The prevalence of the 65-kilodalton isoform of glutamic acid decarboxylase autoantibodies by glucose tolerance status in elderly patients from the cardiovascular health study

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 8, 2006, Pages 2871-2877

  Barinas Mitchell, Emma ^a   Kuller, Lewis H ^a   Pietropaolo, Susan ^b   Zhang, Ying Jian ^b   Henderson, Tyona ^b   Pietropaolo, Massimo ^a,b  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; AUTOANTIBODY; GLUTAMATE DECARBOXYLASE 65;

AGED; ARTICLE; BLOOD PRESSURE; BODY MASS; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE TOLERANCE; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; UNITED STATES;

EID: 33747632717     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-2667     Document Type: Article

References (33)

1. Haffner SM 1998 Epidemiology of type 2 diabetes: risk factors. Diabetes Care 21:3C-6C
2. Mokdad AH, Ford ES, Bowman BA, Nelson DE, Engelgau MM, Vinicor F, Marks JS 2000 Diabetes trends in the U.S.: 1990-1998. Diabetes Care 23:1278-1283
3. Boyle J, Honeycutt AA, Narayan KMV, Hoerger TJ, Geiss LS, Chen H, Thompson TJ 2001 Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the U.S. Diabetes Care 24:1936-1940
4. Humphrey AR, Mcarty DJ, Mackay IR, Rowley MJ, Dwyer T, Zimmet P 1998 Autoantibodies to glutamic acid decarboxylase and phenotypic features associated with early insulin treatment in individuals with adult-onset diabetes mellitus. Diabet Med 15:113-119
5. Juneja R, Hirsch IB, Naik RG, Brooks-Worrell BM, Greenbaum CJ, Palmer JP 2001 Islet cell antibodies and glutamic acid decarboxylase antibodies, but not the clinical phenotype, help to identify type 1 (1/2) diabetes in patients presenting with type 2 diabetes. Metab Clin Exp 50:1008-1013
6. Pietropaolo M, Barinas-Mitchell E, Pietropaolo SL, Kuller LH, Trucco M 2000 Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes mellitus. Diabetes 49:32-38
7. Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase PH, Eisenbarth GS 1996 Prediction of type I diabetes mellitus in first degree relatives using a combination of insulin, glutamic acid decarboxylase and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-933
8. Pietropaolo M, Eisenberth GS 2001 Autoantibodies in human diabetes. Curr Dir Autoimmun 4:252-282
9. Tuomi T, Carlsson Å, Li H, Isomaa B, Miettien A, Nilssoon A, Nissén M, Ehrnström B-O, Forsén B, Snickars B, Lahti K, Forsblom C, Saloranta C, Taskinen M-R, Groop LC 1999 Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies. Diabetes 48:150-157
10. Turner R, Stratton I, Horton V, Manley S, Zimmet P, Mackay IR, Shattock M, Bottazzo GF, Holman R, for UK Prospective Diabetes Study (UKPDS) Group 1997 UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. Lancet 350:1288-1293
11. Borg H, Gottsater A, Fernlund P, Sundkvist G 2002 A 12-year prospective study of the relationship between islet antibodies and β-cell function at and after diagnosis in patients with adult-onset diabetes. Diabetes 51:1754-1762
12. Alberti KGMM, Zimmet PZ, for the WHO Consultation 1998 Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet Med 15:539-553
13. Zimmet PZ, Tuomi T, Mackay IR, Rowley MJ, Knowles W, Cohen M, Lang DA 1994 Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency. Diabet Med 11:299-303
14. Groop LC, Botazzo GF, Doniach D 1986 Islet cell antibodies identify latent type 1 diabetes in patients aged 35-75 years at diagnosis. Diabetes 35:237-241
15. Torn C, Landin-Olsson M, Ostman J, Schersten B, Arnqvist H, Blohme G, Bjork E, Bolinder J, Eriksson J, Littorin B, Nystrom L, Sundkvist G, Lernmark A 2000 Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as type 1 diabetes on clinical grounds. Diabet Metab Res Rev 16:442-447
16. Grasso YZ, Reddy SK, Rosenfeld CR, Hussein WI, Hoogwerf BJ, Faiman C, Gupta MK 2001 Autoantibodies to IA-2 and GAD65 in patients with type 2 diabetes mellitus of varied duration: prevalence and correlation with clinical features. Endocr Pract 7:339-345
17. Barinas-Mitchell E, Pietropaolo S, Zhang Y-J, Henderson T, Trucco M, Kuller L, Pietropaolo M 2004 Islet cell autoimmunity in a triethnic adult population of the National Health and Nutrition Examination Survey (NHANES) III. Diabetes 53:1293-1302
18. Tell GS, Fried LP, Lind B, Manolio TA, Newman AB, Borhani NO 1993 Recruitment of adults 65 years and older as participants in the cardiovascular health study. Ann Epidemiol 3:358-366
19. Fried LP, Borhani NO, Enright P, Furberg CD, Gardin JM, Kronmal RA, Kuller LH, Manolio TA, Mittelmark MB, Newman A, O'Leary D, Psaty B, Rautaharju P, Tracy R 1991 The cardiovascular health study: design and rationale. Ann Epidemiol 1:263-276
20. Cushman M, Cornell ES, Howard PR, Bovill EG, Tracy RP 1995 Laboratory methods and quality assurance in the Cardiovascular Health Study. Clin Chem 41:264-270
21. World Health Organization 1985 Diabetes mellitus. Report of a WHO study group. Technical Report Series 727. Geneva: World Health Organization
22. American Diabetes Association 1997 Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 7:1183-1197
23. Baekkeskov S, Aanstoot H, Christgau S, Reetz A, Solimena MS, Cascalho M, Folli F, Richter-Olsen H, DeCamilli P 1990 Identification of the 64K autoantigen in insulin dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347:151-156
24. Grubin, CE, Daniels T, Toivola B, Landin-Olsson M, Hagopian WA, Li L, Karlsen AE, Boel E, Michelsen B, Lernmark A 1994 A novel radio-binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 37:344-350
25. Pietropaolo M, Peakman M, Pietropaolo SL, Zanone MM, Foley TP, Becker DJ, Trucco M 1998 Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus. J Autoimmun 11:1-10
26. Bingley PJ, Bonifacio E, Mueller PW, and participating laboratories 2003 Diabetes antibody standardization program: first assay proficiency evaluation. Diabetes 52:1128-1136
27. Ruige JB, Batstra MR, Aanstoot HJ, Bouter LM, Bruining GJ, De Neeling JN, Heine RJ 1997 Low prevalence of antibodies to GAD65 in a 50- to 74-year-old general Dutch population. The Hoorn Study. Diabetes Care 20:1108-1110
28. Kronmal RA, Barzilay JI, Tracy RP, Savage PJ, Orchard TJ, Burke GL 2004 The relationship of fasting serum radioimmune insulin levels to incident coronary heart disease in an insulin-treated diabetic cohort. J Clin Endocrinol Metab 6:2852-2858
29. Chen M, Bergman RN, Pacini G, Porte Jr D 1985 Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased β-cell function. J Clin Endocrinol Metab 60:13-20
30. 1993 The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 329:977-986
31. Ziegler AG, Hummel M, Schenker M, Bonifacio E 1999 Autoantibody appearance and risk for development of childhood diabetes in offspring parents with type 1 diabetes. The 2-year analysis of the German BABYDIAB study. Diabetes 48:460-468
32. Niskanen LK, Tuomi T, Karjalainen J, Groop LC, Uusitupa M 1995 GAD antibodies in NIDDM. Ten-year follow-up from the diagnosis. Diabetes Care 18:1557-1565
33. Syed MA, Barinas-Mitchell E, Pietropaolo SL, Zhang YJ, Henderson TS, Kelley DE, Korytkowski MT, Donahue RP, Tracy RP, Trucco M, Kuller LH, Pietropaolo M 2002 Is type 2 diabetes a chronic inflammatory/autoimmune disease? Diabetes Nutr Metab 15:68-83