Biology-driven diversity: Concept of focused diversity

Chemical Biology and Drug Design

Volumn 68, Issue 1, 2006, Pages 67-69

  Kiselyov, Alex S ^a  

^a CHEMDIV INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; GENE PRODUCT; MEMBRANE PROTEIN; PHOSPHATASE; PHOSPHOTRANSFERASE; SONIC HEDGEHOG PROTEIN;

ALGORITHM; BIODIVERSITY; BIOLOGY; CELL FUNCTION; DRUG DISCRIMINATION; DRUG SCREENING; DRUG TARGETING; FOCUSED DIVERSITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SHORT SURVEY; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ANIMALS; CONCEPT FORMATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HEDGEHOG PROTEINS; HUMANS; MICE; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; VERATRUM ALKALOIDS;

EID: 33747707613     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2006.00409.x     Document Type: Short Survey

References (3)

1. Oprea T. (2002) Chemical space navigation in lead discovery. Curr Opin Chem Biol;6:384-389.
2. Kiselyov A. (2006) The concept of focused diversity: a new algorithm for building screening libraries. IDrugs;9:193-198.
3. Berman D. Karhadkar S. Hallahan A. Pritchard J. Eberhart C. Watkins D. Chen J., Cooper M., Taipale J., Olson J., Beachy P. (2002) Medulloblastoma growth inhibition by Hedgehog pathway blockade. Science;297:1559-1561.