PRA1 promotes the intracellular trafficking and NF-κB signaling of EBV latent membrane protein 1

EMBO Journal

Volumn 25, Issue 17, 2006, Pages 4120-4130

  Liu, Hao Ping ^a   Wu, Chih Ching ^b   Chang, Yu Sun ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

EBV; Intracellular trafficking; LMP1; NF B; PRA1

Indexed keywords

BREFELDIN A; CD40 LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LATENT MEMBRANE PROTEIN 1; NOCODAZOLE; PROTEIN PRA1; RAB PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE;

ANIMALS; CELL LINE; ENDOPLASMIC RETICULUM; FLUORESCENCE RESONANCE ENERGY TRANSFER; GOLGI APPARATUS; GTP-BINDING PROTEINS; HUMANS; MEMBRANE PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 1; TNF RECEPTOR-ASSOCIATED FACTOR 3; TWO-HYBRID SYSTEM TECHNIQUES; VESICULAR TRANSPORT PROTEINS; VIRAL MATRIX PROTEINS;

HUMAN HERPESVIRUS 4;

EID: 33748340652     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601282     Document Type: Article

References (46)

1. Abdul-Ghani M, Gougeon PY, Prosser DC, Da Silva LF, Ngsee JK (2001) PRA isoforms are targeted to distinct membrane compartments. J Biol Chem 276: 6225-6233
2. Ardila-Osorio H, Clausse B, Mishal Z, Wiels J, Tursz T, Busson P (1999) Evidence of LMP1-TRAF3 interactions in glycosphingolipid-rich complexes of lymphoblastoid and nasopharyngeal carcinoma cells. Int J Cancer 81: 645-649
3. Barlowe C (2003) Signals for COPII-dependent export from the ER: what's the ticket out? Trends Cell Biol 13: 295-300
4. Bivona TG, Wiener HH, Ahearn IM, Silletti J, Chiu VK, Philips MR (2004) Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol 164: 461-470
5. Bonifacino JS, Glick BS (2004) The mechanisms of vesicle budding and fusion. Cell 116: 153-166
6. Brummelkamp TR, Bernards R, Agami R (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553
7. Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB (1999) Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). Biochem Biophys Res Commun 258: 657-662
8. Coffin III WF, Geiger TR, Martin JM (2003) Transmembrane domains 1 and 2 of the latent membrane protein 1 of Epstein-Barr virus contain a lipid raft targeting signal and play a critical role in cytostasis. J Virol 77: 3749-3758
9. Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB (2003) Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. J Biol Chem 278: 35837-35843
10. Eliopoulos AG, Davies C, Blake SS, Murray P, Najafipour S, Tsichlis PN, Young LS (2002) The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-κB signaling downstream of TRAF2. J Virol 76: 4567-4579
11. Eliopoulos AG, Rickinson AB (1998) Epstein-Barr virus: LMP1 masquerades as an active receptor. Curr Biol 8: 196-198
12. Figueroa C, Taylor J, Vojtek AB (2001) Prenylated Rab acceptor protein is a receptor for prenylated small GTPases. J Biol Chem 276: 28219-28225
13. Flanagan J, Middeldorp J, Sculley T (2003) Localization of the Epstein-Barr virus protein LMP1 to exosomes. J Gen Virol 84: 1871-1879
14. Gires O, Zimber-Strobl U, Gonnella R, Ueffing M, Marschall G, Zeidler R, Pich D, Hammerschmidt W (1997) Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule. EMBO J 16: 6131-6140
15. Gougeon PY, Prosser DC, Da Silva LF, Ngsee JK (2002) Disruption of Golgi morphology and trafficking in cells expressing mutant prenylated rab acceptor-1. J Biol Chem 277: 36408-36414
16. Hammond AT, Glick BS (2000) Dynamics of transitional endoplasmic reticulum sites in vertebrate cells. Mol Biol Cell 11: 3013-3030
17. Heino S, Lusa S, Somerharju P, Ehnholm C, Olkkonen VM, Ikonen E (2000) Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface. Proc Natl Acad Sci USA 97: 8375-8380
18. Higuchi M, Izumi KM, Kieff E (2001) Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors. Proc Natl Acad Sci USA 98: 4675-4680
19. Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (2004) Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. EMBO J 23: 1267-1278
20. Hirschberg K, Miller CM, Ellenberg J, Presley JF, Siggia ED, Phair RD, Lippincott-Schwartz J (1998) Kinetic analysis of secretory protein traffic and characterization of Golgi to plasma membrane transport intermediates in living cells. J Cell Biol 143: 1485-1503
21. Horikawa T, Yoshizaki T, Sheen TS, Lee SY, Furukawa M (2000) Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinoma. Cancer 89: 715-723
22. Hutt DM, Da Silva LF, Chang LH, Prosser DC, Ngsee JK (2000) PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1. J Biol Chem 275: 18511-18519
23. Ikonen E (2001) Roles of lipid rafts in membrane transport. Curr Opin Cell Biol 13: 470-477
24. Kasahara K, Nakayama Y, Ikeda K, Fukushima Y, Matsuda D, Horimoto S, Yamaguchi N (2004) Trafficking of Lyn through the Golgi caveolin involves the charged residues on alpha E and alpha I helices in the kinase domain. J Cell Biol 165: 641-652
25. Kaykas A, Worringer K, Sugden B (2001) CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complex. EMBO J 20: 2641-2654
26. Kilger E, Kieser A, Baumann M, Hammerschmidt W (1998) Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor. EMBO J 17: 1700-1709
27. Klausner RD, Donaldson JG, Lippincott-Schwartz J (1992) Brefeldin A: insights into the control of membrane traffic and organelle structure. J Cell Biol 116: 1071-1080
28. Lam N, Sugden B (2003) LMP1, a viral relative of the TNF receptor family, signals principally from intracellular compartments. EMBO J 22: 3027-3038
29. Li LY, Shih HM, Liu MY, Chen JY (2001) The cellular protein PRA1 modulates the anti-apoptotic activity of Epstein-Barr virus BHRF1, a homologue of Bcl-2, through direct interaction. J Biol Chem 276: 27354-27362
30. Lin J, Liang Z, Zhang Z, Li G (2001) Membrane topography and topogenesis of prenylated Rab acceptor (PRA1). J Biol Chem 276: 41733-41741
31. Lippincott-Schwartz J, Cole NB, Marotta A, Conrad PA, Bloom GS (1995) Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic. J Cell Biol 128: 293-306
32. Lo AK, Huang DP, Lo KW, Chui YL, Li HM, Pang JC, Tsao SW (2004) Phenotypic alterations induced by the Hong Kong-prevalent Epstein-Barr virus-encoded LMP1 variant (2117-LMP1) in nasopharyngeal epithelial cells. Int J Cancer 109: 919-925
33. Lowe SL, Peter F, Subramaniam VN, Wong SH, Hong W (1997) A SNARE involved in protein transport through the Golgi apparatus. Nature 389: 881-884
34. Machamer CE, Cresswell P (1984) Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the alpha-beta chain complex. Proc Natl Acad Sci USA 81: 1287-1291
35. Martincic I, Peralta ME, Ngsee JK (1997) Isolation and characterization of a dual prenylated Rab and VAMP2 receptor. J Biol Chem 272: 26991-26998
36. McLaughlin RE, Denny JB (1999) Palmitoylation of GAP-43 by the ER-Golgi intermediate compartment and Golgi apparatus. Biochim Biophys Acta 1451: 82-92
37. Murshid A, Presley JF (2004) ER-to-Golgi transport and cytoskeletal interactions in animal cells. Cell Mol Life Sci 61: 133-145
38. Presley JF, Cole NB, Schroer TA, Hirschberg K, Zaal KJ, Lippincott-Schwartz J (1997) ER-to-Golgi transport visualized in living cells. Nature 389: 81-85
39. Rothenberger S, Rousseaux M, Knecht H, Bender FC, Legler DF, Bron C (2002) Association of the Epstein-Barr virus latent membrane protein 1 with lipid rafts is mediated through its N-terminal region. Cell Mol Life Sci 59: 171-180
40. Sandberg M, Hammerschmidt W, Sugden B (1997) Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3. J Virol 71: 4649-4656
41. Sivars U, Aivazian D, Pfeffer SR (2003) Yip3 catalyses the dissociation of endosomal Rab-GDI complexes. Nature 425: 856-859
42. Storrie B, White J, Rottger S, Stelzer EH, Suganuma T, Nilsson T (1998) Recycling of Golgi-resident glycosyltransferases through the ER reveals a novel pathway and provides an explanation for nocodazole-induced Golgi scattering. J Cell Biol 143: 1505-1521
43. Uchida J, Yasui T, Takaoka-Shichijo Y, Muraoka M, Kulwichit W, Raab-Traub N, Kikutani H (1999) Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses. Science 286: 300-303
44. Xu Y, Martin S, James DE, Hong W (2002) GS15 Forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. Mol Biol Cell 13: 3493-3507
45. Xu Y, Wong SH, Tang BL, Subramaniam VN, Zhang T, Hong W (1998) A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway. J Biol Chem 273: 21783-21789
46. Yasui T, Luftig M, Soni V, Kieff E (2004) Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling. Proc Natl Acad Sci USA 101: 278-283