High dose methylprednisolone in the immediate management of acute, blunt spinal cord injury: What is the current practice in emergency departments, spinal units, and neurosurgical units in the UK?

Emergency Medicine Journal

Volumn 23, Issue 7, 2006, Pages 550-553

  Frampton, Anne E ^a   Eynon, C A ^b  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPREDNISOLONE; STEROID;

ARTICLE; BLUNT TRAUMA; CLINICAL PRACTICE; CONSULTATION; CONTROLLED STUDY; DRUG MEGADOSE; EMERGENCY WARD; HEALTH CARE POLICY; HOSPITAL DEPARTMENT; HUMAN; MEDICAL SPECIALIST; NEUROSURGERY; PATIENT CARE; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUESTIONNAIRE; SPINAL CORD INJURY; UNITED KINGDOM;

ACUTE DISEASE; ADULT; ANTI-INFLAMMATORY AGENTS; EMERGENCY MEDICAL SERVICES; GREAT BRITAIN; HEALTH CARE SURVEYS; HUMANS; METHYLPREDNISOLONE; NEUROPROTECTIVE AGENTS; QUESTIONNAIRES; SPINAL CORD INJURIES; WOUNDS, NONPENETRATING;

EID: 33748063278     PISSN: 14720205     EISSN: None     Source Type: Journal    
DOI: 10.1136/emj.2005.032698     Document Type: Article

References (21)

1. Bracken M, Shepard M, Collins W, et al. A randomised, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. N Engl J Med 1990;322(20):1405-11.
2. Bracken M, Shepard M, Holford T, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the third national spinal cord injury randomised controlled trial. JAMA 1997;277(20):1597-1604.
3. Wallman P, Mackway-Jones K. Towards evidence based emergency medicine: best BETS from the Manchester Royal Infirmary. Corticosteroids in acute spinal cord injury. J Accid Emerg Med 2000;17:215.
4. Bracken M. Steroids for acute spinal cord injury (Cochrane review). Cochrane Library. Issue 2. Chichester, UK: John Wiley and Sons, 2004.
5. Short D, El Masry W, Jones P. High dose methylprednisolone in the management of acute spinal cord injury - a systematic review from a clinical perspective. Spinal Cord 2000;28:273-86.
6. Coleman WP, Benzel E, Cahill D, et al. A critical appraisal of the reporting of the National Acute Spinal Cord Injury Studies (II and III) of methylprednisolone in acute spinal cord injury. J Spinal Disord 2000;13(3):185-99.
7. Short D. Is the role of steroids now resolved? Curr Opin Neurol 2001;14(6):759-63.
8. Hurlbert R. The role of steroids in acute spinal cord injury: an evidence based analysis. Spine 2001;26(24S):S39-46.
9. Appuzo M. Pharmacological therapy after acute cervical spinal cord injury. Neurosurgery 2002;50(3):S63-72.
10. Molloy S, Middleton F, Casey A. Failure to administer methylprednisolone for acute traumatic spinal cord injury - a prospective audit of 100 patients from a regional spinal injuries unit. Injury 2002;33:575-8.
11. O'Conner P, McCormack O, Gavin C, et al. Methylprednisolone in acute spinal cord injuries. Irish J Med Sci 2003;172:24-6.
12. Ducker TB, Zeidman SM. Spinal cord injury: role of steroid therapy. Spine 1994;19:2281-7.
13. Bracken MB, Shepard M, Collins W, et al. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1 year follow up data. J Neurosurg 1992;76:23-31.
14. Hurlbert R, Moulton R. Why do you prescribe methylprednisolone for acute spinal cord injury? A Canadian perspective and position statement. Can J Neurol Sci 2002;29(3):236-9.
15. Hugenholtz H, Cass D, Dvorak M, et al. High-dose methylprednisolone for acute closed spinal cord injury - only a treatment option. Can J Neurol Sci 2002;29(3):227-35.
16. Marwick C. Administering methylprednisolone promptly appears to mitigate cord injury paralysis. JAMA 1990;263(16):2150-1.
17. Hannigan W, Anderson R. Commentary of NASCIS-2. J Spinal Disord 1992;322:1405-11.
18. Gerhart K, Johnson R, Menconi J, et al. Utilization and effectiveness of methylprednisolone in a population-based sample of spinal cord injured persons. Paraplegia 1995;33:316-21.
19. Hugenholtz H. Methylprednisolone for acute spinal cord injury: not a standard of care. CMAJ 2003;168(9):1145.
20. Canadian Task Force on the Periodic Health Examination. The Periodic Health Examination 1. Introduction. CMAJ 1986;134(7):721-9.
21. Molloy S, Price M. Casey A questionnaire survey of the views of the delegates at the European Cervical Spine Research Society meeting on the administration of methylprednisolone for acute traumatic spinal cord injury. Spine 2001;26:E562-4.