Poungvarin, N.3
  • 113
    • 0035964288 scopus 로고    scopus 로고
    • High-dose estradiol improves cognition for women with AD: Results of a randomized study
    • Asthana S, Baker LD, Craft S, et al. High-dose estradiol improves cognition for women with AD: results of a randomized study. Neurology 2001; 57: 605-12
    • (2001) Neurology , vol.57 , pp. 605-612
    • Asthana, S.1    Baker, L.D.2    Craft, S.3
  • 115
    • 2942755831 scopus 로고    scopus 로고
    • Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study
    • Shumaker SA, Legault C, Kuller L, et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA 2004; 291: 2947-58
    • (2004) JAMA , vol.291 , pp. 2947-2958
    • Shumaker, S.A.1    Legault, C.2    Kuller, L.3
  • 116
    • 2942750157 scopus 로고    scopus 로고
    • Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study
    • Espeland MA, Rapp SR, Shumaker SA, et al. Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. JAMA 2004; 291: 2959-68
    • (2004) JAMA , vol.291 , pp. 2959-2968
    • Espeland, M.A.1    Rapp, S.R.2    Shumaker, S.A.3
  • 117
    • 0038386058 scopus 로고    scopus 로고
    • Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: The Women's Health Initiative Memory Study: A randomized controlled trial
    • Shumaker SA, Legault C, Rapp SR, et al. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 2003; 289: 2651-62
    • (2003) JAMA , vol.289 , pp. 2651-2662
    • Shumaker, S.A.1    Legault, C.2    Rapp, S.R.3
  • 118
    • 0038724280 scopus 로고    scopus 로고
    • Effect of estrogen plus progestin on global cognitive function in postmenopausal women: The Women's Health Initiative Memory Study: a randomized controlled trial
    • Rapp SR, Espeland MA, Shumaker SA, et al. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 2003; 289: 2663-72
    • (2003) JAMA , vol.289 , pp. 2663-2672
    • Rapp, S.R.1    Espeland, M.A.2    Shumaker, S.A.3
  • 119
    • 0031974053 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: Chemistry and metabolism
    • Bhavnani BR. Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism. Proc Soc Exp Biol Med 1998; 217: 6-16
    • (1998) Proc Soc Exp Biol Med , vol.217 , pp. 6-16
    • Bhavnani, B.R.1
  • 120
    • 0041887216 scopus 로고    scopus 로고
    • Estrogens and menopause: Pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's
    • Bhavnani BR. Estrogens and menopause: pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's. J Steroid Biochem Mol Biol 2003; 85: 473-82
    • (2003) J Steroid Biochem Mol Biol , vol.85 , pp. 473-482
    • Bhavnani, B.R.1
  • 121
    • 0022638587 scopus 로고
    • Enhanced hepatic extraction of estrogens used for replacement therapy
    • Steingold KA, Cefalu W, Pardridge W, et al. Enhanced hepatic extraction of estrogens used for replacement therapy. J Clin Endocrinol Metab 1986; 62: 761-6
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 761-766
    • Steingold, K.A.1    Cefalu, W.2    Pardridge, W.3
  • 122
    • 25144438043 scopus 로고    scopus 로고
    • Surgical menopause, estrogen, and cognitive function in women: What do the findings tell us?
    • Sherwin BB. Surgical menopause, estrogen, and cognitive function in women: what do the findings tell us? Ann N Y Acad Sci 2005; 1052: 3-10
    • (2005) Ann N Y Acad Sci , vol.1052 , pp. 3-10
    • Sherwin, B.B.1
  • 124
    • 18844392598 scopus 로고    scopus 로고
    • Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's Health Initiative
    • Wise PM, Dubal DB, Rau SW, et al. Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's Health Initiative. Endocr Rev 2005; 26: 308-12
    • (2005) Endocr Rev , vol.26 , pp. 308-312
    • Wise, P.M.1    Dubal, D.B.2    Rau, S.W.3
  • 125
    • 20444488688 scopus 로고    scopus 로고
    • From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens
    • Amantea D, Russo R, Bagetta G, et al. From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens. Pharmacol Res 2005; 52: 119-32
    • (2005) Pharmacol Res , vol.52 , pp. 119-132
    • Amantea, D.1    Russo, R.2    Bagetta, G.3
  • 126
    • 0033118665 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons
    • Singer CA, Figueroa-Masot XA, Batchelor RH, et al. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J Neurosci 1999; 19: 2455-63
    • (1999) J Neurosci , vol.19 , pp. 2455-2463
    • Singer, C.A.1    Figueroa-Masot, X.A.2    Batchelor, R.H.3
  • 127
    • 0035666912 scopus 로고    scopus 로고
    • Interactions of estrogens and insulin-like growth factor-I in the brain: Implications for neuroprotection
    • Cardona-Gomez GP, Mendez P, DonCarlos LL, et al. Interactions of estrogens and insulin-like growth factor-I in the brain: implications for neuroprotection. Brain Res Brain Res Rev 2001; 37: 320-34
    • (2001) Brain Res Brain Res Rev , vol.37 , pp. 320-334
    • Cardona-Gomez, G.P.1    Mendez, P.2    Doncarlos, L.L.3
  • 128
    • 0028971169 scopus 로고
    • 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro
    • Behl C, Widmann M, Trapp T, et al. 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun 1995; 216: 473-82
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 473-482
    • Behl, C.1    Widmann, M.2    Trapp, T.3
  • 129
    • 0030700217 scopus 로고    scopus 로고
    • Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat
    • Simpkins JW, Rajakumar G, Zhang Y-Q, et al. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg 1997; 87: 724-30
    • (1997) J Neurosurg , vol.87 , pp. 724-730
    • Simpkins, J.W.1    Rajakumar, G.2    Zhang, Y.-Q.3
  • 131
    • 0033497678 scopus 로고    scopus 로고
    • Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: Evidence for a receptor-independent antioxidative mechanism
    • Culmsee C, Vedder H, Ravati A, et al. Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: evidence for a receptor-independent antioxidative mechanism. J Cereb Blood Flow Metab 1999; 19: 1263-9
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 1263-1269
    • Culmsee, C.1    Vedder, H.2    Ravati, A.3
  • 132
  • 133
    • 0035852657 scopus 로고    scopus 로고
    • Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury
    • Dubal DB, Zhu H, Yu J, et al. Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci U S A 2001; 98: 1952-7
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1952-1957
    • Dubal, D.B.1    Zhu, H.2    Yu, J.3
  • 134
    • 0041922555 scopus 로고    scopus 로고
    • Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol
    • Vegeto E, Belcredito S, Etteri S, et al. Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol. Proc Natl Acad Sci U S A 2003; 100: 9614-9
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9614-9619
    • Vegeto, E.1    Belcredito, S.2    Etteri, S.3
  • 135
    • 0022775491 scopus 로고
    • The blood-brain barrier
    • Goldstein GW, Betz AL. The blood-brain barrier. Sci Am 1986; 255 (3): 74-83
    • (1986) Sci Am , vol.255 , Issue.3 , pp. 74-83
    • Goldstein, G.W.1    Betz, A.L.2
  • 137
    • 0029871091 scopus 로고    scopus 로고
    • The blood-brain barrier: Principles for targeting peptides and drugs to the central nervous system
    • Begley DJ. The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system. J Pharm Pharmacol 1996; 48: 136-46
    • (1996) J Pharm Pharmacol , vol.48 , pp. 136-146
    • Begley, D.J.1
  • 138
    • 0031706070 scopus 로고    scopus 로고
    • Octanol-water partition: Searching for predictive models
    • Buchwald P, Bodor N. Octanol-water partition: searching for predictive models. Curr Med Chem 1998; 5: 353-80
    • (1998) Curr Med Chem , vol.5 , pp. 353-380
    • Buchwald, P.1    Bodor, N.2
  • 139
    • 13244271912 scopus 로고    scopus 로고
    • Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models
    • Abbott NJ. Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models. Drug Discov Today Technol 2004; 1: 407-16
    • (2004) Drug Discov Today Technol , vol.1 , pp. 407-416
    • Abbott, N.J.1
  • 140
    • 1642536206 scopus 로고    scopus 로고
    • Brain-targeted delivery: Experiences to date
    • Bodor N, Buchwald P. Brain-targeted delivery: experiences to date. Am J Drug Deliv 2003; 1: 13-26
    • (2003) Am J Drug Deliv , vol.1 , pp. 13-26
    • Bodor, N.1    Buchwald, P.2
  • 141
    • 0020314516 scopus 로고
    • Problems of delivery of drugs to the brain
    • Bodor N, Brewster ME. Problems of delivery of drugs to the brain. Pharmacol Ther 1983; 19: 337-86
    • (1983) Pharmacol Ther , vol.19 , pp. 337-386
    • Bodor, N.1    Brewster, M.E.2
  • 142
    • 0000189131 scopus 로고
    • Chemical delivery systems
    • Juliano RL, editor. Berlin: Springer
    • Bodor N, Brewster ME. Chemical delivery systems. In: Juliano RL, editor. Targeted drug delivery. Berlin: Springer, 1991: 231-84
    • (1991) Targeted Drug Delivery , pp. 231-284
    • Bodor, N.1    Brewster, M.E.2
  • 143
    • 0033526158 scopus 로고    scopus 로고
    • Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems
    • Bodor N, Buchwald P. Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems. Adv Drug Deliv Rev 1999; 36: 229-54
    • (1999) Adv Drug Deliv Rev , vol.36 , pp. 229-254
    • Bodor, N.1    Buchwald, P.2
  • 145
    • 84891005452 scopus 로고    scopus 로고
    • Targeting of neuropharmaceuticals by chemical delivery systems
    • Dermietzel R, Spray DC, Needergard M, editors. Weinheim: Wiley-VCH
    • Bodor N, Buchwald P. Targeting of neuropharmaceuticals by chemical delivery systems. In: Dermietzel R, Spray DC, Needergard M, editors. Blood-brain interfaces: from ontogeny to artificial barriers. Weinheim: Wiley-VCH, 2006: 463-500
    • (2006) Blood-brain Interfaces: From Ontogeny to Artificial Barriers , pp. 463-500
    • Bodor, N.1    Buchwald, P.2
  • 146
    • 0021245591 scopus 로고
    • The interaction of C-17 esters of estradiol with the estrogen receptor
    • Janocko L, Lamer JM, Hochberg RB. The interaction of C-17 esters of estradiol with the estrogen receptor. Endocrinology 1984; 114: 1180-6
    • (1984) Endocrinology , vol.114 , pp. 1180-1186
    • Janocko, L.1    Lamer, J.M.2    Hochberg, R.B.3
  • 147
    • 0029585471 scopus 로고
    • Efficacy of a 3-substituted versus 17-substituted chemical delivery system for estradiol brain targeting
    • Brewster ME, Druzgala PJ, Anderson WR, et al. Efficacy of a 3-substituted versus 17-substituted chemical delivery system for estradiol brain targeting. J Pharm Sci 1995; 84: 38-43
    • (1995) J Pharm Sci , vol.84 , pp. 38-43
    • Brewster, M.E.1    Druzgala, P.J.2    Anderson, W.R.3
  • 148
    • 0028116644 scopus 로고
    • Effect of molecular manipulation on the estrogenic activity of a brain-targeting estradiol chemical delivery system
    • Brewster ME, Bartruff MSM, Anderson WR, et al. Effect of molecular manipulation on the estrogenic activity of a brain-targeting estradiol chemical delivery system. J Med Chem 1994; 37: 4237-44
    • (1994) J Med Chem , vol.37 , pp. 4237-4244
    • Brewster, M.E.1    Bartruff, M.S.M.2    Anderson, W.R.3
  • 149
    • 0024269519 scopus 로고
    • Improved delivery through biological membranes. XXXI. Solubilization and stabilization of an estradiol chemical delivery system by modified β-cyclodextrins
    • Brewster ME, Estes KE, Loftsson T, et al. Improved delivery through biological membranes. XXXI. Solubilization and stabilization of an estradiol chemical delivery system by modified β-cyclodextrins. J Pharm Sci 1988; 77: 981-5
    • (1988) J Pharm Sci , vol.77 , pp. 981-985
    • Brewster, M.E.1    Estes, K.E.2    Loftsson, T.3
  • 150
    • 0021810514 scopus 로고
    • Amorphous water-soluble derivatives of cyclodextrins: Nontoxic dissolution enhancing excipients
    • Pitha J, Pitha J. Amorphous water-soluble derivatives of cyclodextrins: nontoxic dissolution enhancing excipients. J Pharm Sci 1985; 74: 987-90
    • (1985) J Pharm Sci , vol.74 , pp. 987-990
    • Pitha, J.1    Pitha, J.2
  • 151
    • 0022592084 scopus 로고
    • Hydroxypropyl-β-cyclodextrin: Preparation and characterization, effects on solubility of drugs
    • Pitha J, Milecki J, Fales H, et al. Hydroxypropyl-β-cyclodextrin: preparation and characterization, effects on solubility of drugs. Int J Pharm 1986; 29: 73-82
    • (1986) Int J Pharm , vol.29 , pp. 73-82
    • Pitha, J.1    Milecki, J.2    Fales, H.3
  • 152
    • 0023676038 scopus 로고
    • Pharmaceutical evaluation of hydroxyalkyl ethers of β-cyclodextrins
    • Yoshida A, Arima H, Uekama K, et al. Pharmaceutical evaluation of hydroxyalkyl ethers of β-cyclodextrins. Int J Pharm 1988; 46: 217-22
    • (1988) Int J Pharm , vol.46 , pp. 217-222
    • Yoshida, A.1    Arima, H.2    Uekama, K.3
  • 153
    • 0025216407 scopus 로고
    • An intravenous toxicity study of 2-hydroxypropyl-β-cyclodextrin, a useful drug solubilizer, in rats and monkeys
    • Brewster ME, Estes KS, Bodor N. An intravenous toxicity study of 2-hydroxypropyl-β-cyclodextrin, a useful drug solubilizer, in rats and monkeys. Int J Pharm 1990; 59: 231-43
    • (1990) Int J Pharm , vol.59 , pp. 231-243
    • Brewster, M.E.1    Estes, K.S.2    Bodor, N.3
  • 154
    • 0023153469 scopus 로고
    • Improved delivery through biological membranes. XXII. Synthesis and distribution of brain-selective estrogen delivery systems
    • Bodor N, McCornack J, Brewster ME. Improved delivery through biological membranes. XXII. Synthesis and distribution of brain-selective estrogen delivery systems. Int J Pharm 1987; 35: 47-59
    • (1987) Int J Pharm , vol.35 , pp. 47-59
    • Bodor, N.1    McCornack, J.2    Brewster, M.E.3
  • 155
    • 0023950207 scopus 로고
    • High performance liquid chromatographic assay of a central nervous system (CNS)-directed estradiol chemical delivery system and its application after intravenous administration in rats
    • Mullersman G, Derendorf H, Brewster ME, et al. High performance liquid chromatographic assay of a central nervous system (CNS)-directed estradiol chemical delivery system and its application after intravenous administration in rats. Pharm Res 1988; 5: 172-7
    • (1988) Pharm Res , vol.5 , pp. 172-177
    • Mullersman, G.1    Derendorf, H.2    Brewster, M.E.3
  • 156
    • 0024315609 scopus 로고
    • Chronic inhibition of hypothalamic-pituitary-ovarian axis and body weight gain by brain-directed delivery of estradiol-17β in female rats
    • Sarkar DK, Friedman SJ, Yen SSC, et al. Chronic inhibition of hypothalamic-pituitary-ovarian axis and body weight gain by brain-directed delivery of estradiol-17β in female rats. Neuroendocrinology 1989; 50: 204-10
    • (1989) Neuroendocrinology , vol.50 , pp. 204-210
    • Sarkar, D.K.1    Friedman, S.J.2    Yen, S.S.C.3
  • 157
    • 0025153540 scopus 로고
    • Dose and time-course evaluation of a redox-based estradiol-chemical delivery system for the brain: I. tissue distribution
    • Rahimy MH, Simpkins JW, Bodor N. Dose and time-course evaluation of a redox-based estradiol-chemical delivery system for the brain: I. tissue distribution. Pharm Res 1990; 7: 1061-7
    • (1990) Pharm Res , vol.7 , pp. 1061-1067
    • Rahimy, M.H.1    Simpkins, J.W.2    Bodor, N.3
  • 158
    • 0025880328 scopus 로고
    • A redox-based chemical delivery system that enhances estradiol distribution to the brain: Disposition studies in the rat
    • Estes KS, Keuth V, Dietzel K, et al. A redox-based chemical delivery system that enhances estradiol distribution to the brain: disposition studies in the rat. Pharm Res 1991; 8: 1180-5
    • (1991) Pharm Res , vol.8 , pp. 1180-1185
    • Estes, K.S.1    Keuth, V.2    Dietzel, K.3
  • 159
    • 0025052376 scopus 로고
    • A redox-based system that enhances delivery of estradiol to the brain: Pharmacokinetic evaluation in the dog
    • Dietzel K, Keuth V, Estes KS, et al. A redox-based system that enhances delivery of estradiol to the brain: pharmacokinetic evaluation in the dog. Pharm Res 1990; 7: 879-83
    • (1990) Pharm Res , vol.7 , pp. 879-883
    • Dietzel, K.1    Keuth, V.2    Estes, K.S.3
  • 160
    • 0023117641 scopus 로고
    • A novel redox system for CNS-directed delivery of estradiol causes sustained LH suppression in castrate rats
    • Estes KS, Brewster ME, Simpkins JW, et al. A novel redox system for CNS-directed delivery of estradiol causes sustained LH suppression in castrate rats. Life Sci 1987; 40: 1327-34
    • (1987) Life Sci , vol.40 , pp. 1327-1334
    • Estes, K.S.1    Brewster, M.E.2    Simpkins, J.W.3
  • 161
    • 0022500777 scopus 로고
    • Sustained brain-specific delivery of estradiol causes long-term suppression of luteinizing hormone secretion
    • Simpkins JW, McCornack J, Estes KS, et al. Sustained brain-specific delivery of estradiol causes long-term suppression of luteinizing hormone secretion. J Med Chem 1986; 29: 1809-12
    • (1986) J Med Chem , vol.29 , pp. 1809-1812
    • Simpkins, J.W.1    McCornack, J.2    Estes, K.S.3
  • 162
    • 0023845611 scopus 로고
    • A redox system for brain targeted estrogen delivery causes chronic body weight decrease in rats
    • Estes KS, Brewster ME, Bodor NS. A redox system for brain targeted estrogen delivery causes chronic body weight decrease in rats. Life Sci 1988; 42: 1077-84
    • (1988) Life Sci , vol.42 , pp. 1077-1084
    • Estes, K.S.1    Brewster, M.E.2    Bodor, N.S.3
  • 163
    • 0024268645 scopus 로고
    • Chronic weight loss in lean and obese rats with a brain-enhanced chemical delivery system for estradiol
    • Simpkins JW, Anderson WR, Dawson R, et al. Chronic weight loss in lean and obese rats with a brain-enhanced chemical delivery system for estradiol. Physiol Behav 1988; 44: 573-80
    • (1988) Physiol Behav , vol.44 , pp. 573-580
    • Simpkins, J.W.1    Anderson, W.R.2    Dawson, R.3
  • 164
    • 0024342303 scopus 로고
    • Effects of a brain-enhanced chemical delivery system for estradiol on body weight and food intake in intact and ovariectomized rats
    • Simpkins JW, Anderson WR, Dawson R, et al. Effects of a brain-enhanced chemical delivery system for estradiol on body weight and food intake in intact and ovariectomized rats. Pharm Res 1989; 6: 592-600
    • (1989) Pharm Res , vol.6 , pp. 592-600
    • Simpkins, J.W.1    Anderson, W.R.2    Dawson, R.3
  • 165
    • 0027282081 scopus 로고
    • Suppression of plasma testosterone and prostate carcinoma size by a redox-based, brain-targeted estrogen delivery system in the rat
    • Rahimy MH, Bodor N, Simpkins JW. Suppression of plasma testosterone and prostate carcinoma size by a redox-based, brain-targeted estrogen delivery system in the rat. Prostate 1993; 23: 79-90
    • (1993) Prostate , vol.23 , pp. 79-90
    • Rahimy, M.H.1    Bodor, N.2    Simpkins, J.W.3
  • 166
    • 0025977413 scopus 로고
    • Effects of a brain-enhanced estrogen delivery system on tail-skin temperature of the rat: Implications for menopausal hot flush
    • Rahimy MH, Bodor N, Simpkins JW. Effects of a brain-enhanced estrogen delivery system on tail-skin temperature of the rat: implications for menopausal hot flush. Maturitas 1991; 13: 51-63
    • (1991) Maturitas , vol.13 , pp. 51-63
    • Rahimy, M.H.1    Bodor, N.2    Simpkins, J.W.3
  • 168
    • 0016378897 scopus 로고
    • Biphasic effect of estrogen on the sensitivity of the pituitary to luteinizing hormone-releasing factor (LRF)
    • Apr
    • Libertun C, Orias R, McCann SM. Biphasic effect of estrogen on the sensitivity of the pituitary to luteinizing hormone-releasing factor (LRF). Endocrinology 1974 Apr; 94 (4): 1094-100
    • (1974) Endocrinology , vol.94 , Issue.4 , pp. 1094-1100
    • Libertun, C.1    Orias, R.2    McCann, S.M.3
  • 169
    • 0017622515 scopus 로고
    • Oestradiol-17beta and pituitary responsiveness to luteinizing hormone releasing factor in the rat: A study using rectangular pulses of oestradiol-17beta monitored by non-chromatographic radioimmunoassay
    • Jun
    • Henderson SR, Baker C, Fink G. Oestradiol-17beta and pituitary responsiveness to luteinizing hormone releasing factor in the rat: a study using rectangular pulses of oestradiol-17beta monitored by non-chromatographic radioimmunoassay. J Endocrinol 1977 Jun; 73 (3): 441-53
    • (1977) J Endocrinol , vol.73 , Issue.3 , pp. 441-453
    • Henderson, S.R.1    Baker, C.2    Fink, G.3
  • 170
    • 33748363735 scopus 로고
    • A brain-enhanced delivery system for gonadal steroids: Implication for neurogenerative diseases
    • Meyer EM, Simpkins JW, Yamamoto J, editors. New York: Plenum Press
    • Simpkins JW, Rahimy MH, Bodor N. A brain-enhanced delivery system for gonadal steroids: implication for neurogenerative diseases. In: Meyer EM, Simpkins JW, Yamamoto J, editors. Novel approaches to the treatment of Alzheimer's disease. New York: Plenum Press, 1989: 197-212
    • (1989) Novel Approaches to the Treatment of Alzheimer's Disease , pp. 197-212
    • Simpkins, J.W.1    Rahimy, M.H.2    Bodor, N.3
  • 171
    • 0031194114 scopus 로고    scopus 로고
    • 17 β-estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum
    • Rabbani O, Panickar KS, Rajakumar G, et al. 17 β-estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum. Exp Neurol 1997; 146: 179-86
    • (1997) Exp Neurol , vol.146 , pp. 179-186
    • Rabbani, O.1    Panickar, K.S.2    Rajakumar, G.3
  • 172
    • 0023919867 scopus 로고
    • A dihydropyridine conjugate which generates high and sustained levels of the corresponding pyridinium salt in the brain does not exhibit neurotoxicity in cynomolgus monkeys
    • Brewster ME, Estes KS, Perchalski R, et al. A dihydropyridine conjugate which generates high and sustained levels of the corresponding pyridinium salt in the brain does not exhibit neurotoxicity in cynomolgus monkeys. Neurosci Lett 1988; 87: 277-82
    • (1988) Neurosci Lett , vol.87 , pp. 277-282
    • Brewster, M.E.1    Estes, K.S.2    Perchalski, R.3
  • 173
    • 0001129142 scopus 로고
    • A pilot study with PR-63 in postmenopausal volunteers
    • abstract no. 181
    • Howes J, Bodor N, Brewster ME, et al. A pilot study with PR-63 in postmenopausal volunteers [abstract no. 181]. J Clin Pharmacol 1988; 28: 951
    • (1988) J Clin Pharmacol , vol.28 , pp. 951
    • Howes, J.1    Bodor, N.2    Brewster, M.E.3
  • 174
    • 0025994997 scopus 로고
    • A redox-based chemical delivery system (CDS) applied to estradiol
    • Estes KS, Dewland PM, Brewster ME, et al. A redox-based chemical delivery system (CDS) applied to estradiol. Pharm Ztg Wiss 1991; 136: 153-8
    • (1991) Pharm Ztg Wiss , vol.136 , pp. 153-158
    • Estes, K.S.1    Dewland, P.M.2    Brewster, M.E.3
  • 175
    • 0028457099 scopus 로고
    • Evaluation of an estradiol chemical delivery system (CDS) designed to provide enhanced and sustained hormone levels in the brain
    • Estes KS, Brewster ME, Bodor N. Evaluation of an estradiol chemical delivery system (CDS) designed to provide enhanced and sustained hormone levels in the brain. Adv Drug Deliv Rev 1994; 14: 167-75
    • (1994) Adv Drug Deliv Rev , vol.14 , pp. 167-175
    • Estes, K.S.1    Brewster, M.E.2    Bodor, N.3
  • 176
    • 84982817797 scopus 로고
    • Buccal and parenteral clinical evaluation of a brain-targeting estradiol chemical delivery system (E2-CDS)
    • Howes J, Brewster M, Harris A, et al. Buccal and parenteral clinical evaluation of a brain-targeting estradiol chemical delivery system (E2-CDS). Clin Pharmacol Ther 1995; 57: 172
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 172
    • Howes, J.1    Brewster, M.2    Harris, A.3
  • 177
    • 33748345422 scopus 로고    scopus 로고
    • Intravenous and buccal 2-hydroxypropyl-β-cyclodextrin formulations of E2-CDS: Phase I clinical trials
    • 1996 Mar 30-Apr 2; Paris. Paris: Editions de Sante
    • Brewster ME, Howes J, Griffith W, et al. Intravenous and buccal 2-hydroxypropyl-β-cyclodextrin formulations of E2-CDS: phase I clinical trials. Proceedings of the 8th International Cyclodextrins Symposium; 1996 Mar 30-Apr 2; Paris. Paris: Editions de Sante, 1996
    • (1996) Proceedings of the 8th International Cyclodextrins Symposium
    • Brewster, M.E.1    Howes, J.2    Griffith, W.3


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