Development of a gradient elution preparative high performance liquid chromatography method for the recovery of the antibiotic ertapenem from crystallization process streams

Journal of Chromatography A

Volumn 1126, Issue 1-2, 2006, Pages 365-372

  Sajonz, Peter ^a   Vailaya, Anant ^a   Sudah, Osama ^a   McPherson, Lynette ^a   Capodanno, Vincent ^a   Natishan, Theresa K ^a   Helmy, Roy ^a   Antia, Firoz D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antibiotics; Carbapenem; Ertapenem; Preparative chromatography; Process streams; Product recovery; Scale up

Indexed keywords

ACETIC ACID; ANTIBIOTICS; CHROMATOGRAPHY; CRYSTALLIZATION; IMPURITIES; YIELD STRESS;

CARBAPENEM; ERTAPENEM; PREPARATIVE CHROMATOGRAPHY; PROCESS STREAMS; PRODUCT RECOVERY;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ACETIC ACID; ACETONITRILE; ANTIBIOTIC AGENT; ERTAPENEM;

AQUEOUS SOLUTION; ARTICLE; CHROMATOGRAPHY; CRYSTALLIZATION; ELUTION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PRODUCTIVITY;

BETA-LACTAMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; DRUG INDUSTRY;

EID: 33747758794     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2006.04.077     Document Type: Article

References (25)

1. Vailaya A., Sajonz P., Sudah O., Capodanno V., Helmy R., and Antia F.D. J. Chromatogr. A 1079 (2005) 80
2. Prescribing Information for Invanz, Merck & Co. Inc., Whitehouse Station, NJ, 2003.
3. Cunha B.A. Drugs Today 38 (2002) 195
4. Mouton J.W., Touw D.J., Horrevorts A.M., and Vinks A.A. Clin. Pharmacokinet. 39 (2000) 185
5. Sader H.S., and Gales A.C. Drugs 61 (2001) 553
6. Wong B.K., Bruhin P.J., and Lin J.H. J. Pharm. Sci 88 (1999) 277
7. Gesser R.M., McCarroll K., Teppler H., and Woods G.L. J. Antimicrob. Chemother. 51 (2003) 1253
8. Bonfiglio G., Russo G., and Nicoletti G. Expert Opin. Investig. Drugs 11 (2002) 529
9. Brands K.M.J., Jobson R.B., Conrad K.M., Williams J.M., Pipik B., Cameron M., Davies A.J., Houghton P.G., Ashwood M.S., Cottrell I.F., Reamer R.A., Kennedy D.J., Dolling U.-H., and Reider P.J. J. Org. Chem. 67 (2002) 4771
10. Sajonz P., Natishan T.K., Wu Y., Williams J.M., Pipik B., DiMichele L., Novak T.J., Pitzenberger S., Dubost D., and Almarsson O. J. Liq. Chromatogr. Related Technol. 24 (2001) 2999
11. Williams J.M., Brands K.M.J., Skerlj R.T., Jobson R.B., Marchesini G., Conrad K.M., Pipik B., Savary K.A., Tsay F.-R., Houghton P.G., Sidler D.R., Dolling U.-H., DiMichele L.M., and Novak T.J. J. Org. Chem. 70 (2005) 7479
12. Takeuchi Y., Sunagawa M., Isobe Y., Hamazume Y., and Noguchi T. Chem. Pharm. Bull. 43 (1995) 689
13. Li H.-B., Lai J.-P., Jiang J., and Chen F. J. Chromatogr. A 943 (2002) 235
14. Ma X., Zhang T., Wei Y., Tu P., Chen Y., and Ito Y. J. Chromatogr. A 962 (2002) 243
15. Du Q., Cai W., Xia M., and Ito Y. J. Chromatogr. A 973 (2002) 217
16. Delaunay J.-C., Castagnio C., Chèze C., and Vercauteren J. J. Chromatogr. A 964 (2002) 123
17. Horowitz M., and Licht P. Gen. Comp. Endocrinol. 104 (1996) 364
18. Ko E.-M., Leem Y.-E., and Choi H.T. Appl. Microbiol. Biotechnol. 57 (2001) 98
19. Suzuki J., Tomizawa S., Arai H., Seki Y., Maruyama K., and Kuroume T. Nephron 66 (1994) 386
20. Abbott T.P., Holser R.A., Plattner B.J., Plattner R.D., and Purcell H.C. Ind. Crops Prod. 10 (1999) 65
21. Medina I. J. Liq. Chromatogr. Related Technol. 22 (1999) 1987
22. Kennedy J.H., Bowers J.L., Dodge J.A., Lugar C.W., Shepherd T.A., and Sharp V.S. J. Chromatogr. A 872 (2000) 75
23. Roush D.J., Antia F.D., and Göklen K.E. J. Chromatogr. A 827 (1998) 373
24. Medina I. J. Liq. Chromatogr. Related Technol. 21 (1998) 2689
25. Sun B., Belchior G.P., Ricardo-da-Silvab J.M., and Spranger M.I. J. Chromatogr. A 841 (1999) 115