Recurrence of proteinuria 10 years post-transplant in NPHS2-associated focal segmental glomerulosclerosis after conversion from cyclosporin A to sirolimus

Pediatric Nephrology

Volumn 21, Issue 10, 2006, Pages 1476-1479

  Höcker, Britta ^a   Knüppel, Tanja ^a   Waldherr, Rüdiger ^b   Schaefer, Franz ^a   Weber, Stefanie ^a   Tönshoff, Burkhard ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Group Practice of Pathology   (Germany)

Author keywords

Cyclosporin A; Focal segmental glomerulosclerosis; Nephrotic syndrome; NPHS2 gene; Podocin; Proteinuria; Sirolimus

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; LYMPHOCYTE ANTIBODY; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PODOCIN; PREDNISONE; RAPAMYCIN;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; CASE REPORT; DRUG RESPONSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; FOCAL GLOMERULOSCLEROSIS; GENE MUTATION; GRAFT RECIPIENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; NEPHROTIC SYNDROME; NEPHROTOXICITY; PERITONEAL DIALYSIS; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEINURIA; RECURRENCE RISK; THERAPY RESISTANCE;

ADOLESCENT; CYCLOSPORINE; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; LIVING DONORS; MEMBRANE PROTEINS; MUTATION; NEPHROTIC SYNDROME; PROTEINURIA; RECURRENCE; RENAL INSUFFICIENCY; RISK FACTORS; SIROLIMUS; TIME FACTORS;

EID: 33747845291     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-006-0148-9     Document Type: Article

References (12)

1. Vincenti F, Ghiggeri GM (2005) New insights into the pathogenesis and the therapy of recurrent focal glomerulosclerosis. Am J Transplant 5:1179-1185
2. Weber S, Tönshoff B (2005) Recurrence of focal-segmental glomerulosclerosis in children after renal transplantation: Clinical and genetic aspects. Transplantation 80:S128-S134
3. Schwartz GJ, Brion LP, Spitzer A (1987) The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am 34:571-590
4. Chapman JR, O'Connell PJ, Nankivell BJ (2005) Chronic renal allograft dysfunction. J Am Soc Nephrol 16:3015-3026
5. Carraro M, Caridi G, Bruschi M, Artero M, Bertelli R, Zennaro C, Musante L, Candiano G, Perfumo F, Ghiggeri GM (2002) Serum glomerular permeability activity in patients with podocin mutations (NPHS2) and steroid-resistant nephrotic syndrome. J Am Soc Nephrol 13:1946-1952
6. Shkiri H, Morelon E, Noel LH, Mamzer-Bruneel MF, Legendre C, Peraldi MN, Kreis H (2005) Unusual post-transplantation recurrence of focal segmental glomerulosclerosis which resolved with cyclosporine but not with sirolimus. Transpl Int 18:458-460
7. Callis L, Vila A, Carrera M, Nieto J (1999) Long-term effects of cyclosporine A in Alport's syndrome. Kidney Int 55:1051-1056
8. Dittrich E, Schmaldienst S, Soleiman A, Hörl WH, Pohanka E (2004) Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy. Transpl Int 17:215-220
9. Franz S, Faul C, Mundel PJ (2005) Cyclosporin protects podocyte stress fibers through stabilization of synaptopodin protein expression. J Am Soc Nephrol 16:ABstract SA-FC123
10. Takeda A, Uchida K, Haba T, Tominaga Y, Katayama A, Yoshida A, Oikawa T, Morozumi K (2001) Chronic cyclosporine nephropathy: Long-term effects of cyclosporine on renal allografts. Clin Transplant 15(Suppl 5): 22-29.
11. Mihatsch MJ, Antonovych T, Bohmann SO, Habib R, Helmchen U, Noel LH, Olsen S, Sibley RK, Kemeny E, Feutren G (1994) Cyclosporin A nephropathy: Standardization of the evaluation of kidney biopsies. Clin Nephrol 41:23-32
12. Takeda A, Morozumi K, Koyama K, Yoshida A, Uchida K, Tominaga Y, Haba T, Oikawa T, Usami T, Sugito K, Takeuchi O, Fujinami T, Yokoyama I, Tagaki H (1997) Severe cyclosporine arteriolopathy with focal segmental glomerulosclerosis is not a fatal finding in chronic renal allograft failure after year 5 of transplantation using cyclosporine. Transplant Proc 29:96-99