Expression of Helicobacter pylori cag12 gene in Lactococcus lactis MG1363 and its oral administration to induce systemic anti-Cag12 immune response in mice

Applied Microbiology and Biotechnology

Volumn 72, Issue 3, 2006, Pages 462-470

  Kim, Su Jung ^a,b   Jun, Do Youn ^a   Yang, Chae Ha ^c   Kim, Young Ho ^a  

^a Kyungpook National University   (South Korea)

^b Daegu Health College   (South Korea)

^c Daegu Haany University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; DRUG DOSAGE; ESCHERICHIA COLI; IMMUNOLOGY; PATIENT TREATMENT; PROTEINS; VACCINES;

HELICOBACTER PYLORI CAG12 GENE; IMMUNE RESPONSE; LACTOCOCCUS LACTIS; POLYMERASE CHAIN REACTION (PCR);

GENES;

BACTERIAL PROTEIN; BACTERIAL VACCINE; GENOMIC DNA; HYBRID PROTEIN; OUTER MEMBRANE PROTEIN; POLYCLONAL ANTIBODY; PROTEIN ANTIBODY; PROTEIN CAG12; PROTEIN CAG12 ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY; BACTERIUM; DNA; DRUG DEVELOPMENT; GENE EXPRESSION; IMMUNE RESPONSE; ORAL HEALTH; POLYMERASE CHAIN REACTION; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; ASIAN; BACTERIAL GENE; BACTERIUM ISOLATE; BACTERIUM TRANSFORMATION; CAG12 GENE; CELL SECRETION; CONTROLLED STUDY; DNA SEQUENCE; ESCHERICHIA COLI; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC TRANSFORMATION; HELICOBACTER PYLORI; KOREA; LACTOCOCCUS LACTIS; MOLECULAR CLONING; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SEQUENCE HOMOLOGY; SHUTTLE VECTOR; WESTERN BLOTTING;

ESCHERICHIA COLI; HELICOBACTER PYLORI; LACTOCOCCUS LACTIS;

EID: 33747740791     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-005-0285-2     Document Type: Article

References (29)

1. Alm RA, Ling LS, Moir DT, King BL, Brown ED, Doig PC, Smith DR, Noonan B, Guild BC, deJonge BL, Carmel G, Tummino PJ, Caruso A, Uria-Nickelsen M, Mills DM, Ives C, Gibson R, Merberg D, Mills SD, Jiang Q, Taylor DE, Vovis GF, Trust TJ (1999) Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 397:176-180
2. Bermudez-Humaran LG, Langella P, Miyoshi A, Gruss A, Guerra RT, Montes de Oca-Luna R, Y Le Loir Y (2002) Production of human papillomavirus type 16 E7 protein in Lactococcus lactis. Appl Environ Microbiol 68:917-922
3. Chen M, Chen J, Liao W, Zhu S, Yu J, Leung WK, Hu P, Sung JJ (2003) Immunization with attenuated Salmonella typhimurium producing catalase in protection against gastric Helicobacter pylori infection in mice. Helicobacter 8:613-625
4. Cheun HI, Kawamoto K, Hiramatsu M, Tamaoki H, Shirahata T, Igimi S, Makino SI (2004) Protective immunity of SpaA-antigen producing Lactococcus lactis against Erysipelothrix rhusiopathiae infection. J Appl Microbiol 96:1347-1353
5. Crespo A, Suh B (2001) Helicobacter pylori infection: epidemiology, pathophysiology, and therapy. Arch Pharm Res 24:485-498
6. Czinn SJ (2004) Helicobacter infection: pathogenesis. Curr Opin Gastroenterol 20:10-15
7. Holo H, Nes IF (1989) High-frequency transformation by electroporation of Lactococcuslactis subsp. cemoris grown with glycine in osmotically stabilized media. Appl Environ Microbiol 55:3119-3123
8. Jun DY, Rue SW, Kim BW, Kim YH (2003) Detection of mitotic centromere-associated kinesin (MCAK) during cell cycle progression of human Jurkat T cells using polyclonal antibody raised against its N-terminal region overexpressed in E. coli. J Microbiol Biotechnol 13:912-918
9. Kim SJ, Jun DY, Yang JH, Kim YH (2006) Cloning and Expression of hpaA Gene of Korean Strain Helicobacter pylori K51 in Oral Vaccine Delivery Vehicle Lactococcus lactis subsp. lactis MG1363. J Microbiol Biotechnol (in press)
10. Lee MH, Roussel Y, Wiks M, Tabaqchali S (2001) Expression of Helicobacter pylori urease subunit B gene in Lactococcus lactis MG 1363 and its use as a vaccine delivery system against H. pylori infection in mice. Vaccine 19:3927-3935
11. Lee WK, Choi SH, Park SG, Choi YJ, Choe MY, Park JW, Jung SA, Byun EY, Song JY, Jung TS, Lee BS, Baik SC, Cho MJ, Youn HS, Ko GH, Kim YS, Park JH, Lee DS, Yoo HS, Ghim SY, Lee KH (1999) Genomic diversity of Helicobacter pylori. J Kor Soc Microbiol 34:519-532
12. Liu XL, Li SQ, Liu CJ, Tao HX, Zang ZS (2004) Antigen epitope of Helicobacter pylori vacuolating cytotoxin A. World J Gastroenterol 10:2340-2343
13. Llosa M, O'Callaghan D (2004) Euroconference on the biology of Type IV secretion processes: bacterial gates into the outer world. Mol Microbiol 53:1-8
14. Nakayama Y, Graham DY (2004) Helicobacter pylori infection: diagnosis and treatment. Expert Rev Anti Infect Ther 2:599-610
15. Nouaille S, Ribeiro LA, Miyoshi A, Pontes D, Le Loir Y, Oliverira SC, Langella P, Azevedo V (2003) Heterologous protein production and delivery systems for Lactococcus lactis. Genet Mol Res 2:102-111
16. Pei H, Liu J, Cheng Y, Sun C, Wang C, Lu Y, Ding J, Zhou J, Xiang H (2005) Expression of SARS-coronavirus nucleocapsid protein in Escherichia coli and Lactococcus lactis for serodiagnosis and mucosal vaccination. Appl Microbiol Biotechnol 68:220-227
17. Prinz C, Hafsi N, Voland P (2003) Helicobacter pylori virulence factors and the host immune response: implications for therapeutic vaccination. Trends Microbiol 11:134-138
18. Ribeiro LA, Azevedo V, Le Loir Y, Oliveira SC, Dieye Y, Piard JC, Gruss A, Langella P (2002) Production and targeting of the Brucella abortus antigen L7/L12 in Lactococcus lactis: a first step towards food-grade live vaccines against brucellosis. Appl Environ Microbiol 68:910-916
19. Robinson K, Chamberlain LM, Lopez MC, Rush CM, Marcotte H, Le Page RW, Wells JM (2004) Mucosal and cellular immune responses elicited by recombinant Lactococcus lactis strains expressing tetanus toxin fragment C. Infect Immun 72:2753-2761
20. Rohde M, Puls J, Buhrdorf R, Fischer W, Haas R (2003) A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system. Mol Microbiol 49:219-234
21. Satin B, Del Giudice G, Della Bianca V, Dusi S, Laudanna C, Tonello F, Kelleher D, Rappuoli R, Montecucco C, Rossi F (2000) The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor. J Exp Med 191:1467-1476
22. Steidler L, Hans W, Schotte L, Neirynck S, Obermeier F, Falk W, Fiers W, Remaut E (2000) Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 289:1352-1355
23. Tanaka J, Suzuki T, Mimuro H, Sasakawa C (2003) Structural definition on the surface of Helicobacter pylori type IV secretion apparatus. Cell Microbiol 5:395-404
24. Theisen M, Soe S, Brunstedt K, Follmann F, Bredmose L, Israelsen H, Madsen SM, Druilhe P (2004) A Plasmodium falciparum GLURP-MSP3 chimeric protein; expression in Lactococcus lactis, immunogenicity and induction of biologically active antibodies. Vaccine 22:1188-1198
25. Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388:539-547
26. Van De Guchte M, Jos M, Der Vossen BM, Kok J, Venema G (1989) Construction of a Lactococcal expression vector: expression of hen egg white lysozyme in Lactococcus lactis subsp. lactis. Appl Environ Microbiol 55:224-228
27. Xin KQ, Hoshino Y, Toda Y, Igimi S, Kojima Y, Jounai N, Ohba K, Kushiro A, Kiwaki M, Hamajima K, Klinman D, Okuda K (2003) Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env. Blood 102:223-228
28. Xu C, Li ZS, Du YQ, Tu ZX, Gong YF, Jin J, Wu HY, Xu GM (2005) Construction of a recombinant attenuated Salmonella typhimurium DNA vaccine carrying Helicobacter pylori hpaA. World J Gastroenterol 11:114-117
29. Zendehdel N, Nasseri-Moghaddam S, Malekzadeh R, Massarrat S, Sotoudeh M, Siavoshi F (2005) Helicobacter pylori reinfection rate 3 years after successful eradication. J Gastroenterol Hepatol 20:401-404