Trials and Tribulations of Noninferiority: The Ximelagatran Experience

Journal of the American College of Cardiology

Volumn 48, Issue 5, 2006, Pages 1058-

  Albers, Gregory W ^a   Diener, Hans Christoph ^a   Frison, Lars ^a   Grind, Margaretha ^a   Horrow, Jay ^a   Nevinson, Mark ^a   Olsson, S Bertil ^a   Partridge, Stephen ^a   Petersen, Palle ^a   Vahanian, Alec ^a   Halperin, Jonathan L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

WARFARIN; XIMELAGATRAN;

CLINICAL PRACTICE; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; HEART ATRIUM FIBRILLATION; HUMAN; LETTER; PRIORITY JOURNAL; SECONDARY PREVENTION; STROKE; THROMBOEMBOLISM; TREATMENT OUTCOME;

ANTICOAGULANTS; AZETIDINES; BENZYLAMINES; CEREBROVASCULAR ACCIDENT; DATA INTERPRETATION, STATISTICAL; ENDPOINT DETERMINATION; HUMANS; RANDOMIZED CONTROLLED TRIALS; RESEARCH DESIGN; WARFARIN;

EID: 33747880684     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2006.06.004     Document Type: Letter

References (5)

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2. Halperin J.L., Executive Steering Committee, and SPORTIF Investigators. Ximelagatran compared with warfarin for prevention of thromboembolism in patients with nonvalvular atrial fibrillation. rationale, objectives, and design of a pair of clinical studies and baseline patient characteristics. (SPORTIF III and V). Am Heart J 146 (2003) 431-438
3. Hart R.G., Benavente O., McBride R., and Pearce L.A. Antithrombotic therapy to prevent stroke in patients with atrial fibrillation. a meta-analysis. Ann Intern Med 131 (1999) 492-501
4. European Atrial Fibrillation Trial Study Group. Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. Lancet 342 (1993) 1255-1262
5. Ezekowitz M.D., Bridgers S.L., James K.E., et al. Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation. N Engl J Med 327 (1992) 1406-1412