Characterization of DNA release from composites of oligo(poly(ethylene glycol) fumarate) and cationized gelatin microspheres in vitro

Journal of Biomedical Materials Research - Part A

Volumn 78, Issue 4, 2006, Pages 823-835

  Kasper, F Kurtis ^a   Jerkins, Erin ^a   Tanahashi, Kazuhiro ^a   Barry, Michael A ^a,b   Tabata, Yasuhiko ^c   Mikos, Antonios G ^a  

^a Rice University   (United States)

^b CENTER FOR CELL AND GENE THERAPY   (United States)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Controlled release; Degradable hydrogel; Gelatin microspheres; Plasmid DNA; Tissue engineering

Indexed keywords

COMPOSITE MATERIALS; ELECTROPHORESIS; FLUORESCENCE; HYDROGELS; MICROSCOPES; POLYETHYLENE GLYCOLS; SWELLING; SYNTHESIS (CHEMICAL);

CATIONIZED GELATIN MICROSPHERES (CGMS); DEGRADABLE HYDROGEL; GELATIN; GELATIN MICROSPHERES; PLASMID DNA; TISSUE ENGINEERING;

DNA;

DNA; DOUBLE STRANDED DNA; GELATIN; MACROGOL; MICROSPHERE; OLIGO[POLY(ETHYLENE GLYCOL)FUMARATE]; PLASMID DNA; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; DEGRADATION; DNA CONFORMATION; DNA STRUCTURE; FLUORESCENCE; GEL ELECTROPHORESIS; GENE TARGETING; HYDROGEL; IN VITRO STUDY; KINETICS; MASS; MATERIALS; MOLECULAR WEIGHT; SYNTHESIS;

DNA; GELATIN; MICROSPHERES; PLASMIDS; POLYETHYLENE GLYCOLS; TISSUE ENGINEERING;

EID: 33748056798     PISSN: 00219304     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.30736     Document Type: Article

References (30)

1. Fu K, Klibanov AM, Langer R. Protein stability in controlled-release systems. Nat Biotechnol 2000;18:24-25.
2. Goldstein SA, Bonadio J. Potential role for direct gene transfer in the enhancement of fracture healing. Clin Orthop Relat Res 1998;355 (Suppl):S154-S162.
3. Fukunaka Y, Iwanaga K, Morimoto K, Kakemi M, Tabata Y. Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation. J Control Release 2002;80:333-343.
4. Kushibiki T, Tomoshige R, Fukunaka Y, Kakemi M, Tabata Y. In vivo release and gene expression of plasmid DNA by hydrogels of gelatin with different cationization extents. J Control Release 2003;90:207-216.
5. Kushibiki T, Matsumoto K, Nakamura T, Tabata Y. Suppression of tumor metastasis by NK4 plasmid DNA released from cationized gelatin. Gene Ther 2004;11:1205-1214.
6. Kushibiki T, Matsumoto K, Nakamura T, Tabata Y. Suppression of the progress of disseminated pancreatic cancer cells by NK4 plasmid DNA released from cationized gelatin microspheres. Pharm Res 2004;21:1109-1118.
7. Hosseinkhani H, Aoyama T, Ogawa O, Tabata Y. Ultrasound enhancement of in vitro transfection of plasmid DNA by a cationized gelatin. J Drug Target 2002;10:193-204.
8. Aoyama T, Hosseinkhani H, Yamamoto S, Ogawa O, Tabata Y. Enhanced expression of plasmid DNA-cationized gelatin complex by ultrasound in murine muscle. J Control Release 2002;80(1/3):345-356.
9. Aoyama T, Yamamoto S, Kanematsu A, Ogawa O, Tabata Y. Local delivery of matrix metalloproteinase gene prevents the onset of renal sclerosis in streptozotocin-induced diabetic mice. Tissue Eng 2003;9:1289-1299.
10. Fisher JP, Vehof JW, Dean D, van der Waerden JP, Holland TA, Mikos AG, Jansen JA. Soft and hard tissue response to photocrosslinked poly(propylene fumarate) scaffolds in a rabbit model. J Biomed Mater Res 2002;59:547-556.
11. Shin H, Quinten Ruhe P, Mikos AG, Jansen JA. In vivo bone and soft tissue response to injectable, biodegradable oligo(poly(ethylene glycol) fumarate) hydrogels. Biomaterials 2003;24:3201-3211.
12. Shin H, Zygourakis K, Farach-Carson MC, Yaszemski MJ, Mikos AG. Attachment, proliferation, and migration of marrow stromal osteoblasts cultured on biomimetic hydrogels modified with an osteopontin-derived peptide. Biomaterials 2004;25:895-906.
13. Shin H, Jo S, Mikos AG. Modulation of marrow stromal osteoblast adhesion on biomimetic oligo[poly(ethylene glycol) fumarate] hydrogels modified with Arg-Gly-Asp peptides and a poly(ethyleneglycol) spacer. J Biomed Mater Res 2002;61:169-179.
14. Temenoff JS, Steinbis ES, Mikos AG. Effect of drying history on swelling properties and cell attachment to oligo(poly(ethylene glycol) fumarate) hydrogels for guided tissue regeneration applications. J Biomater Sci Polym Ed 2003;14:989-1004.
15. Temenoff JS, Park H, Jabbari E, Conway DE, Sheffield TL, Ambrose CG, Mikos AG. Thermally cross-linked oligo(poly(ethylene glycol) fumarate) hydrogels support osteogenic differentiation of encapsulated marrow stromal cells in vitro. Biomacromolecules 2004;5(1):5-10.
16. Temenoff JS, Park H, Jabbari E, Sheffield TL, LeBaron RG, Ambrose CG, Mikos AG. In vitro osteogenic differentiation of marrow stromal cells encapsulated in biodegradable hydrogels. J Biomed Mater Res A 2004;70:235-244.
17. Kasper FK, Seidlits SK, Tang A, Crowther RS, Carney DH, Barry MA, Mikos AG. In vitro release of plasmid DNA from oligo(poly(ethylene glycol) fumarate) hydrogels. J Control Release 2005;104:521-539.
18. Kasper FK, Kushibiki T, Kimura Y, Mikos AG, Tabata Y. In vivo release of plasmid DNA from composites of oligo(poly(ethylene glycol) fumarate) and cationized gelatin microspheres. J Control Release 2005;107:547-561.
19. Jo S, Shin H, Mikos AG. Modification of oligo(poly(ethylene glycol) fumarate) macromer with a GRGD peptide for the preparation of functionalized polymer networks. Biomacromolecules 2001;2:255-261.
20. Ikada Y, Tabata Y. Protein release from gelatin matrices. Adv Drug Deliv Rev 1998;31:287-301.
21. Yoshihara Y, Nakamura H, Obata K, Yamada H, Hayakawa T, Fujikawa K, Okada Y. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis 2000;59:455-461.
22. Taylor JR. An Introduction to Error Analysis. Mill Valley, CA: University Science Books; 1982.
23. Holland TA, Tabata Y, Mikos AG. In vitro release of transforming growth factor-β 1 from gelatin microparticles encapsulated in biodegradable, injectable oligo(poly(ethylene glycol) fumarate) hydrogels. J Control Release 2003;91:299-313.
24. Ledley FD. Pharmaceutical approach to somatic gene therapy. Pharm Res 1996;13:1595-1614.
25. Peppas NA, Barr-Howell BD. Characterization of the cross-linked structure of hydrogels. In: Peppas NA, editor. Hydrogels in Medicine and Pharmacy: Fundamentals. Boca Raton: CRC; 1986. p 27-56.
26. Timmer MD, Jo SB, Wang CY, Ambrose CG, Mikos AG. Characterization of the cross-linked structure of fumarate-based degradable polymer networks. Macromolecules 2002;35:4373-4379.
27. Quick DJ, Anseth KS. Gene delivery in tissue engineering: A photopolymer platform to coencapsulate cells and plasmid DNA. Pharm Res 2003;20:1730-1737.
28. Quick DJ, Anseth KS. DNA delivery from photocrosslinked PEG hydrogels: Encapsulation efficiency, release profiles, and DNA quality. J Control Release 2004;96:341-351.
29. Kimoto H, Taketo A. Studies on electrotransfer of DNA into Escherichia coli: Effect of molecular form of DNA. Biochim Biophys Acta 1996;1307:325-330.
30. Xie TD, Sun L, Zhao HG, Fuchs JA, Tsong TY. Study of mechanisms of electric field-induced DNA transfection. IV. Effects of DNA topology on cell uptake and transfection efficiency. Biophys J 1992;63:1026-1031.