Prolonged intestinal mucosal acidosis is associated with multiple organ failure in human acute pancreatitis: Gastric tonometry revisited

World Journal of Gastroenterology

Volumn 12, Issue 30, 2006, Pages 4892-4896

  Kovacs, Gabor C ^a   Telek, Geza ^a   Hamar, Janos ^b   Furesz, Jozsef ^c   Regoly Merei, Janos ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b Orszagos Traumatologiai Intezet   (Hungary)

^c Institute of Health Protection Budapest   (Hungary)

Author keywords

Acute pancreatitis; Bacterial translocation; Human studies; Intramucosal pH; Mucosal barrier dysfunction; Multiple organ dysfunction; Septic complications

Indexed keywords

ACIDOSIS; ACUTE PANCREATITIS; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FATALITY; FEMALE; HOSPITALIZATION; HUMAN; INTESTINE MUCOSA; MALE; MULTIPLE ORGAN FAILURE; NON INVASIVE MEASUREMENT; PATIENT MONITORING; PH MEASUREMENT; SURVIVAL RATE; TONOMETRY;

EID: 33748307753     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i30.4892     Document Type: Article

References (19)

1. Schmid SW, Uhl W, Friess H, Malfertheiner P, Buchler MW. The role of infection in acute pancreatitis. Gut 1999; 45: 311-316
2. Luiten EJ, Hop WC, Endtz HP, Bruining HA. Prognostic importance of gram-negative intestinal colonization preceding pancreatic infection in severe acute pancreatitis. Results of a controlled clinical trial of selective decontamination. Intensive Care Med 1998; 24: 438-445
3. Meakins JL, Marshall JC. The gut as the motor of multiple organ system failure. In: Splanchnic Ischemia and Multiple Organ Failure. Marston A, Bulkley GB, Fiddian-Green RG, Haglund UH (eds). St Louis: CV Mosby, 1989: 339-348
4. Cicalese L, Sahai A, Sileri P, Rastellini C, Subbotin V, Ford H, Lee K. Acute pancreatitis and bacterial translocation. Dig Dis Sci 2001; 46: 1127-1132
5. Alverdy JC, Laughlin RS, Wu L. Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined. Crit Care Med 2003; 31: 598-607
6. Brown SD, Gutierrez G. Does gastric tonometry work? Yes. Crit Care Clin 1996; 12: 569-585
7. Salzman AL, Strong KE, Wang H, Wollert PS, Vandermeer TJ, Fink MP. Intraluminal "balloonless" air tonometry: a new method for determination of gastrointestinal mucosal carbon dioxide tension. Crit Care Med 1994; 22: 126-134
8. Fiddian-Green RG, Pittenger G, Whitehouse WM Jr. Back-diffusion of CO2 and its influence on the intramural pH in gastric mucosa. J Surg Res 1982; 33: 39-48
9. Bonham MJ, Abu-Zidan FM, Simovic MO, Windsor JA. Gastric intramucosal pH predicts death in severe acute pancreatitis. Br J Surg 1997; 84: 1670-1674
10. Parviainen I, Vaisanen O, Ruokonen E, Takala J. Effect of nasogastric suction and ranitidine on the calculated gastric intramucosal pH. Intensive Care Med 1996; 22: 319-323
11. Doglio GR, Pusajo JF, Egurrola MA, Bonfigli GC, Parra C, Vetere L, Hernandez MS, Fernandez S, Palizas F, Gutierrez G. Gastric mucosal pH as a prognostic index of mortality in critically ill patients. Crit Care Med 1991; 19: 1037-1040
12. Juvonen PO, Alhava EM, Takala JA. Gastric tonometry in assessing splanchnic tissue perfusion in acute pancreatitis. Scand J Gastroenterol 2000; 35: 318-321
13. Soong CV, Lewis HG, Halliday MI, Rowlands BJ. Intramucosal acidosis and the inflammatory response in acute pancreatitis. Am J Gastroenterol 1999; 94: 2423-2429
14. Hynninen M, Valtonen M, Markkanen H, Vaara M, Kuusela P, Jousela I, Piilonen A, Takkunen O. Intramucosal pH and endotoxin and cytokine release in severe acute pancreatitis. Shock 2000; 13: 79-82
15. Wang P, Ba ZF, Chaudry IH. Nitric oxide. To block or enhance its production during sepsis? Arch Surg 1994; 129: 1137-1142; discussion 1142-1143
16. Alverdy J, Holbrook C, Rocha F, Seiden L, Wu RL, Musch M, Chang E, Ohman D, Suh S. Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Ann Surg 2000; 232: 480-489
17. Ljungdahl M, Lundholm M, Katouli M, Rasmussen I, Engstrand L, Haglund U. Bacterial translocation in experimental shock is dependent on the strains in the intestinal flora. Scand J Gastroenterol 2000; 35: 389-397
18. Weiss M, Moldawer LL, Schneider EM. Granulocyte colony-stimulating factor to prevent the progression of systemic nonresponsiveness in systemic inflammatory response syndrome and sepsis. Blood 1999; 93: 425-439
19. Telek G, Kovacs GC, Pasquier C, Jakab F, Hamar J, Rozé C. Polymorphonuclear leukocytes enter into apoptosis early in the course of taurocholate-induced acute pancreatitis in rats. The role of oxidative stress. Gastroenterology 2000; 118 Suppl 2: 5319