메뉴 건너뛰기




Volumn 7, Issue 1, 2006, Pages 33-41

Emerging role of novel combinations for induction therapy in multiple myeloma

Author keywords

Bone marrow microenvironment; Bortezomib; Chemotherapy resistance; Lenalidomide; Pegylated liposomal doxorubicin; Thalidomide

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA INTERFERON; AMOXICILLIN; ANTHRACYCLINE; BORTEZOMIB; CISPLATIN; CLARITHROMYCIN; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DEXAMETHASONE; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOMODULATING AGENT; LENALIDOMIDE; LOW MOLECULAR WEIGHT HEPARIN; MELPHALAN; PREDNISONE; PROTEASOME INHIBITOR; THALIDOMIDE; VALACICLOVIR; VINCRISTINE;

EID: 33748305704     PISSN: 15579190     EISSN: None     Source Type: Journal    
DOI: 10.3816/CLM.2006.n.037     Document Type: Review
Times cited : (9)

References (66)
  • 1
    • 0015381240 scopus 로고
    • Combination chemotherapy for multiple myeloma
    • Alexanian R, Bonnet J, Gehan E, et al. Combination chemotherapy for multiple myeloma. Cancer 1972; 30:382-389.
    • (1972) Cancer , vol.30 , pp. 382-389
    • Alexanian, R.1    Bonnet, J.2    Gehan, E.3
  • 2
    • 0344076348 scopus 로고    scopus 로고
    • Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: An overview of 6,633 patients from 27 randomized trials. Myeloma Trialist's Collaborative Group
    • Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: an overview of 6,633 patients from 27 randomized trials. Myeloma Trialist's Collaborative Group. J Clin Oncol 1998; 16:3832-3842.
    • (1998) J Clin Oncol , vol.16 , pp. 3832-3842
  • 3
    • 32644438680 scopus 로고    scopus 로고
    • Dexamethasone-based regimens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy
    • Facon T, Mary JY, Pegourie B, et al. Dexamethasone-based regimens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy. Blood 2006; 107:1292-1298.
    • (2006) Blood , vol.107 , pp. 1292-1298
    • Facon, T.1    Mary, J.Y.2    Pegourie, B.3
  • 4
    • 8944220233 scopus 로고    scopus 로고
    • A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome
    • Attal M, Harousseau JL, Stoppa AM, et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome. N Engl J Med 1996; 335:91-97.
    • (1996) N Engl J Med , vol.335 , pp. 91-97
    • Attal, M.1    Harousseau, J.L.2    Stoppa, A.M.3
  • 5
    • 0037739753 scopus 로고    scopus 로고
    • High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma
    • Child JA, Morgan GJ, Davies FE, et al. High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med 2003; 348:1875-1883.
    • (2003) N Engl J Med , vol.348 , pp. 1875-1883
    • Child, J.A.1    Morgan, G.J.2    Davies, F.E.3
  • 7
    • 1942534043 scopus 로고    scopus 로고
    • The evolution of thalidomide and its IMiD derivatives as anticancer agents
    • Bartlett JB, Dredge K, Dalgleish AG. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer 2004; 4:314-322.
    • (2004) Nat Rev Cancer , vol.4 , pp. 314-322
    • Bartlett, J.B.1    Dredge, K.2    Dalgleish, A.G.3
  • 9
    • 0028362802 scopus 로고
    • Bone marrow angiogenesis and progression in multiple myeloma
    • Vacca A, Ribatti D, Roncali L, et al. Bone marrow angiogenesis and progression in multiple myeloma. Br J Haematol 1994; 87:503-508.
    • (1994) Br J Haematol , vol.87 , pp. 503-508
    • Vacca, A.1    Ribatti, D.2    Roncali, L.3
  • 10
    • 0029146128 scopus 로고
    • Bone marrow of patients with active multiple myeloma: Angiogenesis and plasma cell adhesion molecules LFA-1, VLA-4, LAM-1, and CD44
    • Vacca A, Di Loreto M, Ribatti D, et al. Bone marrow of patients with active multiple myeloma: angiogenesis and plasma cell adhesion molecules LFA-1, VLA-4, LAM-1, and CD44. Am J Hematol 1995; 50:9-14.
    • (1995) Am J Hematol , vol.50 , pp. 9-14
    • Vacca, A.1    Di Loreto, M.2    Ribatti, D.3
  • 11
    • 0033134764 scopus 로고    scopus 로고
    • Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma
    • Vacca A, Ribatti D, Presta M, et al. Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood 1999; 93:3064-3073.
    • (1999) Blood , vol.93 , pp. 3064-3073
    • Vacca, A.1    Ribatti, D.2    Presta, M.3
  • 12
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 1999; 341:1565-1571.
    • (1999) N Engl J Med , vol.341 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 13
    • 0034331194 scopus 로고    scopus 로고
    • Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy
    • Hideshisna T, Chauhan D, Shima Y, et al. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood 2000; 96:2943-2950.
    • (2000) Blood , vol.96 , pp. 2943-2950
    • Hideshisna, T.1    Chauhan, D.2    Shima, Y.3
  • 14
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies FE, Raje N, Hideshima T, et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 2001; 98:210-216.
    • (2001) Blood , vol.98 , pp. 210-216
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3
  • 15
    • 0037097595 scopus 로고    scopus 로고
    • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 2002; 99:4525-4230.
    • (2002) Blood , vol.99 , pp. 4230-4525
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 16
    • 0027960892 scopus 로고
    • Interleukin-6 prevents dexamethasone-induced myeloma cell death
    • Hardin J, MacLeod S, Grigorieva I, et al. Interleukin-6 prevents dexamethasone-induced myeloma cell death. Blood 1994; 84:3063-3070.
    • (1994) Blood , vol.84 , pp. 3063-3070
    • Hardin, J.1    MacLeod, S.2    Grigorieva, I.3
  • 17
    • 0029019664 scopus 로고
    • Interleukin-6 inhibits apoptosis of malignant plasma cells
    • Lichtenstein A, Tu Y, Fady C, et al. Interleukin-6 inhibits apoptosis of malignant plasma cells. Cell Immunol 1995; 162:248-255.
    • (1995) Cell Immunol , vol.162 , pp. 248-255
    • Lichtenstein, A.1    Tu, Y.2    Fady, C.3
  • 18
    • 0347383742 scopus 로고    scopus 로고
    • Thalidomide with or without dexamethasone for refractory or relapsing multiple myeloma
    • Alexanian R, Weber D, Anagnostopoulos A, et al. Thalidomide with or without dexamethasone for refractory or relapsing multiple myeloma. Semin Hematol 2003; 40:3-7.
    • (2003) Semin Hematol , vol.40 , pp. 3-7
    • Alexanian, R.1    Weber, D.2    Anagnostopoulos, A.3
  • 19
    • 0037495116 scopus 로고    scopus 로고
    • Thalidomide and dexamethasone for resistant multiple myeloma
    • Anagnostopoulos A, Weber D, Rankin K, et al. Thalidomide and dexamethasone for resistant multiple myeloma. Br J Haematol 2003; 121:768-771.
    • (2003) Br J Haematol , vol.121 , pp. 768-771
    • Anagnostopoulos, A.1    Weber, D.2    Rankin, K.3
  • 20
    • 0034899464 scopus 로고    scopus 로고
    • Thalidomide and dexamethasone combination for refractory multiple myeloma
    • Dimopoulos MA, Zervas K, Kouvatseas G, et al. Thalidomide and dexamethasone combination for refractory multiple myeloma. Ann Oncol 2001; 12:991-995.
    • (2001) Ann Oncol , vol.12 , pp. 991-995
    • Dimopoulos, M.A.1    Zervas, K.2    Kouvatseas, G.3
  • 21
    • 0036843032 scopus 로고    scopus 로고
    • Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma
    • Rajkumar SV, Hayman S, Gertz MA, et al. Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma. J Clin Oncol 2002; 20:4319-4323.
    • (2002) J Clin Oncol , vol.20 , pp. 4319-4323
    • Rajkumar, S.V.1    Hayman, S.2    Gertz, M.A.3
  • 22
    • 0037208595 scopus 로고    scopus 로고
    • Thalidomide alone or with dexamethasone for previously untreated multiple myeloma
    • Weber D, Rankin K, Gavino M, et al. Thalidomide alone or with dexamethasone for previously untreated multiple myeloma. J Clin Oncol 2003; 21:16-19.
    • (2003) J Clin Oncol , vol.21 , pp. 16-19
    • Weber, D.1    Rankin, K.2    Gavino, M.3
  • 23
    • 3242760702 scopus 로고    scopus 로고
    • First-line therapy with thalidomide and dexamethasone in preparation for autologous stem cell transplantation for multiple myeloma
    • Cavo M, Zamagni E, Tosi P, et al. First-line therapy with thalidomide and dexamethasone in preparation for autologous stem cell transplantation for multiple myeloma. Haematologica 2004; 89:826-831.
    • (2004) Haematologica , vol.89 , pp. 826-831
    • Cavo, M.1    Zamagni, E.2    Tosi, P.3
  • 24
    • 23744432513 scopus 로고    scopus 로고
    • First-line thalidomide-dexamethasone therapy in preparation for autologous stem cell transplantation in young patients (< 61 years) with symptomatic multiple myeloma
    • Abdelkefi A, Torjman L, Beri Romdhane N, et al. First-line thalidomide-dexamethasone therapy in preparation for autologous stem cell transplantation in young patients (< 61 years) with symptomatic multiple myeloma. Bone Marrow Transplant 2005; 36:193-198.
    • (2005) Bone Marrow Transplant , vol.36 , pp. 193-198
    • Abdelkefi, A.1    Torjman, L.2    Beri Romdhane, N.3
  • 25
    • 22044452126 scopus 로고    scopus 로고
    • Superiority of thalidomide and dexamethasone over vincristine-doxorubicindexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma
    • Cavo M, Zamagni E, Tosi P, et al. Superiority of thalidomide and dexamethasone over vincristine-doxorubicindexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma. Blood 2005; 106:35-39.
    • (2005) Blood , vol.106 , pp. 35-39
    • Cavo, M.1    Zamagni, E.2    Tosi, P.3
  • 26
    • 33644831033 scopus 로고    scopus 로고
    • Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the Eastern Cooperative Oncology Group
    • Rajkumar SV, Blood E, Vesole D, et al. Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol 2006; 24:431-436.
    • (2006) J Clin Oncol , vol.24 , pp. 431-436
    • Rajkumar, S.V.1    Blood, E.2    Vesole, D.3
  • 27
    • 85030603860 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind, placebo-controlled trial of thalidomide plus dexamethasone versus dexamethasone alone as initial therapy for newly diagnosed multiple myeloma
    • Presented at: 2006 Annual Meeting of American Society of Clinical Oncology; June 2-6, 2006; Atlanta, GA. Abstract #7517
    • Rajkumar S, Hussein M, Catalano J, et al. A multicenter, randomized, double-blind, placebo-controlled trial of thalidomide plus dexamethasone versus dexamethasone alone as initial therapy for newly diagnosed multiple myeloma. Presented at: 2006 Annual Meeting of American Society of Clinical Oncology; June 2-6, 2006; Atlanta, GA. Abstract #7517.
    • Rajkumar, S.1    Hussein, M.2    Catalano, J.3
  • 28
    • 25144435821 scopus 로고    scopus 로고
    • Oral melphalan, prednisone, and thalidomide for newly diagnosed patients with myeloma
    • Palumbo A, Bertola A, Musto P, et al. Oral melphalan, prednisone, and thalidomide for newly diagnosed patients with myeloma. Cancer 2005; 104:1428-1433.
    • (2005) Cancer , vol.104 , pp. 1428-1433
    • Palumbo, A.1    Bertola, A.2    Musto, P.3
  • 29
    • 33644828072 scopus 로고    scopus 로고
    • Oral melphalan, prednisone, and thalidomide for multiple myeloma
    • (Abstract #779)
    • Palumbo A, Bringhen S, Musto P, et al. Oral melphalan, prednisone, and thalidomide for multiple myeloma. Blood 2005; 106:230a (Abstract #779).
    • (2005) Blood , vol.106
    • Palumbo, A.1    Bringhen, S.2    Musto, P.3
  • 30
    • 33646901123 scopus 로고    scopus 로고
    • Major superiority of melphalan-prednisone (MP) + thalidomide (THAL) over MP and autologous stem cell transplantation in the treatment of newly diagnosed elderly patients with multiple myeloma
    • (Abstract #780)
    • Facon T, Mary JY, Hulin C, et al. Major superiority of melphalan-prednisone (MP) + thalidomide (THAL) over MP and autologous stem cell transplantation in the treatment of newly diagnosed elderly patients with multiple myeloma. Blood 2005; 106:230a (Abstract #780).
    • (2005) Blood , vol.106
    • Facon, T.1    Mary, J.Y.2    Hulin, C.3
  • 31
    • 0029858387 scopus 로고    scopus 로고
    • TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
    • Wang CY, Mayo MW, Baldwin AS Jr. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 1996; 274:784-787.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin Jr., A.S.3
  • 32
    • 0035933772 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity
    • Keifer JA, Guttridge DC, Ashburner BP, et al. Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity. J Biol Chem 2001; 276:22382-22387.
    • (2001) J Biol Chem , vol.276 , pp. 22382-22387
    • Keifer, J.A.1    Guttridge, D.C.2    Ashburner, B.P.3
  • 33
    • 19944430150 scopus 로고    scopus 로고
    • Thalidomide in combination with vincristine, epirubicin and dexamethasone (VED) for previously untreated patients with multiple myeloma
    • Schutt P, Ebeling P, Buttkereit U, et al. Thalidomide in combination with vincristine, epirubicin and dexamethasone (VED) for previously untreated patients with multiple myeloma. Eur J Haematol 2005; 74:40-46.
    • (2005) Eur J Haematol , vol.74 , pp. 40-46
    • Schutt, P.1    Ebeling, P.2    Buttkereit, U.3
  • 34
    • 25144466254 scopus 로고    scopus 로고
    • VAD-t (vincristine, adriamycin, dexamethasone, and low-dose thalidomide) is an effective initial therapy with high response rates for patients with treatment naive multiple myeloma (MM)
    • (Abstract #3463)
    • Chanan-Khan A, Miller KC, McCarthy P, et al. VAD-t (vincristine, adriamycin, dexamethasone, and low-dose thalidomide) is an effective initial therapy with high response rates for patients with treatment naive multiple myeloma (MM). Blood 2004; 104:943a (Abstract #3463).
    • (2004) Blood , vol.104
    • Chanan-Khan, A.1    Miller, K.C.2    McCarthy, P.3
  • 35
    • 9144226204 scopus 로고    scopus 로고
    • Primary treatment of multiple myeloma with thalidomide, vincristine, liposomal doxorubicin and dexamethasone (T-VAD doxil): A phase II multicenter study
    • Zervas K, Dimopoulos MA, Hatzicharissi E, et al. Primary treatment of multiple myeloma with thalidomide, vincristine, liposomal doxorubicin and dexamethasone (T-VAD doxil): a phase II multicenter study. Ann Oncol 2004; 15:134-138.
    • (2004) Ann Oncol , vol.15 , pp. 134-138
    • Zervas, K.1    Dimopoulos, M.A.2    Hatzicharissi, E.3
  • 36
    • 11144334520 scopus 로고    scopus 로고
    • Pegylated doxorubicin (D), vincristine (V), reduced frequency dexamethasone (d) and thalidomide (T) (DVdT) in newly diagnosed (Nmm) and relapsed/refractory (Rmm) multiple myeloma patients
    • (Abstract #831)
    • Agrawal N, Hussein MA, Elson P, et al. Pegylated doxorubicin (D), vincristine (V), reduced frequency dexamethasone (d) and thalidomide (T) (DVdT) in newly diagnosed (Nmm) and relapsed/refractory (Rmm) multiple myeloma patients. Blood 2003; 102:237a (Abstract #831).
    • (2003) Blood , vol.102
    • Agrawal, N.1    Hussein, M.A.2    Elson, P.3
  • 37
    • 33748294482 scopus 로고    scopus 로고
    • Doxil, vincristine, reduced frequency dexamethasone in combination with thalidomide (DVd-T) is associated with higher overall and progression free survival as compared to DVd in patients with multiple myeloma (MM)
    • (Abstract #2557)
    • Almhanna K, Suppiah R, Baz R, et al. Doxil, vincristine, reduced frequency dexamethasone in combination with thalidomide (DVd-T) is associated with higher overall and progression free survival as compared to DVd in patients with multiple myeloma (MM). Blood 2005; 106:718a (Abstract #2557).
    • (2005) Blood , vol.106
    • Almhanna, K.1    Suppiah, R.2    Baz, R.3
  • 38
    • 33644833147 scopus 로고    scopus 로고
    • Thalidomide and hematopoietic-cell transplantation for multiple myeloma
    • Barlogie B, Tricot G, Anaissie E, et al. Thalidomide and hematopoietic-cell transplantation for multiple myeloma. N Engl J Med 2006; 354:1021-1030.
    • (2006) N Engl J Med , vol.354 , pp. 1021-1030
    • Barlogie, B.1    Tricot, G.2    Anaissie, E.3
  • 39
    • 33644825694 scopus 로고    scopus 로고
    • Maintenance treatment with thalidomide after autologous transplantation for myeloma: Final analysis of a prospective randomized study of the "Intergroupe Francophone du Myelome."
    • (Abstract #1148)
    • Attal M, Harousseau J-L, Leyvraz S, et al. Maintenance treatment with thalidomide after autologous transplantation for myeloma: final analysis of a prospective randomized study of the "Intergroupe Francophone du Myelome." Blood 2005; 106:335a (Abstract #1148).
    • (2005) Blood , vol.106
    • Attal, M.1    Harousseau, J.-L.2    Leyvraz, S.3
  • 40
    • 33748314819 scopus 로고    scopus 로고
    • HOVON 50/GMMGHD3-Trial: Phase III study on the effect of thalidomide combined with high dose melphalan in myeloma patients up to 65 years
    • (Abstract #424)
    • Goldschmidt H, Sonneveld P, Breitkrenz I, et al. HOVON 50/GMMGHD3-Trial: phase III study on the effect of thalidomide combined with high dose melphalan in myeloma patients up to 65 years. Blood 2005; 106:128a (Abstract #424).
    • (2005) Blood , vol.106
    • Goldschmidt, H.1    Sonneveld, P.2    Breitkrenz, I.3
  • 41
    • 0036839013 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
    • Richardson PG, Schlossman RL, Weller E, et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 2002; 100:3063-3067.
    • (2002) Blood , vol.100 , pp. 3063-3067
    • Richardson, P.G.1    Schlossman, R.L.2    Weller, E.3
  • 42
    • 25844481422 scopus 로고    scopus 로고
    • Evaluating oral lenalidomide (Revlimid) and dexamethasone versus placebo and dexamethasone in patients with relapsed or refractory multiple myeloma
    • (Abstract #0402)
    • Dimopoulos M, Weber D, Chen C, et al. Evaluating oral lenalidomide (Revlimid) and dexamethasone versus placebo and dexamethasone in patients with relapsed or refractory multiple myeloma. Haematologica 2005; 90:160 (Abstract #0402).
    • (2005) Haematologica , vol.90 , pp. 160
    • Dimopoulos, M.1    Weber, D.2    Chen, C.3
  • 43
    • 27744492561 scopus 로고    scopus 로고
    • Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
    • Rajkumar SV, Hayman SR, Lacy MQ, et al. Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma. Blood 2005;106:4050-4053.
    • (2005) Blood , vol.106 , pp. 4050-4053
    • Rajkumar, S.V.1    Hayman, S.R.2    Lacy, M.Q.3
  • 44
    • 33744779580 scopus 로고    scopus 로고
    • BiRD (Biaxin®/Revlimid®/dexamethasone) combination therapy (Rx) results in high complete remissions (CR) and overall responses in myeloma (MM) with poor prognostic features
    • (Abstract #642)
    • Niesvizky R, Pekle K, Gelbshtein U, et al. BiRD (Biaxin® /Revlimid®/ dexamethasone) combination therapy (Rx) results in high complete remissions (CR) and overall responses in myeloma (MM) with poor prognostic features. Blood 2005; 106:190a (Abstract #642).
    • (2005) Blood , vol.106
    • Niesvizky, R.1    Pekle, K.2    Gelbshtein, U.3
  • 45
    • 33745291854 scopus 로고    scopus 로고
    • Oral Revlimid® plus melphalan and prednisone (R-MP) for newly diagnosed multiple myeloma
    • (Abstract #785)
    • Palumbo A, Falco P, Musto P, et al. Oral Revlimid® plus melphalan and prednisone (R-MP) for newly diagnosed multiple myeloma. Blood 2005; 106:231a (Abstract #785).
    • (2005) Blood , vol.106
    • Palumbo, A.1    Falco, P.2    Musto, P.3
  • 46
    • 0346333293 scopus 로고    scopus 로고
    • The proteasome as a target for cancer therapy
    • Voorhees PM, Dees EC, O'Neil B, et al. The proteasome as a target for cancer therapy. Clin Cancer Res 2003; 9:6316-6325.
    • (2003) Clin Cancer Res , vol.9 , pp. 6316-6325
    • Voorhees, P.M.1    Dees, E.C.2    O'Neil, B.3
  • 47
    • 0033152760 scopus 로고    scopus 로고
    • Proteasome inhibitors: A novel class of potent and effective antitumor agents
    • Adams J, Palombella VJ, Sausville EA, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 1999; 59:2615-2622.
    • (1999) Cancer Res , vol.59 , pp. 2615-2622
    • Adams, J.1    Palombella, V.J.2    Sausville, E.A.3
  • 48
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T, Richardson P, Chauhan D, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001; 61:3071-3076.
    • (2001) Cancer Res , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3
  • 49
    • 0036735298 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
    • LeBlanc R, Catley LP, Hideshima T, et al. Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res 2002; 62:4996-5000.
    • (2002) Cancer Res , vol.62 , pp. 4996-5000
    • LeBlanc, R.1    Catley, L.P.2    Hideshima, T.3
  • 50
    • 0037443551 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications
    • Mitsiades N, Mitsiades CS, Richardson PG, et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 2003; 101:2377-2380.
    • (2003) Blood , vol.101 , pp. 2377-2380
    • Mitsiades, N.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 51
    • 0037342894 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents
    • Ma MH, Yang HH, Parker K, et al. The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res 2003; 9:1136-1144.
    • (2003) Clin Cancer Res , vol.9 , pp. 1136-1144
    • Ma, M.H.1    Yang, H.H.2    Parker, K.3
  • 52
    • 0037111832 scopus 로고    scopus 로고
    • Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
    • Orlowski RZ, Stinchcombe TE, Mitchell BS, et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002; 20:4420-4427.
    • (2002) J Clin Oncol , vol.20 , pp. 4420-4427
    • Orlowski, R.Z.1    Stinchcombe, T.E.2    Mitchell, B.S.3
  • 53
    • 0037973279 scopus 로고    scopus 로고
    • A phase 2 study of bortezomib in relapsed, refractory myeloma
    • Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003; 348:2609-2617.
    • (2003) N Engl J Med , vol.348 , pp. 2609-2617
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 54
    • 20444433230 scopus 로고    scopus 로고
    • Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
    • Richardson PG, Sonneveld P, Schuster MW, et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med 2005; 352:2487-2498.
    • (2005) N Engl J Med , vol.352 , pp. 2487-2498
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.W.3
  • 55
    • 21344469223 scopus 로고    scopus 로고
    • Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma
    • Jagannath S, Durie BG, Wolf J, et al. Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma. Br J Haematol 2005; 129:776-783.
    • (2005) Br J Haematol , vol.129 , pp. 776-783
    • Jagannath, S.1    Durie, B.G.2    Wolf, J.3
  • 56
    • 21344464281 scopus 로고    scopus 로고
    • Bortezomib (Velcade®) plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: Preliminary results of an IFM phase II study
    • (Abstract #1490)
    • Harousseau J-L, Attal M, Leleu X, et al. Bortezomib (Velcade®) plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: preliminary results of an IFM phase II study. Blood 2004; 104:416a (Abstract #1490).
    • (2004) Blood , vol.104
    • Harousseau, J.-L.1    Attal, M.2    Leleu, X.3
  • 57
    • 20144387627 scopus 로고    scopus 로고
    • Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies
    • Orlowski RZ, Voorhees PM, Garcia RA, et al. Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood 2005; 105:3058-3065.
    • (2005) Blood , vol.105 , pp. 3058-3065
    • Orlowski, R.Z.1    Voorhees, P.M.2    Garcia, R.A.3
  • 58
    • 21344435052 scopus 로고    scopus 로고
    • PAD combination therapy (PS-341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma
    • Oakervee HE, Popat R, Curry N, et al. PAD combination therapy (PS-341/ bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma. Br J Haematol 2005; 129:755-762.
    • (2005) Br J Haematol , vol.129 , pp. 755-762
    • Oakervee, H.E.1    Popat, R.2    Curry, N.3
  • 59
    • 33745765108 scopus 로고    scopus 로고
    • Reduced dose PAD combination therapy (PS-341/bortezomib, adriamycin and dexamethasone) for previously untreated patients with multiple myeloma
    • (Abstract #2554)
    • Popat R, Oakervee HE, Curry N, et al. Reduced dose PAD combination therapy (PS-341/bortezomib, adriamycin and dexamethasone) for previously untreated patients with multiple myeloma. Blood 2005; 106:717a (Abstract #2554).
    • (2005) Blood , vol.106
    • Popat, R.1    Oakervee, H.E.2    Curry, N.3
  • 60
    • 33644916110 scopus 로고    scopus 로고
    • Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma
    • Berenson JR, Yang HH, Sadler K, et al. Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma. J Clin Oncol 2006; 24:937-944.
    • (2006) J Clin Oncol , vol.24 , pp. 937-944
    • Berenson, J.R.1    Yang, H.H.2    Sadler, K.3
  • 61
    • 33646554703 scopus 로고    scopus 로고
    • A phase I/II national, multicenter, open-label study of bortezomib plus melphalan and prednisone in elderly untreated multiple myeloma (MM) patients
    • (Abstract #786)
    • Mateos M, Hernandez J, Mediavilla J, et al. A phase I/II national, multicenter, open-label study of bortezomib plus melphalan and prednisone in elderly untreated multiple myeloma (MM) patients. Blood 2005; 106:232a (Abstract #786).
    • (2005) Blood , vol.106
    • Mateos, M.1    Hernandez, J.2    Mediavilla, J.3
  • 62
    • 33746340326 scopus 로고    scopus 로고
    • Velcade (V)-thalidomide (T)-dexamethasone (D) for advanced and refractory multiple myeloma (MM): Long-term follow-up of phase I-II trial UARK 2001-37: Superior outcome in patients with normal cytogenetics and no prior T
    • (Abstract #2552)
    • Zangari M, Barlogie B, Burns MJ, et al. Velcade (V)-thalidomide (T)-dexamethasone (D) for advanced and refractory multiple myeloma (MM): long-term follow-up of phase I-II trial UARK 2001-37: superior outcome in patients with normal cytogenetics and no prior T. Blood 2005; 106:717a (Abstract #2552).
    • (2005) Blood , vol.106
    • Zangari, M.1    Barlogie, B.2    Burns, M.J.3
  • 63
    • 33645662389 scopus 로고    scopus 로고
    • Rapid control of previously untreated multiple myeloma with bortezomib-thalidomide-dexamethasone followed by early intensive therapy
    • (Abstract #784)
    • Wang M, Delasalle K, Giralt S, et al. Rapid control of previously untreated multiple myeloma with bortezomib-thalidomide-dexamethasone followed by early intensive therapy. Blood 2005; 106:231a (Abstract #784).
    • (2005) Blood , vol.106
    • Wang, M.1    Delasalle, K.2    Giralt, S.3
  • 64
    • 33746352833 scopus 로고    scopus 로고
    • R (V) into upfront management of multiple myeloma (MM): Comparison with TT2 + thalidomide (T)
    • (Abstract #1154)
    • R (V) into upfront management of multiple myeloma (MM): comparison with TT2 + thalidomide (T). Blood 2005; 106:337a (Abstract #1154).
    • (2005) Blood , vol.106
    • Barlogie, B.1    Tricot, G.2    Rasmussen, E.3
  • 65
    • 33748287071 scopus 로고    scopus 로고
    • Hematopoietic progenitor cell (HPC) mobilization after initial therapy of multiple myeloma including Velcade: Ability to collect HPC as a function of Velcade dosing
    • (Abstract #2884)
    • Cottler-Fox M, Holley D, Whigham L, et al. Hematopoietic progenitor cell (HPC) mobilization after initial therapy of multiple myeloma including Velcade: ability to collect HPC as a function of Velcade dosing. Blood 2004; 104:788a (Abstract #2884).
    • (2004) Blood , vol.104
    • Cottler-Fox, M.1    Holley, D.2    Whigham, L.3
  • 66
    • 33746356913 scopus 로고    scopus 로고
    • A multicenter phase II trial of bortezomib in patients with previously untreated multiple myeloma: Efficacy with manageable toxicity in patients with unexpectedly high rates of baseline peripheral neuropathy
    • (Abstract #2548)
    • Richardson P, Chanan-Khan A, Schlossman R, et al. A multicenter phase II trial of bortezomib in patients with previously untreated multiple myeloma: efficacy with manageable toxicity in patients with unexpectedly high rates of baseline peripheral neuropathy. Blood 2005; 106:716a (Abstract #2548).
    • (2005) Blood , vol.106
    • Richardson, P.1    Chanan-Khan, A.2    Schlossman, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.