메뉴 건너뛰기




Volumn 73, Issue 4, 2006, Pages 178-192

Chronic myelogenous leukemia: From molecular biology to clinical aspects and novel targeted therapies

Author keywords

Chronic myelogenous leukemia; Imatinib; Transgenic mice

Indexed keywords

BCR ABL PROTEIN; DASATINIB; IMATINIB; NILOTINIB; PROTEIN TYROSINE KINASE;

EID: 33747694441     PISSN: 13454676     EISSN: 13473409     Source Type: Journal    
DOI: 10.1272/jnms.73.178     Document Type: Review
Times cited : (11)

References (89)
  • 1
    • 0000358195 scopus 로고
    • Case of hypertrophy of the spleen and liver, in which death took place from suppuration of the blood
    • Bennett JH: Case of hypertrophy of the spleen and liver, in which death took place from suppuration of the blood. Edinburgh Medical and Surgical Journal 1845; 64: 413-423.
    • (1845) Edinburgh Medical and Surgical Journal , vol.64 , pp. 413-423
    • Bennett, J.H.1
  • 2
    • 0000358194 scopus 로고
    • Case of disease of the spleen, in which death took place in consequence of the presence of purulent matter in the blood
    • Cragie D: Case of disease of the spleen, in which death took place in consequence of the presence of purulent matter in the blood. Edinburgh Medical and Surgical Journal 1845; 64: 400-413.
    • (1845) Edinburgh Medical and Surgical Journal , vol.64 , pp. 400-413
    • Cragie, D.1
  • 3
  • 5
    • 0000286732 scopus 로고
    • Minute chromosome in human chrnic granulocytic leukemia
    • Nowell PC, Hungerford DAA: minute chromosome in human chrnic granulocytic leukemia. Science 1960; 132: 1497.
    • (1960) Science , vol.132 , pp. 1497
    • Nowell, P.C.1    Hungerford, D.A.A.2
  • 6
    • 0015694748 scopus 로고
    • A new consistent chromosomal abnormality in chrnic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley JD: A new consistent chromosomal abnormality in chrnic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973; 243: 290-293.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 7
    • 0021346853 scopus 로고
    • Philaderphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
    • Groffen J, Stephenson JR, Heinterkamp N, De Klein A, Bartram CR, Grosveld G: Philaderphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 1984; 36: 93-99.
    • (1984) Cell , vol.36 , pp. 93-99
    • Groffen, J.1    Stephenson, J.R.2    Heinterkamp, N.3    De Klein, A.4    Bartram, C.R.5    Grosveld, G.6
  • 8
    • 0021802841 scopus 로고
    • Fused transcript of abl and bcr genes in chrnic myelogenous leukemia
    • Shtivelman E, Lifshitz B, Gale RP, Canaani E: Fused transcript of abl and bcr genes in chrnic myelogenous leukemia. Nature 1985; 315: 550-554.
    • (1985) Nature , vol.315 , pp. 550-554
    • Shtivelman, E.1    Lifshitz, B.2    Gale, R.P.3    Canaani, E.4
  • 10
    • 0035174344 scopus 로고    scopus 로고
    • The SH2 domain of Bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype
    • Zhang X, Rong R, Hao SX, Pear WS, Ren R: The SH2 domain of Bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype. Blood 2001; 97: 277-287.
    • (2001) Blood , vol.97 , pp. 277-287
    • Zhang, X.1    Rong, R.2    Hao, S.X.3    Pear, W.S.4    Ren, R.5
  • 11
    • 0032841181 scopus 로고    scopus 로고
    • Growth factor independence and BCR/ABL transformation: Promise and pitfalls of murine model systems and assays
    • Ghaffari S, Daley GQ, Lodish HF: Growth factor independence and BCR/ABL transformation: promise and pitfalls of murine model systems and assays. Leukemia 1999; 13: 1200-1206.
    • (1999) Leukemia , vol.13 , pp. 1200-1206
    • Ghaffari, S.1    Daley, G.Q.2    Lodish, H.F.3
  • 12
    • 0025766195 scopus 로고
    • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner
    • Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON: BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell 1991; 66: 161-171.
    • (1991) Cell , vol.66 , pp. 161-171
    • Pendergast, A.M.1    Muller, A.J.2    Havlik, M.H.3    Maru, Y.4    Witte, O.N.5
  • 13
    • 0031459864 scopus 로고    scopus 로고
    • dok a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells
    • dok a constitutively tyrosine-phosphorylated , GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 1997; 88: 197-204.
    • (1997) Cell , vol.88 , pp. 197-204
    • Carpino, N.1    Wisniewski, D.2    Strife, A.3
  • 14
    • 0030917924 scopus 로고    scopus 로고
    • Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells
    • Bhat A, Kolibaba K, Oda T, Ohno-Jones S, Heaney C, Druker BJ: Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells. J Biol Chem 1997; 272: 16170-16175.
    • (1997) J Biol Chem , vol.272 , pp. 16170-16175
    • Bhat, A.1    Kolibaba, K.2    Oda, T.3    Ohno-Jones, S.4    Heaney, C.5    Druker, B.J.6
  • 15
    • 0035166003 scopus 로고    scopus 로고
    • The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase
    • Roumiantsev S, de Aos IE, Varticovski L, Ilaria R, Van Etten RA: The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase. Blood 2001; 97: 4-13.
    • (2001) Blood , vol.97 , pp. 4-13
    • Roumiantsev, S.1    De Aos, I.E.2    Varticovski, L.3    Ilaria, R.4    Van Etten, R.A.5
  • 16
    • 0034641709 scopus 로고    scopus 로고
    • Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity
    • Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity. Proc Natl Acad Sci USA 2000; 97: 10538-10543.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10538-10543
    • Jiang, Y.1    Zhao, R.C.H.2    Verfaillie, C.M.3
  • 17
  • 19
    • 0026608119 scopus 로고
    • Initiation of dysregulated growth of multipotent progenitor cells by bcr-abl in vitro
    • Gishizky ML, Witte ON: Initiation of dysregulated growth of multipotent progenitor cells by bcr-abl in vitro. Science 1992; 256: 836-839.
    • (1992) Science , vol.256 , pp. 836-839
    • Gishizky, M.L.1    Witte, O.N.2
  • 20
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Sawyers CL: Chronic myeloid leukemia. N Engl J Med 1999; 340: 1330-1340.
    • (1999) N Engl J Med , vol.340 , pp. 1330-1340
    • Sawyers, C.L.1
  • 21
    • 0030725775 scopus 로고    scopus 로고
    • The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates Gl-to-S phase transition in hematopoietic cells
    • Cortez D, Reuther G, Pendergast AM: The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates Gl-to-S phase transition in hematopoietic cells. Oncogene 1997; 15: 2333-2342.
    • (1997) Oncogene , vol.15 , pp. 2333-2342
    • Cortez, D.1    Reuther, G.2    Pendergast, A.M.3
  • 22
    • 0027368352 scopus 로고
    • BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein
    • Pendergast AM, Quilliam LA, Cripe LD, et al.: BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 1993; 75: 175-185.
    • (1993) Cell , vol.75 , pp. 175-185
    • Pendergast, A.M.1    Quilliam, L.A.2    Cripe, L.D.3
  • 23
    • 0030710188 scopus 로고    scopus 로고
    • Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway
    • Skorski T, Bellacosa A, Nieborowska-Skorska M, et al.: Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J 1997; 16: 6151-6161.
    • (1997) EMBO J , vol.16 , pp. 6151-6161
    • Skorski, T.1    Bellacosa, A.2    Nieborowska-Skorska, M.3
  • 24
    • 0024309743 scopus 로고
    • A bcr-v-abl oncogene induces lymphomas in transgenic mice
    • Hariharan IK, Harris AW, Crawford M, et al.: A bcr-v-abl oncogene induces lymphomas in transgenic mice. Molecular Cell Biology 1989; 9: 2798-2805.
    • (1989) Molecular Cell Biology , vol.9 , pp. 2798-2805
    • Hariharan, I.K.1    Harris, A.W.2    Crawford, M.3
  • 26
    • 0032533257 scopus 로고    scopus 로고
    • Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow
    • Pear WS, Miller JP, Xu L, et al.: Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow. Blood 1998; 92: 3780-3792.
    • (1998) Blood , vol.92 , pp. 3780-3792
    • Pear, W.S.1    Miller, J.P.2    Xu, L.3
  • 27
    • 0032533620 scopus 로고    scopus 로고
    • Bcr-Abl Efficiently Induces a Myeloproliferative Disease and Production of Excess Interleukin-3 and Granulocyte-Macrophage Colony-Stimulating Factor in Mice: A Novel Model for Chronic Myelogenous Leukemia
    • Zhang X, Ren R: Bcr-Abl Efficiently Induces a Myeloproliferative Disease and Production of Excess Interleukin-3 and Granulocyte-Macrophage Colony-Stimulating Factor in Mice: A Novel Model for Chronic Myelogenous Leukemia. Blood 1998; 92: 3829-3840.
    • (1998) Blood , vol.92 , pp. 3829-3840
    • Zhang, X.1    Ren, R.2
  • 28
    • 0033519238 scopus 로고    scopus 로고
    • The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity
    • Li S, Ilaria RJ, Million RP, Daley GQ, Van Etten RA: The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med 1999; 189: 1399-1412.
    • (1999) J Exp Med , vol.189 , pp. 1399-1412
    • Li, S.1    Ilaria, R.J.2    Million, R.P.3    Daley, G.Q.4    Van Etten, R.A.5
  • 29
    • 0030221263 scopus 로고    scopus 로고
    • Normal and leukemic human stem cells assayed in SCID mice
    • Dick JE: Normal and leukemic human stem cells assayed in SCID mice. Semin Immunol 1996; 8: 197-206.
    • (1996) Semin Immunol , vol.8 , pp. 197-206
    • Dick, J.E.1
  • 30
    • 0029826591 scopus 로고    scopus 로고
    • Phenotype and function of human hematopoietic cells engrafting immune- deficient CB 17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells
    • Pflumio F, Izac B, Katz A, Shultz LD, Vainchenker W, Coulombel L: Phenotype and function of human hematopoietic cells engrafting immune- deficient CB 17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells. Blood 1996; 88: 3731-3740.
    • (1996) Blood , vol.88 , pp. 3731-3740
    • Pflumio, F.1    Izac, B.2    Katz, A.3    Shultz, L.D.4    Vainchenker, W.5    Coulombel, L.6
  • 31
    • 0030925298 scopus 로고    scopus 로고
    • Kinetic Evidence of the Regeneration of Multilineage Hematopoiesis from Primitive Cells in Normal Human Bone Marrow Transplanted into Immunodeficient Mice
    • Cashman JD, Lapidot T, Wang JCY, et al.: Kinetic Evidence of the Regeneration of Multilineage Hematopoiesis From Primitive Cells in Normal Human Bone Marrow Transplanted Into Immunodeficient Mice. Blood 1997; 89: 4307-4316.
    • (1997) Blood , vol.89 , pp. 4307-4316
    • Cashman, J.D.1    Lapidot, T.2    Wang, J.C.Y.3
  • 32
    • 13344262695 scopus 로고    scopus 로고
    • Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis
    • Sirard C, Lapidot T, Vormoor J, et al.: Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis. Blood 1996; 87: 1539-1548.
    • (1996) Blood , vol.87 , pp. 1539-1548
    • Sirard, C.1    Lapidot, T.2    Vormoor, J.3
  • 33
    • 0032529306 scopus 로고    scopus 로고
    • The Kinetics and Extent of Engraftment of Chronic Myelogenous Leukemia Cells in Non-Obese Diabetic/Severe Combined Immunodeficiency Mice Reflect the Phase of the Donor's Disease: An in vivo Model of Chronic Myelogenous Leukemia Biology
    • Dazzi F, Capelli D, Hesserjian R, et al.: The Kinetics and Extent of Engraftment of Chronic Myelogenous Leukemia Cells in Non-Obese Diabetic/Severe Combined Immunodeficiency Mice Reflect the Phase of the Donor's Disease: An In vivo Model of Chronic Myelogenous Leukemia Biology. Blood 1998; 92: 1390-1396.
    • (1998) Blood , vol.92 , pp. 1390-1396
    • Dazzi, F.1    Capelli, D.2    Hesserjian, R.3
  • 35
    • 0035344668 scopus 로고    scopus 로고
    • Models of chronic myeloid leukemia
    • Van Etten RA: Models of chronic myeloid leukemia. Curr Oncol Rep 2001; 3: 228-237.
    • (2001) Curr Oncol Rep , vol.3 , pp. 228-237
    • Van Etten, R.A.1
  • 38
    • 0038240346 scopus 로고    scopus 로고
    • Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: Longer disease latency, thrombocytosis, and mild leukocytosis
    • Inokuchi K, Dan K, Takatori M, et al.: Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis. Blood 2003; 102: 320-322.
    • (2003) Blood , vol.102 , pp. 320-322
    • Inokuchi, K.1    Dan, K.2    Takatori, M.3
  • 39
    • 0033987718 scopus 로고    scopus 로고
    • Reversibility of acute B-cell leukaemia induced by BCR-ABL1
    • Huettner CS, Zhang P, Van Etten RA, Tenen DG: Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nat Genet 2000; 24: 57-60.
    • (2000) Nat Genet , vol.24 , pp. 57-60
    • Huettner, C.S.1    Zhang, P.2    Van Etten, R.A.3    Tenen, D.G.4
  • 40
    • 0142183447 scopus 로고    scopus 로고
    • Inducible expression of BCR/ABL using human CD 34 regulatory elements results in a megakaryocytic myeloproliferative syndrome
    • Huettner CS, Koschmieder S, Iwasaki H, et al.: Inducible expression of BCR/ABL using human CD 34 regulatory elements results in a megakaryocytic myeloproliferative syndrome. Blood 2003; 102: 3363-3370.
    • (2003) Blood , vol.102 , pp. 3363-3370
    • Huettner, C.S.1    Koschmieder, S.2    Iwasaki, H.3
  • 41
    • 19944426030 scopus 로고    scopus 로고
    • Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis
    • Koschmieder S, Gottgens B, Zhang P, et al.: Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis. Blood 2005; 105: 324-334.
    • (2005) Blood , vol.105 , pp. 324-334
    • Koschmieder, S.1    Gottgens, B.2    Zhang, P.3
  • 42
    • 0036569823 scopus 로고    scopus 로고
    • Neutrophilic-chronic myeloid leukemia: Low levels of p230 BCR/ABL mRNA and undetectable BCR/ABL protein may predict an indolent course
    • Verstovsek S, Lin H, Kantarjian H, et al.: Neutrophilic-chronic myeloid leukemia: low levels of p230 BCR/ABL mRNA and undetectable BCR/ABL protein may predict an indolent course. Cancer 2002; 94: 2416-2425.
    • (2002) Cancer , vol.94 , pp. 2416-2425
    • Verstovsek, S.1    Lin, H.2    Kantarjian, H.3
  • 43
    • 0029976933 scopus 로고    scopus 로고
    • Elevated platelet count features the variant type of BCR/ABL junction in chronic myelogenous leukaemia
    • Yamagata T, Mitani K, Kanda Y, Yazaki Y, Hirai H: Elevated platelet count features the variant type of BCR/ABL junction in chronic myelogenous leukaemia. Br J Haematol 1996; 94: 370-372.
    • (1996) Br J Haematol , vol.94 , pp. 370-372
    • Yamagata, T.1    Mitani, K.2    Kanda, Y.3    Yazaki, Y.4    Hirai, H.5
  • 44
    • 0035166003 scopus 로고    scopus 로고
    • The Src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase
    • Roumiantsev S, de Aos I, Varticovski L, Ilaria RL, Van Etten RA: The Src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase. Blood 2001; 97: 4-13.
    • (2001) Blood , vol.97 , pp. 4-13
    • Roumiantsev, S.1    De Aos, I.2    Varticovski, L.3    Ilaria, R.L.4    Van Etten, R.A.5
  • 45
    • 0036280235 scopus 로고    scopus 로고
    • Bcb-Abl variants: Biological and clinical aspects
    • Advani AS, Pendergast AM: Bcb-Abl variants: biological and clinical aspects. Leukem Res 2002; 26: 713-720.
    • (2002) Leukem Res , vol.26 , pp. 713-720
    • Advani, A.S.1    Pendergast, A.M.2
  • 46
    • 0029060662 scopus 로고
    • Establishment and molecular characterization of a novel leukemic cell line with Philadelphia chromosome expressing p230 BCR/ABL fusion protein
    • Wada H, Mizutani S, Nishimura J, et al.: Establishment and molecular characterization of a novel leukemic cell line with Philadelphia chromosome expressing p230 BCR/ABL fusion protein. Cancer Res 1995; 55: 3192-3196.
    • (1995) Cancer Res , vol.55 , pp. 3192-3196
    • Wada, H.1    Mizutani, S.2    Nishimura, J.3
  • 47
    • 0025873083 scopus 로고
    • Bcr encodes a GTPase-activating protein for p21rac
    • Diekmann D, Brill S, Garrett MD, et al.: Bcr encodes a GTPase-activating protein for p21rac. Nature 1991; 351: 400-402.
    • (1991) Nature , vol.351 , pp. 400-402
    • Diekmann, D.1    Brill, S.2    Garrett, M.D.3
  • 48
    • 0029348008 scopus 로고
    • Abl tyrosine protein kinase
    • Laneuville P: Abl tyrosine protein kinase. Semin Immunol 1995; 7: 255-266.
    • (1995) Semin Immunol , vol.7 , pp. 255-266
    • Laneuville, P.1
  • 49
    • 2442465000 scopus 로고    scopus 로고
    • Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
    • Hu Y, Liu Y, Pelletier S, et al.: Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet 2004; 36: 453-461.
    • (2004) Nat Genet , vol.36 , pp. 453-461
    • Hu, Y.1    Liu, Y.2    Pelletier, S.3
  • 50
    • 0029816460 scopus 로고    scopus 로고
    • The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype
    • Melo JV: The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood 1996; 88: 2375-2384.
    • (1996) Blood , vol.88 , pp. 2375-2384
    • Melo, J.V.1
  • 51
    • 0023142769 scopus 로고
    • A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukemia
    • Kurzrock R, Shtalrid M, Romero P, et al.: A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukemia. Nature 1987; 325: 631-635.
    • (1987) Nature , vol.325 , pp. 631-635
    • Kurzrock, R.1    Shtalrid, M.2    Romero, P.3
  • 52
    • 0023105320 scopus 로고
    • A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukemia
    • Chan L, Karhi KK, Rayter SI, et al.: A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukemia. Nature 1987; 325: 635-637.
    • (1987) Nature , vol.325 , pp. 635-637
    • Chan, L.1    Karhi, K.K.2    Rayter, S.I.3
  • 53
    • 0034192222 scopus 로고    scopus 로고
    • Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases
    • Quackenbush RQ, Reuther GW, Miller JP, Courtney KD, Pear WS, Pendergast AM: Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. Blood 2000; 95: 2913-2921.
    • (2000) Blood , vol.95 , pp. 2913-2921
    • Quackenbush, R.Q.1    Reuther, G.W.2    Miller, J.P.3    Courtney, K.D.4    Pear, W.S.5    Pendergast, A.M.6
  • 54
    • 10144254429 scopus 로고    scopus 로고
    • Neutrophilic-chronic myeloid leukemia: A distinct disease with a specific molecular marker BCR/ABL with C3/A2 junction
    • Pane F, Friger F, Sindona M, et al.: Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker BCR/ABL with C3/A2 junction. Blood 1996; 88: 2410-2414.
    • (1996) Blood , vol.88 , pp. 2410-2414
    • Pane, F.1    Friger, F.2    Sindona, M.3
  • 55
    • 0024551255 scopus 로고
    • Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells
    • McLaughlin J, Chianese E, Witte ON: Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells. Mol Cell Biol 1989; 9: 1866-1874.
    • (1989) Mol Cell Biol , vol.9 , pp. 1866-1874
    • McLaughlin, J.1    Chianese, E.2    Witte, O.N.3
  • 56
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
    • Lugo TG, Pendergast AM, Muller AJ, Witte ON: Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 1990; 247: 1079-1082.
    • (1990) Science , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3    Witte, O.N.4
  • 57
    • 0029845079 scopus 로고    scopus 로고
    • p210 BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines
    • Okuda K, Golub TR, Gilliland DG, Griffin JD: p210 BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines. Oncogene 1996; 13: 1147-1152.
    • (1996) Oncogene , vol.13 , pp. 1147-1152
    • Okuda, K.1    Golub, T.R.2    Gilliland, D.G.3    Griffin, J.D.4
  • 58
    • 0024425981 scopus 로고
    • Rac, a novel ras-related family of proteins that are botulinum toxin substrates
    • Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R: Rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem 1989; 264: 16378-16382.
    • (1989) J Biol Chem , vol.264 , pp. 16378-16382
    • Didsbury, J.1    Weber, R.F.2    Bokoch, G.M.3    Evans, T.4    Snyderman, R.5
  • 59
    • 0030670095 scopus 로고    scopus 로고
    • Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein
    • McWhirter JR, Wang JY: Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein. Oncogene 1997; 15: 1625-1634.
    • (1997) Oncogene , vol.15 , pp. 1625-1634
    • McWhirter, J.R.1    Wang, J.Y.2
  • 60
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • Ridley AJ, Hall A: The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992; 70: 389-399.
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 61
    • 0023756869 scopus 로고
    • The site of the breakpoint within the bcr is a prognostic factor in Philadelphia-positive CML patients
    • Mills KI, Anderson VA, Burns JH, Birnie GD: The site of the breakpoint within the bcr is a prognostic factor in Philadelphia-positive CML patients. Blood 1988; 72: 1237-1241.
    • (1988) Blood , vol.72 , pp. 1237-1241
    • Mills, K.I.1    Anderson, V.A.2    Burns, J.H.3    Birnie, G.D.4
  • 62
    • 0027236472 scopus 로고
    • Clinical impact of breakpoint position within M-bcr in chronic myeloid leukemia
    • Fioretos T, Nilsson PG, Aman P, et al.: Clinical impact of breakpoint position within M-bcr in chronic myeloid leukemia. Leukemia 1993; 7: 1225-1231.
    • (1993) Leukemia , vol.7 , pp. 1225-1231
    • Fioretos, T.1    Nilsson, P.G.2    Aman, P.3
  • 63
    • 0028960453 scopus 로고
    • Analysis of molecular breakpoint and m-RNA transcripts in a prospective randomized trial of interferon in chronic myeloid leukaemia: No correlation with clinical features, cytogenetic response, duration of chronic phase, or survival
    • Shepherd P, Suffolk R, Halsey J, Allan N: Analysis of molecular breakpoint and m-RNA transcripts in a prospective randomized trial of interferon in chronic myeloid leukaemia: no correlation with clinical features, cytogenetic response, duration of chronic phase, or survival. Br J Haematol 1995; 89: 546-554.
    • (1995) Br J Haematol , vol.89 , pp. 546-554
    • Shepherd, P.1    Suffolk, R.2    Halsey, J.3    Allan, N.4
  • 64
    • 0026345834 scopus 로고
    • A possible correlation between the type of bcr-abl hybrid messenger RNA and platelet count in Philadelphia-positive chronic myelogenous leukemia
    • Inokuchi K, Inoue T, Tojo A, et al.: A possible correlation between the type of bcr-abl hybrid messenger RNA and platelet count in Philadelphia-positive chronic myelogenous leukemia. Blood 1991; 78: 3125-3127.
    • (1991) Blood , vol.78 , pp. 3125-3127
    • Inokuchi, K.1    Inoue, T.2    Tojo, A.3
  • 65
    • 0026411131 scopus 로고
    • The relationship between the site of breakpoints within the bcr gene and thrombopoiesis of Philadelphia-positive chronic myelocytic leukemia
    • Inokuchi K, Futaki M, Yamada T, et al.: The relationship between the site of breakpoints within the bcr gene and thrombopoiesis of Philadelphia-positive chronic myelocytic leukemia. Leukemia Research 1991; 15: 1067-1073.
    • (1991) Leukemia Research , vol.15 , pp. 1067-1073
    • Inokuchi, K.1    Futaki, M.2    Yamada, T.3
  • 66
    • 0033934404 scopus 로고    scopus 로고
    • The possible influences of B2A2 and B3A2 BCR/ABL protein structure on thrombopoiesis in chronic myeloid leukaemia
    • Perego RA, Costantini M, Cornacchini G, et al.: The possible influences of B2A2 and B3A2 BCR/ABL protein structure on thrombopoiesis in chronic myeloid leukaemia. Eur J Cancer 2000; 36: 1395-1401.
    • (2000) Eur J Cancer , vol.36 , pp. 1395-1401
    • Perego, R.A.1    Costantini, M.2    Cornacchini, G.3
  • 67
    • 0036282898 scopus 로고    scopus 로고
    • Younger age and shorter chronic phase in b2a2-positive chronic myeloid leukemia adults with high white blood cell count at diagnosis
    • Martinez-Mancilla M, Gutierrez M, Zafra de la Rosa G, Garcia-Carranca A, Gariglio P, Miranda E: Younger age and shorter chronic phase in b2a2-positive chronic myeloid leukemia adults with high white blood cell count at diagnosis. Haematologica 2002; 87: 666-668.
    • (2002) Haematologica , vol.87 , pp. 666-668
    • Martinez-Mancilla, M.1    Gutierrez, M.2    Zafra De La Rosa, G.3    Garcia-Carranca, A.4    Gariglio, P.5    Miranda, E.6
  • 68
    • 0027209326 scopus 로고
    • Will molecular biology contribute to refine prognosis and to select treatment?
    • The Molecular Biology Committee. Italian Cooperative Study Group on Chronic Myeloid Leukemia
    • Zaccaria A, Martinelli G, Buzzi M, Farabegoli P: Will molecular biology contribute to refine prognosis and to select treatment? The Molecular Biology Committee. Italian Cooperative Study Group on Chronic Myeloid Leukemia. Leuk Lymphoma 1993; 11, Suppl 1: 81-89.
    • (1993) Leuk Lymphoma , vol.11 , Issue.1 SUPPL. , pp. 81-89
    • Zaccaria, A.1    Martinelli, G.2    Buzzi, M.3    Farabegoli, P.4
  • 69
    • 0030035440 scopus 로고    scopus 로고
    • Chronic myeloid leukemia of thrombocythemic onset: A CML subtype with distinct hematological and molecular features?
    • Cervantes F, Colomer D, Vives-Corrons JL, Rozman C, Montserrat E: Chronic myeloid leukemia of thrombocythemic onset: a CML subtype with distinct hematological and molecular features? Leukemia 1996; 10: 1241-1243.
    • (1996) Leukemia , vol.10 , pp. 1241-1243
    • Cervantes, F.1    Colomer, D.2    Vives-Corrons, J.L.3    Rozman, C.4    Montserrat, E.5
  • 70
    • 0030852332 scopus 로고    scopus 로고
    • BCR-ABL transcripts in bone marrow aspirates of Philadelphia-negative essential thrombocytopenia patients: Clinical presentation
    • Blickstein D, Aviram A, Luboshitz J, et al.: BCR-ABL transcripts in bone marrow aspirates of Philadelphia-negative essential thrombocytopenia patients: clinical presentation. Blood 1997; 90: 2768-2771.
    • (1997) Blood , vol.90 , pp. 2768-2771
    • Blickstein, D.1    Aviram, A.2    Luboshitz, J.3
  • 71
    • 0036569823 scopus 로고    scopus 로고
    • Neutrophilic-chronic myeloid leukemia: Low levels of p230 BCR/ABL mRNA and undetectable p230 BCR/ABL protein may predict an indolent course
    • Verstovsek S, Lin H, Kantarjian H, et al.: Neutrophilic-chronic myeloid leukemia: Low levels of p230 BCR/ABL mRNA and undetectable p230 BCR/ABL protein may predict an indolent course. Cancer 2002; 94: 2416-2425.
    • (2002) Cancer , vol.94 , pp. 2416-2425
    • Verstovsek, S.1    Lin, H.2    Kantarjian, H.3
  • 72
    • 0037049764 scopus 로고    scopus 로고
    • BCR/ABL genes and leukemic phenotype: From molecular mechanisms to clinical correlations
    • Pane F, Intrieri M, Quintarelli C, Izzo B, Muccioli GC, Salvatore F: BCR/ABL genes and leukemic phenotype: from molecular mechanisms to clinical correlations. Oncogene 2002; 21: 8652-8667.
    • (2002) Oncogene , vol.21 , pp. 8652-8667
    • Pane, F.1    Intrieri, M.2    Quintarelli, C.3    Izzo, B.4    Muccioli, G.C.5    Salvatore, F.6
  • 73
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al.: Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996; 2: 561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 74
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
    • Buchdunger E, Zimmermann J, Mett H, et al.: Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 1996; 56: 100-104.
    • (1996) Cancer Res , vol.56 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3
  • 76
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al.: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344: 1031-1037.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 77
    • 0036094117 scopus 로고    scopus 로고
    • Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia
    • Cohen MH, Williams G, Johnson JR, et al.: Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin Cancer Res 2002; 8: 935-942.
    • (2002) Clin Cancer Res , vol.8 , pp. 935-942
    • Cohen, M.H.1    Williams, G.2    Johnson, J.R.3
  • 78
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, et al.: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293: 876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 79
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI 571) resistance
    • Branford S, Rudzki Z, Walsh S, et al.: High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI 571) resistance. Blood 2002; 99: 3472-3475.
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 80
    • 0034161460 scopus 로고    scopus 로고
    • Induction of resistance to the Abelson inhibitor STI 571 in human leukemic cells through gene amplification
    • Le Coutre P, Tassi E, Varella-Garcia M, et al.: Induction of resistance to the Abelson inhibitor STI 571 in human leukemic cells through gene amplification. Blood 2000; 95: 1758-1766.
    • (2000) Blood , vol.95 , pp. 1758-1766
    • Le Coutre, P.1    Tassi, E.2    Varella-Garcia, M.3
  • 81
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
    • Hochhaus A, Kreil S, Corbin AS, et al.: Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 2002; 16: 2190-2196.
    • (2002) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.S.3
  • 83
    • 13844251975 scopus 로고    scopus 로고
    • Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
    • Weisberg E, Manley PW, Breitenstein W, et al.: Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 2005; 7: 129-141.
    • (2005) Cancer Cell , vol.7 , pp. 129-141
    • Weisberg, E.1    Manley, P.W.2    Breitenstein, W.3
  • 84
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL: Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004; 305: 399-401.
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3    Chen, P.4    Norris, D.5    Sawyers, C.L.6
  • 85
    • 13844261144 scopus 로고    scopus 로고
    • A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance
    • Gumireddy K, Baker SJ, Cosenza SC, et al.: A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance. Proc Natl Acad Sci USA 2005; 102: 1992-1997.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1992-1997
    • Gumireddy, K.1    Baker, S.J.2    Cosenza, S.C.3
  • 86
    • 0025614040 scopus 로고
    • The location of the Philadelphia chromosomal breakpoint site and prognosis in chronic granulocytic leukemia
    • Tefferi A, Bren GD, Wagner KV, Schaid DJ, Ash RC, Thinbodeau SN: The location of the Philadelphia chromosomal breakpoint site and prognosis in chronic granulocytic leukemia. Leukemia 1990; 4: 839-842.
    • (1990) Leukemia , vol.4 , pp. 839-842
    • Tefferi, A.1    Bren, G.D.2    Wagner, K.V.3    Schaid, D.J.4    Ash, R.C.5    Thinbodeau, S.N.6
  • 87
    • 0026688906 scopus 로고
    • Molecular breakpoints and platelet counts in chrnic myeloid leukemia
    • Shepherd PCA, Bond C, Allan NC: Molecular breakpoints and platelet counts in chrnic myeloid leukemia. Blood 1992; 80: 556-557.
    • (1992) Blood , vol.80 , pp. 556-557
    • Shepherd, P.C.A.1    Bond, C.2    Allan, N.C.3
  • 88
    • 18344365978 scopus 로고    scopus 로고
    • Transgenic mouse models of BCR/ABL-positive chronic myelogenous leukemia: A Review
    • Inokuchi K: Transgenic mouse models of BCR/ABL-positive chronic myelogenous leukemia: A Review. Curr Genom 2005; 6: 89-95.
    • (2005) Curr Genom , vol.6 , pp. 89-95
    • Inokuchi, K.1
  • 89
    • 0027172203 scopus 로고
    • The relationship between the type of bcr-abl hybrid messenger RNA and thrombopoiesis in Philadelphia-positive chrnic myelogenous leukemia
    • Inokuchi K, Nomura T: The relationship between the type of bcr-abl hybrid messenger RNA and thrombopoiesis in Philadelphia-positive chrnic myelogenous leukemia. Leukem Lymphom 1993; 10: 9-15.
    • (1993) Leukem Lymphom , vol.10 , pp. 9-15
    • Inokuchi, K.1    Nomura, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.