The M3C process: A new multicolumn chromatographic process integrating a concentration step. I - The equilibrium model

Separation Science and Technology

Volumn 41, Issue 12, 2006, Pages 2639-2663

  Abdelmoumen, Souhir ^a   Muhr, Laurence ^a   Bailly, Michel ^a,c   Ludemann Hombourger, Olivier ^b  

^a UNIVERSITÉ DE LORRAINE   (France)

^b NOVASEP SAS   (France)

^c UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Displacement effect; Equilibrium theory; M3C process; Multicolumn continuous chromatography; Preparative chromatography

Indexed keywords

ADSORPTION; ADSORPTION ISOTHERMS; CONCENTRATION (PROCESS); MATHEMATICAL MODELS;

DISPLACEMENT EFFECT; EQUILIBRIUM THEORY; M3C PROCESS; MULTICOLUMN CONTINUOUS CHROMATOGRAPHY; PREPARATIVE CHROMATOGRAPHY;

COLUMN CHROMATOGRAPHY;

ADSORPTION; ADSORPTION ISOTHERMS; COLUMN CHROMATOGRAPHY; CONCENTRATION (PROCESS); MATHEMATICAL MODELS;

ADSORPTION ISOTHERM; CHROMATOGRAPHY; CONCENTRATION; MATHEMATICAL MODEL; RECYCLING;

EID: 33748269279     PISSN: 01496395     EISSN: 15205754     Source Type: Journal    
DOI: 10.1080/01496390600829992     Document Type: Article

References (23)

1. Broughton, D.B., Gerhold, C.G. (May 23, 1961) Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets. U.S. Patent 2,985,589.
2. Ludemann-Hombourger, O., Nicoud, R.M., and Bailly, M. (2000) The VARICOL Process: A New Multicolumn Continuous Chromatographic Process. Sep. Sci. and Technol., 35: 1829.
3. Schramm, H., Kienle, A., Kaspereit, M., and Seidel-Morgenstern, A. (2003) Improved operation of simulated moving bed processes through cyclic modulation of feed flow and feed concentration. Chem. Eng. Sci., 58 (23-24): 5217.
4. Kloppenburg, E. and Gilles, E.D. (1999) A new concept for operating simulated moving-bed processes. Chem. Eng. Technol., 22 (10): 813.
5. Glueckauf, E. (1949) Theory of chromatography. VII. The general theory of two solutes following nonlinear isotherms. Disc. Farad. Soc. Lond., 7: 12.
6. Rhee, H-K., Ans, R., and Amundson, N.R. (1970) On the theory of multicomponent chromatography. Phil. Trans. Roy. Soc. Lond., 296 A: 1182, 419.
7. Tondeur, D. (1969) Théorie des colonnes d'échange d'ions. PhD Thesis, Nancy, France.
8. Helfferich, F.G. and Klein, G. (1970) Multicomponent Chromatography; Marcel Dekker, Inc.: New York.
9. Rhee, H-K., Aris, R., and Amundson, N.R. (1971) Multicomponent adsorption in continuous countercurrent exchangers. Phil. Trans. Roy. Soc. Lond., 269 A (1194): 187.
10. Storti, S., Mazzotti, M., Morbidelli, M., and Carrà, S. (1993) Robust design of binary countercurrent adsorption separation processes. AIChE J., 39 (3): 471.
11. Nicoud, R.M.; Bailly, M. (June 19, 1997) Méthode pour optimiser le fonctionnement d'un système de séparation des constituants d'un mélange. French Patent 2,764,822.
12. Pais, L.S. and Rodrigues, A.E. (2003) Design of simulated moving bed and Varicol processes for preparative separations with a low number of columns. J. Chromatogr. A, 1006 (1-2): 33.
13. Nicolaos, A., Muhr, L., Gotteland, P., Nicoud, R.M., and Bailly, M. (2001) Application of the equilibrium theory to ternary moving bed configurations (4+4, 5+4, 8 and 9 zones): II. Langmuir case. J. Chromatogr. A, 908 (1-2): 87.
14. Storti, G., Masi, M., Carra, S., and Morbidelli, M. (1989) Optimal design of multicomponent countercurrent adsorption separation processes involving nonlinear equilibria. Chem. Eng. Sci., 44 (6): 1329.
15. Mazzotti, M., Storti, G., and Morbidelli, M. (1994) Robust design of countercurrent adsorption separation processes: 2. Multicomponent systems. AIChE J., 40(11): 1825.
16. Migliorini, M., Mazzotti, M., and Morbidelli, M. (2000) Design of simulated moving bed multicomponent separations: Langmuir systems. Sep. & Purif. Technol., 20(1): 19.
17. Bailly, M., Nicoud, R.M., Adam, P., and Ludemann-Hombourger, O., (April 30, 2004) Procede et dispositif de Chromatographie integrant une etape de concentration. French Patent 2,846,252.
18. Tondeur, D. and Bailly, M. (1987) Unifying concepts in non-linear unsteady processes part II: Multicomponent waves, competition and diffusion. Chem. Eng. Process, 22(2): 91.
19. Helfferich, F.G. and Carr, P.W. (1993) Non-linear waves in chromatography: I. Waves, shocks, and shapes. J. Chromatogr. A, 629 (2): 97.
20. Helfferich, F.G. (1997) Non-linear waves in chromatography III. Multicomponent Langmuir and Langmuir-like systems. J. Chromatogr. A, 768 (2): 169.
21. Charton, F. (1995) Optimisation des coupes et recyclages en chromatographie preparative industrielle. Thesis, INPL-ENSIC, Nancy, France.
22. Charton, F. and Nicoud, R.M. (1995) Complete design of a simulated moving bed. J. Chromatogr. A, 702 (1-2): 97.
23. Abdelmoumen, S. (2005) Etude théorique et expérimentale d'un nouveau procédé multicolonnes continu de chromatographie preparative integrant une étape de concentration. Thesis, INPL-ENSIC, Nancy, France.