Dobutamine-induced hyperaemia inversely correlates with coronary artery stenosis severity and highlights dissociation between myocardial blood flow and oxygen consumption

Heart

Volumn 92, Issue 9, 2006, Pages 1230-1237

  Jagathesan, R ^b,d   Barnes, E ^b   Rosen, S D ^c   Foale, R ^c   Camici, Paolo G ^a,b,d  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d National Heart and Lung Institute   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; DOBUTAMINE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; CORONARY VASCULAR RESISTANCE; CORRELATION ANALYSIS; DEMOGRAPHY; DISEASE SEVERITY; DRUG DOSE REGIMEN; FEMALE; HEART MUSCLE; HEART MUSCLE BLOOD FLOW; HUMAN; HYPEREMIA; MALE; OXYGEN CONSUMPTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

AGED; BLOOD VOLUME; CARDIOTONIC AGENTS; CASE-CONTROL STUDIES; CORONARY CIRCULATION; CORONARY STENOSIS; DOBUTAMINE; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; MYOCARDIUM; OXYGEN; OXYGEN CONSUMPTION; VASCULAR RESISTANCE;

EID: 33748067439     PISSN: 13556037     EISSN: None     Source Type: Journal    
DOI: 10.1136/hrt.2005.075101     Document Type: Article

References (34)

1. De Silva R, Camici PG. Role of positron emission tomography in the investigation of human coronary circulatory function. Cardiovasc Res 1994;28:1595-612.
2. Uren NG, Melin JA, de Bruyne B, et al. Relation between myocardial blood flow and the severity of coronary-artery stenosis. N Engl J Med 1994;330:1782-8.
3. Di Carli M, Czernin J, Hoh CK, et al. Relation among stenosis severity, myocardial blood flow, and flow reserve in patients with coronary artery disease. Circulation 1995;91:1944-51.
4. Severi S, Underwood R, Mohiaddin RH, et al. Dobutamine stress: effects on regional myocardial blood flow and wall motion. J Am Coll Cardiol 1995;26:1187-95.
5. Krivokapich J, Czernin J, Schelbert HR. Dobutamine positron emission tomography: absolute quantilation of rest and dobutamine myocardial blood flow and correlation with cardiac work and percent diameter stenosis in patients with and without coronary artery disease. J Am Coll Cardiol 1996;28:565-72.
6. Diamond GA, Forrester JS. Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. N Engl J Med 1979;300:1350-8.
7. Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 1995;333:1301-7.
8. Hermansen F, Ashburner J, Spinks TJ, et al. Generation of myocardial factor images directly from the dynamic oxygen-15-water scan without use of an oxygen-15-carbon monoxide blood-pool scan. J Nucl Med 1998;39:1696-702.
9. Hermansen F, Rosen SD, Fath-Ordoubadi F, et al. Measurement of myocardial blood flow with oxygen-15 labelled water: comparison of different administration protocols. Eur J Nucl Med 1998;25:751-9.
10. Hermansen F, Bloomfield PM, Ashburner J, et al. Linear dimension reduction of sequences of medical images: II. Direct sum decomposition. Phys Med Biol 1995;40:1921-41.
11. Hermansen F, Lammertsma AA. Linear dimension reduction of sequences of medical images: III. Factor analysis in signal space. Phys Med Biol 1996;41:1469-81.
12. Schiller NB, Foster E. Analysis of left ventricular systolic function. Heart 1996;75(6 Suppl 2):17-26.
13. Camici P, Marraccini P, Marzilli M, et al. Coronary hemodynamics and myocardial metabolism during and after pacing stress in normal humans. Am J Physiol 1989;257:E309-17.
14. Uren NG, Marraccini P, Gistri R, et al. Altered coronary vasodilator reserve and metabolism in myocardium subtended by normal arteries in patients with coronary artery disease. J Am Coll Cardiol 1993;22:650-8.
15. Sambuceti G, Parodi O, Marcassa C, et al. Alteration in regulation of myocardial blood flow in one-vessel coronary artery disease determined by positron emission tomography. Am J Cardiol 1993;72:538-43.
16. Buda AJ, Lefkowitz CA, Gallagher KP. Augmentation of regional function in nonischemic myocardium during coronary occlusion measured with two-dimensional echocardiography. J Am Coll Cardiol 1990;16:175-80.
17. Naccarella FF, Weintraub WS, Agarwal JB, et al. Evaluation of "ischemia at a distance": effects of coronary occlusion on a remote area of left ventricle. Am J Cardiol 1984;54:869-74.
18. Smalling RW, Ekas RD, Felli PR, et al. Reciprocal functional interaction of adjacent myocardial segments during regional ischemia: an intraventricular loading phenomenon affecting apparent regional contractile function in the intact heart. J Am Coll Cardiol 1986;7:1335-46.
19. Camici P, Ferrannini E, Opie LH. Myocardial metabolism in ischemic heart disease: basic principles and application to imaging by positron emission tomography. Prog Cardiovasc Dis 1989;32:217-38.
20. Heusch G. Alpha-adrenergic mechanisms in myocardial ischemia. Circulation 1990;81:1-13.
21. Rimoldi O, Spyrou N, Foale R, et al. Limitation of coronary reserve after successful angioplasty is prevented by oral pretreatment with an alpha 1-adrenergic antagonist. J Cardiovasc Pharmacol 2000;36:310-5.
22. Marcus ML, Koyanagi S, Harrison DG, et al. Abnormalities in the coronary circulation that occur as a consequence of cardiac hypertrophy. Am J Med 1983;75:62-6.
23. Zeiher AM, Drexler H, Wollschlager H, et al. Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 1991;83:391-401.
24. Vanoverschelde JL, Wijns W, Essamri B, et al. Hemodynamic and mechanical determinants of myocardial O2 consumption in normal human heart: effects of dobutamine. Am J Physiol 1993;265:H1884-92.
25. Vatner SF, McRitchie RJ, Braunwald E. Effects of dobutamine on left ventricular performance, coronary dynamics, and distribution of cardiac output in conscious dogs. J Clin Invest 1974;53:1265-73.
26. Willerson JT, Hutton I, Watson JT, et al. Influence of dobutamine on regional myocardial blood flow and ventricular performance during acute and chronic myocardial ischemia in dogs. Circulation 1976;53:828-33.
27. Skopicki HA, Abraham SA, Picard MH, et al. Effects of dobutamine at maximally tolerated dose on myocardial blood flow in humans with ischemic heart disease. Circulation 1997;96:3346-52.
28. Daher E, Dione DP, Heller EN, et al. Acute ischemic dysfunction alters coronary flow reserve in remote nonischemic regions: potential mechanical etiology identified in an acute canine model. J Nucl Cardiol 2000;7:112-22.
29. Gobel FL, Norstrom LA, Nelson RR, et al. The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris. Circulation 1978;57:549-56.
30. Kim C, Kwok YS, Heagerty P, et al. Pharmacologic stress testing for coronary disease diagnosis: a meta-analysis. Am Heart J 2001;142:934-44.
31. Uren NG, Camici PG, Melin JA, et al. Effect of aging on myocardial perfusion reserve. J Nucl Med 1995;36:2032-6.
32. Czernin J, Muller P, Chan S, et al. Influence of age and hemodynamics on myocardial blood flow and flow reserve. Circulation 1993;88:62-9.
33. Chareonthaitawee P, Kaufmann PA, Rimoldi O, et al. Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans. Cardiovasc Res 2001;50:151-61.
34. Chan SY, Brunken RC, Czernin J, et al. Comparison of maximal myocardial blood Dow during adenosine infusion with that of intravenous dipyridamole in normal men. J Am Coll Cardiol 1992;20:979-85.