메뉴 건너뛰기




Volumn 19, Issue 3, 2006, Pages 299-306

Functional magnetic resonance imaging of cholinergic modulation in mild cognitive impairment

Author keywords

Acetylcholine; Alzheimer's disease; Functional magnetic resonance imaging; Mild cognitive impairment

Indexed keywords

ANTIDEPRESSANT AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR;

EID: 33748138102     PISSN: 09517367     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.yco.0000218602.25346.c6     Document Type: Review
Times cited : (17)

References (94)
  • 2
    • 0037425565 scopus 로고    scopus 로고
    • Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: A meta-analysis
    • Trinh NH, Hoblyn J, Mohanty S, et al. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA 2003; 289:210-216.
    • (2003) JAMA , vol.289 , pp. 210-216
    • Trinh, N.H.1    Hoblyn, J.2    Mohanty, S.3
  • 3
    • 3042857903 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Cummings JL. Alzheimer's disease. N Engl J Med 2004; 351:56-67.
    • (2004) N Engl J Med , vol.351 , pp. 56-67
    • Cummings, J.L.1
  • 4
    • 4344580888 scopus 로고    scopus 로고
    • Strategies for disease modification in Alzheimer's disease
    • Citron M. Strategies for disease modification in Alzheimer's disease. Nat Rev Neurosci 2004; 5:677-685. An insightful review of three major approaches to the development of disease-modifying therapy for Alzheimer's disease.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 677-685
    • Citron, M.1
  • 5
    • 16344382740 scopus 로고    scopus 로고
    • Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer's disease
    • Dickerson BC, Sperling RA. Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer's disease. NeuroRx 2005; 2:348-360.
    • (2005) NeuroRx , vol.2 , pp. 348-360
    • Dickerson, B.C.1    Sperling, R.A.2
  • 6
    • 33646168245 scopus 로고    scopus 로고
    • Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
    • E-pub ahead of print
    • Scheff SW, Price DA, Schmitt FA, et al. Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol Aging 2005 [E-pub ahead of print]. The first postmortem human study demonstrating synapse loss in the hippocampal dentate gyrus in MCI and Alzheimer's disease. This investigation, which employed stereologic and electron microscopic techniques, demonstrated correlations between synapse number and cognitive test measures, but no correlation with Braak neuropathologic stage.
    • (2005) Neurobiol Aging
    • Scheff, S.W.1    Price, D.A.2    Schmitt, F.A.3
  • 7
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe DJ. Alzheimer's disease is a synaptic failure. Science 2002; 298:789-791.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 8
    • 5344272541 scopus 로고    scopus 로고
    • A focus on the synapse for neuroprotection in Alzheimer disease and other dementias
    • Coleman P, Federoff H, Kurlan R. A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology 2004; 63:1155-1162.
    • (2004) Neurology , vol.63 , pp. 1155-1162
    • Coleman, P.1    Federoff, H.2    Kurlan, R.3
  • 9
    • 0242363668 scopus 로고    scopus 로고
    • Looking backward to move forward: Early detection of neurodegenerative disorders
    • DeKosky ST, Marek K. Looking backward to move forward: early detection of neurodegenerative disorders. Science 2003; 302:830-834.
    • (2003) Science , vol.302 , pp. 830-834
    • DeKosky, S.T.1    Marek, K.2
  • 10
    • 0036197656 scopus 로고    scopus 로고
    • Memory decline: The boundary between aging and age-related disease
    • Albert MS. Memory decline: the boundary between aging and age-related disease. Ann Neurol 2002; 51:282-284.
    • (2002) Ann Neurol , vol.51 , pp. 282-284
    • Albert, M.S.1
  • 11
    • 18544367850 scopus 로고    scopus 로고
    • Predictors of preclinical Alzheimer disease and dementia: A clinicopathologic study
    • Galvin JE, Powlishta KK, Wilkins K, et al. Predictors of preclinical Alzheimer disease and dementia: a clinicopathologic study. Arch Neurol 2005; 62:758-765. A longitudinal clinicopathologic study showing that clinical evaluation can detect subtle cognitive impairment that predicts dementia and Alzheimer's disease neuropathology.
    • (2005) Arch Neurol , vol.62 , pp. 758-765
    • Galvin, J.E.1    Powlishta, K.K.2    Wilkins, K.3
  • 12
    • 4544335597 scopus 로고    scopus 로고
    • Mild cognitive impairment as a diagnostic entity
    • Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256:183-194.
    • (2004) J Intern Med , vol.256 , pp. 183-194
    • Petersen, R.C.1
  • 13
    • 4544350756 scopus 로고    scopus 로고
    • Mild cognitive impairment - Beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment
    • Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment - beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 2004; 256:240-246.
    • (2004) J Intern Med , vol.256 , pp. 240-246
    • Winblad, B.1    Palmer, K.2    Kivipelto, M.3
  • 14
    • 33144484244 scopus 로고    scopus 로고
    • Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI)
    • Mueller SG, Weiner MW, Thal LJ, et al. Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI). Alzheimer's Dement 2005; 1:55-66.
    • (2005) Alzheimer's Dement , vol.1 , pp. 55-66
    • Mueller, S.G.1    Weiner, M.W.2    Thal, L.J.3
  • 15
    • 20344365107 scopus 로고    scopus 로고
    • Mild cognitive impairment - No benefit from vitamin E, little from donepezil
    • Blacker D. Mild cognitive impairment - no benefit from vitamin E, little from donepezil. N Engl J Med 2005; 352:2439-2441.
    • (2005) N Engl J Med , vol.352 , pp. 2439-2441
    • Blacker, D.1
  • 16
    • 0035099984 scopus 로고    scopus 로고
    • Mild cognitive impairment represents early-stage Alzheimer disease
    • Morris JC, Storandt M, Miller JP, et al. Mild cognitive impairment represents early-stage Alzheimer disease. Arch Neurol 2001; 58:397-405.
    • (2001) Arch Neurol , vol.58 , pp. 397-405
    • Morris, J.C.1    Storandt, M.2    Miller, J.P.3
  • 17
    • 0032988610 scopus 로고    scopus 로고
    • Mild cognitive impairment: Clinical characterization and outcome
    • Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999; 56:303-308.
    • (1999) Arch Neurol , vol.56 , pp. 303-308
    • Petersen, R.C.1    Smith, G.E.2    Waring, S.C.3
  • 18
    • 9144267765 scopus 로고    scopus 로고
    • Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials
    • Grundman M, Petersen RC, Ferris SH, et al. Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol 2004; 61:59-66.
    • (2004) Arch Neurol , vol.61 , pp. 59-66
    • Grundman, M.1    Petersen, R.C.2    Ferris, S.H.3
  • 19
    • 0037261836 scopus 로고    scopus 로고
    • Mild cognitive impairment: Conceptual issues and structural and functional brain correlates
    • Saykin AJ, Wishart HA. Mild cognitive impairment: conceptual issues and structural and functional brain correlates. Semin Clin Neuropsychiatry 2003; 8:12-30.
    • (2003) Semin Clin Neuropsychiatry , vol.8 , pp. 12-30
    • Saykin, A.J.1    Wishart, H.A.2
  • 20
    • 23244445918 scopus 로고    scopus 로고
    • Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
    • Dickerson BC, Salat DH, Greve DN, et al. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology 2005; 65:404-411.
    • (2005) Neurology , vol.65 , pp. 404-411
    • Dickerson, B.C.1    Salat, D.H.2    Greve, D.N.3
  • 21
    • 14644416500 scopus 로고    scopus 로고
    • Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
    • Bennett DA, Schneider JA, Bienias JL, et al. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology 2005; 64:834-841. This study reported that longitudinally defined MCI can result from multiple neuropathologic etiologies, including Alzheimer's disease and cerebrovascular disease.
    • (2005) Neurology , vol.64 , pp. 834-841
    • Bennett, D.A.1    Schneider, J.A.2    Bienias, J.L.3
  • 22
    • 3042714810 scopus 로고    scopus 로고
    • Medial temporal lobe function and structure in mild cognitive impairment
    • Dickerson BC, Salat DH, Bates JF, et al. Medial temporal lobe function and structure in mild cognitive impairment. Ann Neurol 2004; 56:27-35.
    • (2004) Ann Neurol , vol.56 , pp. 27-35
    • Dickerson, B.C.1    Salat, D.H.2    Bates, J.F.3
  • 23
    • 0030859067 scopus 로고    scopus 로고
    • Clinical dementia rating training and reliability in multicenter studies: The Alzheimer's Disease Cooperative Study experience
    • Morris JC, Ernesto C, Schafer K, et al. Clinical dementia rating training and reliability in multicenter studies: the Alzheimer's Disease Cooperative Study experience. Neurology 1997; 48:1508-1510.
    • (1997) Neurology , vol.48 , pp. 1508-1510
    • Morris, J.C.1    Ernesto, C.2    Schafer, K.3
  • 24
    • 0034068646 scopus 로고    scopus 로고
    • Predicting conversion to Alzheimer disease using standardized clinical information
    • Daly E, Zaitchik D, Copeland M, et al. Predicting conversion to Alzheimer disease using standardized clinical information. Arch Neurol 2000; 57:675-680.
    • (2000) Arch Neurol , vol.57 , pp. 675-680
    • Daly, E.1    Zaitchik, D.2    Copeland, M.3
  • 25
    • 0842281804 scopus 로고    scopus 로고
    • Use of IQ-adjusted norms to predict progressive cognitive decline in highly intelligent older individuals
    • Rentz DM, Huh TJ, Faust RR, et al. Use of IQ-adjusted norms to predict progressive cognitive decline in highly intelligent older individuals. Neuropsychology 2004; 18:38-49. This study demonstrated that adjustment for standard measures of intelligence enables the detection of subtle neuropsychological deficits that may predict cognitive decline.
    • (2004) Neuropsychology , vol.18 , pp. 38-49
    • Rentz, D.M.1    Huh, T.J.2    Faust, R.R.3
  • 26
    • 0015965912 scopus 로고
    • Human memory and the cholinergic system. A relationship to aging?
    • Drachman DA, Leavitt J. Human memory and the cholinergic system. A relationship to aging? Arch Neurol 1974; 30:113-121.
    • (1974) Arch Neurol , vol.30 , pp. 113-121
    • Drachman, D.A.1    Leavitt, J.2
  • 27
    • 0141522452 scopus 로고    scopus 로고
    • Acetylcholine modulation of neural systems involved in learning and memory
    • Gold PE. Acetylcholine modulation of neural systems involved in learning and memory. Neurobiol Learn Mem 2003; 80:194-210.
    • (2003) Neurobiol Learn Mem , vol.80 , pp. 194-210
    • Gold, P.E.1
  • 28
    • 0017133142 scopus 로고
    • Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies
    • Bowen DM, Smith CB, White P, et al. Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Brain 1976; 99:459-496.
    • (1976) Brain , vol.99 , pp. 459-496
    • Bowen, D.M.1    Smith, C.B.2    White, P.3
  • 29
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies P, Maloney AJ. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 1976; 2:1403.
    • (1976) Lancet , vol.2 , pp. 1403
    • Davies, P.1    Maloney, A.J.2
  • 30
    • 0017360731 scopus 로고
    • Necropsy evidence of central cholinergic deficits in senile dementia
    • Perry EK, Perry RH, Blessed G, et al. Necropsy evidence of central cholinergic deficits in senile dementia. Lancet 1977; 1:189.
    • (1977) Lancet , vol.1 , pp. 189
    • Perry, E.K.1    Perry, R.H.2    Blessed, G.3
  • 31
    • 0020072221 scopus 로고
    • Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
    • Whitehouse PJ, Price DL, Struble RG, et al. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 1982; 215:1237-1239.
    • (1982) Science , vol.215 , pp. 1237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Struble, R.G.3
  • 32
    • 0034125843 scopus 로고    scopus 로고
    • On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis
    • Bartus RT. On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp Neurol 2000; 163:495-529.
    • (2000) Exp Neurol , vol.163 , pp. 495-529
    • Bartus, R.T.1
  • 33
    • 0037645793 scopus 로고    scopus 로고
    • PET studies in dementia
    • Herholz K. PET studies in dementia. Ann Nucl Med 2003; 17:79-89.
    • (2003) Ann Nucl Med , vol.17 , pp. 79-89
    • Herholz, K.1
  • 34
    • 0033867948 scopus 로고    scopus 로고
    • Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: A positron emission tomography study
    • Shinotoh H, Namba H, Fukushi K, et al. Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: a positron emission tomography study. Ann Neurol 2000; 48:194-200.
    • (2000) Ann Neurol , vol.48 , pp. 194-200
    • Shinotoh, H.1    Namba, H.2    Fukushi, K.3
  • 35
    • 0034084601 scopus 로고    scopus 로고
    • Brain acetylcholinesterase activity in Alzheimer disease measured by positron emission tomography
    • Shinotoh H, Namba H, Fukushi K, et al. Brain acetylcholinesterase activity in Alzheimer disease measured by positron emission tomography. Alzheimer Dis Assoc Disord 2000; 14 (Suppl 1):S114-S118.
    • (2000) Alzheimer Dis Assoc Disord , vol.14 , Issue.1 SUPPL.
    • Shinotoh, H.1    Namba, H.2    Fukushi, K.3
  • 36
    • 1642451941 scopus 로고    scopus 로고
    • In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease
    • Herholz K, Weisenbach S, Zundorf G, et al. In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease. Neuroimage 2004; 21:136-143.
    • (2004) Neuroimage , vol.21 , pp. 136-143
    • Herholz, K.1    Weisenbach, S.2    Zundorf, G.3
  • 37
    • 0034524262 scopus 로고    scopus 로고
    • In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: Comparison with blood flow and glucose metabolism
    • Herholz K, Bauer B, Wienhard K, et al. In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism. J Neural Transm 2000; 107:1457-1468.
    • (2000) J Neural Transm , vol.107 , pp. 1457-1468
    • Herholz, K.1    Bauer, B.2    Wienhard, K.3
  • 38
    • 27744453518 scopus 로고    scopus 로고
    • Cerebral acetylcholine esterase activity in mild cognitive impairment
    • Herholz K, Weisenbach S, Kalbe E, et al. Cerebral acetylcholine esterase activity in mild cognitive impairment. Neuroreport 2005; 16:1431-1434. In-vivo human PET demonstration that cortical acetylcholinesterase activity is decreased in some, but not all, patients with MCI.
    • (2005) Neuroreport , vol.16 , pp. 1431-1434
    • Herholz, K.1    Weisenbach, S.2    Kalbe, E.3
  • 39
    • 0344009739 scopus 로고    scopus 로고
    • Functional studies of cholinergic activity in normal and Alzheimer disease states by imaging technique
    • Nordberg A. Functional studies of cholinergic activity in normal and Alzheimer disease states by imaging technique. Prog Brain Res 2004; 145:301-310.
    • (2004) Prog Brain Res , vol.145 , pp. 301-310
    • Nordberg, A.1
  • 40
    • 0036315509 scopus 로고    scopus 로고
    • Neuropsychiatric symptoms in the dementias
    • Assal F, Cummings JL. Neuropsychiatric symptoms in the dementias. Curr Opin Neurol 2002; 15:445-450.
    • (2002) Curr Opin Neurol , vol.15 , pp. 445-450
    • Assal, F.1    Cummings, J.L.2
  • 41
    • 2542511697 scopus 로고    scopus 로고
    • Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum
    • Mesulam M, Shaw P, Mash D, et al. Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. Ann Neurol 2004; 55:815-828. This is a pathologic study of longitudinally followed older adults demonstrating the presence of subtle tauopathic change in nucleus basalis neurons in patients with early cognitive impairment.
    • (2004) Ann Neurol , vol.55 , pp. 815-828
    • Mesulam, M.1    Shaw, P.2    Mash, D.3
  • 42
    • 0842304284 scopus 로고    scopus 로고
    • The cholinergic lesion of Alzheimer's disease: Pivotal factor or side show?
    • Mesulam M. The cholinergic lesion of Alzheimer's disease: pivotal factor or side show? Learn Mem 2004; 11:43-49.
    • (2004) Learn Mem , vol.11 , pp. 43-49
    • Mesulam, M.1
  • 43
    • 0036156958 scopus 로고    scopus 로고
    • Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    • DeKosky ST, Ikonomovic MD, Styren SD, et al. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol 2002; 51:145-155.
    • (2002) Ann Neurol , vol.51 , pp. 145-155
    • DeKosky, S.T.1    Ikonomovic, M.D.2    Styren, S.D.3
  • 44
    • 0032539039 scopus 로고    scopus 로고
    • Randomized event-related experimental designs allow for extremely rapid presentation rates using functional MRI
    • Burock MA, Buckner RL, Woldorff MG, et al. Randomized event-related experimental designs allow for extremely rapid presentation rates using functional MRI. Neuroreport 1998; 9:3735-739.
    • (1998) Neuroreport , vol.9 , pp. 3735-3739
    • Burock, M.A.1    Buckner, R.L.2    Woldorff, M.G.3
  • 45
    • 0032862230 scopus 로고    scopus 로고
    • Scanning patients with tasks they can perform
    • Price CJ, Friston KJ. Scanning patients with tasks they can perform. Hum Brain Mapp 1999; 8:102-108.
    • (1999) Hum Brain Mapp , vol.8 , pp. 102-108
    • Price, C.J.1    Friston, K.J.2
  • 46
    • 0034059767 scopus 로고    scopus 로고
    • FMRI of visual encoding: Reproducibility of activation
    • Machielsen WC, Rombouts SA, Barkhof F, et al. FMRI of visual encoding: reproducibility of activation. Hum Brain Mapp 2000; 9:156-164.
    • (2000) Hum Brain Mapp , vol.9 , pp. 156-164
    • Machielsen, W.C.1    Rombouts, S.A.2    Barkhof, F.3
  • 47
    • 0034970546 scopus 로고    scopus 로고
    • Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects
    • Manoach DS, Halpern EF, Kramer TS, et al. Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects. Am J Psychiatry 2001; 158:955-958.
    • (2001) Am J Psychiatry , vol.158 , pp. 955-958
    • Manoach, D.S.1    Halpern, E.F.2    Kramer, T.S.3
  • 48
    • 18244361850 scopus 로고    scopus 로고
    • Functional MRI detection of pharmacologically induced memory impairment
    • Sperling R, Greve D, Dale A, et al. Functional MRI detection of pharmacologically induced memory impairment. Proc Natl Acad Sci U S A 2002; 99:455-460.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 455-460
    • Sperling, R.1    Greve, D.2    Dale, A.3
  • 49
    • 0034255212 scopus 로고    scopus 로고
    • Pharmacological magnetic resonance imaging: A new application for functional MRI
    • Leslie RA, James MF. Pharmacological magnetic resonance imaging: a new application for functional MRI. Trends Pharmacol Sci 2000; 21:314-318.
    • (2000) Trends Pharmacol Sci , vol.21 , pp. 314-318
    • Leslie, R.A.1    James, M.F.2
  • 50
    • 3042569770 scopus 로고    scopus 로고
    • Human pharmacological MRI
    • Honey G, Bullmore E. Human pharmacological MRI. Trends Pharmacol Sci 2004; 25:366-374. Definitive review of recent advances in phMRI.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 366-374
    • Honey, G.1    Bullmore, E.2
  • 51
    • 0033834953 scopus 로고    scopus 로고
    • Effects of dextroamphetamine on cognitive performance and cortical activation
    • Mattay VS, Callicott JH, Bertolino A, et al. Effects of dextroamphetamine on cognitive performance and cortical activation. Neuroimage 2000; 12:268-275.
    • (2000) Neuroimage , vol.12 , pp. 268-275
    • Mattay, V.S.1    Callicott, J.H.2    Bertolino, A.3
  • 52
    • 0035449412 scopus 로고    scopus 로고
    • Pharmacological modulation of behavioral and neuronal correlates of repetition priming
    • Thiel CM, Henson RN, Morris JS, et al. Pharmacological modulation of behavioral and neuronal correlates of repetition priming. J Neurosci 2001; 21:6846-6852.
    • (2001) J Neurosci , vol.21 , pp. 6846-6852
    • Thiel, C.M.1    Henson, R.N.2    Morris, J.S.3
  • 53
    • 0034746694 scopus 로고    scopus 로고
    • The noradrenergic alpha2 agonist clonidine modulates behavioural and neuroanatomical correlates of human attentional orienting and alerting
    • Coull JT, Nobre AC, Frith CD. The noradrenergic alpha2 agonist clonidine modulates behavioural and neuroanatomical correlates of human attentional orienting and alerting. Cereb Cortex 2001; 11:73-84.
    • (2001) Cereb Cortex , vol.11 , pp. 73-84
    • Coull, J.T.1    Nobre, A.C.2    Frith, C.D.3
  • 54
    • 33748181649 scopus 로고    scopus 로고
    • Raloxifene treatment enhances brain activation during recognition of familiar items: A pharmacological fMRI study in healthy elderly males
    • E-pub ahead of print
    • Goekoop R, Barkhof F, Duschek EJ, et al. Raloxifene treatment enhances brain activation during recognition of familiar items: a pharmacological fMRI study in healthy elderly males. Neuropsychopharmacology 2005 [E-pub ahead of print].
    • (2005) Neuropsychopharmacology
    • Goekoop, R.1    Barkhof, F.2    Duschek, E.J.3
  • 55
    • 27144524949 scopus 로고    scopus 로고
    • Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging
    • Goldstein JM, Jerram M, Poldrack R, et al. Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging. J Neurosci 2005; 25:9309-9316.
    • (2005) J Neurosci , vol.25 , pp. 9309-9316
    • Goldstein, J.M.1    Jerram, M.2    Poldrack, R.3
  • 56
    • 32944468236 scopus 로고    scopus 로고
    • Individual capacity differences predict working memory performance and prefrontal activity following dopamine receptor stimulation
    • Gibbs SE, D'Esposito M. Individual capacity differences predict working memory performance and prefrontal activity following dopamine receptor stimulation. Cogn Affect Behav Neurosci 2005; 5:212-221. A phMRI study demonstrating that bromocriptine produced greater behavioral improvement in individuals with lower working-memory span, and that prefrontal activity was greater after bromocriptine in individuals with slower memory retrieval rates.
    • (2005) Cogn Affect Behav Neurosci , vol.5 , pp. 212-221
    • Gibbs, S.E.1    D'Esposito, M.2
  • 57
    • 9844233166 scopus 로고    scopus 로고
    • Acute effects of cocaine on human brain activity and emotion
    • Breiter HC, Gollub RL, Weisskoff RM, et al. Acute effects of cocaine on human brain activity and emotion. Neuron 1997; 19:591-611.
    • (1997) Neuron , vol.19 , pp. 591-611
    • Breiter, H.C.1    Gollub, R.L.2    Weisskoff, R.M.3
  • 58
    • 0031444839 scopus 로고    scopus 로고
    • Functional magnetic resonance imaging studies of emotional processing in normal and depressed patients: Effects of venlafaxine
    • Kalin NH, Davidson RJ, Irwin W, et al. Functional magnetic resonance imaging studies of emotional processing in normal and depressed patients: effects of venlafaxine. J Clin Psychiatry 1997; 58 (Suppl 16):32-39.
    • (1997) J Clin Psychiatry , vol.58 , Issue.16 SUPPL. , pp. 32-39
    • Kalin, N.H.1    Davidson, R.J.2    Irwin, W.3
  • 59
    • 0033539488 scopus 로고    scopus 로고
    • Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical anti-psychotic drugs in patients with schizophrenia
    • Honey GD, Bullmore ET, Soni W, et al. Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical anti-psychotic drugs in patients with schizophrenia. Proc Natl Acad Sci U S A 1999; 96:13432-13437.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13432-13437
    • Honey, G.D.1    Bullmore, E.T.2    Soni, W.3
  • 60
    • 0036154591 scopus 로고    scopus 로고
    • Dopaminergic modulation of cortical function in patients with Parkinson's disease
    • Mattay VS, Tessitore A, Callicott JH, et al. Dopaminergic modulation of cortical function in patients with Parkinson's disease. Ann Neurol 2002; 51:156-164.
    • (2002) Ann Neurol , vol.51 , pp. 156-164
    • Mattay, V.S.1    Tessitore, A.2    Callicott, J.H.3
  • 61
    • 4444225019 scopus 로고    scopus 로고
    • Attenuation of the neural response to sad faces in major depression by antidepressant treatment: A prospective, event-related functional magnetic resonance imaging study
    • Fu CH, Williams SC, Cleare AJ, et al. Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry 2004; 61:877-889. A phMRI study demonstrating that changes in pregenual cingulate and ventral striatal activation correlate with symptomatic improvement in depression after fluoxetine therapy.
    • (2004) Arch Gen Psychiatry , vol.61 , pp. 877-889
    • Fu, C.H.1    Williams, S.C.2    Cleare, A.J.3
  • 62
    • 0037228029 scopus 로고    scopus 로고
    • The neural substrates of affective processing in depressed patients treated with venlafaxine
    • Davidson RJ, Irwin W, Anderle MJ, et al. The neural substrates of affective processing in depressed patients treated with venlafaxine. Am J Psychiatry 2003; 160:64-75.
    • (2003) Am J Psychiatry , vol.160 , pp. 64-75
    • Davidson, R.J.1    Irwin, W.2    Anderle, M.J.3
  • 63
    • 4744376592 scopus 로고    scopus 로고
    • Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia
    • Bertolino A, Caforio G, Blasi G, et al. Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. Am J Psychiatry 2004; 161:1798-1805.
    • (2004) Am J Psychiatry , vol.161 , pp. 1798-1805
    • Bertolino, A.1    Caforio, G.2    Blasi, G.3
  • 64
    • 27144511228 scopus 로고    scopus 로고
    • Scopolamine reduces persistent activity related to long-term encoding in the parahippocampal gyrus during delayed matching in humans
    • Schon K, Atri A, Hasselmo ME, et al. Scopolamine reduces persistent activity related to long-term encoding in the parahippocampal gyrus during delayed matching in humans. J Neurosci 2005; 25:9112-9123.
    • (2005) J Neurosci , vol.25 , pp. 9112-9123
    • Schon, K.1    Atri, A.2    Hasselmo, M.E.3
  • 65
    • 0036298584 scopus 로고    scopus 로고
    • Scopolamine but not lorazepam modulates face repetition priming: A psychopharmacological fMRI study
    • Thiel CM, Henson RN, Dolan RJ. Scopolamine but not lorazepam modulates face repetition priming: a psychopharmacological fMRI study. Neuropsychopharmacology 2002; 27:282-292.
    • (2002) Neuropsychopharmacology , vol.27 , pp. 282-292
    • Thiel, C.M.1    Henson, R.N.2    Dolan, R.J.3
  • 66
    • 0036454892 scopus 로고    scopus 로고
    • Effects of cholinergic enhancement on conditioning-related responses in human auditory cortex
    • Thiel CM, Bentley P, Dolan RJ. Effects of cholinergic enhancement on conditioning-related responses in human auditory cortex. Eur J Neurosci 2002; 16:2199-2206.
    • (2002) Eur J Neurosci , vol.16 , pp. 2199-2206
    • Thiel, C.M.1    Bentley, P.2    Dolan, R.J.3
  • 67
    • 0036685550 scopus 로고    scopus 로고
    • Cholinergic modulation of experience-dependent plasticity in human auditory cortex
    • Thiel CM, Friston KJ, Dolan RJ. Cholinergic modulation of experience-dependent plasticity in human auditory cortex. Neuron 2002; 35:567-574.
    • (2002) Neuron , vol.35 , pp. 567-574
    • Thiel, C.M.1    Friston, K.J.2    Dolan, R.J.3
  • 68
    • 0041815963 scopus 로고    scopus 로고
    • Effects of attention and emotion on repetition priming and their modulation by cholinergic enhancement
    • Bentley P, Vuilleumier P, Thiel CM, et al. Effects of attention and emotion on repetition priming and their modulation by cholinergic enhancement. J Neurophysiol 2003; 90:1171-1181.
    • (2003) J Neurophysiol , vol.90 , pp. 1171-1181
    • Bentley, P.1    Vuilleumier, P.2    Thiel, C.M.3
  • 69
    • 30744446162 scopus 로고    scopus 로고
    • Age and cholinergic effects on hemodynamics and functional coherence of human hippocampus
    • E-pub ahead of print
    • Wink AM, Bernard F, Salvador R, et al. Age and cholinergic effects on hemodynamics and functional coherence of human hippocampus. Neurobiol Aging 2005 [E-pub ahead of print]. The first phMRI study of cholinergic modulation in aging, demonstrating effects of scopolamine on hippocampal activity.
    • (2005) Neurobiol Aging
    • Wink, A.M.1    Bernard, F.2    Salvador, R.3
  • 70
    • 0036901184 scopus 로고    scopus 로고
    • Alterations in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease
    • Rombouts SA, Barkhof F, Van Meel CS, et al. Alterations in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2002; 73:665-671.
    • (2002) J Neurol Neurosurg Psychiatry , vol.73 , pp. 665-671
    • Rombouts, S.A.1    Barkhof, F.2    Van Meel, C.S.3
  • 71
    • 0141763651 scopus 로고    scopus 로고
    • Cholinergic modulation of learning and memory in the human brain as detected with functional neuroimaging
    • Thiel CM. Cholinergic modulation of learning and memory in the human brain as detected with functional neuroimaging. Neurobiol Learn Mem 2003; 80:234-244.
    • (2003) Neurobiol Learn Mem , vol.80 , pp. 234-244
    • Thiel, C.M.1
  • 72
    • 0242268555 scopus 로고    scopus 로고
    • Alterations in the BOLD fMRI signal with ageing and disease: A challenge for neuroimaging
    • D'Esposito M, Deouell LY, Gazzaley A. Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging. Nat Rev Neurosci 2003; 4:863-872.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 863-872
    • D'Esposito, M.1    Deouell, L.Y.2    Gazzaley, A.3
  • 73
    • 0035171447 scopus 로고    scopus 로고
    • Functional brain imaging of young, nondemented, and demented older adults
    • Buckner RL, Snyder AZ, Sanders AL, et al. Functional brain imaging of young, nondemented, and demented older adults. J Cogn Neurosci 2000; 12 (Suppl 2):24-34.
    • (2000) J Cogn Neurosci , vol.12 , Issue.2 SUPPL. , pp. 24-34
    • Buckner, R.L.1    Snyder, A.Z.2    Sanders, A.L.3
  • 74
    • 0031033953 scopus 로고    scopus 로고
    • Regulation of cerebral blood flow response to somatosensory stimulation through the cholinergic system: A positron emission tomography study in unanesthetized monkeys
    • Tsukada H, Kakiuchi T, Ando I, et al. Regulation of cerebral blood flow response to somatosensory stimulation through the cholinergic system: a positron emission tomography study in unanesthetized monkeys. Brain Res 1997; 749:10-17.
    • (1997) Brain Res , vol.749 , pp. 10-17
    • Tsukada, H.1    Kakiuchi, T.2    Ando, I.3
  • 75
    • 27744435326 scopus 로고    scopus 로고
    • Cholinergic deafferentation of the entorhinal cortex in rats impairs encoding of novel but not familiar stimuli in a delayed nonmatch-to-sample task
    • McGaughy J, Koene RA, Eichenbaum H, et al. Cholinergic deafferentation of the entorhinal cortex in rats impairs encoding of novel but not familiar stimuli in a delayed nonmatch-to-sample task. J Neurosci 2005; 25:10273-10281.
    • (2005) J Neurosci , vol.25 , pp. 10273-10281
    • McGaughy, J.1    Koene, R.A.2    Eichenbaum, H.3
  • 76
    • 13844306206 scopus 로고    scopus 로고
    • Challenging the cholinergic system in mild cognitive impairment: A pharmacological fMRI study
    • Goekoop R, Rombouts SA, Jonker C, et al. Challenging the cholinergic system in mild cognitive impairment: a pharmacological fMRI study. Neuroimage 2004; 23:1450-1459.
    • (2004) Neuroimage , vol.23 , pp. 1450-1459
    • Goekoop, R.1    Rombouts, S.A.2    Jonker, C.3
  • 77
    • 3142547230 scopus 로고    scopus 로고
    • Cholinergic enhancement of frontal lobe activity in mild cognitive impairment
    • Saykin AJ, Wishart HA, Rabin LA, et al. Cholinergic enhancement of frontal lobe activity in mild cognitive impairment. Brain 2004; 127 (Pt 7):1574-1583.
    • (2004) Brain , vol.127 , Issue.7 PART , pp. 1574-1583
    • Saykin, A.J.1    Wishart, H.A.2    Rabin, L.A.3
  • 78
    • 0037227004 scopus 로고    scopus 로고
    • fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease
    • Sperling RA, Bates JF, Chua EF, et al. fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease. J Neurol Neurosurg Psychiatry 2003; 74:44-50.
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 44-50
    • Sperling, R.A.1    Bates, J.F.2    Chua, E.F.3
  • 79
    • 0037319161 scopus 로고    scopus 로고
    • Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease
    • Grady CL, McIntosh AR, Beig S, et al. Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease. J Neurosci 2003; 23:986-993.
    • (2003) J Neurosci , vol.23 , pp. 986-993
    • Grady, C.L.1    McIntosh, A.R.2    Beig, S.3
  • 80
    • 0037066123 scopus 로고    scopus 로고
    • Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia
    • Jack CR Jr, Dickson DW, Parisi JE, et al. Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology 2002; 58:750-757.
    • (2002) Neurology , vol.58 , pp. 750-757
    • Jack Jr., C.R.1    Dickson, D.W.2    Parisi, J.E.3
  • 81
    • 0034116224 scopus 로고    scopus 로고
    • The relationship between fMRI activation and cerebral atrophy: Comparison of normal aging and Alzheimer disease
    • Johnson SC, Saykin AJ, Baxter LC, et al. The relationship between fMRI activation and cerebral atrophy: comparison of normal aging and Alzheimer disease. Neuroimage 2000; 11:179-187.
    • (2000) Neuroimage , vol.11 , pp. 179-187
    • Johnson, S.C.1    Saykin, A.J.2    Baxter, L.C.3
  • 82
    • 21644434863 scopus 로고    scopus 로고
    • Relating medial temporal lobe volume to frontal fMRI activation for memory encoding in older adults
    • Rosen AC, Gabrieli JD, Stoub T, et al. Relating medial temporal lobe volume to frontal fMRI activation for memory encoding in older adults. Cortex 2005; 41:595-602.
    • (2005) Cortex , vol.41 , pp. 595-602
    • Rosen, A.C.1    Gabrieli, J.D.2    Stoub, T.3
  • 83
    • 30344460006 scopus 로고    scopus 로고
    • Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation - A pharmacological fMRI study
    • Goekoop R, Scheltens P, Barkhof F, et al. Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation - a pharmacological fMRI study. Brain 2006; 129 (Pt 1):141-157.
    • (2006) Brain , vol.129 , Issue.1 PART , pp. 141-157
    • Goekoop, R.1    Scheltens, P.2    Barkhof, F.3
  • 84
    • 24944557159 scopus 로고    scopus 로고
    • Plasma level-dependent effects of methylphenidate on task-related functional magnetic resonance imaging signal changes
    • Berl
    • Muller U, Suckling J, Zelaya F, et al. Plasma level-dependent effects of methylphenidate on task-related functional magnetic resonance imaging signal changes. Psychopharmacology (Berl) 2005; 180:624-633. The first phMRI study with pharmacokinetic measures demonstrating an association between plasma levels of methylphenidate and changes in regional brain activation during a reaction time task.
    • (2005) Psychopharmacology , vol.180 , pp. 624-633
    • Muller, U.1    Suckling, J.2    Zelaya, F.3
  • 86
    • 0344198488 scopus 로고    scopus 로고
    • Functional deactivations: Change with age and dementia of the Alzheimer type
    • Lustig C, Snyder AZ, Bhakta M, et al. Functional deactivations: change with age and dementia of the Alzheimer type. Proc Natl Acad Sci U S A 2003; 100:14504-14509.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14504-14509
    • Lustig, C.1    Snyder, A.Z.2    Bhakta, M.3
  • 87
    • 1842427969 scopus 로고    scopus 로고
    • Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
    • Greicius MD, Srivastava G, Reiss AL, et al. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A 2004; 101:4637-4642.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4637-4642
    • Greicius, M.D.1    Srivastava, G.2    Reiss, A.L.3
  • 88
    • 23944444806 scopus 로고    scopus 로고
    • Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory
    • Buckner RL, Snyder AZ, Shannon BJ, et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci 2005; 25:7709-7717. An important conceptual paper showing the spatial correspondence between brain regions involved in the 'default-mode' resting network and memory retrieval tasks, and those affected in Alzheimer's disease (with hypometabolism, atrophy, and amyloid accumulation). The authors hypothesize that longstanding cerebral metabolic patterns across the lifespan may predispose to Alzheimer's disease neuropathology.
    • (2005) J Neurosci , vol.25 , pp. 7709-7717
    • Buckner, R.L.1    Snyder, A.Z.2    Shannon, B.J.3
  • 89
    • 0142106045 scopus 로고    scopus 로고
    • Putting names to faces: Successful encoding of associative memories activates the anterior hippocampal formation
    • Sperling R, Chua E, Cocchiarella A, et al. Putting names to faces: successful encoding of associative memories activates the anterior hippocampal formation. Neuroimage 2003; 20:1400-1410.
    • (2003) Neuroimage , vol.20 , pp. 1400-1410
    • Sperling, R.1    Chua, E.2    Cocchiarella, A.3
  • 90
    • 0037161294 scopus 로고    scopus 로고
    • Women at risk for AD show increased parietal activation during a fluency task
    • Smith CD, Andersen AH, Kryscio RJ, et al. Women at risk for AD show increased parietal activation during a fluency task. Neurology 2002; 58:1197-1202.
    • (2002) Neurology , vol.58 , pp. 1197-1202
    • Smith, C.D.1    Andersen, A.H.2    Kryscio, R.J.3
  • 91
    • 0034680078 scopus 로고    scopus 로고
    • Patterns of brain activation in people at risk for Alzheimer's disease
    • Bookheimer SY, Strojwas MH, Cohen MS, et al. Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J Med 2000; 343:450-456.
    • (2000) N Engl J Med , vol.343 , pp. 450-456
    • Bookheimer, S.Y.1    Strojwas, M.H.2    Cohen, M.S.3
  • 92
    • 13244274910 scopus 로고    scopus 로고
    • fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease
    • Bondi MW, Houston WS, Eyler LT, et al. fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease. Neurology 2005; 64:501-508.
    • (2005) Neurology , vol.64 , pp. 501-508
    • Bondi, M.W.1    Houston, W.S.2    Eyler, L.T.3
  • 93
    • 20344381835 scopus 로고    scopus 로고
    • Vitamin E and donepezil for the treatment of mild cognitive impairment
    • Petersen RC, Thomas RG, Grundman M, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 2005; 352:2379-2388.
    • (2005) N Engl J Med , vol.352 , pp. 2379-2388
    • Petersen, R.C.1    Thomas, R.G.2    Grundman, M.3
  • 94
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    • Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol 2004; 55:306-319. The first report in humans of in-vivo fibrillar amyloid imaging using a PET radioligand, proving the principle that Alzheimer neuropathology can be detected with imaging in living human patients with clinical Alzheimer's disease.
    • (2004) Ann Neurol , vol.55 , pp. 306-319
    • Klunk, W.E.1    Engler, H.2    Nordberg, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.