Methotrexate in combination with ursodeoxycholic acid is ineffective in the treatment of primary biliary cirrhosis: Commentary

Evidence-Based Gastroenterology

Volumn 7, Issue 1, 2006, Pages 21-22

  Zaman, Atif ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; METHOTREXATE; MONOCLONAL ANTIBODY; PLACEBO; URSODEOXYCHOLIC ACID;

ADULT; AGE DISTRIBUTION; AGED; ALBUMIN BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BIOCHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TREATMENT FAILURE; FEMALE; FOLLOW UP; HUMAN; IMMUNOASSAY; INFORMED CONSENT; INTERMETHOD COMPARISON; KAPLAN MEIER METHOD; LIVER FAILURE; LIVER HISTOLOGY; LIVER TRANSPLANTATION; LOG RANK TEST; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; NOTE; OVERALL SURVIVAL; PRIMARY BILIARY CIRRHOSIS; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SURVIVAL; SYMPTOMATOLOGY; TREATMENT OUTCOME; UNIVARIATE ANALYSIS;

EID: 33748196459     PISSN: 15278557     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ebg.0000202916.43066.ec     Document Type: Note

References (4)

1. Jones DEJ, Watt FE, Matcalf JV, et al. Familial primary biliary cirrhosis reassessed: a geographically-based population study. J Hepatol. 1999;30:404-407.
2. Poupon RE, Lindor KD, Cauch-Dudek K, et al. Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis. Gastroenterology. 1997;113:884-890.
3. Corpechot C, Carrat F, Connand AM, et al. The effect of ursodeoxycholic acid therapy on liver fibrosis in primary biliary cirrhosis. Hepatology. 2000;32:1196-1199.
4. Poupon RE, Bonnand AM, Chretien S, et al. Ten-year survival in ursodeoxycholic acid treated patients in primary biliary cirrhosis. Hepatology. 1999;29:1668-1671.