A computational tool for testing dose-related trend using an age-adjusted bootstrap-based poly-k test

Journal of Statistical Software

Volumn 16, Issue 7, 2006, Pages 1-14

  Moon, Hojin ^a,c   Ahn, Hongshik ^b   Kodell, Ralph L ^a  

^a NCTR   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Bioassay; Competing risks; Likelihood; Sacrifice; Survival adjusted test

Indexed keywords

EID: 33747866631     PISSN: 15487660     EISSN: 15487660     Source Type: Journal    
DOI: 10.18637/jss.v016.i07     Document Type: Article

References (24)

1. Ahn H, Kodell RL (1998). Analysis of Long-Term Carcinogenicity Studies. Marcel Dekker, New York.
2. Armitage P (1955). "Tests for Linear Trends in Proportions and Frequencies." Biometrics, 11, 375-386.
3. Armitage P (ed.) (1971). Statistical Methods in Medical Research. John Wiley, New York.
4. Bailer AJ, Portier CJ (1988). "Effects of Treatment-induced Mortality and Tumor-induced Mortality on Tests for Carcinogenicity in Small Samples." Biometrics, 44, 417-431.
5. Bieler GS, Williams RL (1993). "Ratio Estimates, the Delta Method, and Quantal Response Tests for Increased Carcinogenicity." Biometrics, 49, 793-801.
6. 2 tests." Biometrics, 10, 417-451.
7. Efron B, Tibshirani RJ (1993). An Introduction to the Bootstrap. Chapman and Hall, New York.
8. Farrar DB, Crump KS (1990). "Exact Statistical Tests for any Carcinogenic Effect in Animal Bioassays: II. Age-adjusted Tests." Fundamental and Applied Toxicology, 15, 710-721.
9. Hoel D, Walburg HE (1972). "Statistical Analysis of Survival Experiments." Journal of National Cancer Institute, 49, 361-372.
10. Kodell RL, Chen JJ, Moore GE (1994). "Comparing Distributions of Time to Onset of Disease in Animal Tumorigenicity Experiments." Communications in Statistics - Theory and Methods, 23, 959-980.
11. Kodell RL, Lin KK, Thorn BT, Chen JJ (2000). "Bioassays of Shortened Duration for Drugs: Statistical Implications." Toxicological Sciences, 55, 415-432.
12. Lee PN, Fry JS, Fairweather WR, Haseman JK, Kodell RL, Chen JJ, Roth AJ, Soper K, Morton D (2002). "Current Issues: Statistical Methods for Carcinogenicity Studies." Toxicological Pathology, 30, 403-414.
13. Mancuso JY, Ahn H, Chen JJ, Mancuso JP (2002). "Age-adjusted Exact Trend Tests in the Event of Rare Occurrences." Biometrics, 58, 403-412.
14. Mantel N, Haenszel W (1959). "Statistical Aspects of the Analysis of Data from Retrospective Studies of Disease." Journal of National Cancer Institute, 22, 719-728.
15. Moon H, Ahn H, Kodell RL (2002). "Extension of Peto's Test by Attribution of Tumor Lethality in the Absence of Cause-of-Death Information." Biometrical Journal, 44, 982-1001.
16. Moon H, Ahn H, Kodell RL (2005). "An Age-adjusted Bootstrap-based Poly-k Test." Statistics in Medicine, 24, 1233-1244.
17. Moon H, Ahn H, Kodell RL, Lee JJ (2003). "Estimation of k for the Poly-k Test." Statistics in Medicine, 22, 2619-2636.
18. 1 Mice (Gavage Studies)." NTP Technical Report 402, National Toxicology Program, Research Triangle Park, NC.
19. Office of the Federal Register (1985). "Chemical Carcinogens; A Review of the Science and Its Associated Principles." Federal Register II, Office of Science and Technology Policy.
20. Peto R, Pike MC, Day NE, Gray RG, Lee PN, Parish S, Peto J, Richards S, Wahrendorf J (1980). "Guidelines for Simple, Sensitive Significance Tests for Carcinogenic Effects in Long-Term Animal Experiments. Annex to: Long-term and Short-term Screening Assays for Carcinogens: a Critical Appraisal." IARC Monographs, Supplement 2, International Agency for Research on Cancer, Lyon, France.
21. STP Peto Analysis Working Group (2001). "The Society of Toxicologie Pathology's Position on Statistical Methods for Rodent Carcinogenicity Studies." Toxicological Pathology, 29, 670-672.
22. STP Peto Analysis Working Group (2002). "The Society of Toxicologie Pathology's Recommendations on Statistical Analysis of Rodent Carcinogenicity Studies." Toxicological Pathology, 30, 415-418.
23. US Food and Drug Administration (2001). "Guidance for Industry: Statistical Aspects of the Design, Analysis, and Interpretation of Chronic Rodent Carcinogenicity Studies of Pharmaceuticals." Federal Register, 66, 23266-23267.
24. Woodruff RS (1971). "A Simple Method for Approximating the Variance of a Complicated Estimate." Journal of the American Statistical Association, 66, 411-414.