Autoimmune hepatitis in the elderly: What is the difference?

Journal of Hepatology

Volumn 45, Issue 4, 2006, Pages 480-482

  Strassburg, Christian P ^a   Manns, Michael P ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; STEROID;

ACUTE HEPATITIS; AGED HOSPITAL PATIENT; AUTOIMMUNE HEPATITIS; CELLULAR IMMUNITY; CELLULAR IMMUNODEFICIENCY; DISEASE COURSE; DISEASE SEVERITY; EDITORIAL; HUMAN; IMMUNOGENETICS; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FIBROSIS; PATIENT COMPLIANCE; PRIORITY JOURNAL; RECURRENCE RISK; REMISSION; SCREENING; SYMPTOM; TREATMENT FAILURE; TREATMENT INDICATION; TREATMENT OUTCOME; TREATMENT PLANNING; TREATMENT RESPONSE;

AGED; AGING; HEPATITIS, AUTOIMMUNE; HUMANS;

EID: 33748108995     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2006.07.008     Document Type: Editorial

References (24)

1. Manns M.P., and Strassburg C.P. Autoimmune hepatitis: clinical challenges. Gastroenterology 120 (2001) 1502-1517
2. Kirk A.P., Jain S., Pocock S., Thomas H.C., and Sherlock S. Late results of the Royal Free Hospital prospective controlled trial of prednisolone therapy in hepatitis B surface antigen negative chronic active hepatitis. Gut 21 (1980) 7893
3. Soloway R.D., Summerskill W.H., Baggenstoss A.H., Geall M.G., Gitnick G.L., Elveback I.R., et al. Clinical, biochemical, and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis. Gastroenterology 63 (1972) 820-833
4. Strassburg C.P., and Manns M.P. Autoantibodies and autoantigens in autoimmune hepatitis. Semin Liver Dis 22 (2002) 339-352
5. Tan E.M., Chan E.K.L., Sullivan K.F., and Rubin R.L. Antinuclear antibodies (ANAs): diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity. Clin Immunol Immunopathol 47 (1988) 121-141
6. Beaune P., Dansette P.M., Mansuy D., Kiffel L., Finck M., Amar C., et al. Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug. Proc Natl Acad Sci USA 84 (1987) 551-555
7. Strassburg C.P., Obermayer-Straub P., Alex B., Durazzo M., Rizzetto M., Tukey R.H., et al. Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis. Gastroenterology 111 (1996) 1576-1586
8. Obermayer-Straub P., Perheentupa J., Braun S., Kayser A., Barut A., Loges S., et al. Hepatic autoantigens in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Gastroenterology 121 (2001) 668-677
9. Bridoux-Henno L., Maggiore G., Johanet C., Fabre M., Vajro P., Dommergues J.P., et al. Features and outcome of autoimmune hepatitis type 2 presenting with isolated positivity for anti-liver cytosol antibody. Clin Gastroenterol Hepatol 2 (2004) 825-830
10. Gregorio G.V., Portmann B., Reid F., Donaldson P.T., Doherty D.G., McCartney M., et al. Autoimmune hepatitis in childhood: a 20-year experience. Hepatology 25 (1997) 541-547
11. Oettinger R., Brunnberg A., Gerner P., Wintermeyer P., Jenke A., and Wirth S. Clinical features and biochemical data of Caucasian children at diagnosis of autoimmune hepatitis. J Autoimmun 24 (2005) 79-84
12. Parker D.R., and Kingham J.G. Type 1 autoimmune hepatitis is primarily a disease of later life. Qjm 90 (1997) 289-296
13. Waldenström J. Leber, Blutproteine und Nahrungseiweisse. Dtsch Gesellsch Verd Stoffw 15 (1950) 113-119
14. Kunkel H.G., Ahrens E.H.J., and Eisenmenger W.J. Extreme hypergammaglobulinemia in young women with liver disease of unknown ethiology. J Clin Invest 30 (1951) 654
15. Mackay I.R., Taft L.I., and Cowling D.C. Lupoid hepatitis. Lancet 2 (1956) 1323-1326
16. McFarlane I.G. The relationship between autoimmune markers and different clinical syndromes in autoimmune hepatitis. Gut 42 (1998) 599-602
17. Nikias G.A., Batts K.P., and Czaja A.J. The nature and prognostic implications of autoimmune hepatitis with acute presentation. J Hepatol 21 (1994) 866-871
18. Newton J.L., Burt A.D., Park J.B., Mathew J., Bassendine M.F., and James O.F. Autoimmune hepatitis in older patients. Age Ageing 26 (1997) 441-444
19. Schramm C., Kanzler S., zum Buschenfelde K.H., Galle P.R., and Lohse A.W. Autoimmune hepatitis in the elderly. Am J Gastroenterol 96 (2001) 1587-1591
20. Czaja A.J., and Carpenter H.A. Distinctive clinical phenotype and treatment outcome of type 1 autoimmune hepatitis in the elderly. Hepatology 43 (2006) 532-538
21. Czaja A.J., Carpenter H.A., Santrach P.J., and Moore S.B. Significance of HLA DR4 in type 1 autoimmune hepatitis. Gastroenterology 105 (1993) 1502-1507
22. Al-Chalabi T., Boccato S., Portmann B.C., McFarlane I.G., and Heneghan M.A. Autoimmune hepatitis (AIH) in the elderly: A systematic retrospective analysis of a large group of consecutive patients with definite AIH followed at a tertiary referral centre. J Hepatol 45 (2006) 575-583
23. Prelog M. Aging of the immune system: a risk factor for autoimmunity?. Autoimmun Rev 5 (2006) 136-139
24. Talor E., and Rose N.R. Hypothesis: the aging paradox and autoimmune disease. Autoimmunity 8 (1991) 245-249