Isolation and structural elucidation of tiamulin metabolites formed in liver microsomes of pigs

Journal of Pharmaceutical and Biomedical Analysis

Volumn 42, Issue 2, 2006, Pages 223-231

  Lykkeberg, Anne Kruse ^a   Cornett, Claus ^a   Halling Sørensen, Bent ^a   Hansen, Steen Honoré ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

LC MS; Liver microsomes; Metabolism; N deethyl tiamulin; NMR; Swine; Tiamulin

Indexed keywords

2BETA HYDROXY N DEETHYLTIAMULIN; 2BETA HYDROXYTIAMULIN; 8ALPHA HYDROXY N DEETHYLTIAMULIN; 8ALPHA HYDROXYTIAMULIN; DRUG METABOLITE; N DEETHYLTIAMULIN; PERCHLORIC ACID; TIAMULIN; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG METABOLISM; DRUG PURIFICATION; DRUG STRUCTURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; LIVER MICROSOME; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; SOLID PHASE EXTRACTION; SWINE; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DITERPENES; FEMALE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NADP; SWINE;

EID: 33747767215     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.03.023     Document Type: Article

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