In vivo exposure of Swiss albino mice to chronic low dose of dimethylnitrosamine (DMN) lowers poly-ADP-ribosylation (PAR) of bone marrow cell and blood lymphocyte proteins

Molecular and Cellular Biochemistry

Volumn 288, Issue 1-2, 2006, Pages 143-149

  Kma, L ^a   Sharan, R N ^a  

^a NORTH EASTERN HILL UNIVERSITY   (India)

Author keywords

Dimethylnitrosamine (DMN); Immunoprobe assay of PAR; In vivo; Mice; Poly ADP ribosylation (PAR); Slot and western blot

Indexed keywords

3 AMINOBENZAMIDE; CELL PROTEIN; DIMETHYLNITROSAMINE; HISTONE H1; POLY(ADENOSINE DIPHOSPHATE RIBOSE); TUMOR MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CANCER SCREENING; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; DRUG EXPOSURE; FEMALE; IN VIVO STUDY; LYMPHOCYTE; MOUSE; NONHUMAN; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; WESTERN BLOTTING;

ANIMALS; BENZAMIDES; BLOOD PROTEINS; BLOTTING, WESTERN; BONE MARROW CELLS; DIMETHYLNITROSAMINE; HISTONES; LYMPHOCYTES; MICE; MICE, INBRED BALB C; POLY(ADP-RIBOSE) POLYMERASES;

EID: 33748193031     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-9130-x     Document Type: Article

References (22)

1. Althaus FR, Richter C: Poly (ADP-ribose) biosynthesis. In: Solioz M (ed). ADP-Ribosylation of Proteins -- Enzymology and Biological Significance: Molecular Biology, Biochemistry and Biophysics. Springer-Verlag, New York, 1987, pp 1-230
2. Boulikas T: Poly (ADP-ribosylation), DNA strand breaks, chromatin and cancer. Toxicological Letters 67: 129-150, 1993
3. Miwa M, Sugimura T: ADP-ribosylation and carcinogenesis. In: Moss J and Vaughan M (eds). ADP-ribosylating Toxins and G-proteins: Insights into signal transduction. American Society for Microbiology, Washington DC, 1990, pp 543-560
4. Pariat T, Sharan RN: Qualitative change in mice liver HMG proteins after low dose chronic administration of aqueous extract of betel nut and diethylnitrosamine. Hepatology Research 12: 177-185, 1998
5. Saikia JR, Schneeweiss FHA, Sharan RN: Arecoline induced changes of poly-ADP-ribosylation of cellular proteins and its influence on chromatin organization. Cancer Letters 139: 59-65, 1999
6. Pariat T, Sharan RN: Role of mouse spleen cell HMG proteins and their poly ADP-ribosylation in betel nut induced carcinogenesis. Indian Journal of Biochemistry and Biophysics 39: 130-135, 2002
7. Kma L, Sharan RN: Negative correlation between poly-ADP-ribosylation of mouse blood lymphocytes proteins and dimethylnitrosamine induced initiation of carcinogenesis as revealed by Slot- and Western blot immunoassays. Proceedings of the National Academy of Sciences, India 73B: 43-51, 2003
8. Devi BJ, Schneeweiss FHA, Sharan RN: Negative correlation between poly-ADP-ribosylation of spleen cell histone proteins and initial duration of dimethylnitrosamine exposure to mice in vivo measured by Western blot immunoprobe assay: A possible biomarker for cancer detection. Cancer Detection and Prevention 29: 66-71, 2005
9. Devi BJ, Sharan RN: Progressive reduction in poly-ADP-ribosylation of histone proteins during Dalton's lymphoma induced ascites tumorigenesis in mice. Cancer Letters (in press), 2005 doi:10.1016/ j.canlet.2005.07.014.
10. Sharan RN, Devi BJ, Humtsoe JO, Sailkia JR, Kma L Detection and quantification of poly-ADP-ribosylated cellular proteins of spleen and liver tissues of mice in vivo by slot and Western blot immunoprobing using polyclonal antibody against mouse ADP-ribose polymer. Molecular and Cellular Biochemistry 278: 213-221, 2005
11. Sharan RN, Devi BJ, Humtsoe JO, Schneeweiss FHA: Immunodetection of cellular poly-ADP-ribosylation. In: Sharan RN (ed). Trends in Radiation and Cancer Biology. Forschungszentrum Juelich GmbH, Germany, International Co-operation Bilateral Seminars Series volume 29, 1998, pp 240-243
12. Sharan RN: Association of betel nut with carcinogenesis (review). The Cancer Journal 9: 13-19, 1986
13. Christine MI, Bernard BS: Inhibition of poly (ADP-ribose) synthesis may affect DNA repair prior to ligation. Carcinogenesis 8: 39-43, 1987
14. Purnell MR, Whish WJD: Novel inhibitors of poly (ADP-ribose) synthetase. Biochemical Journal 185: 775-777, 1980
15. Pariat T, Sharan RN: Low dose exposure of diethylnitrosamine affects mice liver thymidine kinase. Life Sciences 57: 2431-2437, 1995
16. Boyum A: Separation of leucocytes from blood and bone marrow. Scandinavian Journal of Clinical Laboratory Investigation 21: 77-89, 1968
17. Keller SE, Schleifer SJ, McKegney SJ, Camerino M, Stein M: A simplified method for assessing PHA-induced stimulation of rat peripheral blood lymphocytes. Journal of Immunological Methods 51: 287-291, 1982
18. Rosenberg IM: Antibody preparation. In: Protein Analysis and Purification, Benchtop Techniques, Birkhauser, 1996, pp 370-371
19. Bradford MM: A rapid and sensitive method for quantification of microgram quantities of proteins using the principle of dye binding. Analytical Biochemistry 72: 248-254, 1976
20. Boulikas T: Poly (ADP-ribosylated) histones in chromatin replication. Journal of Biological Chemistry 265: 14638-14647, 1990
21. Millar BC: Cell biology of cancer. In: Horwich A (ed). Oncology -- A Multidisciplinary Text Book. Chapman and Hall, London, 1995
22. Simbulan-Rosenthal CM, Rosenthal DS, Luo R, Li JH, Zhang J, Smulson ME: Inhibition of poly (ADP-ribose) polymerase activity is insufficient to induce tetraploidy. Nucleic Acids Research 29: 841-849, 2001