Expression and regulation of PLUNC in human nasal epithelium

Acta Oto-Laryngologica

Volumn 126, Issue 10, 2006, Pages 1073-1078

  Kim, Chang Hoon ^a   Kim, Kyubo ^a   Kim, Hyun Jik ^a   Kim, Jin Kook ^b   Lee, Jeung Gweon ^a   Yoon, Joo Heon ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

Author keywords

Host defense; Nasal epithelial cells; PLUNC; Secreted protein

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; EPITHELIUM CELL; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; LUNG; MEDIATOR RELEASE; MOLECULAR CLONING; MUCOCILIARY TRANSPORT; NOSE MUCOSA; NUCLEOTIDE SEQUENCE; PALATE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; TURBINATE;

BLOTTING, WESTERN; CELLS, CULTURED; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; NASAL MUCOSA; PEPTIDE FRAGMENTS; PHOSPHOPROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; TURBINATES;

EID: 33747723440     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.1080/00016480600606749     Document Type: Article

References (16)

1. Bingle CD, Craven CJ. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. Hum Mol Genet 2002;11:937-43.
2. LeClair EE. Four reasons to consider a novel class of innate immune molecules in the oral epithelium. J Dent Res 2003;82:944-50.
3. Bingle CD, Gorr SU. Host defense in oral and airway epithelia: chromosome 20 contributes a new protein family. Int J Biochem Cell Biol 2004;36:2144-52.
4. Bingle CD, Bingle L. Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern. Biochim Biophys Acta 2000;1493:363-7.
5. Yoon JH, Kim KS, Kim SS, Lee JG, Park IY. Secretory differentiation of serially-passaged normal human nasal epithelial cells by retinoic acid: expression of mucin and lysozyme. Ann Otol Rhinol Laryngol 2000;109:594-601.
6. Yoon JH, Moon HJ, Seong JK, Kim CH, Lee JJ, Choi JY, et al. Mucociliary differentiation according to time in human nasal epithelial cell culture. Differentiation 2002;70:77-83.
7. Weston WM, LeClair EE, Trzyna W, McHugh KM, Nugent P, Lafferty CM, et al. Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung. J Biol Chem 1999;274:13698-703.
8. Sung YK, Moon C, Yoo JY, Moon C, Pearse D, Pevsner J, et al. Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy. J Biol Chem 2002;277:12762-9.
9. Wheeler TT, Haigh BJ, McCracken JY, Wilkins RJ, Morris CA, Grigor MR. The BSP30 salivary proteins from cattle, LUNX/PLUNC and von Ebner's minor salivary gland protein are members of the PSP/LBP superfamily of proteins. Biochim Biophys Acta 2002;1579:92-100.
10. LeClair EE, Nguyen L, Bingle L, MacGowan A, Singleton V, Ward SJ, et al. Genomic organization of the mouse plunc gene and expression in the developing airways and thymus. Biochem Biophys Res Commun 2001;284:792-7.
11. Iwao K, Watanabe T, Fujiwara Y, Takami K, Kodama K, Higashiyama M, et al. Isolation of a novel human lungspecific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Int J Cancer 2001;91:433-7.
12. Di YP, Harper R, Zhao Y, Pahlavan N, Finkbeiner W, Wu R. Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts. J Biol Chem 2003;278:1165-73.
13. Lindahl M, Stahlbom B, Tagesson C. Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight. Electrophoresis 2001;22:1795-800.
14. Ghafouri B, Stahlbom B, Tagesson C, Lindahl M. Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting. Proteomics 2002;2:112-20.
15. Vitorino R, Lobo MJ, Ferrer-Correira AJ, Dubin JR, Tomer KB, Domingues PM, et al. Identification of human whole saliva protein components using proteomics. Proteomics 2004;4:1109-15.
16. Campos MA, Abreu AR, Nlend MC, Cobas MA, Conner GE, Whitney PL. Purification and characterization of PLUNC from human tracheobronchial secretions. Am J Respir Cell Mol Biol 2004;30:184-92