Hydrogen Bonding Markedly Reduces the pK of Buried Carboxyl Groups in Proteins

Journal of Molecular Biology

Volumn 362, Issue 3, 2006, Pages 594-604

  Thurlkill, Richard L ^a,b   Grimsley, Gerald R ^a   Scholtz, J Martin ^a,b   Pace, C Nick ^a,b  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

carboxyl groups; hydrogen bonds; pK values; protein stability

Indexed keywords

CARBOXYL GROUP; HYDROGEN; PROTEIN; RIBONUCLEASE; WATER;

ARTICLE; CHEMICAL BOND; CORRELATION ANALYSIS; HYDROGEN BOND; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; WILD TYPE;

EID: 33748106496     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.07.056     Document Type: Article

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