An electronically controlled microfluidic approach towards artificial cells

Complexus

Volumn 3, Issue 1-3, 2006, Pages 48-57

  Tangen, Uwe ^a   Wagler, Patrick F ^a   Chemnitz, Steffen ^a   Goranovic, Goran ^b   Maeke, Thomas ^a   McCaskill, John S ^a,c  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

DNA; Fluorescence detection; Micro reactor; Microelectrode; Microfluidics; Polydimethylsiloxane; Reconfigurable hardware

Indexed keywords

ELECTROLYTE; SILICON DIOXIDE;

BIOTECHNOLOGY; CONFERENCE PAPER; DIPOLE; ELECTROLYSIS; ELECTRONICS; ELECTROOSMOSIS; ELECTROPHORESIS; FLUORESCENCE; GEL ELECTROPHORESIS; GEOMETRY; HYBRID; HYDRODYNAMICS; MICROFLUIDICS; ONLINE SYSTEM; PRIORITY JOURNAL;

EID: 33748146526     PISSN: 14248492     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094187     Document Type: Conference Paper

References (31)

1. Sanders GHW, Manz A: Chip-based microsystems for genomic and proteomic analysis. TrAC Trends Anal Chem 2000; 19: 364-378.
2. McCaskill JS, Wagler P: From reconfigurability to evolution in construction systems: spanning the electronic, microfluidic and biomolecular domains. Lect Notes Comp Sci 2000; 1896: 286-299.
3. Ekins R, Chu FW: Microarrays: their origins and applications. Trends Biotechnol 1999; 17: 217-218.
4. Service RF: Will patents flights hold DNA chips hostage. Science 1998; 282: 397.
5. Edman C, Raymond D, Wu D, Tu E, Sosnowski R, Butler W, Nerenberg M, Heller M: Electric field directed nucleic acid hybridization on microchips. Nucleic Acids Res 1997; 25: 4907-4914.
6. Schmidt K, Foerster P, Bochmann A, McCaskill JS: Microsructured flow reactors for two-dimensional experiments; in Microreaction Technology. First International Conference on Microreaction Technology. Berlin, Springer, 1998, pp 233-244.
7. McCaskill JS, Maeke T, Wagler P: US Patent Publication 'Configurable Microreactor Network'. Application No. 09/935,740, 2000.
8. van Noort D, Wagler P, McCaskill JS: Hybrid poly(dimethylsiloxane)- silicon microreactors used for molecular computing. Smart Mater Struct 2002; 11: 756-760.
9. Wagler P, Gohlke M, van Noort D, McCaskill JS: Three-dimensional microfluidic systems for computation with DNA molecules. 12th Micromechanics Europe Workshop MME 2001, Cork, 2001.
10. McCaskill JS: Optically programming DNA computing in microflow reactors. Biosystems 2001; 59: 125-138.
11. Rasmussen S, Chen L, Nilsson M, Abe S: Bridging non-living and living matter. Artif Life 2003; 9: 269-316.
12. Rasmussen S, Chen L, Deamer D, Krakauer DC, Packard NH, Stadler PF, Bedau MA: Transitions from non-living to living matter. Science 2004; 303: 963-965.
13. Noireaux V, Libchaber A: A vesicle bioreactor as a step toward an artificial cell assembly. Proc Natl Acad Sci USA 2004; 101: 17669-17674.
14. Tan Y-C, Fisher JS, Lee AI, Cristini V, Lee AP: Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting. LabChip 2004; 4: 292-298, DOI 10.1039/b403280m.
15. Wagler P, Tangen U, Maeke T, Chemnitz S, Heymann M, Jünger M, Palutke T, McCaskill JS: Dynamical multiphase structures in the microsystem approach to artificial cells. MicroTas 2005, Boston, 2005.
16. Brask A, Goranovic G, Jensen MJ, Bruus H: A novel electroosmotic pump design for nonconducting liquids: theoretical analysis of flow-rate-pressure characteristics and stability. J Micromech Microeng 2005; 15: 883-891.
17. Wagler PF, Tangen U, Maeke T, Mathis HP, McCaskill JS: Microfabrication of a biomodule composed of microfluidics and digitally controlled microelectrodes for processing biomolecules. Smart Mater Struct 2003; 12: 757-762.
18. Duffy DC, Cooper McDonald J, Schneller OJA, White sides GM: Rapid prototyping of microfluidic systems in poly(dimethylsiloxane). Anal Chem 1998; 70: 4974-4984.
19. Ocvirk G, Munroe M, Tang T, Oleschuk R, Westra K, Harrison DJ: Electrokinetic control of fluid flow in native poly(dimethylsiloxane) capillary electrophoresis devices. Electrophoresis 2000; 21: 107-115.
20. Kirby BJ, Hasselbrink EF Jr: Zeta potential of microfluidic substrates. 1. Theory, experimental techniques, and effects on separations. Electrophoresis 2004; 25: 187-202.
21. Liu Y, Fanguy JC, Bledsoe JM, Henry CS: Dynamic coating using polyelectrolyte multilayers for chemical control of electroosmotic flow in capillary electrophoresis. Anal Chem 2000; 72: 5939-5944.
22. Lin C-H, Fu L-M, Lee K-H, Yang R-J, Lee G-B: Novel surface modification methods and surface property analysis for separation of DNA bio-molecules using capillary electrophoresis. MicroTAS, Squaw Valley, 2003, pp 1081-1084.
23. Bianchi F, Wagner F, Hoffmann P, Girault HH: Electroosmotic flow in composite microchannels and implications in microcapillary electrophoresis systems. Anal Chem 2001; 73: 829-836.
24. Mao C, Sun W, Shen Z, Seeman NC: A nanomechanical device based on the B-Z transition of DNA. Nature 1999; 397: 144-146.
25. Tangen U, Maeke T, McCaskill JS: Advanced simulation in the configurable massively parallel hardware: MereGen; in 3rd Caesarium 2000. Berlin, Springer, 2001, pp 107-108.
26. Alur R, Courcoubetis C, Henzinger TA, Ho P-H: Hybrid automata: an algorithmic approach to the specification and verification of hybrid systems. Hybrid Systems, Lecture Notes in Computer Science. Berlin, Springer, 1993, vol 736, pp 209-229.
27. Bujorianu ML, Lygeros J: General stochastic hybrid systems: modelling and optimal control. 43rd IEEE Conference on Decision and Control, Bahamas, 2004.
28. Abate A, Ames AD, Sastry SS: Stochastic approximations of hybrid systems. 24th American Control Conference 2005 (ACC'05), Portland, 2005.
29. Piazza C, Mishra B: Stability of hybrid systems and related questions from systems biology (in honor of Professor Pravin Varaiya on his 65th birthday); in Basar T (ed): Systems and Control: Foundations and Applications. Basel, Birkhäuser, in press.
30. http://www.cis.upenn.edu/group/mobies/charon
31. http://control.ee.ethz.ch/,hybrid/hysdel