What are the long-term effects of neural grafting in patients with Huntington's disease? Commentary

Nature Clinical Practice Neurology

Volumn 2, Issue 9, 2006, Pages 470-471

  Isacson, Ole ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MCLEAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN FUNCTION; BRAIN METABOLISM; CELL TRANSPLANTATION; CHOREA; CLINICAL ARTICLE; COGNITION; CORPUS STRIATUM; DATA ANALYSIS; DETERIORATION; DYSTONIA; ELECTRONEUROLOGY; FETUS CELL; FOLLOW UP; FRONTAL CORTEX; GENERAL CONDITION IMPROVEMENT; HUMAN; HUNTINGTON CHOREA; IMAGE ANALYSIS; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROBLAST; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT MONITORING; PILOT STUDY; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; RATING SCALE; SHORT SURVEY;

EID: 33747806936     PISSN: 1745834X     EISSN: 17458358     Source Type: Journal    
DOI: 10.1038/ncpneuro0264     Document Type: Short Survey

References (5)

1. Seo H et al. (2004) Generalized brain and skin proteasome inhibition in Huntington's disease. Ann Neurol 56: 319-328
2. Zuccato C et al. (2001) Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science 293: 493-498
3. Levivier M et al. (1995) Time course of the neuroprotective effect of transplantation on quinolinic acid-induced lesions of the striatum. Neuroscience 69: 43-60
4. Bachoud-Lévi AC et al. (2000) Motor and cognitive improvements in patients with Huntington's disease after neural transplantation. Lancet 356: 1975-1979
5. Freeman TB et al. (2000) Transplanted fetal striatum in Huntington's disease: Phenotypic development and lack of pathology. Proc Natl Acad Sci USA 97: 13877-13882