Clinical laboratory findings associated with in-hospital mortality

Clinica Chimica Acta

Volumn 372, Issue 1-2, 2006, Pages 1-13

  ten Boekel, Edwin ^a   Vroonhof, Karen ^b   Huisman, Albert ^c   van Kampen, Corine ^a   de Kieviet, Wim ^a  

^a ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Biomarkers; Critically ill patients; In hospital mortality

Indexed keywords

ALBUMIN; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BILIRUBIN; BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; GLUCOSE; LACTIC ACID; LIPID; PEPTIDE DERIVATIVE; POTASSIUM; PROCALCITONIN; SODIUM; TROPONIN; UNCLASSIFIED DRUG;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ALBUMIN BLOOD LEVEL; APACHE; BILIRUBIN BLOOD LEVEL; BLOOD CLOTTING DISORDER; BURN; CRITICAL ILLNESS; DISEASE SEVERITY; DISORDERS OF ACID BASE BALANCE; ELECTROLYTE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HOSPITAL PATIENT; HUMAN; HYPERGLYCEMIA; HYPERLACTATEMIA; HYPOALBUMINEMIA; HYPONATREMIA; INFECTION; INFLAMMATION; INJURY; INTENSIVE CARE UNIT; LABORATORY DIAGNOSIS; LABORATORY TEST; LACTIC ACIDOSIS; LEUKOCYTE COUNT; LIPID BLOOD LEVEL; LOGISTIC REGRESSION ANALYSIS; LUNG EMBOLISM; MORTALITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REVIEW; RISK ASSESSMENT; SEPSIS; SEPTIC SHOCK; SURVIVAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

HOSPITAL MORTALITY; HUMANS; LABORATORY TECHNIQUES AND PROCEDURES;

EID: 33747836009     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2006.03.024     Document Type: Review

References (164)

1. Rocker G., Cook D., Sjokvist P., et al. Clinician predictions of intensive care unit mortality. Crit Care Med 32 (2004) 1149-1154
2. Knaus W.A., Wagner D.P., Draper E.A., et al. The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 100 (1991) 1619-1636
3. Marshall J.C., Cook D.J., Christou N.V., Bernard G.R., Sprung C.L., and Sibbald W.J. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 23 (1995) 1638-1652
4. Vincent J.L., De Mendonca A., Cantraine F., et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med 26 (1998) 1793-1800
5. den Boer S., de Keizer N.F., and de Jonge E. Performance of prognostic models in critically ill cancer patients-a review. Crit Care 9 (2005) R458-R463
6. Jones A.E., Fitch M.T., and Kline J.A. Operational performance of validated physiologic scoring systems for predicting in-hospital mortality among critically ill emergency department patients. Crit Care Med 33 (2005) 974-978
7. Oda S., Hirasawa H., Sugai T., Shiga H., Matsuda K., and Ueno H. Cellular injury score for multiple organ failure severity scoring system. J Trauma 45 (1998) 304-310
8. Vincent J.L. Lactate levels in critically ill patients. Acta Anaesthesiol Scand Suppl 107 (1995) 261-266
9. Bakker J., and de Lima A.P. Increased blood lactate levels: an important warning signal in surgical practice. Crit Care 8 (2004) 96-98
10. Maillet J.M., Le Besnerais P., Cantoni M., et al. Frequency, risk factors, and outcome of hyperlactatemia after cardiac surgery. Chest 123 (2003) 1361-1366
11. Shapiro N.I., Wolfe R.E., Moore R.B., Smith E., Burdick E., and Bates D.W. Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med 31 (2003) 670-675
12. Vroonhof K., van Solinge W.W., Rovers M.M., and Huisman A. Differences in mortality on the basis of laboratory parameters in an unselected population at the Emergency Department. Clin Chem Lab Med 43 (2005) 536-541
13. Bakker J., Gris P., Coffernils M., Kahn R.J., and Vincent J.L. Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg 171 (1996) 221-226
14. Husain F.A., Martin M.J., Mullenix P.S., Steele S.R., and Elliott D.C. Serum lactate and base deficit as predictors of mortality and morbidity. Am J Surg 185 (2003) 485-491
15. Levraut J., Ichai C., Petit I., Ciebiera J.P., Perus O., and Grimaud D. Low exogenous lactate clearance as an early predictor of mortality in normolactatemic critically ill septic patients. Crit Care Med 31 (2003) 705-710
16. Manikis P., Jankowski S., Zhang H., Kahn R.J., and Vincent J.L. Correlation of serial blood lactate levels to organ failure and mortality after trauma. Am J Emerg Med 13 (1995) 619-622
17. Abramson D., Scalea T.M., Hitchcock R., Trooskin S.Z., Henry S.M., and Greenspan J. Lactate clearance and survival following injury. J Trauma 35 (1993) 584-588
18. McNelis J., Marini C.P., Jurkiewicz A., et al. Prolonged lactate clearance is associated with increased mortality in the surgical intensive care unit. Am J Surg 182 (2001) 481-485
19. Suistomaa M., Ruokonen E., Kari A., and Takala J. Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions. Shock 14 (2000) 8-12
20. Nguyen H.B., Rivers E.P., Knoblich B.P., et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 32 (2004) 1637-1642
21. Balasubramanyan N., Havens P.L., and Hoffman G.M. Unmeasured anions identified by the Fencl-Stewart method predict mortality better than base excess, anion gap, and lactate in patients in the pediatric intensive care unit. Crit Care Med 27 (1999) 1577-1581
22. Kaplan L.J., and Kellum J.A. Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury. Crit Care Med 32 (2004) 1120-1124
23. Cusack R.J., Rhodes A., Lochhead P., et al. The strong ion gap does not have prognostic value in critically ill patients in a mixed medical/surgical adult ICU. Intensive Care Med 28 (2002) 864-869
24. Martin M., Murray J., Berne T., Demetriades D., and Belzberg H. Diagnosis of acid-base derangements and mortality prediction in the trauma intensive care unit: the physiochemical approach. J Trauma 58 (2005) 238-243
25. Rocktaeschel J., Morimatsu H., Uchino S., and Bellomo R. Unmeasured anions in critically ill patients: can they predict mortality?. Crit Care Med 31 (2003) 2131-2136
26. Omron E.M., and Gilbert R.C. Strong ion gap. Crit Care Med 33 (2005) 266-267
27. Skrifvars M.B., Pettila V., Rosenberg P.H., and Castren M. A multiple logistic regression analysis of in-hospital factors related to survival at six months in patients resuscitated from out-of-hospital ventricular fibrillation. Resuscitation 59 (2003) 319-328
28. Stevens M.S., and Dunlay R.W. Hyperkalemia in hospitalized patients. Int Urol Nephrol 32 (2000) 177-180
29. Goldberg A., Hammerman H., Petcherski S., et al. Prognostic importance of hyponatremia in acute ST-elevation myocardial infarction. Am J Med 117 (2004) 242-248
30. Klein L., O'Connor C.M., Leimberger J.D., et al. Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study. Circulation 111 (2005) 2454-2460
31. Borroni G., Maggi A., Sangiovanni A., Cazzaniga M., and Salerno F. Clinical relevance of hyponatraemia for the hospital outcome of cirrhotic patients. Dig Liver Dis 32 (2000) 605-610
32. Hochman I., Cabili S., and Peer G. Hyponatremia in internal medicine ward patients: causes, treatment and prognosis. Isr J Med Sci 25 (1989) 73-76
33. Lee C.T., Guo H.R., and Chen J.B. Hyponatremia in the emergency department. Am J Emerg Med 18 (2000) 264-268
34. Nzerue C.M., Baffoe-Bonnie H., You W., Falana B., and Dai S. Predictors of outcome in hospitalized patients with severe hyponatremia. J Natl Med Assoc 95 (2003) 335-343
35. Nicholson J.P., Wolmarans M.R., and Park G.R. The role of albumin in critical illness. Br J Anaesth 85 (2000) 599-610
36. Vincent J.L., Dubois M.J., Navickis R.J., and Wilkes M.M. Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials. Ann Surg 237 (2003) 319-334
37. Sung J., Bochicchio G.V., Joshi M., et al. Admission serum albumin is predictive of outcome in critically ill trauma patients. Am Surg 70 (2004) 1099-1102
38. Yukl R.L., Bar-Or D., Harris L., Shapiro H., and Winkler J.V. Low albumin level in the emergency department: a potential independent predictor of delayed mortality in blunt trauma. J Emerg Med 25 (2003) 1-6
39. Reinhardt G.F., Myscofski J.W., Wilkens D.B., Dobrin P.B., Mangan Jr. J.E., and Stannard R.T. Incidence and mortality of hypoalbuminemic patients in hospitalized veterans. JPEN J Parenter Enteral Nutr 4 (1980) 357-359
40. McCluskey A., Thomas A.N., Bowles B.J., and Kishen R. The prognostic value of serial measurements of serum albumin concentration in patients admitted to an intensive care unit. Anaesthesia 51 (1996) 724-727
41. Yap F.H., Joynt G.M., Buckley T.A., and Wong E.L. Association of serum albumin concentration and mortality risk in critically ill patients. Anaesth Intensive Care 30 (2002) 202-207
42. Blunt M.C., Nicholson J.P., and Park G.R. Serum albumin and colloid osmotic pressure in survivors and nonsurvivors of prolonged critical illness. Anaesthesia 53 (1998) 755-761
43. Vanhorebeek I., Langouche L., and Van den B.G. Glycemic and nonglycemic effects of insulin: how do they contribute to a better outcome of critical illness?. Curr Opin Crit Care 11 (2005) 304-311
44. Capes S.E., Hunt D., Malmberg K., and Gerstein H.C. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 355 (2000) 773-778
45. Capes S.E., Hunt D., Malmberg K., Pathak P., and Gerstein H.C. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 32 (2001) 2426-2432
46. Umpierrez G.E., Isaacs S.D., Bazargan N., You X., Thaler L.M., and Kitabchi A.E. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab 87 (2002) 978-982
47. Pickkers P., Hoedemaekers A., Netea M.G., et al. Hypothesis: Normalisation of cytokine dysbalance explains the favourable effects of strict glucose regulation in the critically ill. Neth J Med 62 (2004) 143-150
48. Laird A.M., Miller P.R., Kilgo P.D., Meredith J.W., and Chang M.C. Relationship of early hyperglycemia to mortality in trauma patients. J Trauma 56 (2004) 1058-1062
49. Yendamuri S., Fulda G.J., and Tinkoff G.H. Admission hyperglycemia as a prognostic indicator in trauma. J Trauma 55 (2003) 33-38
50. Van den Berghe G., Wouters P., Weekers F., et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 345 (2001) 1359-1367
51. Van den Berghe G., Wilmer A., Hermans G., Meersseman W., Wouters P.J., and Milants I.R.N. Intensive insulin therapy in the medical ICU. N Engl J Med 354 (2006) 449-461
52. Lind L., and Lithell H. Impaired glucose and lipid metabolism seen in intensive care patients is related to severity of illness and survival. Clin Intensive Care 5 (1994) 100-105
53. Mesotten D., Swinnen J.V., Vanderhoydonc F., Wouters P.J., and Van den B.G. Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab 89 (2004) 219-226
54. Hansen T.K., Thiel S., Wouters P.J., Christiansen J.S., and Van den B.G. Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab 88 (2003) 1082-1088
55. Afessa B., Keegan M.T., Gajic O., Hubmayr R.D., and Peters S.G. The influence of missing components of the Acute Physiology Score of APACHE III on the measurement of ICU performance. Intensive Care Med 31 (2005) 1537-1543
56. Harbrecht B.G., Doyle H.R., Clancy K.D., Townsend R.N., Billiar T.R., and Peitzman A.B. The impact of liver dysfunction on outcome in patients with multiple injuries. Am Surg 67 (2001) 122-126
57. Hosotsubo K.K., Nishimura M., and Nishimura S. Hyperbilirubinaemia after major thoracic surgery: comparison between open-heart surgery and oesophagectomy. Crit Care 4 (2000) 180-187
58. Antman E.M., Tanasijevic M.J., Thompson B., et al. Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med 335 (1996) 1342-1349
59. Giannitsis E., Muller-Bardorff M., Lehrke S., et al. Admission troponin T level predicts clinical outcomes, TIMI flow, and myocardial tissue perfusion after primary percutaneous intervention for acute ST-segment elevation myocardial infarction. Circulation 104 (2001) 630-635
60. Morrow D.A., Rifai N., Tanasijevic M.J., Wybenga D.R., de Lemos J.A., and Antman E.M. Clinical efficacy of three assays for cardiac troponin I for risk stratification in acute coronary syndromes: a Thrombolysis In Myocardial Infarction (TIMI) 11B Substudy. Clin Chem 46 (2000) 453-460
61. Ohman E.M., Armstrong P.W., Christenson R.H., et al. Cardiac troponin T levels for risk stratification in acute myocardial ischemia. GUSTO IIA Investigators. N Engl J Med 335 (1996) 1333-1341
62. Jeremias A., and Gibson C.M. Narrative review: alternative causes for elevated cardiac troponin levels when acute coronary syndromes are excluded. Ann Intern Med 142 (2005) 786-791
63. Ammann P., Maggiorini M., Bertel O., et al. Troponin as a risk factor for mortality in critically ill patients without acute coronary syndromes. J Am Coll Cardiol 41 (2003) 2004-2009
64. Guest T.M., Ramanathan A.V., Tuteur P.G., Schechtman K.B., Ladenson J.H., and Jaffe A.S. Myocardial injury in critically ill patients. A frequently unrecognized complication. JAMA 273 (1995) 1945-1949
65. King D.A., Codish S., Novack V., Barski L., and Almog Y. The role of cardiac troponin I as a prognosticator in critically ill medical patients: a prospective observational cohort study. Crit Care 9 (2005) R390-R395
66. Kollef M.H., Ladenson J.H., and Eisenberg P.R. Clinically recognized cardiac dysfunction: an independent determinant of mortality among critically ill patients. Is there a role for serial measurement of cardiac troponin I?. Chest 111 (1997) 1340-1347
67. Landesberg G., Vesselov Y., Einav S., Goodman S., Sprung C.L., and Weissman C. Myocardial ischemia, cardiac troponin, and long-term survival of high-cardiac risk critically ill intensive care unit patients. Crit Care Med 33 (2005) 1281-1287
68. Lim W., Qushmaq I., Cook D.J., Crowther M.A., Heels-Ansdell D., and Devereaux P. Elevated troponin and myocardial infarction in the intensive care unit: a prospective study. Crit Care 9 (2005) R636-R644
69. Quenot J.P., Le Teuff G., Quantin C., et al. Myocardial injury in critically ill patients: relation to increased cardiac troponin I and hospital mortality. Chest 128 (2005) 2758-2764
70. Relos R.P., Hasinoff I.K., and Beilman G.J. Moderately elevated serum troponin concentrations are associated with increased morbidity and mortality rates in surgical intensive care unit patients. Crit Care Med 31 (2003) 2598-2603
71. Wu T.T., Yuan A., Chen C.Y., et al. Cardiac troponin I levels are a risk factor for mortality and multiple organ failure in noncardiac critically ill patients and have an additive effect to the APACHE II score in outcome prediction. Shock 22 (2004) 95-101
72. Gudmundsson G.S., Kahn S.E., and Moran J.F. Association of mild transient elevation of troponin I levels with increased mortality and major cardiovascular events in the general patient population. Arch Pathol Lab Med 129 (2005) 474-480
73. Ammann P., Fehr T., Minder E.I., Gunter C., and Bertel O. Elevation of troponin I in sepsis and septic shock. Intensive Care Med 27 (2001) 965-969
74. Mehta N.J., Khan I.A., Gupta V., Jani K., Gowda R.M., and Smith P.R. Cardiac troponin I predicts myocardial dysfunction and adverse outcome in septic shock. Int J Cardiol 95 (2004) 13-17
75. Spies C., Haude V., Fitzner R., et al. Serum cardiac troponin T as a prognostic marker in early sepsis. Chest 113 (1998) 1055-1063
76. Turner A., Tsamitros M., and Bellomo R. Myocardial cell injury in septic shock. Crit Care Med 27 (1999) 1775-1780
77. ver Elst K.M., Spapen H.D., Nguyen D.N., Garbar C., Huyghens L.P., and Gorus F.K. Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock. Clin Chem 46 (2000) 650-657
78. Booker K.J., Holm K., Drew B.J., et al. Frequency and outcomes of transient myocardial ischemia in critically ill adults admitted for noncardiac conditions. Am J Crit Care 12 (2003) 508-516
79. Kucher N., and Goldhaber S.Z. Cardiac biomarkers for risk stratification of patients with acute pulmonary embolism. Circulation 108 (2003) 2191-2194
80. Douketis J.D., Leeuwenkamp O., Grobara P., et al. The incidence and prognostic significance of elevated cardiac troponins in patients with submassive pulmonary embolism. J Thromb Haemost 3 (2005) 508-513
81. Giannitsis E., Muller-Bardorff M., Kurowski V., et al. Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism. Circulation 102 (2000) 211-217
82. Konstantinides S., Geibel A., Olschewski M., et al. Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism. Circulation 106 (2002) 1263-1268
83. La Vecchia L., Ottani F., Favero L., et al. Increased cardiac troponin I on admission predicts in-hospital mortality in acute pulmonary embolism. Heart 90 (2004) 633-637
84. Pruszczyk P., Kostrubiec M., Bochowicz A., et al. N-terminal pro-brain natriuretic peptide in patients with acute pulmonary embolism. Eur Respir J 22 (2003) 649-653
85. Kucher N., Wallmann D., Carone A., Windecker S., Meier B., and Hess O.M. Incremental prognostic value of troponin I and echocardiography in patients with acute pulmonary embolism. Eur Heart J 24 (2003) 1651-1656
86. Scridon T., Scridon C., Skali H., Alvarez A., Goldhaber S.Z., and Solomon S.D. Prognostic significance of troponin elevation and right ventricular enlargement in acute pulmonary embolism. Am J Cardiol 96 (2005) 303-305
87. Edouard A.R., Felten M.L., Hebert J.L., Cosson C., Martin L., and Benhamou D. Incidence and significance of cardiac troponin I release in severe trauma patients. Anesthesiology 101 (2004) 1262-1268
88. Martin M., Mullenix P., Rhee P., Belzberg H., Demetriades D., and Salim A. Troponin increases in the critically injured patient: mechanical trauma or physiologic stress?. J Trauma 59 (2005) 1086-1091
89. Tung R.H., Garcia C., Morss A.M., et al. Utility of B-type natriuretic peptide for the evaluation of intensive care unit shock. Crit Care Med 32 (2004) 1643-1647
90. Brueckmann M., Huhle G., Lang S., et al. Prognostic value of plasma N-terminal pro-brain natriuretic peptide in patients with severe sepsis. Circulation 112 (2005) 527-534
91. Charpentier J., Luyt C.E., Fulla Y., et al. Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis. Crit Care Med 32 (2004) 660-665
92. Roch A., Allardet-Servent J., Michelet P., et al. NH2 terminal pro-brain natriuretic peptide plasma level as an early marker of prognosis and cardiac dysfunction in septic shock patients. Crit Care Med 33 (2005) 1001-1007
93. Cuthbertson B.H., Patel R.R., Croal B.L., Barclay J., and Hillis G.S. B-type natriuretic peptide and the prediction of outcome in patients admitted to intensive care. Anaesthesia 60 (2005) 16-21
94. Jefic D., Lee J.W., Jefic D., Savoy-Moore R.T., and Rosman H.S. Utility of B-type natriuretic peptide and N-terminal pro B-type natriuretic peptide in evaluation of respiratory failure in critically ill patients. Chest 128 (2005) 288-295
95. Witthaut R., Busch C., Fraunberger P., et al. Plasma atrial natriuretic peptide and brain natriuretic peptide are increased in septic shock: impact of interleukin-6 and sepsis-associated left ventricular dysfunction. Intensive Care Med 29 (2003) 1696-1702
96. Galvani M., Ottani F., Oltrona L., et al. N-terminal pro-brain natriuretic peptide on admission has prognostic value across the whole spectrum of acute coronary syndromes. Circulation 110 (2004) 128-134
97. James S.K., Lindahl B., Siegbahn A., et al. N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open occluded arteries (GUSTO)-IV substudy. Circulation 108 (2003) 275-281
98. Mega J.L., Morrow D.A., de Lemos J.A., et al. B-type natriuretic peptide at presentation and prognosis in patients with ST-segment elevation myocardial infarction: an ENTIRE-TIMI-23 substudy. J Am Coll Cardiol 44 (2004) 335-339
99. Morrow D.A., de Lemos J.A., Sabatine M.S., et al. Evaluation of B-type natriuretic peptide for risk assessment in unstable angina/non-ST-elevation myocardial infarction: B-type natriuretic peptide and prognosis in TACTICS-TIMI 18. J Am Coll Cardiol 41 (2003) 1264-1272
100. Sabatine M.S., Morrow D.A., de Lemos J.A., et al. Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: simultaneous assessment of troponin I, C-reactive protein, and B-type natriuretic peptide. Circulation 105 (2002) 1760-1763
101. Kellett J. The prediction of in-hospital mortality by amino terminal pro-brain natriuretic peptide (NT-proBNP) levels and other independent variables in acutely ill patients with suspected heart disease. Eur J Intern Med 16 (2005) 195-199
102. Heeschen C., Hamm C.W., Mitrovic V., Lantelme N.H., and White H.D. N-terminal pro-B-type natriuretic peptide levels for dynamic risk stratification of patients with acute coronary syndromes. Circulation 110 (2004) 3206-3212
103. Sabatine M.S., Morrow D.A., de Lemos J.A., et al. Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia. J Am Coll Cardiol 44 (2004) 1988-1995
104. Friedman G., Silva E., and Vincent J.L. Has the mortality of septic shock changed with time. Crit Care Med 26 (1998) 2078-2086
105. Dellinger R.P., Carlet J.M., Masur H., et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 32 (2004) 858-873
106. Meisner M. Biomarkers of sepsis: clinically useful?. Curr Opin Crit Care 11 (2005) 473-480
107. Castelli G.P., Pognani C., Meisner M., Stuani A., Bellomi D., and Sgarbi L. Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction. Crit Care 8 (2004) R234-R242
108. Lobo S.M., Lobo F.R., Bota D.P., et al. C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest 123 (2003) 2043-2049
109. Luzzani A., Polati E., Dorizzi R., Rungatscher A., Pavan R., and Merlini A. Comparison of procalcitonin and C-reactive protein as markers of sepsis. Crit Care Med 31 (2003) 1737-1741
110. Meisner M., Tschaikowsky K., Palmaers T., and Schmidt J. Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS. Crit Care (Lond) 3 (1999) 45-50
111. Meisner M., Adina H., and Schmidt J. Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients. Crit Care 10 (2005) R1
112. Claeys R., Vinken S., Spapen H., et al. Plasma procalcitonin and C-reactive protein in acute septic shock: clinical and biological correlates. Crit Care Med 30 (2002) 757-762
113. Morgenthaler N.G., Struck J., Christ-Crain M., Bergmann A., and Muller B. Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study. Crit Care 9 (2005) R37-R45
114. Pettila V., Pentti J., Pettila M., Takkunen O., and Jousela I. Predictive value of antithrombin III and serum C-reactive protein concentration in critically ill patients with suspected sepsis. Crit Care Med 30 (2002) 271-275
115. Reny J.L., Vuagnat A., Ract C., Benoit M.O., Safar M., and Fagon J.Y. Diagnosis and follow-up of infections in intensive care patients: value of C-reactive protein compared with other clinical and biological variables. Crit Care Med 30 (2002) 529-535
116. Clec'h C., Ferriere F., Karoubi P., et al. Diagnostic and prognostic value of procalcitonin in patients with septic shock. Crit Care Med 32 (2004) 1166-1169
117. Harbarth S., Holeckova K., Froidevaux C., et al. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 164 (2001) 396-402
118. Pettila V., Hynninen M., Takkunen O., Kuusela P., and Valtonen M. Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis. Intensive Care Med 28 (2002) 1220-1225
119. Oberhoffer M., Vogelsang H., Russwurm S., Hartung T., and Reinhart K. Outcome prediction by traditional and new markers of inflammation in patients with sepsis. Clin Chem Lab Med 37 (1999) 363-368
120. Waheed U., Williams P., Brett S., Baldock G., and Soni N. White cell count and intensive care unit outcome. Anaesthesia 58 (2003) 180-182
121. Benoit D.D., Vandewoude K.H., Decruyenaere J.M., Hoste E.A., and Colardyn F.A. Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication. Crit Care Med 31 (2003) 104-112
122. Georges H., Leroy O., Vandenbussche C., et al. Epidemiological features and prognosis of severe community-acquired pneumococcal pneumonia. Intensive Care Med 25 (1999) 198-206
123. Kazmierski R., Guzik P., Ambrosius W., Ciesielska A., Moskal J., and Kozubski W. Predictive value of white blood cell count on admission for in-hospital mortality in acute stroke patients. Clin Neurol Neurosurg 107 (2004) 38-43
124. Barron H.V., Harr S.D., Radford M.J., Wang Y., and Krumholz H.M. The association between white blood cell count and acute myocardial infarction mortality in patients > or = 65 years of age: findings from the cooperative cardiovascular project. J Am Coll Cardiol 38 (2001) 1654-1661
125. Cannon CP, McCabe CH, Wilcox RG, Bentley JH, Braunwald E. Association of white blood cell count with increased mortality in acute myocardial infarction and unstable angina pectoris. OPUS-TIMI 16 Investigators Am J Cardiol 2001;87:636-9, A10.
126. Furman M.I., Gore J.M., Anderson F.A., et al. Elevated leukocyte count and adverse hospital events in patients with acute coronary syndromes: findings from the Global Registry of Acute Coronary Events (GRACE). Am Heart J 147 (2004) 42-48
127. Menon V., Lessard D., Yarzebski J., Furman M.I., Gore J.M., and Goldberg R.J. Leukocytosis and adverse hospital outcomes after acute myocardial infarction. Am J Cardiol 92 (2003) 368-372
128. Krumholz H.M., Chen J., Wang Y., Radford M.J., Chen Y.T., and Marciniak T.A. Comparing AMI mortality among hospitals in patients 65 years of age and older: evaluating methods of risk adjustment. Circulation 99 (1999) 2986-2992
129. Elliott D.C., and Wiles III C.E. Low lipid concentrations in critical illness: hypocholesterolemia among trauma patients. Crit Care Med 25 (1997) 1437-1439
130. Fraunberger P., Nagel D., Walli A.K., and Seidel D. Serum cholesterol and mortality in patients with multiple organ failure. Crit Care Med 28 (2000) 3574-3575
131. Gordon B.R., Parker T.S., Levine D.M., et al. Low lipid concentrations in critical illness: implications for preventing and treating endotoxemia. Crit Care Med 24 (1996) 584-589
132. Kitchens R.L., Thompson P.A., Munford R.S., and O'Keefe G.E. Acute inflammation and infection maintain circulating phospholipid levels and enhance lipopolysaccharide binding to plasma lipoproteins. J Lipid Res 44 (2003) 2339-2348
133. Delgado-Rodriguez M., Medina-Cuadros M., Gomez-Ortega A., et al. Cholesterol and serum albumin levels as predictors of cross infection, death, and length of hospital stay. Arch Surg 137 (2002) 805-812
134. Dunham C.M., Fealk M.H., and Sever III W.E. Following severe injury, hypocholesterolemia improves with convalescence but persists with organ failure or onset of infection. Crit Care 7 (2003) R145-R153
135. Gordon B.R., Parker T.S., Levine D.M., et al. Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients. Crit Care Med 29 (2001) 1563-1568
136. Gui D., Spada P.L., De Gaetano A., and Pacelli F. Hypocholesterolemia and risk of death in the critically ill surgical patient. Intensive Care Med 22 (1996) 790-794
137. Windler E., Ewers-Grabow U., Thiery J., Walli A., Seidel D., and Greten H. The prognostic value of hypocholesterolemia in hospitalized patients. Clin Investig 72 (1994) 939-943
138. Onder G., Landi F., Volpato S., et al. Serum cholesterol levels and in-hospital mortality in the elderly. Am J Med 115 (2003) 265-271
139. Stachon A., Boning A., Weisser H., Laczkovics A., Skipka G., and Krieg M. Prognostic significance of low serum cholesterol after cardiothoracic surgery. Clin Chem 46 (2000) 1114-1120
140. van Leeuwen H.J., Heezius E.C., Dallinga G.M., van Strijp J.A., Verhoef J., and van Kessel K.P. Lipoprotein metabolism in patients with severe sepsis. Crit Care Med 31 (2003) 1359-1366
141. Chien J.Y., Jerng J.S., Yu C.J., and Yang P.C. Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis. Crit Care Med 33 (2005) 1688-1693
142. Vauthey C., de Freitas G.R., van Melle G., Devuyst G., and Bogousslavsky J. Better outcome after stroke with higher serum cholesterol levels. Neurology 54 (2000) 1944-1949
143. Roquer J., Rodriguez C.A., Gomis M., Ois A., Munteis E., and Bohm P. Serum lipid levels and in-hospital mortality in patients with intracerebral hemorrhage. Neurology 65 (2005) 1198-1202
144. Joseph J.A., Villalobos-Molinas R., Denisova N.A., Erat S., and Strain J. Cholesterol: a two-edged sword in brain aging. Free Radic Biol Med 22 (1997) 455-462
145. Vatassery G.T., Smith W.E., Quach H.T., and Lai J.C. In vitro oxidation of vitamin E, vitamin C, thiols and cholesterol in rat brain mitochondria incubated with free radicals. Neurochem Int 26 (1995) 527-535
146. Chenaud C., Merlani P.G., Roux-Lombard P., et al. Low apolipoprotein A-I level at intensive care unit admission and systemic inflammatory response syndrome exacerbation. Crit Care Med 32 (2004) 632-637
147. Vermont C.L., den Brinker M., Kakeci N., et al. Serum lipids and disease severity in children with severe meningococcal sepsis. Crit Care Med 33 (2005) 1610-1615
148. Khovidhunkit W., Kim M.S., Memon R.A., et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res 45 (2004) 1169-1196
149. Hyka N., Dayer J.M., Modoux C., et al. Apolipoprotein A-I inhibits the production of interleukin-1beta and tumor necrosis factor-alpha by blocking contact-mediated activation of monocytes by T lymphocytes. Blood 97 (2001) 2381-2389
150. Levi M. Disseminated intravascular coagulation: What's new?. Crit Care Clin 21 (2005) 449-467
151. Kollef M.H., Eisenberg P.R., and Shannon W. A rapid assay for the detection of circulating D-dimer is associated with clinical outcomes among critically ill patients. Crit Care Med 26 (1998) 1054-1060
152. Shorr A.F., Trotta R.F., Alkins S.A., Hanzel G.S., and Diehl L.F. D-dimer assay predicts mortality in critically ill patients without disseminated intravascular coagulation or venous thromboembolic disease. Intensive Care Med 25 (1999) 207-210
153. Shorr A.F., Thomas S.J., Alkins S.A., Fitzpatrick T.M., and Ling G.S. D-dimer correlates with proinflammatory cytokine levels and outcomes in critically ill patients. Chest 121 (2002) 1262-1268
154. ten Boekel E., de Kieviet W., and Bartels P.C. Subjects with a shortened activated partial thromboplastin time show increased in-hospital mortality associated with elevated D-dimer, C-reactive protein and glucose levels. Scand J Clin Lab Invest 63 (2003) 441-448
155. Shitrit D., Izbicki G., Shitrit A.B., et al. Prognostic value of a new quantitative D-dimer test in critically ill patients 24 and 48 h following admission to the intensive care unit. Blood Coagul Fibrinolysis 15 (2004) 15-19
156. Querol-Ribelles J.M., Tenias J.M., Grau E., et al. Plasma D-dimer levels correlate with outcomes in patients with community-acquired pneumonia. Chest 126 (2004) 1087-1092
157. Bakhtiari K., Meijers J.C., de Jonge E., and Levi M. Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med 32 (2004) 2416-2421
158. Sivula M., Tallgren M., and Pettila V. Modified score for disseminated intravascular coagulation in the critically ill. Intensive Care Med 31 (2005) 1209-1214
159. Dhainaut J.F., Shorr A.F., Macias W.L., et al. Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure. Crit Care Med 33 (2005) 341-348
160. Kinasewitz G.T., Zein J.G., Lee G.L., Nazir S.A., and Taylor Jr. F.B. Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis. Crit Care Med 33 (2005) 2214-2221
161. MacLeod J., Lynn M., McKenney M.G., Jeroukhimov I., and Cohn S.M. Predictors of mortality in trauma patients. Am Surg 70 (2004) 805-810
162. Toh C.H., Samis J., Downey C., et al. Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca(+)-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation. Blood 100 (2002) 2522-2529
163. Toh C.H., Ticknor L.O., Downey C., Giles A.R., Paton R.C., and Wenstone R. Early identification of sepsis and mortality risks through simple, rapid clot-waveform analysis. Implications of lipoprotein-complexed C reactive protein formation. Intensive Care Med 29 (2003) 55-61
164. Perkins G.D., McAuley D.F., Davies S., and Gao F. Discrepancies between clinical and postmortem diagnoses in critically ill patients: an observational study. Crit Care 7 (2003) R129-R132