Efficacy of radioiodine therapy in the treatment of elevated serum thyroglobulin in patients with differentiated thyroid carcinoma and negative whole-body iodine scan

Nuclear Medicine Communications

Volumn 27, Issue 7, 2006, Pages 567-572

  Saghari, Mohsen ^a   Gholamrezanezhad, Ali ^a   Mirpour, Sahar ^a   Eftekhari, Mohammad ^a   Takavar, Abbas ^a   Fard Esfahani, Armaghan ^a   Fallahi, Babak ^a   Beiki, Davood ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Differentiated thyroid carcinoma; Thyroglobulin; Whole body scanning

Indexed keywords

IODINE 131; THYROGLOBULIN; THYROTROPIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER RECURRENCE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; DRUG MEGADOSE; DRUG RESPONSE; DRUG UPTAKE; FEMALE; FOLLOW UP; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; LUNG METASTASIS; MALE; ONCOCYTOMA; SCHOOL CHILD; THYROID CARCINOMA; THYROID FOLLICULAR CARCINOMA; THYROID PAPILLARY CARCINOMA; THYROTROPIN BLOOD LEVEL; WHOLE BODY SCINTISCANNING;

ADOLESCENT; ADULT; AGED; CHILD; FEMALE; HUMANS; IODINE RADIOISOTOPES; MALE; MIDDLE AGED; PROGNOSIS; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SENSITIVITY AND SPECIFICITY; THYROGLOBULIN; THYROID NEOPLASMS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; WHOLE BODY IMAGING; WHOLE-BODY COUNTING;

EID: 33748102633     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/00006231-200607000-00004     Document Type: Article

References (26)

1. Pacini F, Pinchera A, Giani C, Grasso L, Baschieri L. Serum thyroglobulin concentration and 131-I whole body scans in the diagnosis of metastases from differentiated thyroid carcinoma (after thyroidectomy). Clin Endocrinol (Oxford) 1980; 13:107-110.
2. Pacini F, Pinchera A, Giani C, et al. Serum thyroglobulin in thyroid carcinoma and other thyroid disorders. J Endocrinol Invest 1980; 3:283-292.
3. Charles MA, Dodson LE Jr, Waldeck N, et al. Serum thyroglobulin levels predict total body iodine scan findings in patients with treated well differentiated thyroid carcinoma. Am J Med 1980; 69:401-407.
4. Ashcraft MW, Van Herle AJ. The comparative value of serum thyroglobulin measurements and iodine-131 total body scans in the follow-up study of patients with treated differentiated thyroid cancer. Am J Med 1981; 71:806-814.
5. Schneider AB, Line BR, Goldman JM, Robbins J. Sequential serum thyroglobulin determination 131-I scan and 131-I uptakes after triiodothyronine withdrawal in patients with thyroid cancer. J Clin Endocrinol Metab 1981; 53:1199-1206.
6. 131I whole-body scanning results? J Nucl Med 2005; 46:1164-1170.
7. Ong SC, Ng DC, Sundram FX. Initial experience in use of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in thyroid carcinoma patients with elevated serum thyroglobulin but negative iodine-131 whole body scans. Singapore Med J 2005; 46:297-301.
8. Pacini F, Agate L, Elisei R, Capezzone M, Ceccarelli C, Lippi F, et al. Outcome of differentiated thyroid cancer with detectable serum Tg and negative diagnostic (131)I whole body scan: comparison of patients treated with high (131)I activities versus untreated patients. J Clin Endocrinol Metab 2001; 86:4092-4097.
9. 131I scanning in the management of treated differentiated thyroid carcinoma. J Med Aust NZ 1982; 12:248-254.
10. Schaap J, Eustatia-Rutten CF, Stokkel M, Links TP, Diamant M, van der Velde EA, et al. Does radioiodine therapy have disadvantageous effects in non-iodine accumulating differentiated thyroid carcinoma? Clin Endocrinol (Oxford) 2002; 57:117-124.
11. Pacini F, Lippi F, Formica N, Elisei R, Anelli S, Ceccarelli C, et al. Therapeutic doses of iodine-131 reveal undiagnosed metastases in thyroid cancer patients with detectable serum thyroglobulin levels. J Nucl Med 1987; 28:1888-1891.
12. Mazzaferri EL. Treating high thyroglobulin with radioiodine: a magic bullet or a shot in the dark? J Clin Endocrinol Metab 1995; 80:1485-1487.
13. Schlumberger M, Mancusi F, Baudin E, Pacini F. 131-I therapy for elevated thyroglobulin levels. Thyroid 1997; 7:273-276.
14. 131I whole-body scan: comparative study. Clin Endocrinol (Oxford) 2003; 58:421-427.
15. de Keizer B, Koppeschaar HPF, Zelissn PMJ, Lips CJM, van Rijk RP, van Dijk A, et al. Efficacy of high therapeutic doses of iodine-131 in patients with differentiated thyroid cancer and detectable serum thyroglobulin. Eur J Nucl Med 2001; 281:198-202.
16. McDougall IR. 131-I treatment of 131-I negative whole body scan, and positive thyroglobulin in differentiated thyroid carcinoma: what is being treated? Thyroid 1997; 7:669-672.
17. Fatourechi V, Hay ID, Javedan H, Wiseman GA, Mullan B, Gorman CA. Lack of impact of radioiodine therapy in Tg-positive, diagnostic whole-body scan-negative patients with follicular cell-derived thyroid cancer. J Clin Endocrinol Metab 2002; 87:1521-1526.
18. Pachucki J, Burmeister LA. Evaluation and treatment of persistent thyroglobulinaemia in patients with well-differentiated thyroid cancer. Eur J Endocrinol 1997; 137:254-261.
19. Fatourechi V, Hay ID. Treating the patient with differentiated thyroid cancer with thyroglobulin-positive iodine-131 diagnostic scan-negative metastases: including comments on the role of serum thyroglobulin monitoring in tumor surveillance. Semin Nucl Med 2000; 30:107-114.
20. 131I therapy useful? J Endocrinol Invest 2001; 24:194-198.
21. 131I whole-body scanning. J Nucl Med 2005; 46:1473-1480.
22. Caplan RH, Wickus GG, Manske BR. Long-term follow-up of a patient with papillary thyroid carcinoma, elevated thyroglobulin levels, and negative imaging studies. Endocr Pract 2005; 11:43-48.
23. Salvatori M, Rufini V, Garganese MC, Di Giuda D. Radioiodine therapy in differentiated thyroid carcinoma. Rays 2000; 25:221-238.
24. Kamel N, Corapcioglu D, Sahin M, Gursoy A, Kucuk O, Aras G. I-131 therapy for thyroglobulin positive patients without anatomical evidence of persistent disease. J Endocrinol Invest 2004; 27:949-953.
25. Rosario PW, Maia FC, Barroso AL, Purisch S. Investigating patients with differentiated thyroid carcinoma and elevated serum thyroglobulin but negative whole-body scan. Arq Bras Endocrinol Metabol 2005; 49:246-252.
26. Alzahrani AS, Raef H, Sultan A, Al Sobhi S, Ingemansson S, Ahmed M, Al Mahfouz A. Impact of cervical lymph node dissection on serum TG and the course of disease in TG-positive, radioactive iodine whole body scan-negative recurrent/persistent papillary thyroid cancer. J Endocrinol Invest 2002; 25:526-531.