Does hemophilia protect against atherosclerosis? A case-control study

Clinical and Applied Thrombosis/Hemostasis

Volumn 12, Issue 2, 2006, Pages 193-198

  Bilora, Franca ^a   Zanon, Ezio ^a   Petrobelli, Francesco ^a   Cavraro, Monica ^a   Prandoni, Paolo ^a   Pagnan, Antonio ^a   Girolami, Antonio ^a  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

Author keywords

Atherosclerosis; FVIII; Hemophilia; Ultrasound

Indexed keywords

BLOOD CLOTTING FACTOR 8;

ABDOMINAL AORTA; ADULT; ARTERY INTIMA; ARTERY MEDIA; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD CLOTTING; BRACHIAL ARTERY; CAROTID ARTERY; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; FEMORAL ARTERY; HEMOPHILIA; HUMAN; MALE; PRIORITY JOURNAL; PROTECTION; ARTERY; COMORBIDITY; DOPPLER ECHOCARDIOGRAPHY; ECHOGRAPHY; HEMOPHILIA A; INCIDENCE; MIDDLE AGED; PHYSIOLOGY;

ADULT; ARTERIES; ATHEROSCLEROSIS; CASE-CONTROL STUDIES; COMORBIDITY; ECHOCARDIOGRAPHY, DOPPLER, COLOR; FACTOR VIII; HEMOPHILIA A; HUMANS; INCIDENCE; MIDDLE AGED;

EID: 33747768257     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/107602960601200207     Document Type: Article

References (11)

1. Sramek A, Reiber JHC, Gerrits WBJ, Rosendaal FR. Decreased coagulability has no clinically relevant effect on atherogenesis. Observation in individuals with hereditary bleeding tendency. Circulation 2001;104:762.
2. Bilora F, Dei Rossi C, Girolami B, et al. Do hemophilia A and von Willebrand disease protect against atherosclerosis? A comparative study between coagulopathics and normal subjects by means of carotid echo color Doppler scan. Clin Appl Thromb Hemost 1999;5:232.
3. Bilora F, Boccioletti V, Zanon E, et al. Haemophilia A, von Willebrand disease and atherosclerosis of abdominal aorta and leg arteries: Factor VIII and von Willebrand factor defects appear to protect abdominal aorta and leg arteries from atherosclerosis. Clin Appl Thromb Hemost 2001;7:311.
4. Sramek A, Bucciarelli P, Federici AB, et al. Patients with type 3 severe von Willebrand disease are not protected against atherosclerosis: Results from a multicenter study in 47 patients. Circulation 2004;109:740.
5. Coleman RW, et al. (eds). Hemostasis and Thrombosis: Basic Principles and Clinical Practice, ed 3. Philadelphia: Lippincott, 1994:1134.
6. Carpenter JP, Lexa FJ, Davis JT, RN, RVT. Determination of duplex Doppler ultrasound criteria appropriate to the North American Symptomatic Carotid Endoarteriectomy Trial. Stroke 1996;27(4):695.
7. Temelkova-Kurktschiev T, Fisher S, Koehler C, et al. Intima media thickness in healthy probands without risk factors for atherosclerosis. Dtsch Med Wochenschr 2001;126(8):193.
8. Schmitz-Huebner U, Thompson SG, Belleisen L. Lack of association between hemostatic variables and the presence or extent of coronary atherosclerosis. Br Heart J 1988;59:287.
9. Conlan MG, Folsom AR, Finch A, et al. Association of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The atherosclerostic Risk in communities (ARIC) Study. Thromb Haemost 1993;70(3):380.
10. Methia N, André P, Denis CV, et al. Localized reduction of atherosclerosis in von Willebrand factor deficient mice. Blood 2001;98:1424.
11. Qin F, Impeduglia T, Schaffer P, Darik H. Overexpression of von Willebrand factor is an indipendent risk factor for pathogenesis of intimal hyperplasia: Preliminary studies. J Vasc Surg 2003;37:433.