Fetal and Neonatal Thrombophilia

Obstetrics and Gynecology Clinics of North America

Volumn 33, Issue 3, 2006, Pages 457-466

  Kenet, Gili ^a   Nowak Göttl, Ulrike ^b  

^a SHEBA MEDICAL CENTER   (Israel)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FETUS; FETUS DISEASE; HUMAN; NEWBORN; NEWBORN DISEASE; PERINATAL MORBIDITY; PLACENTA DISORDER; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; THROMBOPHILIA; THROMBOSIS; VASCULAR DISEASE;

CEREBRAL PALSY; CEREBRAL VEINS; CEREBROVASCULAR ACCIDENT; FEMALE; FETAL DISEASES; GESTATIONAL AGE; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE, DISEASES; PREGNANCY; RENAL VEINS; THROMBOPHILIA; VENOUS THROMBOSIS;

EID: 33748312185     PISSN: 08898545     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ogc.2006.06.001     Document Type: Review

References (81)

1. Andrew M. Developmental hemostasis: relevance to thromboembolic complications in pediatric patients. Thromb Haemost 74 (1995) 415-425
2. Andrew M., David M., Adams M., et al. Venous thromboembolic (VTE) complications in children: first analyses of the Canadian registry of VTE. Blood 83 (1994) 1252-1257
3. Heleen Van-Omen C., Heijboer B.H., Buller H.R., et al. Venous thromboembolism in childhood: a prospective two-year registry in the Netherlands. J Ped 139 (2001) 676-681
4. Schmidt B., and Andrew M. Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics 96 (1995) 939-943
5. Nowak-Gottl U., Von-Kries R., and Gobel U. Neonatal symptomatic thromboembolism in Germany: two year survey. Arch Dis Child Fetal Neonatal Ed 76 (1997) F163-F167
6. Seligsohn U., and Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med 344 (2001) 1222-1231
7. Dalback B. New molecular insights of thrombophilia: resistance to activated protein C caused by Arg506 to Gln mutation in factor V as pathogenetic risk factor for venous thrombosis. Thromb Haemost 74 (1995) 139-148
8. Poort S.R., Rosendal F.R., Rewifman P.H., et al. A common genetic variation in the 3′ untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88 (1996) 3698-3703
9. Frosst P., Bloom H.J., Milos R., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylene-tetrahydrofolate reductase. Nat Genet 10 (1995) 111-113
10. Heller C., Schobess R., Kurnik K., et al. Abdominal thrombosis in neonates and infants: role of prothrombotic risk factors- a multicenter case-control study. BJH 111 (2000) 534-539
11. Lanari M., Lazzarotto T., Papa I., et al. Neonatal aortic arch thrombosis as a result of congenital cytomegalovirus infection. Pediatrics 108 (2001) E114
12. Nowak-Göttl U., Wermes C., Junker R., et al. Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin 20210G > A variant, and further prothrombotic risk factors. Blood 93 (1999) 1595-1599
13. Reverdiau-Moalic P., Delahousse B., Bardos G.B.P., et al. Evolution of blood coagulation activators and inhibitors in the healthy human fetus. Blood 88 (1996) 900-906
14. Manco Johnson M.J. Development of hemostasis in the fetus. Thromb Res 115 Suppl 1 (2005) 55-63
15. Cvirm G., Gallistl S., and Muntean W. Effects of antithrombin and protein C on thrombin generation in newborn and adult plasma. Thromb Res 93 (1999) 183-190
16. Summaria L. Comparison of human normal, full-term, fetal and adult plasminogen by physical and chemical analyses. Haemostasis 19 (1989) 266-273
17. Baier K., Cvirm G., Fritsch P., et al. Higher concentrations of heparin and hirudin are required to inhibit thrombin generation in tissue factor activated cord plasma than in adult plasma. Pediatr Res 57 (2005) 685-689
18. Grandone E., Margaglione M., Collazio D., et al. Genetic susceptibility to pregnancy-related thromboembolism: roles of factor V Leiden, prothrombin G20210A and methylenetetrahydrofolatereductase C677T mutations. Am J Obstet Gynecol 179 (1998) 1324-1328
19. Kuperminc M.J., Eldor A., Steinman N., et al. Increased frequency of gfenetic thrombophilia in women with complications of pregnancy. N Engl J Med 341 (1999) 384
20. Martinelli I., Taioli E., Cetin I., et al. Mutations in coagulation factors in women with unexplained late fetal loss. N Engl J Med 343 (2000) 1015-1018
21. Caldesrwood C.J., and Greer I.A. The role of factor V Leiden in maternal health and the outcome of pregnancy. Curr Drug Targets 6 (2005) 567-576
22. Leistra-Leistra M.J., Timmer A., Van Spronsen F.J., et al. Fetal thrombotic vasculopathy in the placenta: a thrombophilic connection between pregnancy complications and neonatal thrombosis?. Placenta 25 Suppl A (2004) S102-S105
23. Lynch J.K., and Nelson K.B. Epidemiology of perinatal stroke. Curr Opin Pediatr 13 (2001) 499-505
24. Chalmers E.A. Perinatal stroke- risk factors and management. Br J Haematol 130 (2005) 333-343
25. Koelfen W., Freund M., and Varnholt V. Neonatal stroke involving the middle cerebral artery in term infants: clinical presentation, EEG and imaging studies, and outcome. Dev Med Child Neurol 37 (1995) 204-212
26. Golomb M.R., MacGregor D.L., Domi T., et al. Presumed pre- or perinatal arterial ischemic stroke: risk factors and outcomes. Ann Neurol 50 (2001) 163-168
27. Mannino F.L., and Trauner D.A. Stroke in neonates. J Pediatr 102 (1983) 605-610
28. Sreenan C., Bhargava R., and Robertson C.M. Cerebral infarction in the term newborn: clinical presentation and long-term outcome. J Pediatr 137 (2000) 351-355
29. Wu Y.W., March W.M., Croen L.A., et al. Perinatal stroke in children with motor impairment: a population-based study. Pediatrics 114 (2004) 612-619
30. deVeber G.A., MacGregor D., Curtis R., et al. Neurologic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol 15 (2000) 316-324
31. Humphreys P., Whiting S., and Pham B. Hemiparetic cerebral palsy: clinical pattern and imaging in prediction of outcome. Can J Neurol Sci 27 (2000) 210-219
32. Estan J., and Hope P. Unilateral neonatal cerebral infarction in full term infants. Arch Dis Child Fetal Neonatal Ed 76 (1997) F88-F93
33. Wulfeck B.B., Trauner D.A., and Tallal P.A. Neurologic, cognitive, and linguistic features of infants after early stroke. Pediatr Neurol 7 (1991) 266-269
34. Barmada M.A., Moossy J., and Shuman R.M. Cerebral infarcts with arterial occlusion in neonates. Ann Neurol 6 (1979) 495-502
35. Jan M.M., and Camfield P.R. Outcome of neonatal stroke in full-term infants without significant birth asphyxia. Eur J Pediatr 157 (1998) 846-848
36. Govaert P., Matthys E., Zecic A., et al. Perinatal cortical infarction within middle cerebral artery trunks. Arch Dis Child Fetal Neonatal Ed 82 (2000) F59-F63
37. Uvebrant P. Hemiplegic cerebral palsy: aetiology and outcome. Acta Paediatr Scand Suppl 345 (1988) 1-100
38. Wu Y.W., Escobar G.J., Grether J.K., et al. Chorioamnionitis and cerebral palsy in term and near-term infants. JAMA 290 (2003) 2677-2684
39. Lee J., Croen L.A., Backstrand K.H., et al. Maternal and infant characteristics associated with perinatal arterial stroke in the infant. JAMA 293 (2005) 723-729
40. Pellicer A., Cabanas F., Garcia-Alix A., et al. Stroke in neonates with cardiac right-to-left shunt. Brain Dev 14 (1992) 381-385
41. Lien J.M., Towers C.V., Quilligan E.J., et al. Term early-onset neonatal seizures: obstetric characteristics, etiologic classifications, and perinatal care. Obstet Gynecol 85 (1995) 163-169
42. deVeber G.A., and the Canadian Paediatric Ischemic Stroke Study Group. Canadian paediatric ischemic stroke registry: analysis of children with arterial ischemic stroke. Ann Neurol 48 (2000) 514
43. Varelas P.N., Sleight B.J., Rinder H.M., et al. Stroke in a neonate heterozygous for factor V Leiden. Pediatr Neurol 18 (1998) 262-264
44. Pohl M., Zimmerhackl L.B., Heinen F., et al. Bilateral renal vein thrombosis and venous sinus thrombosis in a neonate with factor V mutation (FV Leiden). J Pediatr 132 (1998) 159-161
45. Harum K.H., Hoon Jr. A.H., Kato G.J., et al. Homozygous factor-V mutation as a genetic cause of perinatal thrombosis and cerebral palsy. Dev Med Child Neurol 41 (1999) 777-780
46. Smith R.A., Skelton M., Howard M., et al. Is thrombophilia a factor in the development of hemiplegic cerebral palsy?. Dev Med Child Neurol 43 (2001) 724-730
47. Thorarensen O., Ryan S., Hunter J., et al. Factor V Leiden mutation: an unrecognized cause of hemiplegic cerebral palsy, neonatal stroke, and placental thrombosis. Ann Neurol 42 (1997) 372-375
48. Hagstrom J.N., Walter J., Bluebond-Langner R., et al. Prevalence of the factor V Leiden mutation in children and neonates with thromboembolic disease. J Pediatr 133 (1998) 777-781
49. Gunther G., Junker R., Strater R., et al. Symptomatic ischemic stroke in full-term neonates: role of acquired and genetic prothrombotic risk factors. Stroke 31 (2000) 2437-2441
50. Hogeveen M., Blom H.J., Van Amerongen M., et al. Hyperhomocysteinemia as risk factor for ischemic and hemorrhagic stroke in newborn infants. J Pediatr 141 (2002) 429-431
51. Golomb M.R. The contribution of prothrombotic disorders to peri and neonatal ischemic stroke. Semin Thromb Hemost 29 (2003) 415-424
52. Fattal-Valevski A., Kenet G., Kupferminc M.J., et al. Role of thrombophilic risk factors in children with non-stroke cerebral palsy. Thromb Res 16 (2005) 133-137
53. DeVeber G., Andrew M., Adams C., et al. Cerebral sinovenous thrombosis in children. N Engl J Med 345 (2001) 417-423
54. Baram T.Z., Butler I.J., Nelson M.D., et al. Transverse sinus thrombosis in newborns: clinical and magnetic resonance imaging findings. Ann Neurol 24 (1998) 792-794
55. Barron T.F., Goosnard D.A., Zimmerman R.A., et al. Cerebral venous thrombosis in neonates and children. Pediatr Neurol 8 (1992) 112-116
56. Bonduel M., Sciuccati G., Hepner M., et al. Prethrombotic disorders in children with ischemic stroke and sinovenous thrombosis. Arch Neurol 56 (1999) 967-971
57. Kenet G., Waldman D., Lubetsky A., et al. Paediatric cerebral sinus vein thrombosis: a multi-center, case-controlled study. Thromb Haemost 92 (2004) 713-718
58. Heller C., Heinecke A., Junker R., et al. Cerebral venous thrombosis in children: a multifactorial study. Circulation 108 (2003) 1362-1367
59. Bökenkamp A., von Kries R., Nowak-Göttl U., et al. Neonatal renal venous thrombosis in Germany between 1992 and 1994: epidemiology, treatment and outcome. Eur J Pediatr 59 (2000) 44-48
60. Jobin J., O'Regan S.O., Morgeau J.G., et al. Neonatal renal vein thrombosis: long-term follow-up after conservative management. Clin Nephrol 17 (1982) 36-40
61. Hibbert J., Howlett D.C., Greenwood K.L., et al. The ultrasound appearances of neonatal renal vein thrombosis. Br J Radiol 70 (1997) 1191-1194
62. Keating M.A., and Althausen A.F. The clinical spectrum of renal vein thrombosis. J Urol 133 (1985) 938-945
63. Nowak-Göttl U., Junker R., Kreuz W., et al. Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors. Blood 97 (2001) 858-862
64. Heller C., Schobess R., Kurnik K., et al. Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors: a multicentre case-control study. Br J Haematol 111 (2000) 534-539
65. Pohl M., Zimmerhackl L.B., Heinen F., et al. Bilateral renal vein thrombosis and venous sinus thrombosis in a neonate with factor V mutation (fv Leiden). J Pediatr 132 (1998) 159-161
66. Giordano P., Laforgia N., Di Giulio G., et al. Renal vein thrombosis in a newborn with prothrombotic genetic risk factors. Perinat Med 29 (2001) 163-166
67. Leret N., Cortey A., Maillard C., et al. Neonatal renal vein thrombosis in a heterozygous carrier of both factor V Leiden and prothrombin mutations. Arch Pediatr 8 (2001) 1222-1225
68. Kosch A., Kuwertz Broking E., Heller C., et al. Renal vein thrombosis in neonates: prothrombotic risk factors and long-term follow-up. Blood 104 (2004) 1356-1360
69. Marks S.D., Massicote P., Steele B.T., et al. Neonatal renal vein thrombosis: clinical outcomes and prevalence of prothrombotic disorders. J Pediatr 146 (2005) 811-816
70. Von-Kries R., Junker R., Oberle D., et al. Foetal growth retardation in children with prothrombotic risk factors. Thromb Haemost 86 (2001) 1012-1016
71. Infante-Rivard C., Rivard G.E., Yotov V.W., et al. Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. N Engl J Med 347 (2002) 19-25
72. Pet J., Hiltunen L., and Fellman V. Increased risk of intraventricular hemorrhage in preterm infants with thrombophilia. Ped Res 49 (2001) 643-646
73. Aronis S., Platokouki H., Photopoulos S., et al. Indications of coagulation and/or fibrinolytic system activation in healthy and sick very low birth weight neonates. Biol Neonate 74 (1998) 337-344
74. Hutter J.J., Hathaway W.E., and Wayne E.R. Hematologic abnormalitiesin severe neonatal necrotizing enterocolitis. J Pediatr 88 (1976) 1026-1031
75. Hussain N., Clive J., and Bhandari V. Current incidences of retinopathy of prematurity, 1989-1997. Pediatrics 104 (1999) 26e
76. Seiberth V., and Linderkamp O. risk factors in retinopathy of prematurity: a multivariate analysis. Ophthalmologica 214 (2000) 131-135
77. Shweki D., Itin A., Soffer D., et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359 (1992) 843-845
78. Hellstrom H., Perruzzi C., Ju M., et al. Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci USA 98 (2001) 5804-5808
79. Mintz-Hittner H.A., Miyashiro M.J., Knoght-Nana D.M., et al. Vitroretinal findings similar to retinopathy of prematurity in infants with compound heterozygous protein S deficiency. Ophthalmology 106 (1999) 1525-1530
80. Kenet G., Maayan-Metzger A., Rosenberg N., et al. Thrombophilia does not increase risk for neonatal complications in preterm infants. Thromb Haemost 90 (2003) 823-828
81. Riikonen R., and Kekomki R. Resistance to activated protein C in childhood hydrocephalus. Thromb Hemost 79 (1998) 1059-1060