Small hepatic nodules (≤2cm) in cirrhosis patients: Characterization with contrast-enhanced ultrasonography

Liver International

Volumn 26, Issue 8, 2006, Pages 928-934

  Wang, Jing Houng ^a   Lu, Sheng Nan ^a   Hung, Chao Hung ^a   Chen, Tai Yi ^a   Chen, Chien Hung ^a   Changchien, Chi Sin ^a   Lee, Chuan Mo ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Contrast enhanced ultrasonography (CEUS); Hepatocellular carcinoma (HCC); Liver cirrhosis; Sensitivity; Specificity

Indexed keywords

SHU 508;

ADULT; AGED; BENIGN TUMOR; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; ECHOGRAPHY; FEMALE; HUMAN; IMAGE ANALYSIS; IMAGE QUALITY; INTERMETHOD COMPARISON; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER NODULE; LIVER PARENCHYMA; MALE; MICROBUBBLE; OBSERVER VARIATION; PREDICTION; REVIEW; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CONTRAST MEDIA; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; POLYSACCHARIDES; RETROSPECTIVE STUDIES; ULTRASONOGRAPHY, DOPPLER;

EID: 33748314748     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2006.01318.x     Document Type: Review

References (34)

1. Zhang B H, Yang B H Tang Z Y. Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol 2004; 130: 417-22.
2. Bolondi L, Sofia S, Siringo S, et al. Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: A cost-effectiveness analysis. Gut 2001; 48: 251-9.
3. Matsui O, Kadoya M, Kameyama T, et al. Benign and malignant nodules in cirrhotic livers: Distinction based on blood supply. Radiology 1991; 178: 493-7.
4. Murakami T, Kim T, Oi H, et al. Detectability of hypervascular hepatocellular carcinoma by arterial phase images of MR and spiral CT. Acta Radiol 1995; 36: 372-6.
5. Takayasu K, Moriyama N, Muramatsu Y, et al. The diagnosis of small hepatocellular carcinoma: Efficacy of various imaging procedures in 100 patients. Am J Roentgenol 1990; 155: 49-54.
6. Tanaka S, Kitamra T, Fujita M, Kasugai H, Inoue A, Ishiguro S. Small hepatocellular carcinoma: Differentiation from adenomatous hyperplastic nodule with color Doppler flow imaging. Radiology 1992; 182: 161-5.
7. Koito K, Namieno T, Morita K. Differential diagnosis of small hepatocellular carcinoma and adenomatous hyperplasia with power Doppler sonography. Am J Roentgenol 1998; 170: 157-61.
8. Kumada T, Nakano S, Toyoda H, et al. Assessment of tumor hemodynamics in small hepatocellular carcinoma: Comparison of Doppler ultrasonography, angiography-asisted computed tomography, and pathological findings. Liver Int 2004; 24: 425-31.
9. Fujimoto M, Moriyasu F, Nishikawa K, Nada T, Okuma M. Color Doppler sonography of hepatic tumors with a galatcose-based contrast agent: correlation with angiographic findings. Am J Roentgenol 1994; 163: 1099-104.
10. Quaia E, Callida F, Bertolotto M, et al. Characterization of focal liver lesions with contrast-specific US modes and a sulphur hexafluoride-filled microbubble contrast agent: Diagnostic performance and confidence. Radiology 2004; 232: 420-30.
11. Burns P N, Wilson S R Simpson D H. Pulse inversion imaging of liver blood flow: Improved method for characterizing focal masses with microbubble contrast. Invest Radiol 2000; 35: 58-71.
12. Tanaka S, Ioka T, Oshikawa O, Hamada Y, Yoshioka F. Dynamic sonography of hepatic tumors. Am J Roentgenol 2001; 177: 799-805.
13. Isozaki T, Numata K, Kiba T, et al. Differential diagnosis of hepatic tumors by using contrast enhancement patterns at US. Radiology 2003; 229: 798-805.
14. Wen Y L, Kudo M, Zheng R Q, et al. Characterization of hepatic tumors: value of contrast-enhanced coded phase-inversion harmonic angio. Am J Roentgenol 2004; 182: 1019-26.
15. Kojiro M, Roskams T. Early hepatocellular carcinoma and dysplastic nodules. Semin Liver Dis 2005; 25: 133-42.
16. Numata K, Tanala K, Kiba T, et al. Contrast-enhanced, wide-band harmonic gray imaging of hepatocellular carcinoma: Correlation with helical computed tomographic findings. J Ultrasound Med 2001; 20: 89-98.
17. Giorgio A, Ferraioli G, Tarabntino L, et al. Contrast-enhanced sonographic appearance of hepatocellular carcinoma in patients with cirrhosis: Comparison with contrast-enhanced helical CT appearance. Am J Roentgenol 2004; 483: 1319-26.
18. Gaiani S, Celli N, Piscaglia F, et al. Usefulness of contrast-enhanced perfusional sonography in the assessment of hepatocellular carcinoma hypervascular at spiral computed tomography. J Hepatol 2004; 41: 421-6.
19. Choi B I, Kim T K Han J K, et al. Vascularity of hepatocellular carcinoma: Assessment with contrast-enhanced, second-harmonic versus conventional power Doppler US. Radiology 2000; 214: 381-6.
20. Wang J H, Lu S N Changchien C S, et al. Flash-echo gray-scale imaging in the subtraction mode for assessing perfusion of small hepatocellular carcinoma. J Clin Ultrasound 2003; 31: 451-6.
21. Bruix J, Sherman M, Llovet J M, et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. J Hepatolol 2001; 35: 421-30.
22. Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology 2005; 42: 1208-36.
23. Ding H, Wang W P Huang B J, et al. Imaging of focal liver lesions: low-mechanical-index real-time ultrasonography with Sonovue. J Ultrasound Med 2005; 24: 285-97.
24. Bolondi L, Gaiani S, Celli N, et al. Characterization of small nodules in cirrhosis by assessment of vascularity: The problem of hypovascular hepatocellular carcinoma. Hepatology 2005; 42: 27-34.
25. Nakashima O, Sugihara S, Kage M, Kojiro M. Pathomorphologic characteristics of small hepatocellular carcinoma: A special reference to small hepatocellular carcinoma with indistinct margins. Hepatology 1995; 22: 101-5.
26. Kutami R, Nakashima Y, Nakashima O, et al. Pathomorphologic study on the mechanism of fatty change in small hepatocellular carcinoma of humans. J Hepatol 2000; 33: 282-9.
27. Tanaka M, Nakashima O, Wada Y, Kage M, Kojiro M. Pathomorphological study of Kupffer cells in hepatocellular carcinoma and hyperplastic nodular lesions in the liver. Hepatology 1996; 24: 807-12.
28. Von Herbay A, Vogt C, Haussinger D. Late-phase pulse-inversion sonography using the contrast agent Levovist: Differentiation between benign and malignant focal lesions of the liver. Am J Roentgenol 2002; 179: 1273-9.
29. Albrecht T, Hoffmann C W Schmitz S A, et al. Pulse-inversion sonography during the liver-specific late phase of contrast enhancement: Improved detection of liver metastases. Am J Roentgenol 2001; 176: 1191-8.
30. Suzuki S, Iijima H, Moriyasu F, et al. Differential diagnosis of hepatic nodules using delayed parenchyma phase imaging of Levovist contrast ultrasound: Comparative study with SPIO-MRI. Hepatol Res 2004; 29: 122-6.
31. Kitamura H, Kawasaki S, Nakajima K, Ota H. Correlation between microbubble contrast-enhanced color Doppler sonography and immunostaining for Kupffer cells in assessing the histopathologic grade of hepatocellular carcinoma: Preliminary results. J Clin Ultrasound 2002; 30: 465-71.
32. Nicolau C, Catala V, Vilana R, et al. Evaluation of hepatocellular carcinoma using Sonovue, a second generation ultrasound contrast agent: correlation with cellular differentiation. Eur Radiol 2004; 14: 1092-9.
33. Kojiro M. Focus on dysplastic nodules and early hepatocellular carcinoma: An eastern point of view. Liver Transplant 2004; 10: S3-8.
34. Nakashima O, Kurogi M, Yamaguchi R, et al. Unique hypervascular nodules in alcoholic liver cirrhosis: Identical to focal nodular hyperplasia-like nodules? J Hepatol 2004; 41: 992-8.