Evaluation of the anti-ulcer and toxicity profile of Aloe buettneri in laboratory animals

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 3, Issue 2, 2006, Pages 8-20

  Tan, Paul V ^a   Enow Orock, George E ^b   Dimo, Théophile ^a   Nyasse, Barthelemy ^a   Kimbu, Samuel F ^a  

^a UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^b YAOUNDÉ GENERAL HOSPITAL   (Cameroon)

Author keywords

Aloe buettneri; Antiulcer activity; Toxicity profile

Indexed keywords

ALCOHOL; ALOE BUETTNERI EXTRACT; ANTIULCER AGENT; CIMETIDINE; INDOMETACIN; UNCLASSIFIED DRUG; WATER;

ALOE; ALOE BUETTNERI; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC HEPATITIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG SCREENING; GASTRODUODENAL ULCER; INTERMETHOD COMPARISON; LUNG DISEASE; MALE; MOUSE; NONHUMAN; PERICARDITIS; PLANT LEAF; RAT; SINGLE DRUG DOSE; STOMACH ACID SECRETION; STOMACH MUCUS; STOMACH ULCER; TOXICITY TESTING; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 33748340200     PISSN: 01896016     EISSN: 01896016     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Adjanohoun, I.E., Aboubakar, N, Dramane, K, Ebot, M.E., Ekpere, J.A., Enow-Orock, E.G., Focho, D., Gbile, Z.O., Kamanyi, A., Kamsu-Kom, J., Krim, A., Mbenkum, T., Mbi, C.N., Mbome, L.L, Mbome, L.L., Mobiru, N.K., Nancy, W.L., Nkongmeneck, B., Satabie, B., Sofowora, A., Tamze, V and Wirmum, C.K. (1996). Traditional Medicine and Pharmacopoeia: Contribution to Ethnobotanica 1 and Floristic Studies in Cameroon. Organization of African Unity Scientific, Technical and Research Commission. Centre National de Production de Manuels Scolaires, Porto-Novo, pp263.
2. Ahmed, S, Kapadia, Z, Kalhoro, M.A., Qadiruddin, M.A. and Badar, Y. (1996). Cathartic activity in Aloe vera Linn. Hamdard Medicus 39: 19-26.
3. Arosio, B., Gagliano, N., Fusaro, L.M., Parmeggiani, L., Tagliabue, J., Galetti, P., De Castri, D., Moscheni, C., Annoni G. (2000). Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride. Pharmacology Toxicology. 87(5):229-33.
4. Atherton, P. (1998). First aid plant. Chemistry in Britain. 34 (5): 33-36.
5. Avila, H., Rivero, J., Herrera, F., Fraile, G. (1997). Cytotoxicity of a low molecular weight fraction from Aloe vera (Aloe barbadensis Miller) gel. Toxicon. 35(9):1423-30.
6. Baggenstoss, A.H, Soloway, R.D., Summerskill, W.H.J., Elveback, L.R. and Schoenfield, L.J. (1972) Chronic active liver disease. The range of histological lesions, their responses to treatment and evolution. Human Pathology 3: 183-198.
7. Fan, Y.J., Li, M., Yang, W.L., Qin, L. and Zou, J. (1989). Protective effect of extracts from Aloe vera L. var. chinensis (Haw.) Berg. on experimental hepatic lesions and a primary clinical study on the injection of inpatients with hepatitis. Zhongguo Zhong Yao ZaZhi.14(12):746-748.
8. Hara, N. and Okabe, S. (1985). Effect of gefernate on acute lesions in rats. Folio Pharmacologia Japonica 85:443-448.
9. Konturek, S.J., Piastucki, I., Brozozowski, T., Dembiska-kiec, T.R.A., Muda, A. and Gryglewski, R. (1981). Role of prostaglandins in the formation of aspirin-induced ulcers. Gastroenterology 80: 4-9.
10. Konturek, S.I., Brozozowski, T., Piastucki, I., Radecki, T. and Dembiski-kiec, A. (1982). Role of locally generated prostaglandins in adaptive cytoprotection. Digestive Diseases and Science 27: 967-971
11. Marhuenda, E., Martin, M.J. and Alarcon de la Lastra, C. (1993). Antiulcerogenic activity of Aescine in different experimental models. Phytother. Res. 7: 13-16.
12. Luma, M.A., Bedrossian, C.W.M., Lichtiger, B. and Salem, P.A. (1972). Interstitial pneumonitis association with bleomycin therapy. Amer. J. Clinical Patholgy 58: 501-516.
13. Martin, M.J., Motilva, V. and Alarcon de la Lastra, C. (1993). Quercetin and Naringenin; effects on ulcer formation and gastric secretion in rats. Phyother. Res. 7: 150-153.
14. Miller, T.A. (1982). Protective effect of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Amer. J. Physiol. 245 (Gastrointest. Liver Physiology 8): G601-G603.
15. Myers, J.L., Kennedy, J.L. and Plumb, V.J. (1987). Amioderone lung pathologic findings in clinically toxic patients. Human Pathology. 18: 349-354.
16. Rosemow, E.C. (1972). The spectrum of drug-induced pulmonary disease. Annals internal Medicine 77: 977-991.
17. Scheuer, P.I. (1979). Chronic Hepatitis. In, Macsween, R.N.M., Anthony, P.P., Scheuer, P.J.(eds): Pathology of the Liver. Churchill Livingstone. Edinburgh Medical Division of Longman Group Ltd. Pp343-257.
18. Shay, J.P., Komanov, S.A., Fels, S.S., Meranze, D., Grunstein, M. and Simpler, H. (1945). A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology, 5: 43-61.
19. Sostman, H.D., Mattay, R.A. and Putman, C.E. (1977) Cytotoxic drug-induced lung disease. Amer. J. Medicine 32: 608-615.
20. Tan, P.V., Nditafon, G.N., Yewah, M.P., Ayafor, J.F. and Dimo, T. (1996). Eremomastax speciosa: effects of leaf aqueous extract on ulcer formation and gastric secretion in rats. J. Ethnopharmacol. 54:139-142.
21. Tan, P.V., Njimi, C.K., and Ayafor, J.F. (1997). Screening of some African medicinal plants for antiulcerogenic activity. Part I. Phytother.y Res. 11: 45-47.
22. Tan, P.V., Penlap V.B., Nyasse B., Nguemo J.D. (2000). Anti-ulcer actions of the bark methanol extract of Voacanga africana in different experimental ulcer models in rats.J. Ethnopharmacol. 73(3): 423-428.
23. Telefo, P.B., Moundipa, P.F., Tchouanguep, F.M.(2002). Oestrogenicity and effect on hepatic metabolism of the aqueous extract of the leaf mixture of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus, and Justicia insularis. Fitotherapia 73(6): 472-478.
24. Telefo, P. B., Moundipa, P. F., Tchouanguep, F. M.(2004). Inductive effect of the leaf mixture extract of Aloe buettneri, Justicia insularis, Dicliptera verticillata and Hibiscus macranthus on in vitro production of estradiol. J. Ethnopharmacol. 91(2-3):225-230.
25. Yamamoto, K., Kakegawa, H., Matsumoto, H., Sudo, T. and Satoh, T. (1992). Gastric cytoprotective antiulcerogenic actions of hydroxychalcones in rats. Planta Medica 58, 389-393.
26. Zhou, Y., Feng, Y., Wang, H., Yang, H. (2003). 90-day subchronic toxicity study of aloe whole-leaf powder. Wei Sheng Yan Jiu. 32(6):590-3.