AFP mRNA detected in bone marrow by real-time quantitative RT-PCR analysis predicts survival and recurrence after curative hepatectomy for hepatocellular carcinoma

Annals of Surgery

Volumn 244, Issue 3, 2006, Pages 451-460

  Kamiyama, Toshiya ^a   Takahashi, Masato ^a   Nakagawa, Takahito ^a   Nakanishi, Kazuaki ^a   Kamachi, Hirofumi ^a   Suzuki, Tomomi ^a   Shimamura, Tsuyoshi ^a   Taniguchi, Masahiko ^a   Ozaki, Michitaka ^a   Matsushita, Michiaki ^b   Furukawa, Hiroyuki ^a   Todo, Satoru ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; BIOLOGICAL MARKER; MESSENGER RNA;

ADULT; AGED; ARTICLE; BLOOD; BLOOD ANALYSIS; BLOOD SAMPLING; BONE MARROW; BONE MARROW BIOPSY; CANCER INVASION; CANCER RECURRENCE; CANCER RISK; CANCER SURGERY; CANCER SURVIVAL; CARCINOMA CELL; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOLOGY; DEATH; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; GENE TARGETING; GENETIC IDENTIFICATION; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; MULTIPLE CANCER; MULTIVARIATE ANALYSIS; PATHOLOGY; PORTAL VEIN; POSTOPERATIVE PERIOD; PREDICTION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; SYSTEMIC CIRCULATION; TUMOR DIFFERENTIATION; TUMOR VOLUME; UNIVARIATE ANALYSIS; VASCULARIZATION;

ALPHA-FETOPROTEINS; BONE MARROW; CARCINOMA, HEPATOCELLULAR; FEMALE; FOLLOW-UP STUDIES; HEPATECTOMY; HUMANS; INCIDENCE; JAPAN; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 33747723329     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.sla.0000234840.74526.2b     Document Type: Article

References (26)

1. Kumada T, Nakano S, Takeda I, et al. Patterns of recurrence after initial treatment in patients with small hepatocellular carcinoma. Hepatology. 1997;25:87-92.
2. Yamanaka N, Okamoto E, Fujihara S, et al. Do the tumor cells of hepatocellular carcinomas dislodge into the portal venous stream during hepatic resection? Cancer. 1992;70:2263-2267.
3. Diel IJ, Kaufmann M, Goerner R, et al. Detection of tumor cells in bone marrow of patients with primary breast cancer: a prognostic factor for distant metastasis. J Clin Oncol. 1992;10:1534-1539.
4. Lindemann F, Schlimok G, Dirschedl P, et al. Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet. 1992;340:685-689.
5. Pantel K, Izbicki J, Passlick B, et al. Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases. Lancet. 1996;347:649-653.
6. Soeth E, Vogel I, Roder C, et al. Comparative analysis of bone marrow and venous blood isolates from gastrointestinal cancer patients for the detection of disseminated tumor cells using reverse transcription PCR. Cancer Res. 1997;57:3106-3110.
7. Wiedswang G, Borgen E, Karesen R, et al. Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer. J Clin Oncol. 2003;21:3469-3478.
8. Zhang YL, Feng JG, Gou JM, et al. Detection of CK20mRNA in peripheral blood of pancreatic cancer and its clinical significance. World J Gastroenterol. 2005;11:1023-1027.
9. Matsumura M, Niwa Y, Kato N, et al. Detection of alpha-fetoprotein mRNA, an indicator of hematogenous spreading hepatocellular carcinoma, in the circulation: a possible predictor of metastatic hepatocellular carcinoma. Hepatology. 1994;20:1418-1425.
10. Komeda T, Fukuda Y, Sando T, et al. Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood. Cancer. 1995;75:2214-2219.
11. Lemoine A, Bricon TL, Salvucci M, et al. Prospective evaluation of circulating hepatocytes by alpha-fetoprotein mRNA in humans during liver surgery. Ann Surg. 1997;226:43-50.
12. Okuda N, Nakao A, Takeda S, et al. Clinical significance of alpha-fetoprotein mRNA during perioperative period in HCC. Hepatogastroenterology. 1999;46:381-386.
13. Kienle P, Weitz J, Klaes R, et al. Detection of isolated disseminated tumor cells in bone marrow and blood samples of patients with hepatocellular carcinoma. Arch Surg. 2000;135:213-218.
14. Aselmann H, Wolfes H, Rohde F, et al. Quantification of alpha 1-fetoprotein mRNA in peripheral blood and bone marrow: a tool for perioperative evaluation of patients with hepatocellular carcinoma. Langenbecks Arch Surg. 2001;386:118-123.
15. Ijichi M, Takayama T, Matsumura M, et al. α-Fetoprotein mRNA in the circulation as a predictor of postsurgical recurrence of hepatocellular carcinoma: a prospective study. Hepatology. 2002;35:853-860.
16. Witzigmann H, Geissler F, Benedix F, et al. Prospective evaluation of circulating hepatocytes by alpha-fetoprotein messenger RNA in patients with hepatocellular carcinoma. Surgery. 2002;131:34-43.
17. Gross-Goupil M, Saffroy R, Azoulay D, et al. Real time quantification of AFP mRNA to assess hematogenous dissemination after transarterial chemoembolization of hepatocellular carcinoma. Ann Surg. 2003;238:241-248.
18. Jeng KS, Sheen IS, Tsai YC. Circulating messenger RNA of alpha-fetoprotein: a possible risk factor of recurrence after resection of hepatocellular carcinoma. Arch Surg. 2004;139:1055-1060.
19. Sutcliffe R, Maguire D, Murphy P, et al. Detection and clinical significance of bone marrow micrometastases in patients undergoing liver transplantation for hepatocellular carcinoma. Transplantation. 2005;80:88-94.
20. Morimoto O, Nagano H, Miyamoto A, et al. Association between recurrence of hepatocellular carcinoma and alpha-fetoprotein messenger RNA levels in peripheral blood. Surg Today. 2005;35:1033-1041.
21. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
22. Kar S, Carr BI. Related articles: detection of liver cells in peripheral blood of patients with advanced-stage hepatocellular carcinoma. Hepatology. 1995;21:403-407.
23. Hillaire S, Barbu V, Boucher E, et al. Albumin messenger RNA as a marker of circulating hepatocytes in hepatocellular carcinoma. Gastroenterology. 1994;106:239-242.
24. Chelly J, Concordet JP, Kaplan JC, et al. Illegitimate transcription: transcription of any gene in any cell typa. Proc Natl Acad Sci USA. 1989;86:2617-2621.
25. Esteban C, Trojan J, Macho A, et al. Activation of an alpha-fetoprotein/receptor pathway in human normal and malignant peripheral blood mononuclear cells. Leukemia. 1993;7:1807-1816.
26. Oka H, Kurioka N, Kim K, et al. Prospective study of early detection of hepatocellular carcinoma in patients with cirrhosis. Hepatology. 1990;12:680-687.