Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease

Neurobiology of Aging

Volumn 27, Issue 10, 2006, Pages 1440-1444

  Ozturk, Ayla ^a   DeKosky, Steven T ^a,b   Kamboh, M Ilyas ^a,b  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Age at onset; Alzheimer's disease; CHAT; Genetics; MMSE

Indexed keywords

CHOLINE ACETYLTRANSFERASE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; ONSET AGE; PRIORITY JOURNAL; RISK FACTOR; SAMPLE;

AGE FACTORS; AGED; ALZHEIMER DISEASE; CHOLINE O-ACETYLTRANSFERASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HETEROZYGOTE; HUMANS; INCIDENCE; MALE; PENNSYLVANIA; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; VARIATION (GENETICS);

EID: 33747773695     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2005.08.024     Document Type: Article

References (19)

1. Bartus R.T., Dean III R.L., Beer B., and Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 217 (1982) 408-414
2. Bertram L., Blacker D., Mullin K., Keeney D., Jones J., Basu S., et al. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science 290 (2000) 2302-2303
3. Cook L.J., Ho L.W., Wang L., Terrenoire E., Brayne C., Evans J.G., et al. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. Am J Med Genet (B Neuropsychiatr Genet) 132 (2005) 5-8
4. Ertekin-Taner N., Graff-Radford N., Younkin L.H., Eckman C., Baker M., Adamson J., et al. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science 290 (2000) 2303-2304
5. Harold D., Peirce T., Moskvina V., Myers A., Jones S., Hollingworth P., et al. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Hum Genet 113 (2003) 258-267
6. Ihaka G. A language for data analysis and graphics. J Comp Graphic Stat 5 (1996) 299-314
7. Kamboh M.I. Molecular genetics of late-onset Alzheimer's disease. Ann Hum Genet 68 (2004) 381-404
8. Kim K.W., Suh Y.J., Park W.Y., Jhoo J.H., Lee D.Y., Youn J.C., et al. Choline acetyltransferase G + 4 A polymorphism confers a risk for Alzheimer's disease in concert with Apolipoprotein E epsilon4. Neurosci Lett 366 (2004) 182-186
9. Lewontin R. The interaction of selection and linkage I: general considerations, hetorotic models. Genetics 49 (1964) 49-67
10. Li Y.J., Scott W.K., Hedges D.J., Zhang F., Gaskell P.C., Nance M.A., et al. Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet 70 (2002) 985-993
11. McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 (1984) 939-944
12. Mubumbila V., Sutter A., Ptok U., Heun R., and Quirin-Stricker C. Identification of a single nucleotide polymorphism in the choline acetyltransferase gene associated with Alzheimer's disease. Neurosci Lett 333 (2002) 9-12
13. Myers A., Wavrant De-Vrieze F., Holmans P., Holmans P., Hamshere M., Crook R., et al. Full genome screen for Alzheimer disease: stage II analysis. Am J Med Genet 114 (2002) 235-244
14. Oda Y. Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. Pathol Int 49 (1999) 921-937
15. Schwarz S., Eisele T., Diehl J., Muller U., Forstl H., Kurz A., et al. Lack of association between a single nucleotide polymorphism within the choline acetyltransferase gene and patients with Alzheimer's disease. Neurosci Lett 343 (2003) 167-170
16. Seshadri S., Drachman D.A., and Lippa C.F. Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know. Arch Neurol 52 (1995) 1074-1079
17. Slooter A.J., Cruts M., Kalmijn S., Kalmijn S., Hoffman A., Breteler M.M., et al. Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study. Arch Neurol 55 (1998) 964-968
18. Wang X., DeKosky S.T., Luedecking-Zimmer E., Ganguli M., and Kamboh I.M. Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's disease. Hum Genet 110 (2002) 356-365
19. Wilcock G.K., Esiri M.M., Bowen D.M., and Smith C.C. Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities. J Neurol Sci 57 (1982) 407-417