Antiretroviral agents during pregnancy: Consequences on hematologic parameters in HIV-exposed, uninfected newborn infant

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 128, Issue 1-2, 2006, Pages 59-63

  El Beitune, Patrícia ^a   Duarte, Geraldo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Combination antiretroviral therapy; HIV exposed; Infant toxicity; Umbilical cord blood; Uninfected infant

Indexed keywords

ANTIRETROVIRUS AGENT; HEMOGLOBIN; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE PLUS LAMIVUDINE PLUS NELFINAVIR;

ADOLESCENT; ADULT; ANTHROPOMETRY; APGAR SCORE; ARTICLE; BLOOD TOXICITY; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CORD SERUM; DATA ANALYSIS; DEMOGRAPHY; DRUG EFFECT; FEMALE; FOLLOW UP; GESTATIONAL AGE; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; NEWBORN; NONPARAMETRIC TEST; PREGNANCY; PREGNANT WOMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SIDE EFFECT; THROMBOCYTE COUNT; UMBILICAL CORD;

EID: 33748141985     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2006.01.013     Document Type: Article

References (20)

1. Perinatal HIV Guidelines Working Group Members. Public Health Service Task Force Recommendation for Safety and Toxicity of Individual Antiretroviral Agents in Pregnancy. Available at http://www.hivatis.org, retrieved May 21, 2005.
2. Mandelbrot L., Peytavin G., Firtion G., and Farinotti R. Maternal-fetal transfer and amniotic fluid accumulation of lamivudine in human immunodeficiency virus-infected pregnant women. Am J Obstet Gynecol 184 (2001) 153-158
3. El Beitune P., Duarte G., Quintana S.M., Figueiró-Filho E.A., Marcolin A.C., and Abduch R. Antiretroviral therapy during pregnancy and early neonatal life: consequences for HIV-exposed, uninfected children. Braz J Infect Dis 8 (2004) 140-150
4. Sperling R.S., Shapiro D.E., McSherry G.D., et al. Safety of the maternal-infant zidovudine regimen utilized in the Pediatric AIDS Clinical Trial Group 076 Study. AIDS 12 (1998) 1805-1813
5. Centers for Disease Control Prevention (CDC). Public health service task force recommendations for the use of antiretroviral drugs in pregnant women infected with HIV-1 for maternal health and for reducing perinatal HIV-1 transmission in the United States. MMWR 51 (2002) 1-38
6. El Beitune P., Duarte G., Machado A.A., Quintana S.M., Figueiró-Filho E.A., and Abduch R. Effect of antiretroviral drugs on maternal CD4 lymphocyte counts, HIV-1 RNA levels and anthropometric parameters of their neonates. Clinics 60 (2005) 207-212
7. Andersen K.V., and Hermann N. Placenta flow reduction in pregnant smokers. Acta Obstet Gynecol Scand 63 (1984) 707-709
8. Carneiro M., Sanchez A., Maneiro P., Angelosante W., Perez C., and Vallee M. Vertical HIV-1 transmission: prophylaxis and paediatric follow-up. Placenta 22 (2001) S13-S18
9. Taha T.E., Kumwenda N., Gibbons A., et al. Effect Of HIV-1 antiretroviral prophylaxis on hepatic and hematological parameters of African infants. AIDS 16 (2002) 851-858
10. Connor E.M., Sperling R.S., Gelber R., et al. Reduction of maternal-infant transmission of human immunodeficiency virus Type 1 from mother to infant, Pediatric AIDS Clinical Trial Group Protocol 076 Study Group. N Engl J Med 331 (1994) 1173-1180
11. Shah M.M., Li Y., and Christensen R.D. Effects of perinatal zidovudine on hematopoiesis: a comparison of effects on progenitors from human fetuses versus mothers. AIDS 10 (1996) 1239-1241
12. Watson W.J., Stevens T.P., and Weinberg G.A. Profound anemia in a newborn infant of a mother receiving antiretroviral therapy. Ped Infect Dis J 17 (1998) 435-436
13. European Collaborative Study. Exposure to antiretroviral therapy in Utero or early life: the health of uninfected children born to HIV-infected women. J Acquir Immune Defic Syndr 32 (2003) 380-387
14. Lambert J.S., Nogueira S.A., Abreu T., et al. A pilot study to evaluate the safety and feasibility of the administration of ZDV/3TC fixed dose combination to HIV infected pregnant women and their infants in Rio De Janeiro, Brazil. Sex Transm Infect 79 (2003) 448-452
15. Le Chenadec J., Mayaux M.J., Chantal G.J., and Blanche S. Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants. AIDS 17 (2003) 2053-2061
16. Hanley M.B., Napolitano L.A., and McCune J.M. Growth hormone-induced stimulation of multilineage human hematopoiesis. Stem Cells 23 (2005) 1170-1179
17. El Beitune P., Duarte G., Foss M.C., et al. Effect of maternal use of antiretroviral agents on serum insulin levels of the newborn infant. Diabetes Care 28 (2005) 856-859
18. Culnane M., Fowler M., Lee S.S., et al. Lack of long-term effects of in Utero exposure to zidovudine among uninfected children born to HIV-infected women. Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams. JAMA 281 (1999) 151-157
19. Stevens R.F., and Alexander M.K. A sex difference in the platelet count. Br J Haematol 37 (1977) 295-300
20. Lisse I.M., Aaby P., Whittle H., Jensen H., Engelmann M., and Christensen L.B. T-Lymphocyte subsets in West African children: impact of age, sex and season. J Pediatr 130 (1997) 77-85